<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nPhD, ERT, DSc, FATS, DHonC, <\/span><\/strong>DHonC, DHonC, HonProf, FMRAS and FMWAS<\/span><\/strong>
Professor and Chairman\u00a0<\/strong><\/span>Department of Toxicology & Forensic Science, Medical School, University of Crete<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Real life risk simulations (RLRS) in Safety Toxicology: Another Challenge for Precision Medicine<\/strong><\/span>
Author: Aristidis Tsatsakis, PhD, ERT, DSc<\/span><\/p>\nABSTRACT:<\/span>
Risk assessment for human protection is historically and up to nowadays based on some long-established practices and assumptions for hazard identification and characterisation, such as a) testing in high doses, b) testing only of single chemicals, and c) linear extrapolation to low doses. Though these practices were considered handy and useful for many decades, it is now globally recognised that they are not simulated real life conditions. Real life risk is coming from the exposure to complex mixtures of many different chemicals and their toxicity in mixtures might be altered in relation of their toxicity when studied in isolation. In addition, real life exposure is mainly exposure to low doses. However, the assumption that low dose\u2019s toxicity is covered from experimentation in high doses because all effects are following a linear and monotonic dose-response curve, is seriously challenged through a number ofstudies of the last three decades. As many of the technical drawbacks of the past are nowadays eliminated and new technologies and methodologies are available, we consider that it is time to go ahead with toxicology for Real Life Risk Simulation. As more are known in relation to real life combined exposure, we focus our research in an area with complete lack of data, meaning the low-dose-long-term toxicity testing of complex chemicals\u2019 mixtures that simulates real life exposure. The Toxicology of the 21st century faces with the challenge of explain why from epidemiological studies we found that chemicals in doses consider safety are important factors that lead to the development of different chronic diseases. Precision medicine approach based on metabolome, genome, and microbiome relate data on the effect of toxic exposure to the phenotype. Toxic exposure inflicts damage at metabolic, genetic and microbiome levels, increasing thus cellular turnover, telomere attrition and the rate of aging. Data from our ongoing research in this direction will be presented.<\/p>\nSHORT CV<\/span><\/p>\nAristides Tsatsakis is the Director of the Department of Toxicology and Forensic Sciences of the Medical School at the University of Crete and the University Hospital of Heraklion and also the Chairman of the Division of Morphology of the Medical School of the University of Crete in Greece.
He served as President of the Federation of European Toxicologists and European Societies of Toxicology (EUROTOX) from 2014 through 2016. Dr. Tsatsakis is a member of the Russian Academy of Sciences (RAS) and a member of the World Academy of Sciences (FMWAS). Under his direction, many studies and research projects were performed focusing on the development and improvement of new methods for the analysis of xenobiotics, biomonitoring and recording of their acute and long-term effects on human health, the use of macromolecular systems in nanomedicine and nanotoxicology as carriers for targeting and reducing toxicity and the examination of the length of telomeric ends in cellular aging and their association with chronic diseases.
He is an Emeritus Professor for the Federal Institute of Hygiene and Toxicology in Moscow (2014) and has a Doctor Honoris Causa of the D. Mendeleev University of Chemical Technology of Russia (2016), of the Far Eastern Federal University(FEFU), Vladivostok 2017 and of the University of Medicine and Pharmacy \u201cCarol Davila\u201d (2017). His work consists of over 1000 publications (articles in journals, books and abstracts proceedings), more than 500 of them in ISI journals, he has given over 200 keynote and plenary lectures in international congresses and has been the promoter, organizer and chair of numerous International congresses, symposiums and workshops. As a principal investigator (PI) he has coordinated over 60 scientific research and technology projects and has established worldwide collaborations.
He is the holder of numerous patents and has an extensive array of citations (over 11,000 Google Scholar) and reads\/downloads (over 80,000 Research Gate) of his papers. His current impact factor (IF) index is 51 (GS) and 43 (ISI) and has a long standing activity as an Editor in toxicology journals. Currently he is the Editor in Chief for Toxicology Reports and an editor for Food and Chemical Toxicology and was an editor and guest editor in many other journals, i.a. Toxicology, Food and Chemical Toxicology and Toxicology Letters, Experimental Therapeutic Medicine.
His most current significant research approach is based on interpreting \u201creal-life human exposure\u201d scenarios based on a long-term, low-dose exposure to chemical mixtures as well as \u201creal-life risk simulation\u201d (RLRS) studies.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”on|on|on” _builder_version=”3.19.14″ disabled=”on”][et_pb_column type=”4_4″ _builder_version=”3.19.4″][et_pb_image src=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/02\/Prof.-Aristides-Tsatsakis.png” align=”center” _builder_version=”3.19.4″][\/et_pb_image][et_pb_text _builder_version=”3.19.14″]<\/p>\n
PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS , Academician<\/p>\n
\n
Real life risk simulations (RLRS) in Safety Toxicology: Another Challenge for Precision Medicine<\/strong><\/p>\nAristidis Tsatsakis, PhD, ERT, DSc
Academician RAS (Hygiene-Toxicology), D.HonorisC. (Chem), D.H.C. (Pharm), Honorary Professor (Hygiene), D.H.C. (Environ), FMWAS
Professor and Chairman
Department of Toxicology & Forensic Science, Medical School, University of Crete, Voutes Campus, Heraklion 71003<\/p>\n
Risk assessment for human protection is historically and up to nowadays based on some long-established practices and assumptions for hazard identification and characterisation, such as a) testing in high doses, b) testing only of single chemicals, and c) linear extrapolation to low doses. Though these practices were considered handy and useful for many decades, it is now globally recognised that they are not simulated real life conditions. Real life risk is coming from the exposure to complex mixtures of many different chemicals and their toxicity in mixtures might be altered in relation of their toxicity when studied in isolation. In addition, real life exposure is mainly exposure to low doses. However, the assumption that low dose\u2019s toxicity is covered from experimentation in high doses because all effects are following a linear and monotonic dose-response curve, is seriously challenged through a number ofstudies of the last three decades. As many of the technical drawbacks of the past are nowadays eliminated and new technologies and methodologies are available, we consider that it is time to go ahead with toxicology for Real Life Risk Simulation. As more are known in relation to real life combined exposure, we focus our research in an area with complete lack of data, meaning the low-dose-long-term toxicity testing of complex chemicals\u2019 mixtures that simulates real life exposure. The Toxicology of the 21st century faces with the challenge of explain why from epidemiological studies we found that chemicals in doses consider safety are important factors that lead to the development of different chronic diseases. Precision medicine approach based on metabolome, genome, and microbiome relate data on the effect of toxic exposure to the phenotype. Toxic exposure inflicts damage at metabolic, genetic and microbiome levels, increasing thus cellular turnover, telomere attrition and the rate of aging. Data from our ongoing research in this direction will be presented.<\/p>\n
<\/p>\n
Short CV
Professor Tsatsakis Aristidis<\/p>\n
Professor, Academician Aristidis Tsatsakis, PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS and FMWAS is the Director of the Department of Toxicology and Forensic Sciences of the Medical School at the University of Crete and the University Hospital of Heraklion. Prof Tsatsakis has published well over 1000 works (articles in journals, books and abstracts proceedings), over 500 of them in ISI journals. He is the holder of several patents and has an extensive array of citations (over 11,000 GS) and reads \/downloads (over 80,000 RG) of his papers. His current IF index is 50 (GS) and 41 (ISI). Prof Tsatsakis has given over 200 keynote and plenary lectures in international congresses and has been the promoter and chair of numerous Symposiums and workshops in International Forum. He has coordinated as a PI in over 60 scientific research and technology projects and has established worldwide collaborations. Prof. Tsatsakis has a long standing activity as Editor in toxicology journals; he is currently Editor in chief of Toxicology Reports and editor of Food and Chemical Toxicology and has served as editor and guest editor in many other journals, such as Toxicology, Food and Chemical Toxicology, Toxicology Letters. Aristides Tsatsakis was elected EUROTOX President-Elect in 2012 served as President (2014-2016) of the Federation of European Toxicologists and European Societies of Toxicology. Prof. Tsatsakis is Emeritus Professor for the Federal Institute of Hygiene and Toxicology in Moscow (2014), Doctor Honorary Causa of the Mendeleev Moscow University (2016), of the Far East Federal University (FEFU), Vladivostok 2017 and of the Carol Davila, in Bucharest (2017). In 2016 he was elected Foreign Member of the National Academy of Sciences of Russia (FMRAS), in 2017 Foreign Member of Fellow Academy of Toxicological Sciences (FATS, USA) and in 2018 Full Member of The World Academy of Sciences (FMWAS). In 2017 he was elected Honorary Member of Bulgarian Toxicology Society and in 2018 Honorary President of the European Institute of Nutritional Medicine (E.I.Nu.M.) and Honorary Member of EUROTOX. Aristides Tsatsakis is also the inspirator, founder and chief scientific leader of the University of Crete spin-off Company ToxPlus S.A. The main research interests of Professor Tsatsakis include biomonitoring and risk assessments of xenobiotics as well as links of chronic exposure to them at low doses with health problems and diseases. He developed numerous biomarkers of exposure and of effects for various chemicals, in particular pesticides, pharmaceuticals, etc., uncovering the mechanistic understanding of the mode of action and adverse outcome pathways leading to clinical effects and chronic diseases (metabolic, autoimmune, cancer etc.) Professor Tsatsakis\u2019 long-standing public activities in disseminating science for safety – health and wellbeing of the society and the environment have often been endorsed and awarded by state and municipal authorities. His motivation and basic concept highlights the important role of academia involvement in social life problems. The postulation of real life risks simulation based on low dose combined long term exposures related to health issues, is a crucial element and the central driving force for application of theory to practice on safety evaluations in 21 century.<\/p>\n
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Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS and FMWAS Professor and Chairman\u00a0Department of Toxicology & Forensic Science, Medical School, University of CreteReal life risk simulations (RLRS) in Safety Toxicology: Another Challenge for Precision Medicine Author: Aristidis Tsatsakis, PhD, ERT, DSc ABSTRACT: Risk assessment for human protection is historically and up to nowadays based […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-365","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=365"}],"version-history":[{"count":11,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/365\/revisions"}],"predecessor-version":[{"id":5422,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/365\/revisions\/5422"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
PhD, ERT, DSc, FATS, DHonC, <\/span><\/strong>DHonC, DHonC, HonProf, FMRAS and FMWAS<\/span><\/strong>
Professor and Chairman\u00a0<\/strong><\/span>Department of Toxicology & Forensic Science, Medical School, University of Crete<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Real life risk simulations (RLRS) in Safety Toxicology: Another Challenge for Precision Medicine<\/strong><\/span>
Author: Aristidis Tsatsakis, PhD, ERT, DSc<\/span><\/p>\nABSTRACT:<\/span>
Risk assessment for human protection is historically and up to nowadays based on some long-established practices and assumptions for hazard identification and characterisation, such as a) testing in high doses, b) testing only of single chemicals, and c) linear extrapolation to low doses. Though these practices were considered handy and useful for many decades, it is now globally recognised that they are not simulated real life conditions. Real life risk is coming from the exposure to complex mixtures of many different chemicals and their toxicity in mixtures might be altered in relation of their toxicity when studied in isolation. In addition, real life exposure is mainly exposure to low doses. However, the assumption that low dose\u2019s toxicity is covered from experimentation in high doses because all effects are following a linear and monotonic dose-response curve, is seriously challenged through a number ofstudies of the last three decades. As many of the technical drawbacks of the past are nowadays eliminated and new technologies and methodologies are available, we consider that it is time to go ahead with toxicology for Real Life Risk Simulation. As more are known in relation to real life combined exposure, we focus our research in an area with complete lack of data, meaning the low-dose-long-term toxicity testing of complex chemicals\u2019 mixtures that simulates real life exposure. The Toxicology of the 21st century faces with the challenge of explain why from epidemiological studies we found that chemicals in doses consider safety are important factors that lead to the development of different chronic diseases. Precision medicine approach based on metabolome, genome, and microbiome relate data on the effect of toxic exposure to the phenotype. Toxic exposure inflicts damage at metabolic, genetic and microbiome levels, increasing thus cellular turnover, telomere attrition and the rate of aging. Data from our ongoing research in this direction will be presented.<\/p>\nSHORT CV<\/span><\/p>\nAristides Tsatsakis is the Director of the Department of Toxicology and Forensic Sciences of the Medical School at the University of Crete and the University Hospital of Heraklion and also the Chairman of the Division of Morphology of the Medical School of the University of Crete in Greece.
He served as President of the Federation of European Toxicologists and European Societies of Toxicology (EUROTOX) from 2014 through 2016. Dr. Tsatsakis is a member of the Russian Academy of Sciences (RAS) and a member of the World Academy of Sciences (FMWAS). Under his direction, many studies and research projects were performed focusing on the development and improvement of new methods for the analysis of xenobiotics, biomonitoring and recording of their acute and long-term effects on human health, the use of macromolecular systems in nanomedicine and nanotoxicology as carriers for targeting and reducing toxicity and the examination of the length of telomeric ends in cellular aging and their association with chronic diseases.
He is an Emeritus Professor for the Federal Institute of Hygiene and Toxicology in Moscow (2014) and has a Doctor Honoris Causa of the D. Mendeleev University of Chemical Technology of Russia (2016), of the Far Eastern Federal University(FEFU), Vladivostok 2017 and of the University of Medicine and Pharmacy \u201cCarol Davila\u201d (2017). His work consists of over 1000 publications (articles in journals, books and abstracts proceedings), more than 500 of them in ISI journals, he has given over 200 keynote and plenary lectures in international congresses and has been the promoter, organizer and chair of numerous International congresses, symposiums and workshops. As a principal investigator (PI) he has coordinated over 60 scientific research and technology projects and has established worldwide collaborations.
He is the holder of numerous patents and has an extensive array of citations (over 11,000 Google Scholar) and reads\/downloads (over 80,000 Research Gate) of his papers. His current impact factor (IF) index is 51 (GS) and 43 (ISI) and has a long standing activity as an Editor in toxicology journals. Currently he is the Editor in Chief for Toxicology Reports and an editor for Food and Chemical Toxicology and was an editor and guest editor in many other journals, i.a. Toxicology, Food and Chemical Toxicology and Toxicology Letters, Experimental Therapeutic Medicine.
His most current significant research approach is based on interpreting \u201creal-life human exposure\u201d scenarios based on a long-term, low-dose exposure to chemical mixtures as well as \u201creal-life risk simulation\u201d (RLRS) studies.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”on|on|on” _builder_version=”3.19.14″ disabled=”on”][et_pb_column type=”4_4″ _builder_version=”3.19.4″][et_pb_image src=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/02\/Prof.-Aristides-Tsatsakis.png” align=”center” _builder_version=”3.19.4″][\/et_pb_image][et_pb_text _builder_version=”3.19.14″]<\/p>\n
PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS , Academician<\/p>\n
\n
Real life risk simulations (RLRS) in Safety Toxicology: Another Challenge for Precision Medicine<\/strong><\/p>\nAristidis Tsatsakis, PhD, ERT, DSc
Academician RAS (Hygiene-Toxicology), D.HonorisC. (Chem), D.H.C. (Pharm), Honorary Professor (Hygiene), D.H.C. (Environ), FMWAS
Professor and Chairman
Department of Toxicology & Forensic Science, Medical School, University of Crete, Voutes Campus, Heraklion 71003<\/p>\n
Risk assessment for human protection is historically and up to nowadays based on some long-established practices and assumptions for hazard identification and characterisation, such as a) testing in high doses, b) testing only of single chemicals, and c) linear extrapolation to low doses. Though these practices were considered handy and useful for many decades, it is now globally recognised that they are not simulated real life conditions. Real life risk is coming from the exposure to complex mixtures of many different chemicals and their toxicity in mixtures might be altered in relation of their toxicity when studied in isolation. In addition, real life exposure is mainly exposure to low doses. However, the assumption that low dose\u2019s toxicity is covered from experimentation in high doses because all effects are following a linear and monotonic dose-response curve, is seriously challenged through a number ofstudies of the last three decades. As many of the technical drawbacks of the past are nowadays eliminated and new technologies and methodologies are available, we consider that it is time to go ahead with toxicology for Real Life Risk Simulation. As more are known in relation to real life combined exposure, we focus our research in an area with complete lack of data, meaning the low-dose-long-term toxicity testing of complex chemicals\u2019 mixtures that simulates real life exposure. The Toxicology of the 21st century faces with the challenge of explain why from epidemiological studies we found that chemicals in doses consider safety are important factors that lead to the development of different chronic diseases. Precision medicine approach based on metabolome, genome, and microbiome relate data on the effect of toxic exposure to the phenotype. Toxic exposure inflicts damage at metabolic, genetic and microbiome levels, increasing thus cellular turnover, telomere attrition and the rate of aging. Data from our ongoing research in this direction will be presented.<\/p>\n
<\/p>\n
Short CV
Professor Tsatsakis Aristidis<\/p>\n
Professor, Academician Aristidis Tsatsakis, PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS and FMWAS is the Director of the Department of Toxicology and Forensic Sciences of the Medical School at the University of Crete and the University Hospital of Heraklion. Prof Tsatsakis has published well over 1000 works (articles in journals, books and abstracts proceedings), over 500 of them in ISI journals. He is the holder of several patents and has an extensive array of citations (over 11,000 GS) and reads \/downloads (over 80,000 RG) of his papers. His current IF index is 50 (GS) and 41 (ISI). Prof Tsatsakis has given over 200 keynote and plenary lectures in international congresses and has been the promoter and chair of numerous Symposiums and workshops in International Forum. He has coordinated as a PI in over 60 scientific research and technology projects and has established worldwide collaborations. Prof. Tsatsakis has a long standing activity as Editor in toxicology journals; he is currently Editor in chief of Toxicology Reports and editor of Food and Chemical Toxicology and has served as editor and guest editor in many other journals, such as Toxicology, Food and Chemical Toxicology, Toxicology Letters. Aristides Tsatsakis was elected EUROTOX President-Elect in 2012 served as President (2014-2016) of the Federation of European Toxicologists and European Societies of Toxicology. Prof. Tsatsakis is Emeritus Professor for the Federal Institute of Hygiene and Toxicology in Moscow (2014), Doctor Honorary Causa of the Mendeleev Moscow University (2016), of the Far East Federal University (FEFU), Vladivostok 2017 and of the Carol Davila, in Bucharest (2017). In 2016 he was elected Foreign Member of the National Academy of Sciences of Russia (FMRAS), in 2017 Foreign Member of Fellow Academy of Toxicological Sciences (FATS, USA) and in 2018 Full Member of The World Academy of Sciences (FMWAS). In 2017 he was elected Honorary Member of Bulgarian Toxicology Society and in 2018 Honorary President of the European Institute of Nutritional Medicine (E.I.Nu.M.) and Honorary Member of EUROTOX. Aristides Tsatsakis is also the inspirator, founder and chief scientific leader of the University of Crete spin-off Company ToxPlus S.A. The main research interests of Professor Tsatsakis include biomonitoring and risk assessments of xenobiotics as well as links of chronic exposure to them at low doses with health problems and diseases. He developed numerous biomarkers of exposure and of effects for various chemicals, in particular pesticides, pharmaceuticals, etc., uncovering the mechanistic understanding of the mode of action and adverse outcome pathways leading to clinical effects and chronic diseases (metabolic, autoimmune, cancer etc.) Professor Tsatsakis\u2019 long-standing public activities in disseminating science for safety – health and wellbeing of the society and the environment have often been endorsed and awarded by state and municipal authorities. His motivation and basic concept highlights the important role of academia involvement in social life problems. The postulation of real life risks simulation based on low dose combined long term exposures related to health issues, is a crucial element and the central driving force for application of theory to practice on safety evaluations in 21 century.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS and FMWAS Professor and Chairman\u00a0Department of Toxicology & Forensic Science, Medical School, University of CreteReal life risk simulations (RLRS) in Safety Toxicology: Another Challenge for Precision Medicine Author: Aristidis Tsatsakis, PhD, ERT, DSc ABSTRACT: Risk assessment for human protection is historically and up to nowadays based […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-365","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=365"}],"version-history":[{"count":11,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/365\/revisions"}],"predecessor-version":[{"id":5422,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/365\/revisions\/5422"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Author: Aristidis Tsatsakis, PhD, ERT, DSc<\/span><\/p>\n
ABSTRACT:<\/span> SHORT CV<\/span><\/p>\n Aristides Tsatsakis is the Director of the Department of Toxicology and Forensic Sciences of the Medical School at the University of Crete and the University Hospital of Heraklion and also the Chairman of the Division of Morphology of the Medical School of the University of Crete in Greece. [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”on|on|on” _builder_version=”3.19.14″ disabled=”on”][et_pb_column type=”4_4″ _builder_version=”3.19.4″][et_pb_image src=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/02\/Prof.-Aristides-Tsatsakis.png” align=”center” _builder_version=”3.19.4″][\/et_pb_image][et_pb_text _builder_version=”3.19.14″]<\/p>\n PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS , Academician<\/p>\n \n Real life risk simulations (RLRS) in Safety Toxicology: Another Challenge for Precision Medicine<\/strong><\/p>\n Aristidis Tsatsakis, PhD, ERT, DSc Risk assessment for human protection is historically and up to nowadays based on some long-established practices and assumptions for hazard identification and characterisation, such as a) testing in high doses, b) testing only of single chemicals, and c) linear extrapolation to low doses. Though these practices were considered handy and useful for many decades, it is now globally recognised that they are not simulated real life conditions. Real life risk is coming from the exposure to complex mixtures of many different chemicals and their toxicity in mixtures might be altered in relation of their toxicity when studied in isolation. In addition, real life exposure is mainly exposure to low doses. However, the assumption that low dose\u2019s toxicity is covered from experimentation in high doses because all effects are following a linear and monotonic dose-response curve, is seriously challenged through a number ofstudies of the last three decades. As many of the technical drawbacks of the past are nowadays eliminated and new technologies and methodologies are available, we consider that it is time to go ahead with toxicology for Real Life Risk Simulation. As more are known in relation to real life combined exposure, we focus our research in an area with complete lack of data, meaning the low-dose-long-term toxicity testing of complex chemicals\u2019 mixtures that simulates real life exposure. The Toxicology of the 21st century faces with the challenge of explain why from epidemiological studies we found that chemicals in doses consider safety are important factors that lead to the development of different chronic diseases. Precision medicine approach based on metabolome, genome, and microbiome relate data on the effect of toxic exposure to the phenotype. Toxic exposure inflicts damage at metabolic, genetic and microbiome levels, increasing thus cellular turnover, telomere attrition and the rate of aging. Data from our ongoing research in this direction will be presented.<\/p>\n <\/p>\n Short CV Professor, Academician Aristidis Tsatsakis, PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS and FMWAS is the Director of the Department of Toxicology and Forensic Sciences of the Medical School at the University of Crete and the University Hospital of Heraklion. Prof Tsatsakis has published well over 1000 works (articles in journals, books and abstracts proceedings), over 500 of them in ISI journals. He is the holder of several patents and has an extensive array of citations (over 11,000 GS) and reads \/downloads (over 80,000 RG) of his papers. His current IF index is 50 (GS) and 41 (ISI). Prof Tsatsakis has given over 200 keynote and plenary lectures in international congresses and has been the promoter and chair of numerous Symposiums and workshops in International Forum. He has coordinated as a PI in over 60 scientific research and technology projects and has established worldwide collaborations. Prof. Tsatsakis has a long standing activity as Editor in toxicology journals; he is currently Editor in chief of Toxicology Reports and editor of Food and Chemical Toxicology and has served as editor and guest editor in many other journals, such as Toxicology, Food and Chemical Toxicology, Toxicology Letters. Aristides Tsatsakis was elected EUROTOX President-Elect in 2012 served as President (2014-2016) of the Federation of European Toxicologists and European Societies of Toxicology. Prof. Tsatsakis is Emeritus Professor for the Federal Institute of Hygiene and Toxicology in Moscow (2014), Doctor Honorary Causa of the Mendeleev Moscow University (2016), of the Far East Federal University (FEFU), Vladivostok 2017 and of the Carol Davila, in Bucharest (2017). In 2016 he was elected Foreign Member of the National Academy of Sciences of Russia (FMRAS), in 2017 Foreign Member of Fellow Academy of Toxicological Sciences (FATS, USA) and in 2018 Full Member of The World Academy of Sciences (FMWAS). In 2017 he was elected Honorary Member of Bulgarian Toxicology Society and in 2018 Honorary President of the European Institute of Nutritional Medicine (E.I.Nu.M.) and Honorary Member of EUROTOX. Aristides Tsatsakis is also the inspirator, founder and chief scientific leader of the University of Crete spin-off Company ToxPlus S.A. The main research interests of Professor Tsatsakis include biomonitoring and risk assessments of xenobiotics as well as links of chronic exposure to them at low doses with health problems and diseases. He developed numerous biomarkers of exposure and of effects for various chemicals, in particular pesticides, pharmaceuticals, etc., uncovering the mechanistic understanding of the mode of action and adverse outcome pathways leading to clinical effects and chronic diseases (metabolic, autoimmune, cancer etc.) Professor Tsatsakis\u2019 long-standing public activities in disseminating science for safety – health and wellbeing of the society and the environment have often been endorsed and awarded by state and municipal authorities. His motivation and basic concept highlights the important role of academia involvement in social life problems. The postulation of real life risks simulation based on low dose combined long term exposures related to health issues, is a crucial element and the central driving force for application of theory to practice on safety evaluations in 21 century.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> PhD, ERT, DSc, FATS, DHonC, DHonC, DHonC, HonProf, FMRAS and FMWAS Professor and Chairman\u00a0Department of Toxicology & Forensic Science, Medical School, University of CreteReal life risk simulations (RLRS) in Safety Toxicology: Another Challenge for Precision Medicine Author: Aristidis Tsatsakis, PhD, ERT, DSc ABSTRACT: Risk assessment for human protection is historically and up to nowadays based […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-365","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=365"}],"version-history":[{"count":11,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/365\/revisions"}],"predecessor-version":[{"id":5422,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/365\/revisions\/5422"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Risk assessment for human protection is historically and up to nowadays based on some long-established practices and assumptions for hazard identification and characterisation, such as a) testing in high doses, b) testing only of single chemicals, and c) linear extrapolation to low doses. Though these practices were considered handy and useful for many decades, it is now globally recognised that they are not simulated real life conditions. Real life risk is coming from the exposure to complex mixtures of many different chemicals and their toxicity in mixtures might be altered in relation of their toxicity when studied in isolation. In addition, real life exposure is mainly exposure to low doses. However, the assumption that low dose\u2019s toxicity is covered from experimentation in high doses because all effects are following a linear and monotonic dose-response curve, is seriously challenged through a number ofstudies of the last three decades. As many of the technical drawbacks of the past are nowadays eliminated and new technologies and methodologies are available, we consider that it is time to go ahead with toxicology for Real Life Risk Simulation. As more are known in relation to real life combined exposure, we focus our research in an area with complete lack of data, meaning the low-dose-long-term toxicity testing of complex chemicals\u2019 mixtures that simulates real life exposure. The Toxicology of the 21st century faces with the challenge of explain why from epidemiological studies we found that chemicals in doses consider safety are important factors that lead to the development of different chronic diseases. Precision medicine approach based on metabolome, genome, and microbiome relate data on the effect of toxic exposure to the phenotype. Toxic exposure inflicts damage at metabolic, genetic and microbiome levels, increasing thus cellular turnover, telomere attrition and the rate of aging. Data from our ongoing research in this direction will be presented.<\/p>\n
He served as President of the Federation of European Toxicologists and European Societies of Toxicology (EUROTOX) from 2014 through 2016. Dr. Tsatsakis is a member of the Russian Academy of Sciences (RAS) and a member of the World Academy of Sciences (FMWAS). Under his direction, many studies and research projects were performed focusing on the development and improvement of new methods for the analysis of xenobiotics, biomonitoring and recording of their acute and long-term effects on human health, the use of macromolecular systems in nanomedicine and nanotoxicology as carriers for targeting and reducing toxicity and the examination of the length of telomeric ends in cellular aging and their association with chronic diseases.
He is an Emeritus Professor for the Federal Institute of Hygiene and Toxicology in Moscow (2014) and has a Doctor Honoris Causa of the D. Mendeleev University of Chemical Technology of Russia (2016), of the Far Eastern Federal University(FEFU), Vladivostok 2017 and of the University of Medicine and Pharmacy \u201cCarol Davila\u201d (2017). His work consists of over 1000 publications (articles in journals, books and abstracts proceedings), more than 500 of them in ISI journals, he has given over 200 keynote and plenary lectures in international congresses and has been the promoter, organizer and chair of numerous International congresses, symposiums and workshops. As a principal investigator (PI) he has coordinated over 60 scientific research and technology projects and has established worldwide collaborations.
He is the holder of numerous patents and has an extensive array of citations (over 11,000 Google Scholar) and reads\/downloads (over 80,000 Research Gate) of his papers. His current impact factor (IF) index is 51 (GS) and 43 (ISI) and has a long standing activity as an Editor in toxicology journals. Currently he is the Editor in Chief for Toxicology Reports and an editor for Food and Chemical Toxicology and was an editor and guest editor in many other journals, i.a. Toxicology, Food and Chemical Toxicology and Toxicology Letters, Experimental Therapeutic Medicine.
His most current significant research approach is based on interpreting \u201creal-life human exposure\u201d scenarios based on a long-term, low-dose exposure to chemical mixtures as well as \u201creal-life risk simulation\u201d (RLRS) studies.<\/p>\n
Academician RAS (Hygiene-Toxicology), D.HonorisC. (Chem), D.H.C. (Pharm), Honorary Professor (Hygiene), D.H.C. (Environ), FMWAS
Professor and Chairman
Department of Toxicology & Forensic Science, Medical School, University of Crete, Voutes Campus, Heraklion 71003<\/p>\n
Professor Tsatsakis Aristidis<\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"