<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nProf. Dr. Tatu Alin Lauren\u021biu<\/strong><\/span><\/h4>\nFacultatea de Medicin\u0103 \u015fi Farmacie din Gala\u021bi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Noi posibile perspective de tratament topic pentru vitiligo cu extracte de Piper Nigrum<\/span>
Autori: Mih\u0103il\u0103 Bianca, Dinic\u0103 Rodica Mihaela, Tatu Alin Lauren\u021biu, Buzia Olimpia Dumitriu<\/span><\/p>\nAm realizat un studiu \u00eentr-o echip\u0103 multidisciplinar\u0103 const\u00e2nd \u00een farmaci\u015fti, chimi\u015fti \u015fi medici. Studiul nostru arat\u0103 c\u0103 Piper nigrum (PN) \u0219i principalul s\u0103u alcaloid, piperina, pot promova proliferarea melanocitelor in vivo, confirm\u00e2nd cele c\u00e2teva observa\u0163ii anterioare din literatur\u0103. Piperina pur\u0103 \u0219i extractul de fructe PN au fost \u00eencorporate \u00een dou\u0103 unguente diferite \u0219i testate pe subiec\u021bi umani afecta\u021bi de vitiligo dup\u0103 ce a fost ob\u0163inut avizul Comisiei de Etic\u0103. Au fost tratate zone diferite: unele utiliz\u00e2nd piperin\u0103 pur\u0103, altele doar extractul, unele doar solu\u021bie de travoprost \u0219i altele utiliz\u00e2nd o asociere de solu\u021bie de travoprost (analog de prostaglandin\u0103 F2\u03b1) \u0219i produsele ob\u0163inute de echipa multidisciplinar\u0103. \u00cen grade diferite, pigmentarea a fost ob\u0163inut\u0103 \u00een toate zonele tratate. Extractul a produs rezultate mai rapide \u0219i mai importante dec\u00e2t piperina pur\u0103. Modelul de pigmentare a fost, de asemenea, diferit \u00eentre cele dou\u0103 substan\u0163e \u2013 piperina pur\u0103 \u015fi extractul. Asocierea solu\u021biei de travoprost accelereaz\u0103 procesul \u0219i modific\u0103 modelul de pigmentare, mai ales c\u00e2nd este asociat cu extractul PN. \u00cen acest caz, rezultatele au fost observabile dup\u0103 numai 3 s\u0103pt\u0103m\u00e2ni de aplicare, \u00een timp ce restul pl\u0103cilor au necesitat p\u00e2n\u0103 la 6 s\u0103pt\u0103m\u00e2ni pentru a ob\u021bine pigmentare vizibil\u0103. Efectele secundare au fost rare \u015fi au constat \u00een senza\u021bia de arsur\u0103 \u0219i eritem la nivelul suprafe\u021belor tratate. Prin urmare, extractul de Piper nigrum poate reprezenta, \u00een viitor, o nou\u0103 op\u021biune de tratament pentru vitiligo, \u00een special av\u00e2nd \u00een vedere efectele secundare u\u0219oare ale produselor testate \u0219i timpul redus necesar pentru repigmentare. Cu toate acestea, sunt necesare mai multe studii pentru a valida aceste date experimentale.<\/p>\n
New possible perspectives regarding topical treatment in Vitiligo using Piper Negrum extract<\/span>
Authors: Mih\u0103il\u0103 Bianca, Dinic\u0103 Rodica Mihaela, Tatu Alin Lauren\u021biu, Buzia Olimpia Dumitriu<\/span><\/p>\nIn our study, performed by a multidisciplinary team of pharmacists and doctors, we have proven that Piper Nigrum extract and its main alkaloid piperine, promote melanocytic proliferation in vivo, confirming previous research. Ointments which combine Piper Nigrum fruit extract and pure piperine have been tested on human subjects with vitiligo after acquiring the ethics review. Different body locations have been treated using either pure piperine, or the extract alone. On other body zones it has been applied travoprost (prostaglandin F2\u03b1 analogue) solution or an association of travoprost solution and our products. Every single body zone treated was responsive to treatment. The results obtained using the extract were more rapidly installed and more substantial than the ointment with pure pipericine. Another difference between the two ointments was noted regarding the pattern of repigmentation. Adding travoprost solution, especially to Piper Negrum extract, resulted in speeding the process of repigmentation and modifying the pattern of pigmentation. Results were achieved after 3 weeks of treatment rather than 6 weeks. The side effects were rare, some patients described a slight burning sensation and local redness. Therefore, the Piper negrum extract may become a new therapeutical option for vitiligo, one that has mild side effects and repigmentation occurs in a short period of time. To validate the results of our study, further research should be performed.<\/p>\n
Scurt CV<\/span><\/p>\nN\u0103scut \u00een 1968, urmeaz\u0103 etapele \u015fcolariz\u0103rii fiind absolvent al Liceului de Matematic\u0103 Fizic\u0103 \u201dVasile Alecsandri\u201d Gala\u0163i \u015fi olimpic na\u0163ional la matematic\u0103. Dup\u0103 stagiul militar, studiaz\u0103 apoi la Universitatea de Medicin\u0103 \u015fi Farmacie \u201dCarol Davila\u201d din Bucure\u015fti. Se formeaz\u0103 ca dermatolog \u00een Spitalul Clinic \u201dColentina\u201d sub bagheta Prof dr. Forsea, Prof.dr. Giurc\u0103neanu \u015fi a dr. Smaranda Iosif. Ob\u0163ine primul loc la examenul de medic specialist sus\u0163inut la Bucure\u015fti \u015fi de asemenea primul loc la examenul de medic primar sus\u0163inut la Timi\u015foara. Ob\u0163ine prin concurs postul de medic dermato venerolog la Spitalul de Urgen\u0163\u0103 \u201dSf\u00e2ntul Apostol Andrei\u201d din Gala\u0163i \u015fi lucreaz\u0103 \u00een paralel \u00een sistem privat. Se implic\u0103 \u00een dezvoltarea tematicilor \u015fi programelor noi Facult\u0103\u0163i de Medicin\u0103 \u015fi Farmacie din cadrul Universit\u0103\u0163ii Dun\u0103rea de Jos din Gala\u0163i unde sus\u0163ine ini\u0163ial cursuri \u015fi lucr\u0103ri ca asociat, apoi din 2011 ca titular angajat. \u00cen 2017 sus\u0163ine Teza de Abilitare \u015fi tot din acel an devine Profesor universitar abilitat al Facult\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie din Gala\u0163i. Din 2018 este conduc\u0103tor de doctorat av\u00e2nd \u00een coordonare 3 doctoranzi \u015fi sus\u0163ine cursuri de studii doctorale avansate \u00een cadrul \u015ecolii Doctorale de \u015etiin\u0163e Fundamentale \u015fi Inginere\u015fti. A publicat numeroase articole de specialitate in extenso indexate ISI, BDI realiz\u00e2nd un indice Hirsch 7 la \u00eenceputul lui 2019. Este membru al EADV, AAD, EHRS, ISD, ESDR, ESPD \u015fi al Societ\u0103\u0163ii Japoneze de Dermatologie Investigativ\u0103. Este Board Director \u015fi Vicepre\u015fedinte al Societ\u0103\u0163ii Interna\u0163ionale de Dermatologie\u2013ISD. Domeniile de cercetare de interes sunt reprezentate de Demodex Folliculorum, microbiomul cutanat asociat\/independent de Demodex, Dermoscopia\/Entomodermoscopia, Rozacee, inclusiv cea indus\u0103 steroidian, vitiligo, alter\u0103ri cutanate asociate tulbur\u0103rilor endocrine, prurit, durere cutanat\u0103, alter\u0103ri pilare.<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Prof. Dr. Tatu Alin Lauren\u021biu Facultatea de Medicin\u0103 \u015fi Farmacie din Gala\u021biNoi posibile perspective de tratament topic pentru vitiligo cu extracte de Piper Nigrum Autori: Mih\u0103il\u0103 Bianca, Dinic\u0103 Rodica Mihaela, Tatu Alin Lauren\u021biu, Buzia Olimpia Dumitriu Am realizat un studiu \u00eentr-o echip\u0103 multidisciplinar\u0103 const\u00e2nd \u00een farmaci\u015fti, chimi\u015fti \u015fi medici. Studiul nostru arat\u0103 c\u0103 Piper nigrum […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4069","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4069","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4069"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4069\/revisions"}],"predecessor-version":[{"id":5060,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4069\/revisions\/5060"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Prof. Dr. Tatu Alin Lauren\u021biu<\/strong><\/span><\/h4>\nFacultatea de Medicin\u0103 \u015fi Farmacie din Gala\u021bi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Noi posibile perspective de tratament topic pentru vitiligo cu extracte de Piper Nigrum<\/span>
Autori: Mih\u0103il\u0103 Bianca, Dinic\u0103 Rodica Mihaela, Tatu Alin Lauren\u021biu, Buzia Olimpia Dumitriu<\/span><\/p>\nAm realizat un studiu \u00eentr-o echip\u0103 multidisciplinar\u0103 const\u00e2nd \u00een farmaci\u015fti, chimi\u015fti \u015fi medici. Studiul nostru arat\u0103 c\u0103 Piper nigrum (PN) \u0219i principalul s\u0103u alcaloid, piperina, pot promova proliferarea melanocitelor in vivo, confirm\u00e2nd cele c\u00e2teva observa\u0163ii anterioare din literatur\u0103. Piperina pur\u0103 \u0219i extractul de fructe PN au fost \u00eencorporate \u00een dou\u0103 unguente diferite \u0219i testate pe subiec\u021bi umani afecta\u021bi de vitiligo dup\u0103 ce a fost ob\u0163inut avizul Comisiei de Etic\u0103. Au fost tratate zone diferite: unele utiliz\u00e2nd piperin\u0103 pur\u0103, altele doar extractul, unele doar solu\u021bie de travoprost \u0219i altele utiliz\u00e2nd o asociere de solu\u021bie de travoprost (analog de prostaglandin\u0103 F2\u03b1) \u0219i produsele ob\u0163inute de echipa multidisciplinar\u0103. \u00cen grade diferite, pigmentarea a fost ob\u0163inut\u0103 \u00een toate zonele tratate. Extractul a produs rezultate mai rapide \u0219i mai importante dec\u00e2t piperina pur\u0103. Modelul de pigmentare a fost, de asemenea, diferit \u00eentre cele dou\u0103 substan\u0163e \u2013 piperina pur\u0103 \u015fi extractul. Asocierea solu\u021biei de travoprost accelereaz\u0103 procesul \u0219i modific\u0103 modelul de pigmentare, mai ales c\u00e2nd este asociat cu extractul PN. \u00cen acest caz, rezultatele au fost observabile dup\u0103 numai 3 s\u0103pt\u0103m\u00e2ni de aplicare, \u00een timp ce restul pl\u0103cilor au necesitat p\u00e2n\u0103 la 6 s\u0103pt\u0103m\u00e2ni pentru a ob\u021bine pigmentare vizibil\u0103. Efectele secundare au fost rare \u015fi au constat \u00een senza\u021bia de arsur\u0103 \u0219i eritem la nivelul suprafe\u021belor tratate. Prin urmare, extractul de Piper nigrum poate reprezenta, \u00een viitor, o nou\u0103 op\u021biune de tratament pentru vitiligo, \u00een special av\u00e2nd \u00een vedere efectele secundare u\u0219oare ale produselor testate \u0219i timpul redus necesar pentru repigmentare. Cu toate acestea, sunt necesare mai multe studii pentru a valida aceste date experimentale.<\/p>\n
New possible perspectives regarding topical treatment in Vitiligo using Piper Negrum extract<\/span>
Authors: Mih\u0103il\u0103 Bianca, Dinic\u0103 Rodica Mihaela, Tatu Alin Lauren\u021biu, Buzia Olimpia Dumitriu<\/span><\/p>\nIn our study, performed by a multidisciplinary team of pharmacists and doctors, we have proven that Piper Nigrum extract and its main alkaloid piperine, promote melanocytic proliferation in vivo, confirming previous research. Ointments which combine Piper Nigrum fruit extract and pure piperine have been tested on human subjects with vitiligo after acquiring the ethics review. Different body locations have been treated using either pure piperine, or the extract alone. On other body zones it has been applied travoprost (prostaglandin F2\u03b1 analogue) solution or an association of travoprost solution and our products. Every single body zone treated was responsive to treatment. The results obtained using the extract were more rapidly installed and more substantial than the ointment with pure pipericine. Another difference between the two ointments was noted regarding the pattern of repigmentation. Adding travoprost solution, especially to Piper Negrum extract, resulted in speeding the process of repigmentation and modifying the pattern of pigmentation. Results were achieved after 3 weeks of treatment rather than 6 weeks. The side effects were rare, some patients described a slight burning sensation and local redness. Therefore, the Piper negrum extract may become a new therapeutical option for vitiligo, one that has mild side effects and repigmentation occurs in a short period of time. To validate the results of our study, further research should be performed.<\/p>\n
Scurt CV<\/span><\/p>\nN\u0103scut \u00een 1968, urmeaz\u0103 etapele \u015fcolariz\u0103rii fiind absolvent al Liceului de Matematic\u0103 Fizic\u0103 \u201dVasile Alecsandri\u201d Gala\u0163i \u015fi olimpic na\u0163ional la matematic\u0103. Dup\u0103 stagiul militar, studiaz\u0103 apoi la Universitatea de Medicin\u0103 \u015fi Farmacie \u201dCarol Davila\u201d din Bucure\u015fti. Se formeaz\u0103 ca dermatolog \u00een Spitalul Clinic \u201dColentina\u201d sub bagheta Prof dr. Forsea, Prof.dr. Giurc\u0103neanu \u015fi a dr. Smaranda Iosif. Ob\u0163ine primul loc la examenul de medic specialist sus\u0163inut la Bucure\u015fti \u015fi de asemenea primul loc la examenul de medic primar sus\u0163inut la Timi\u015foara. Ob\u0163ine prin concurs postul de medic dermato venerolog la Spitalul de Urgen\u0163\u0103 \u201dSf\u00e2ntul Apostol Andrei\u201d din Gala\u0163i \u015fi lucreaz\u0103 \u00een paralel \u00een sistem privat. Se implic\u0103 \u00een dezvoltarea tematicilor \u015fi programelor noi Facult\u0103\u0163i de Medicin\u0103 \u015fi Farmacie din cadrul Universit\u0103\u0163ii Dun\u0103rea de Jos din Gala\u0163i unde sus\u0163ine ini\u0163ial cursuri \u015fi lucr\u0103ri ca asociat, apoi din 2011 ca titular angajat. \u00cen 2017 sus\u0163ine Teza de Abilitare \u015fi tot din acel an devine Profesor universitar abilitat al Facult\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie din Gala\u0163i. Din 2018 este conduc\u0103tor de doctorat av\u00e2nd \u00een coordonare 3 doctoranzi \u015fi sus\u0163ine cursuri de studii doctorale avansate \u00een cadrul \u015ecolii Doctorale de \u015etiin\u0163e Fundamentale \u015fi Inginere\u015fti. A publicat numeroase articole de specialitate in extenso indexate ISI, BDI realiz\u00e2nd un indice Hirsch 7 la \u00eenceputul lui 2019. Este membru al EADV, AAD, EHRS, ISD, ESDR, ESPD \u015fi al Societ\u0103\u0163ii Japoneze de Dermatologie Investigativ\u0103. Este Board Director \u015fi Vicepre\u015fedinte al Societ\u0103\u0163ii Interna\u0163ionale de Dermatologie\u2013ISD. Domeniile de cercetare de interes sunt reprezentate de Demodex Folliculorum, microbiomul cutanat asociat\/independent de Demodex, Dermoscopia\/Entomodermoscopia, Rozacee, inclusiv cea indus\u0103 steroidian, vitiligo, alter\u0103ri cutanate asociate tulbur\u0103rilor endocrine, prurit, durere cutanat\u0103, alter\u0103ri pilare.<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Prof. Dr. Tatu Alin Lauren\u021biu Facultatea de Medicin\u0103 \u015fi Farmacie din Gala\u021biNoi posibile perspective de tratament topic pentru vitiligo cu extracte de Piper Nigrum Autori: Mih\u0103il\u0103 Bianca, Dinic\u0103 Rodica Mihaela, Tatu Alin Lauren\u021biu, Buzia Olimpia Dumitriu Am realizat un studiu \u00eentr-o echip\u0103 multidisciplinar\u0103 const\u00e2nd \u00een farmaci\u015fti, chimi\u015fti \u015fi medici. Studiul nostru arat\u0103 c\u0103 Piper nigrum […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4069","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4069","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4069"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4069\/revisions"}],"predecessor-version":[{"id":5060,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4069\/revisions\/5060"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Noi posibile perspective de tratament topic pentru vitiligo cu extracte de Piper Nigrum<\/span> Am realizat un studiu \u00eentr-o echip\u0103 multidisciplinar\u0103 const\u00e2nd \u00een farmaci\u015fti, chimi\u015fti \u015fi medici. Studiul nostru arat\u0103 c\u0103 Piper nigrum (PN) \u0219i principalul s\u0103u alcaloid, piperina, pot promova proliferarea melanocitelor in vivo, confirm\u00e2nd cele c\u00e2teva observa\u0163ii anterioare din literatur\u0103. Piperina pur\u0103 \u0219i extractul de fructe PN au fost \u00eencorporate \u00een dou\u0103 unguente diferite \u0219i testate pe subiec\u021bi umani afecta\u021bi de vitiligo dup\u0103 ce a fost ob\u0163inut avizul Comisiei de Etic\u0103. Au fost tratate zone diferite: unele utiliz\u00e2nd piperin\u0103 pur\u0103, altele doar extractul, unele doar solu\u021bie de travoprost \u0219i altele utiliz\u00e2nd o asociere de solu\u021bie de travoprost (analog de prostaglandin\u0103 F2\u03b1) \u0219i produsele ob\u0163inute de echipa multidisciplinar\u0103. \u00cen grade diferite, pigmentarea a fost ob\u0163inut\u0103 \u00een toate zonele tratate. Extractul a produs rezultate mai rapide \u0219i mai importante dec\u00e2t piperina pur\u0103. Modelul de pigmentare a fost, de asemenea, diferit \u00eentre cele dou\u0103 substan\u0163e \u2013 piperina pur\u0103 \u015fi extractul. Asocierea solu\u021biei de travoprost accelereaz\u0103 procesul \u0219i modific\u0103 modelul de pigmentare, mai ales c\u00e2nd este asociat cu extractul PN. \u00cen acest caz, rezultatele au fost observabile dup\u0103 numai 3 s\u0103pt\u0103m\u00e2ni de aplicare, \u00een timp ce restul pl\u0103cilor au necesitat p\u00e2n\u0103 la 6 s\u0103pt\u0103m\u00e2ni pentru a ob\u021bine pigmentare vizibil\u0103. Efectele secundare au fost rare \u015fi au constat \u00een senza\u021bia de arsur\u0103 \u0219i eritem la nivelul suprafe\u021belor tratate. Prin urmare, extractul de Piper nigrum poate reprezenta, \u00een viitor, o nou\u0103 op\u021biune de tratament pentru vitiligo, \u00een special av\u00e2nd \u00een vedere efectele secundare u\u0219oare ale produselor testate \u0219i timpul redus necesar pentru repigmentare. Cu toate acestea, sunt necesare mai multe studii pentru a valida aceste date experimentale.<\/p>\n New possible perspectives regarding topical treatment in Vitiligo using Piper Negrum extract<\/span> In our study, performed by a multidisciplinary team of pharmacists and doctors, we have proven that Piper Nigrum extract and its main alkaloid piperine, promote melanocytic proliferation in vivo, confirming previous research. Ointments which combine Piper Nigrum fruit extract and pure piperine have been tested on human subjects with vitiligo after acquiring the ethics review. Different body locations have been treated using either pure piperine, or the extract alone. On other body zones it has been applied travoprost (prostaglandin F2\u03b1 analogue) solution or an association of travoprost solution and our products. Every single body zone treated was responsive to treatment. The results obtained using the extract were more rapidly installed and more substantial than the ointment with pure pipericine. Another difference between the two ointments was noted regarding the pattern of repigmentation. Adding travoprost solution, especially to Piper Negrum extract, resulted in speeding the process of repigmentation and modifying the pattern of pigmentation. Results were achieved after 3 weeks of treatment rather than 6 weeks. The side effects were rare, some patients described a slight burning sensation and local redness. Therefore, the Piper negrum extract may become a new therapeutical option for vitiligo, one that has mild side effects and repigmentation occurs in a short period of time. To validate the results of our study, further research should be performed.<\/p>\n Scurt CV<\/span><\/p>\n N\u0103scut \u00een 1968, urmeaz\u0103 etapele \u015fcolariz\u0103rii fiind absolvent al Liceului de Matematic\u0103 Fizic\u0103 \u201dVasile Alecsandri\u201d Gala\u0163i \u015fi olimpic na\u0163ional la matematic\u0103. Dup\u0103 stagiul militar, studiaz\u0103 apoi la Universitatea de Medicin\u0103 \u015fi Farmacie \u201dCarol Davila\u201d din Bucure\u015fti. Se formeaz\u0103 ca dermatolog \u00een Spitalul Clinic \u201dColentina\u201d sub bagheta Prof dr. Forsea, Prof.dr. Giurc\u0103neanu \u015fi a dr. Smaranda Iosif. Ob\u0163ine primul loc la examenul de medic specialist sus\u0163inut la Bucure\u015fti \u015fi de asemenea primul loc la examenul de medic primar sus\u0163inut la Timi\u015foara. Ob\u0163ine prin concurs postul de medic dermato venerolog la Spitalul de Urgen\u0163\u0103 \u201dSf\u00e2ntul Apostol Andrei\u201d din Gala\u0163i \u015fi lucreaz\u0103 \u00een paralel \u00een sistem privat. Se implic\u0103 \u00een dezvoltarea tematicilor \u015fi programelor noi Facult\u0103\u0163i de Medicin\u0103 \u015fi Farmacie din cadrul Universit\u0103\u0163ii Dun\u0103rea de Jos din Gala\u0163i unde sus\u0163ine ini\u0163ial cursuri \u015fi lucr\u0103ri ca asociat, apoi din 2011 ca titular angajat. \u00cen 2017 sus\u0163ine Teza de Abilitare \u015fi tot din acel an devine Profesor universitar abilitat al Facult\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie din Gala\u0163i. Din 2018 este conduc\u0103tor de doctorat av\u00e2nd \u00een coordonare 3 doctoranzi \u015fi sus\u0163ine cursuri de studii doctorale avansate \u00een cadrul \u015ecolii Doctorale de \u015etiin\u0163e Fundamentale \u015fi Inginere\u015fti. A publicat numeroase articole de specialitate in extenso indexate ISI, BDI realiz\u00e2nd un indice Hirsch 7 la \u00eenceputul lui 2019. Este membru al EADV, AAD, EHRS, ISD, ESDR, ESPD \u015fi al Societ\u0103\u0163ii Japoneze de Dermatologie Investigativ\u0103. Este Board Director \u015fi Vicepre\u015fedinte al Societ\u0103\u0163ii Interna\u0163ionale de Dermatologie\u2013ISD. Domeniile de cercetare de interes sunt reprezentate de Demodex Folliculorum, microbiomul cutanat asociat\/independent de Demodex, Dermoscopia\/Entomodermoscopia, Rozacee, inclusiv cea indus\u0103 steroidian, vitiligo, alter\u0103ri cutanate asociate tulbur\u0103rilor endocrine, prurit, durere cutanat\u0103, alter\u0103ri pilare.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> Prof. Dr. Tatu Alin Lauren\u021biu Facultatea de Medicin\u0103 \u015fi Farmacie din Gala\u021biNoi posibile perspective de tratament topic pentru vitiligo cu extracte de Piper Nigrum Autori: Mih\u0103il\u0103 Bianca, Dinic\u0103 Rodica Mihaela, Tatu Alin Lauren\u021biu, Buzia Olimpia Dumitriu Am realizat un studiu \u00eentr-o echip\u0103 multidisciplinar\u0103 const\u00e2nd \u00een farmaci\u015fti, chimi\u015fti \u015fi medici. Studiul nostru arat\u0103 c\u0103 Piper nigrum […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4069","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4069","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4069"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4069\/revisions"}],"predecessor-version":[{"id":5060,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4069\/revisions\/5060"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Mih\u0103il\u0103 Bianca, Dinic\u0103 Rodica Mihaela, Tatu Alin Lauren\u021biu, Buzia Olimpia Dumitriu<\/span><\/p>\n
Authors: Mih\u0103il\u0103 Bianca, Dinic\u0103 Rodica Mihaela, Tatu Alin Lauren\u021biu, Buzia Olimpia Dumitriu<\/span><\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"