<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nProf. Dr. Ciocoiu Manuela<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
Aspecte fiziopatologice \u015fi perspective terapeutice ale utiliz\u0103rii compu\u0219ilor fenolici \u00een afec\u0163iuni dermatologice<\/span>
Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\n\n
Dovezile existente indic\u0103 faptul c\u0103 polifenolii pot aduce beneficii pacien\u021bilor cu alopecie, acnee vulgar\u0103, infec\u021bii fungice, hiperpigmentare sau piele \u00eemb\u0103tr\u00e2nit\u0103 de soare R\u0103spunsurile antiinflamatorii exercitate de polifenoli implic\u0103 sc\u0103derea secre\u0163iei de IL-1\u00df \u015fi activit\u0103\u0163ii NF-kB. Unii polifenoli au caracteristici sinergistice cu agen\u021bii chimioterapeutici \u00eempotriva cancerului. Astfel, o combina\u021bie adecvat\u0103 a polifenolilor cu medicamentele chimioterapeutice existente va conduce la reducerea efectelor secundare f\u0103r\u0103 a sc\u0103dea efectele agen\u021bilor chimioterapeutici. Administrarea compu\u0219ilor fenolici a determinat o protec\u0163ie semnificativ\u0103 fa\u0163\u0103 de fotocarcinogenez\u0103 \u00een termeni de indice tumoral, multiplicitate tumoral\u0103 \u015fi cre\u015ftere tumoral\u0103. Aplica\u0163ia topic\u0103 de (-)-epigalocatechin-3-galat (EGCG), un chemoprotector major, a dus la inhibarea cre\u015fterii tumorilor cutanate induse de radia\u0163iile ultraviolete. Administrarea de polifenoli are efecte antiangiogenetice puternice \u015fi are poten\u0163ialul de a controla cre\u015fterea, sau determina regresia tumoral\u0103 prin acest mecanism. Inhibarea antigenului nuclear al prolifer\u0103rii celulare (PCNA) \u00een micromediul tumoral sprijin\u0103 conceptul c\u0103 proliferarea celulelor tumorale este suprimat\u0103 de compu\u0219ii fenolici. Polifenolii ac\u0163ioneaz\u0103 la nivele diferite ale semnaliz\u0103rii intracelulare, suger\u00e2nd astfel ideea c\u0103 o asociere de polifenoli ar inhiba mai eficient evolu\u0163ia tumoral\u0103 dec\u00e2t anumi\u0163i constituien\u0163i polifenolici separat. Compu\u0219i fenolici precum EGCG, epicatechina, quercetina, myricetina \u015fi naringinina, \u00een condi\u0163iile unui pH neutru sau alcalin, sufer\u0103 degrad\u0103ri structurale care determin\u0103 o cre\u015ftere remarcabil\u0103 \u00een inhibarea telomerazei. Abilitatea compu\u0219ilor fenolici de a ac\u0163iona prin aceste mecanisme le confer\u0103 o caracteristic\u0103 suplimentar\u0103 benefic\u0103 fa\u0163\u0103 de terapia utilizat\u0103 \u00een prezent. Polifenolii naturali, sau scheletele lor moleculare, pot reprezenta punctul de plecare \u00een dezvoltarea de noi medicamente, concepute special pentru combaterea st\u0103rilor inflamatorii cronice \u015fi cancerogenezei.<\/p>\n
\n
The pathophysiological aspects and therapeutic perspectives of using phenolic compounds in dermatological conditions<\/span>
Manuela Ciocoiu, Iuliana Hunea, Codruta Badescu<\/span><\/p>\n\n
Alopecia, acne vulgaris, fungal infections or cutaneous hyperpigmentations may, nowadays, be treated efficiently with the help of polyphenols. The anti-inflammatory response demonstrated by these decreases the secretion of 1\u00df-interleukin and the activity of the kB nuclear factor. Some polyphenols have characteristics that are synergic with anticancer chemotherapeutic agents. Therefore, an adequate combined usage of polyphenols and chemotherapy drugs leads to the reduction of side effects without lowering the efficiency rates of the latter. The administration of these has strong anti-angiogenic effects, with a prospective of being able to control overgrowth or to induce tumoral regression. The inhibition of the proliferating cell nuclear antigen (PCNA) inside the tumoral microsystem supports the concept of malignant cell proliferation being supressed by phenolic compounds. Given the requirements of a neutral or more alkaline pH, phenolic compounds suffer structural breakdown, which determines a remarkable increase in the inhibition of the telomerase. An association of polyphenols inhibits more efficiently the tumoral evolution than individually administered constituents, through mechanism involved distinctly in intracellular signaling.<\/p>\n
\u00a0Scurt CV<\/span><\/p>\nCoordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiAspecte fiziopatologice \u015fi perspective terapeutice ale utiliz\u0103rii compu\u0219ilor fenolici \u00een afec\u0163iuni dermatologice Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu Dovezile existente indic\u0103 faptul c\u0103 polifenolii pot aduce beneficii pacien\u021bilor cu alopecie, acnee vulgar\u0103, infec\u021bii fungice, hiperpigmentare sau piele \u00eemb\u0103tr\u00e2nit\u0103 de soare R\u0103spunsurile antiinflamatorii exercitate […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4247","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4247"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247\/revisions"}],"predecessor-version":[{"id":6723,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247\/revisions\/6723"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nProf. Dr. Ciocoiu Manuela<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
Aspecte fiziopatologice \u015fi perspective terapeutice ale utiliz\u0103rii compu\u0219ilor fenolici \u00een afec\u0163iuni dermatologice<\/span>
Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\n\n
Dovezile existente indic\u0103 faptul c\u0103 polifenolii pot aduce beneficii pacien\u021bilor cu alopecie, acnee vulgar\u0103, infec\u021bii fungice, hiperpigmentare sau piele \u00eemb\u0103tr\u00e2nit\u0103 de soare R\u0103spunsurile antiinflamatorii exercitate de polifenoli implic\u0103 sc\u0103derea secre\u0163iei de IL-1\u00df \u015fi activit\u0103\u0163ii NF-kB. Unii polifenoli au caracteristici sinergistice cu agen\u021bii chimioterapeutici \u00eempotriva cancerului. Astfel, o combina\u021bie adecvat\u0103 a polifenolilor cu medicamentele chimioterapeutice existente va conduce la reducerea efectelor secundare f\u0103r\u0103 a sc\u0103dea efectele agen\u021bilor chimioterapeutici. Administrarea compu\u0219ilor fenolici a determinat o protec\u0163ie semnificativ\u0103 fa\u0163\u0103 de fotocarcinogenez\u0103 \u00een termeni de indice tumoral, multiplicitate tumoral\u0103 \u015fi cre\u015ftere tumoral\u0103. Aplica\u0163ia topic\u0103 de (-)-epigalocatechin-3-galat (EGCG), un chemoprotector major, a dus la inhibarea cre\u015fterii tumorilor cutanate induse de radia\u0163iile ultraviolete. Administrarea de polifenoli are efecte antiangiogenetice puternice \u015fi are poten\u0163ialul de a controla cre\u015fterea, sau determina regresia tumoral\u0103 prin acest mecanism. Inhibarea antigenului nuclear al prolifer\u0103rii celulare (PCNA) \u00een micromediul tumoral sprijin\u0103 conceptul c\u0103 proliferarea celulelor tumorale este suprimat\u0103 de compu\u0219ii fenolici. Polifenolii ac\u0163ioneaz\u0103 la nivele diferite ale semnaliz\u0103rii intracelulare, suger\u00e2nd astfel ideea c\u0103 o asociere de polifenoli ar inhiba mai eficient evolu\u0163ia tumoral\u0103 dec\u00e2t anumi\u0163i constituien\u0163i polifenolici separat. Compu\u0219i fenolici precum EGCG, epicatechina, quercetina, myricetina \u015fi naringinina, \u00een condi\u0163iile unui pH neutru sau alcalin, sufer\u0103 degrad\u0103ri structurale care determin\u0103 o cre\u015ftere remarcabil\u0103 \u00een inhibarea telomerazei. Abilitatea compu\u0219ilor fenolici de a ac\u0163iona prin aceste mecanisme le confer\u0103 o caracteristic\u0103 suplimentar\u0103 benefic\u0103 fa\u0163\u0103 de terapia utilizat\u0103 \u00een prezent. Polifenolii naturali, sau scheletele lor moleculare, pot reprezenta punctul de plecare \u00een dezvoltarea de noi medicamente, concepute special pentru combaterea st\u0103rilor inflamatorii cronice \u015fi cancerogenezei.<\/p>\n
\n
The pathophysiological aspects and therapeutic perspectives of using phenolic compounds in dermatological conditions<\/span>
Manuela Ciocoiu, Iuliana Hunea, Codruta Badescu<\/span><\/p>\n\n
Alopecia, acne vulgaris, fungal infections or cutaneous hyperpigmentations may, nowadays, be treated efficiently with the help of polyphenols. The anti-inflammatory response demonstrated by these decreases the secretion of 1\u00df-interleukin and the activity of the kB nuclear factor. Some polyphenols have characteristics that are synergic with anticancer chemotherapeutic agents. Therefore, an adequate combined usage of polyphenols and chemotherapy drugs leads to the reduction of side effects without lowering the efficiency rates of the latter. The administration of these has strong anti-angiogenic effects, with a prospective of being able to control overgrowth or to induce tumoral regression. The inhibition of the proliferating cell nuclear antigen (PCNA) inside the tumoral microsystem supports the concept of malignant cell proliferation being supressed by phenolic compounds. Given the requirements of a neutral or more alkaline pH, phenolic compounds suffer structural breakdown, which determines a remarkable increase in the inhibition of the telomerase. An association of polyphenols inhibits more efficiently the tumoral evolution than individually administered constituents, through mechanism involved distinctly in intracellular signaling.<\/p>\n
\u00a0Scurt CV<\/span><\/p>\nCoordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiAspecte fiziopatologice \u015fi perspective terapeutice ale utiliz\u0103rii compu\u0219ilor fenolici \u00een afec\u0163iuni dermatologice Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu Dovezile existente indic\u0103 faptul c\u0103 polifenolii pot aduce beneficii pacien\u021bilor cu alopecie, acnee vulgar\u0103, infec\u021bii fungice, hiperpigmentare sau piele \u00eemb\u0103tr\u00e2nit\u0103 de soare R\u0103spunsurile antiinflamatorii exercitate […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4247","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4247"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247\/revisions"}],"predecessor-version":[{"id":6723,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247\/revisions\/6723"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Prof. Dr. Ciocoiu Manuela<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
Aspecte fiziopatologice \u015fi perspective terapeutice ale utiliz\u0103rii compu\u0219ilor fenolici \u00een afec\u0163iuni dermatologice<\/span>
Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\n\n
Dovezile existente indic\u0103 faptul c\u0103 polifenolii pot aduce beneficii pacien\u021bilor cu alopecie, acnee vulgar\u0103, infec\u021bii fungice, hiperpigmentare sau piele \u00eemb\u0103tr\u00e2nit\u0103 de soare R\u0103spunsurile antiinflamatorii exercitate de polifenoli implic\u0103 sc\u0103derea secre\u0163iei de IL-1\u00df \u015fi activit\u0103\u0163ii NF-kB. Unii polifenoli au caracteristici sinergistice cu agen\u021bii chimioterapeutici \u00eempotriva cancerului. Astfel, o combina\u021bie adecvat\u0103 a polifenolilor cu medicamentele chimioterapeutice existente va conduce la reducerea efectelor secundare f\u0103r\u0103 a sc\u0103dea efectele agen\u021bilor chimioterapeutici. Administrarea compu\u0219ilor fenolici a determinat o protec\u0163ie semnificativ\u0103 fa\u0163\u0103 de fotocarcinogenez\u0103 \u00een termeni de indice tumoral, multiplicitate tumoral\u0103 \u015fi cre\u015ftere tumoral\u0103. Aplica\u0163ia topic\u0103 de (-)-epigalocatechin-3-galat (EGCG), un chemoprotector major, a dus la inhibarea cre\u015fterii tumorilor cutanate induse de radia\u0163iile ultraviolete. Administrarea de polifenoli are efecte antiangiogenetice puternice \u015fi are poten\u0163ialul de a controla cre\u015fterea, sau determina regresia tumoral\u0103 prin acest mecanism. Inhibarea antigenului nuclear al prolifer\u0103rii celulare (PCNA) \u00een micromediul tumoral sprijin\u0103 conceptul c\u0103 proliferarea celulelor tumorale este suprimat\u0103 de compu\u0219ii fenolici. Polifenolii ac\u0163ioneaz\u0103 la nivele diferite ale semnaliz\u0103rii intracelulare, suger\u00e2nd astfel ideea c\u0103 o asociere de polifenoli ar inhiba mai eficient evolu\u0163ia tumoral\u0103 dec\u00e2t anumi\u0163i constituien\u0163i polifenolici separat. Compu\u0219i fenolici precum EGCG, epicatechina, quercetina, myricetina \u015fi naringinina, \u00een condi\u0163iile unui pH neutru sau alcalin, sufer\u0103 degrad\u0103ri structurale care determin\u0103 o cre\u015ftere remarcabil\u0103 \u00een inhibarea telomerazei. Abilitatea compu\u0219ilor fenolici de a ac\u0163iona prin aceste mecanisme le confer\u0103 o caracteristic\u0103 suplimentar\u0103 benefic\u0103 fa\u0163\u0103 de terapia utilizat\u0103 \u00een prezent. Polifenolii naturali, sau scheletele lor moleculare, pot reprezenta punctul de plecare \u00een dezvoltarea de noi medicamente, concepute special pentru combaterea st\u0103rilor inflamatorii cronice \u015fi cancerogenezei.<\/p>\n
\n
The pathophysiological aspects and therapeutic perspectives of using phenolic compounds in dermatological conditions<\/span>
Manuela Ciocoiu, Iuliana Hunea, Codruta Badescu<\/span><\/p>\n\n
Alopecia, acne vulgaris, fungal infections or cutaneous hyperpigmentations may, nowadays, be treated efficiently with the help of polyphenols. The anti-inflammatory response demonstrated by these decreases the secretion of 1\u00df-interleukin and the activity of the kB nuclear factor. Some polyphenols have characteristics that are synergic with anticancer chemotherapeutic agents. Therefore, an adequate combined usage of polyphenols and chemotherapy drugs leads to the reduction of side effects without lowering the efficiency rates of the latter. The administration of these has strong anti-angiogenic effects, with a prospective of being able to control overgrowth or to induce tumoral regression. The inhibition of the proliferating cell nuclear antigen (PCNA) inside the tumoral microsystem supports the concept of malignant cell proliferation being supressed by phenolic compounds. Given the requirements of a neutral or more alkaline pH, phenolic compounds suffer structural breakdown, which determines a remarkable increase in the inhibition of the telomerase. An association of polyphenols inhibits more efficiently the tumoral evolution than individually administered constituents, through mechanism involved distinctly in intracellular signaling.<\/p>\n
\u00a0Scurt CV<\/span><\/p>\nCoordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiAspecte fiziopatologice \u015fi perspective terapeutice ale utiliz\u0103rii compu\u0219ilor fenolici \u00een afec\u0163iuni dermatologice Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu Dovezile existente indic\u0103 faptul c\u0103 polifenolii pot aduce beneficii pacien\u021bilor cu alopecie, acnee vulgar\u0103, infec\u021bii fungice, hiperpigmentare sau piele \u00eemb\u0103tr\u00e2nit\u0103 de soare R\u0103spunsurile antiinflamatorii exercitate […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4247","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4247"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247\/revisions"}],"predecessor-version":[{"id":6723,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247\/revisions\/6723"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\n
\n
Dovezile existente indic\u0103 faptul c\u0103 polifenolii pot aduce beneficii pacien\u021bilor cu alopecie, acnee vulgar\u0103, infec\u021bii fungice, hiperpigmentare sau piele \u00eemb\u0103tr\u00e2nit\u0103 de soare R\u0103spunsurile antiinflamatorii exercitate de polifenoli implic\u0103 sc\u0103derea secre\u0163iei de IL-1\u00df \u015fi activit\u0103\u0163ii NF-kB. Unii polifenoli au caracteristici sinergistice cu agen\u021bii chimioterapeutici \u00eempotriva cancerului. Astfel, o combina\u021bie adecvat\u0103 a polifenolilor cu medicamentele chimioterapeutice existente va conduce la reducerea efectelor secundare f\u0103r\u0103 a sc\u0103dea efectele agen\u021bilor chimioterapeutici. Administrarea compu\u0219ilor fenolici a determinat o protec\u0163ie semnificativ\u0103 fa\u0163\u0103 de fotocarcinogenez\u0103 \u00een termeni de indice tumoral, multiplicitate tumoral\u0103 \u015fi cre\u015ftere tumoral\u0103. Aplica\u0163ia topic\u0103 de (-)-epigalocatechin-3-galat (EGCG), un chemoprotector major, a dus la inhibarea cre\u015fterii tumorilor cutanate induse de radia\u0163iile ultraviolete. Administrarea de polifenoli are efecte antiangiogenetice puternice \u015fi are poten\u0163ialul de a controla cre\u015fterea, sau determina regresia tumoral\u0103 prin acest mecanism. Inhibarea antigenului nuclear al prolifer\u0103rii celulare (PCNA) \u00een micromediul tumoral sprijin\u0103 conceptul c\u0103 proliferarea celulelor tumorale este suprimat\u0103 de compu\u0219ii fenolici. Polifenolii ac\u0163ioneaz\u0103 la nivele diferite ale semnaliz\u0103rii intracelulare, suger\u00e2nd astfel ideea c\u0103 o asociere de polifenoli ar inhiba mai eficient evolu\u0163ia tumoral\u0103 dec\u00e2t anumi\u0163i constituien\u0163i polifenolici separat. Compu\u0219i fenolici precum EGCG, epicatechina, quercetina, myricetina \u015fi naringinina, \u00een condi\u0163iile unui pH neutru sau alcalin, sufer\u0103 degrad\u0103ri structurale care determin\u0103 o cre\u015ftere remarcabil\u0103 \u00een inhibarea telomerazei. Abilitatea compu\u0219ilor fenolici de a ac\u0163iona prin aceste mecanisme le confer\u0103 o caracteristic\u0103 suplimentar\u0103 benefic\u0103 fa\u0163\u0103 de terapia utilizat\u0103 \u00een prezent. Polifenolii naturali, sau scheletele lor moleculare, pot reprezenta punctul de plecare \u00een dezvoltarea de noi medicamente, concepute special pentru combaterea st\u0103rilor inflamatorii cronice \u015fi cancerogenezei.<\/p>\n
\n
The pathophysiological aspects and therapeutic perspectives of using phenolic compounds in dermatological conditions<\/span> \n Alopecia, acne vulgaris, fungal infections or cutaneous hyperpigmentations may, nowadays, be treated efficiently with the help of polyphenols. The anti-inflammatory response demonstrated by these decreases the secretion of 1\u00df-interleukin and the activity of the kB nuclear factor. Some polyphenols have characteristics that are synergic with anticancer chemotherapeutic agents. Therefore, an adequate combined usage of polyphenols and chemotherapy drugs leads to the reduction of side effects without lowering the efficiency rates of the latter. The administration of these has strong anti-angiogenic effects, with a prospective of being able to control overgrowth or to induce tumoral regression. The inhibition of the proliferating cell nuclear antigen (PCNA) inside the tumoral microsystem supports the concept of malignant cell proliferation being supressed by phenolic compounds. Given the requirements of a neutral or more alkaline pH, phenolic compounds suffer structural breakdown, which determines a remarkable increase in the inhibition of the telomerase. An association of polyphenols inhibits more efficiently the tumoral evolution than individually administered constituents, through mechanism involved distinctly in intracellular signaling.<\/p>\n \u00a0Scurt CV<\/span><\/p>\n Coordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiAspecte fiziopatologice \u015fi perspective terapeutice ale utiliz\u0103rii compu\u0219ilor fenolici \u00een afec\u0163iuni dermatologice Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu Dovezile existente indic\u0103 faptul c\u0103 polifenolii pot aduce beneficii pacien\u021bilor cu alopecie, acnee vulgar\u0103, infec\u021bii fungice, hiperpigmentare sau piele \u00eemb\u0103tr\u00e2nit\u0103 de soare R\u0103spunsurile antiinflamatorii exercitate […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4247","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4247"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247\/revisions"}],"predecessor-version":[{"id":6723,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4247\/revisions\/6723"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Manuela Ciocoiu, Iuliana Hunea, Codruta Badescu<\/span><\/p>\n
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"