<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nAsist. Univ. Dr. Nedelea Irena<\/span><\/strong>
Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj-Napoca<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
Tratamentul de desensibilizare la agen\u021bi biologici<\/span>
\nAutori: Irena Nedelea, Diana Deleanu<\/span><\/p>\nDesensibilizarea la medicamente este indicat\u0103 atunci c\u00e2nd acestea sunt indispensabile schemei terapeutice, la indivizi cu reac\u021bii de hipersensibilitate la preparatul vizat. Aceasta reprezint\u0103 administrarea unor doze progresiv cresc\u0103toare din medicamentul incriminat, p\u00e2n\u0103 la atingerea dozei terapeutice, cu scopul inducerii toleran\u021bei imunologice.
\nActual, desensibilizarea la medicamente este utilizat\u0103 cu succes pentru antibiotice, aspirin\u0103, chimioterapice, precum \u0219i pentru agen\u021bi biologici.
\nDesensibilizarea este eficient\u0103 la indivizii cu reactii de hipersensibilitate imediat\u0103, IgE-mediat\u0103 la medicamente, \u00eens\u0103 date publicate \u00een literatur\u0103 sus\u021bin eficacitatea acesteia \u0219i \u00een reac\u021bii de hipersensibilitate tardiv\u0103, de tipul IV. Adeseori, un medicament induce reac\u021bii adverse mediate prin mecanisme imunologice diferite \u0219i intricate. \u00cen aceast\u0103 categorie sunt inclu\u0219i anticorpii monoclonali. Reac\u021biile adverse fa\u021b\u0103 de ace\u0219tia se abat de la regula reac\u021biilor de hipersensibilitate clasificate de Gell \u0219i Coombs. \u00centruc\u00e2t statusul de toleran\u021b\u0103 este tranzitor \u0219i men\u021binut doar \u00een contextul administr\u0103rii zilnice a medicamentului, desensibilizarea la agen\u021bi biologici cu alt ritm de administrare, precum cel s\u0103pt\u0103m\u00e2nal, reprezint\u0103 o adevarat\u0103 provocare pentru clinician \u0219i pacient deopotriv\u0103. Reac\u021biile alergice din cursul desensibiliz\u0103rii r\u0103m\u00e2n un obstacol redutabil. O mai bun\u0103 \u00een\u021belegere a mecanismelor patologice ale reac\u021biilor de hipersensibilitate la medicamente, precum \u0219i a celor care stau la baza desensibiliz\u0103rii sunt premisele succesului acestei metode.
\nLucrarea de fa\u021b\u0103 este o punere la punct \u00een tema desensibiliz\u0103rii la agen\u021bi biologici \u0219i expune mecanismele prin care se induce toleran\u021ba imunologic\u0103, protocolul, indica\u021biile, contraindica\u021biile, posibilele reac\u021bii adverse \u0219i evolu\u021bia dup\u0103 desensibilizare, al\u0103turi de prezentarea unor cazuri de desensibilizare la agen\u021bi biologici, realizate \u00een Departamentul de Alergologie al Institutului Regional de Gastroenterologie \u0219i Hepatologie \u201cProfesor Doctor Octavian Fodor\u201d, Cluj-Napoca.<\/p>\n
Desensitization treatment of biological agents<\/span>
\nAuthors: Irena Nedelea, Diana Deleanu<\/span><\/p>\nDesensitization to drugs is indicated when they are indispensable to the therapeutic regimen in individuals with hypersensitivity reactions to the used drug. This implies the administration of progressively increasing doses of the incriminated drug until reaching the therapeutic dose in order to induce immunological tolerance.
\nCurrently, drug desensitization is successfully used for antibiotics, aspirin, chemotherapeutic agents, as well as biological agents.
\nDesensitization is effective in individuals with immediate, IgE mediated hypersensitivity reactions, but data published in the literature support its efficacy in delayed type IV hypersensitivity reactions. Often, a drug induces adverse reactions mediated by different and complex immunological mechanisms. This category includes monoclonal antibodies. Adverse reactions to them deviate from the rule of hypersensitivity reactions as classified by Gell and Coombs. Because tolerance status is transient and maintained only in the context of daily drug administration, desensitization to biological agents at a different rate of administration, such as weekly, is a real challenge for both clinician and patient alike. Allergic reactions during desensitization remain a great obstacle. A better understanding of the pathological mechanisms of drug hypersensitivity reactions as well as those underlying desensitization are the premises for the success of this method.
\nThis paper focuses on the topic of desensitization to biological agents and exposes the mechanisms by which immunological tolerance are induced, the protocol, indications, contraindications, possible adverse reactions and evolution after desensitization, along with the presentation of cases of desensitization to biological agents in the Department of Allergology of the “Professor Doctor Octavian Fodor” Regional Institute of Gastroenterology and Hepatology in Cluj-Napoca.<\/p>\n
\u00a0Scurt CV<\/p>\n
Grad didactic: <\/strong>
\nAsistent Universitar<\/p>\nFunc\u0163ie: <\/strong>
\nMedic specialist<\/p>\nLoc de munc\u0103: <\/strong>
\nUniversitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Institutul Regional de Gastroenterologie si Hepatologie Profesor Doctor Octavian Fodor, Cluj-Napoca<\/p>\nSpecializ\u0103ri:<\/strong>
\nAlergologie si Imunologie Clinica<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
\nMembru Societatea Romana de Alergologie si Imunologie Clinica, membru EEACI[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\nContacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Asist. Univ. Dr. Nedelea Irena Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj-NapocaTratamentul de desensibilizare la agen\u021bi biologici Autori: Irena Nedelea, Diana Deleanu Desensibilizarea la medicamente este indicat\u0103 atunci c\u00e2nd acestea sunt indispensabile schemei terapeutice, la indivizi cu reac\u021bii de hipersensibilitate la preparatul vizat. Aceasta reprezint\u0103 administrarea unor doze progresiv cresc\u0103toare din medicamentul incriminat, p\u00e2n\u0103 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4286","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4286"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4286\/revisions"}],"predecessor-version":[{"id":6738,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4286\/revisions\/6738"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Asist. Univ. Dr. Nedelea Irena<\/span><\/strong>
Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj-Napoca<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
Tratamentul de desensibilizare la agen\u021bi biologici<\/span>
\nAutori: Irena Nedelea, Diana Deleanu<\/span><\/p>\nDesensibilizarea la medicamente este indicat\u0103 atunci c\u00e2nd acestea sunt indispensabile schemei terapeutice, la indivizi cu reac\u021bii de hipersensibilitate la preparatul vizat. Aceasta reprezint\u0103 administrarea unor doze progresiv cresc\u0103toare din medicamentul incriminat, p\u00e2n\u0103 la atingerea dozei terapeutice, cu scopul inducerii toleran\u021bei imunologice.
\nActual, desensibilizarea la medicamente este utilizat\u0103 cu succes pentru antibiotice, aspirin\u0103, chimioterapice, precum \u0219i pentru agen\u021bi biologici.
\nDesensibilizarea este eficient\u0103 la indivizii cu reactii de hipersensibilitate imediat\u0103, IgE-mediat\u0103 la medicamente, \u00eens\u0103 date publicate \u00een literatur\u0103 sus\u021bin eficacitatea acesteia \u0219i \u00een reac\u021bii de hipersensibilitate tardiv\u0103, de tipul IV. Adeseori, un medicament induce reac\u021bii adverse mediate prin mecanisme imunologice diferite \u0219i intricate. \u00cen aceast\u0103 categorie sunt inclu\u0219i anticorpii monoclonali. Reac\u021biile adverse fa\u021b\u0103 de ace\u0219tia se abat de la regula reac\u021biilor de hipersensibilitate clasificate de Gell \u0219i Coombs. \u00centruc\u00e2t statusul de toleran\u021b\u0103 este tranzitor \u0219i men\u021binut doar \u00een contextul administr\u0103rii zilnice a medicamentului, desensibilizarea la agen\u021bi biologici cu alt ritm de administrare, precum cel s\u0103pt\u0103m\u00e2nal, reprezint\u0103 o adevarat\u0103 provocare pentru clinician \u0219i pacient deopotriv\u0103. Reac\u021biile alergice din cursul desensibiliz\u0103rii r\u0103m\u00e2n un obstacol redutabil. O mai bun\u0103 \u00een\u021belegere a mecanismelor patologice ale reac\u021biilor de hipersensibilitate la medicamente, precum \u0219i a celor care stau la baza desensibiliz\u0103rii sunt premisele succesului acestei metode.
\nLucrarea de fa\u021b\u0103 este o punere la punct \u00een tema desensibiliz\u0103rii la agen\u021bi biologici \u0219i expune mecanismele prin care se induce toleran\u021ba imunologic\u0103, protocolul, indica\u021biile, contraindica\u021biile, posibilele reac\u021bii adverse \u0219i evolu\u021bia dup\u0103 desensibilizare, al\u0103turi de prezentarea unor cazuri de desensibilizare la agen\u021bi biologici, realizate \u00een Departamentul de Alergologie al Institutului Regional de Gastroenterologie \u0219i Hepatologie \u201cProfesor Doctor Octavian Fodor\u201d, Cluj-Napoca.<\/p>\n
Desensitization treatment of biological agents<\/span>
\nAuthors: Irena Nedelea, Diana Deleanu<\/span><\/p>\nDesensitization to drugs is indicated when they are indispensable to the therapeutic regimen in individuals with hypersensitivity reactions to the used drug. This implies the administration of progressively increasing doses of the incriminated drug until reaching the therapeutic dose in order to induce immunological tolerance.
\nCurrently, drug desensitization is successfully used for antibiotics, aspirin, chemotherapeutic agents, as well as biological agents.
\nDesensitization is effective in individuals with immediate, IgE mediated hypersensitivity reactions, but data published in the literature support its efficacy in delayed type IV hypersensitivity reactions. Often, a drug induces adverse reactions mediated by different and complex immunological mechanisms. This category includes monoclonal antibodies. Adverse reactions to them deviate from the rule of hypersensitivity reactions as classified by Gell and Coombs. Because tolerance status is transient and maintained only in the context of daily drug administration, desensitization to biological agents at a different rate of administration, such as weekly, is a real challenge for both clinician and patient alike. Allergic reactions during desensitization remain a great obstacle. A better understanding of the pathological mechanisms of drug hypersensitivity reactions as well as those underlying desensitization are the premises for the success of this method.
\nThis paper focuses on the topic of desensitization to biological agents and exposes the mechanisms by which immunological tolerance are induced, the protocol, indications, contraindications, possible adverse reactions and evolution after desensitization, along with the presentation of cases of desensitization to biological agents in the Department of Allergology of the “Professor Doctor Octavian Fodor” Regional Institute of Gastroenterology and Hepatology in Cluj-Napoca.<\/p>\n
\u00a0Scurt CV<\/p>\n
Grad didactic: <\/strong>
\nAsistent Universitar<\/p>\nFunc\u0163ie: <\/strong>
\nMedic specialist<\/p>\nLoc de munc\u0103: <\/strong>
\nUniversitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Institutul Regional de Gastroenterologie si Hepatologie Profesor Doctor Octavian Fodor, Cluj-Napoca<\/p>\nSpecializ\u0103ri:<\/strong>
\nAlergologie si Imunologie Clinica<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
\nMembru Societatea Romana de Alergologie si Imunologie Clinica, membru EEACI[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\nContacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Asist. Univ. Dr. Nedelea Irena Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj-NapocaTratamentul de desensibilizare la agen\u021bi biologici Autori: Irena Nedelea, Diana Deleanu Desensibilizarea la medicamente este indicat\u0103 atunci c\u00e2nd acestea sunt indispensabile schemei terapeutice, la indivizi cu reac\u021bii de hipersensibilitate la preparatul vizat. Aceasta reprezint\u0103 administrarea unor doze progresiv cresc\u0103toare din medicamentul incriminat, p\u00e2n\u0103 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4286","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4286"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4286\/revisions"}],"predecessor-version":[{"id":6738,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4286\/revisions\/6738"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nAutori: Irena Nedelea, Diana Deleanu<\/span><\/p>\n
Desensibilizarea la medicamente este indicat\u0103 atunci c\u00e2nd acestea sunt indispensabile schemei terapeutice, la indivizi cu reac\u021bii de hipersensibilitate la preparatul vizat. Aceasta reprezint\u0103 administrarea unor doze progresiv cresc\u0103toare din medicamentul incriminat, p\u00e2n\u0103 la atingerea dozei terapeutice, cu scopul inducerii toleran\u021bei imunologice.
\nActual, desensibilizarea la medicamente este utilizat\u0103 cu succes pentru antibiotice, aspirin\u0103, chimioterapice, precum \u0219i pentru agen\u021bi biologici.
\nDesensibilizarea este eficient\u0103 la indivizii cu reactii de hipersensibilitate imediat\u0103, IgE-mediat\u0103 la medicamente, \u00eens\u0103 date publicate \u00een literatur\u0103 sus\u021bin eficacitatea acesteia \u0219i \u00een reac\u021bii de hipersensibilitate tardiv\u0103, de tipul IV. Adeseori, un medicament induce reac\u021bii adverse mediate prin mecanisme imunologice diferite \u0219i intricate. \u00cen aceast\u0103 categorie sunt inclu\u0219i anticorpii monoclonali. Reac\u021biile adverse fa\u021b\u0103 de ace\u0219tia se abat de la regula reac\u021biilor de hipersensibilitate clasificate de Gell \u0219i Coombs. \u00centruc\u00e2t statusul de toleran\u021b\u0103 este tranzitor \u0219i men\u021binut doar \u00een contextul administr\u0103rii zilnice a medicamentului, desensibilizarea la agen\u021bi biologici cu alt ritm de administrare, precum cel s\u0103pt\u0103m\u00e2nal, reprezint\u0103 o adevarat\u0103 provocare pentru clinician \u0219i pacient deopotriv\u0103. Reac\u021biile alergice din cursul desensibiliz\u0103rii r\u0103m\u00e2n un obstacol redutabil. O mai bun\u0103 \u00een\u021belegere a mecanismelor patologice ale reac\u021biilor de hipersensibilitate la medicamente, precum \u0219i a celor care stau la baza desensibiliz\u0103rii sunt premisele succesului acestei metode.
\nLucrarea de fa\u021b\u0103 este o punere la punct \u00een tema desensibiliz\u0103rii la agen\u021bi biologici \u0219i expune mecanismele prin care se induce toleran\u021ba imunologic\u0103, protocolul, indica\u021biile, contraindica\u021biile, posibilele reac\u021bii adverse \u0219i evolu\u021bia dup\u0103 desensibilizare, al\u0103turi de prezentarea unor cazuri de desensibilizare la agen\u021bi biologici, realizate \u00een Departamentul de Alergologie al Institutului Regional de Gastroenterologie \u0219i Hepatologie \u201cProfesor Doctor Octavian Fodor\u201d, Cluj-Napoca.<\/p>\n
Desensitization treatment of biological agents<\/span> Desensitization to drugs is indicated when they are indispensable to the therapeutic regimen in individuals with hypersensitivity reactions to the used drug. This implies the administration of progressively increasing doses of the incriminated drug until reaching the therapeutic dose in order to induce immunological tolerance. \u00a0Scurt CV<\/p>\n Grad didactic: <\/strong> Func\u0163ie: <\/strong> Loc de munc\u0103: <\/strong> Specializ\u0103ri:<\/strong> Apartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong> Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> Asist. Univ. Dr. Nedelea Irena Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj-NapocaTratamentul de desensibilizare la agen\u021bi biologici Autori: Irena Nedelea, Diana Deleanu Desensibilizarea la medicamente este indicat\u0103 atunci c\u00e2nd acestea sunt indispensabile schemei terapeutice, la indivizi cu reac\u021bii de hipersensibilitate la preparatul vizat. Aceasta reprezint\u0103 administrarea unor doze progresiv cresc\u0103toare din medicamentul incriminat, p\u00e2n\u0103 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4286","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4286"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4286\/revisions"}],"predecessor-version":[{"id":6738,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4286\/revisions\/6738"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nAuthors: Irena Nedelea, Diana Deleanu<\/span><\/p>\n
\nCurrently, drug desensitization is successfully used for antibiotics, aspirin, chemotherapeutic agents, as well as biological agents.
\nDesensitization is effective in individuals with immediate, IgE mediated hypersensitivity reactions, but data published in the literature support its efficacy in delayed type IV hypersensitivity reactions. Often, a drug induces adverse reactions mediated by different and complex immunological mechanisms. This category includes monoclonal antibodies. Adverse reactions to them deviate from the rule of hypersensitivity reactions as classified by Gell and Coombs. Because tolerance status is transient and maintained only in the context of daily drug administration, desensitization to biological agents at a different rate of administration, such as weekly, is a real challenge for both clinician and patient alike. Allergic reactions during desensitization remain a great obstacle. A better understanding of the pathological mechanisms of drug hypersensitivity reactions as well as those underlying desensitization are the premises for the success of this method.
\nThis paper focuses on the topic of desensitization to biological agents and exposes the mechanisms by which immunological tolerance are induced, the protocol, indications, contraindications, possible adverse reactions and evolution after desensitization, along with the presentation of cases of desensitization to biological agents in the Department of Allergology of the “Professor Doctor Octavian Fodor” Regional Institute of Gastroenterology and Hepatology in Cluj-Napoca.<\/p>\n
\nAsistent Universitar<\/p>\n
\nMedic specialist<\/p>\n
\nUniversitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Institutul Regional de Gastroenterologie si Hepatologie Profesor Doctor Octavian Fodor, Cluj-Napoca<\/p>\n
\nAlergologie si Imunologie Clinica<\/p>\n
\nMembru Societatea Romana de Alergologie si Imunologie Clinica, membru EEACI[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"