<\/strong><\/span><\/h4>\n<\/strong><\/span><\/p>\n<\/strong><\/span><\/p>\n<\/strong><\/span><\/p>\nProf. Dr.\u00a0Deleanu Diana<\/strong><\/span>
Universitatea de Medicin\u0103 \u0219i Farmacie”Iuliu Ha\u021bieganu”, Cluj Napoca<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
Reac\u021biile de hipersensibilitate la agen\u021bi biologici <\/span>
Autori: Diana Deleanu, Irena Nedelea<\/span><\/p>\nUltimul deceniu aduce, gra\u021bie terapiei imunomodulatoare, rezultate spectaculoase \u00een tratamentul \u021bintit al unor afec\u021biuni inflamatorii, autoimune, neoplazice. Utilizarea pe scar\u0103 larg\u0103 a agen\u021bilor biologici este grefat\u0103 \u00eens\u0103 de cre\u0219terea num\u0103rului de reac\u021bii adverse medicamentoase mediate imunologic.
Scopul lucr\u0103rii este prezentarea reac\u021biilor adverse la biologice.
Alergia medicamentoas\u0103 reprezint\u0103 reac\u021bia advers\u0103 imprevizibil\u0103 ce survine in urma administr\u0103rii unui medicament \u00eentr-o anumit\u0103 doz\u0103, tolerat\u0103 de subiec\u021bii normali produsa prin mecanism imunologic, IgE sau non-IgE mediat (prin IgG sau limfocite). Unul sau mai multe mecanisme imune pot concura la dezvoltarea reac\u021biilor alergice la medicamente.
Agent biologic este definit de ca un medicament ce contine una sau mai multe substante active produse de sau derivate dintr-o sursa biologica. Acestea include: vaccinurile, imunoterapiile, substantele biosimilare, terapia genica si celulele stem sau terapia tisulara. In inteles restrins, terapia biologica se refera la medicamentele bazate pe protein (de ex. Insulina, anticorpii monoclonali de tipul ixekizumab etc) Reactiile adverse fata de biologice se pot clasifica in 3 categorii: reacti induse de cytokine in concentratie mare (furtuna citokinelor); reactii de hipersensibilitate si in imunodeficiente secundare. Vom prezenta cu precadere reactiile de hipersensibilitate mediate imun. Reactiile de anafilaxie sunt cele mai alarmante, dar sunt putine. Exista posibilitatea desensibilizarii in cazul reactiilor mediate prin IgE. Si alte forme de reactii mediate imun se pot produce: boala serului.
In concluzie: Exista un risc scazut de reactii alergice la biologice. Unele dintre ele, mediate IgE pot beneficia de \u201edesensibilizare\u201d.<\/p>\n
Hyperreactivity Reactions to Biologics <\/span>
Authors: Diana Deleanu, Irena Nedelea<\/span><\/p>\nIn the last 10 years, due to the successful result of immunological therapies, many biologics are emerging as a significant therapeutic option for debilitating inflammatory and autoimmune conditions. Adverse reaction to biologics were reported due to increased number and large used of them.
The aim of presentation is adverse events to biologics and their possible therapy.
Drug allergy is an imprevizible reaction after the administration of a biologic in normal dose (tolerated by the majority of subjects) and it is produced by an activation of immune system, either IgE-mediated, either non-IgE-mediated (activation of lymphocytes, or IgGs). One or more mechanism may play a role in hypersensitivity adverse reactions.
Biologics are defined as medication to contain one or more active substances from a biological source. They include: vaccines, immunotherapy, biosimilars, genic therapy, stem cells and tissue therapy. Usually, biologics include mainly drugs containing proteins (eg Insulin, Monoclonal Antibodies as ixekizumab etc). Adverse reactions of biologics may be classified in 3 groups: reaction induced by high amount of cytokine (cytokine storm); hypersensitivity reactions, and secondary immunodeficiency. Our presentations refer mainly to immune-mediated reactions. Anaphylactic reactions are most severe, but happily the are very few. It is possible to induce tolerance by \u201cdesensitization\u201d Other type of mediated-immune reaction may develop (eg serum sickness).
In conclusion: There is a low risk of allergioc reaction to biologics. In some cases it is possible to induce tolerance by \u201edesensititation\u201d<\/p>\n
Scurt CV<\/span><\/p>\nA absolvit Facultatea de Medicina si Farmacie a Institutului de Medicina si Farmacie Cluj-Napoca (actuala Universitate de Medicina si Farmacie Iuliu Hatieganu) in 1983. Este medic primar de Medicina Interna si de Alergologie si Imunologie Clinica (din 1995). Este angajata la UMF Iuliu Hatieganu, disciplina de Imunologie si Alergologie (sef de disciplina) si la Institutul Regional de Gastroenterologie si Hepatologie (IRGH) \u201cProf. dr. Octavian Fodor\u201d, sectia Medicina Interna (sef de sectie) cu compartimente de Alergologie si de Imunologie. Conduce programul nationale pentru boli rare \u2013 imunodeficiente primare.
Specializari la UMF Cluj-Napoca, UMF Carol Davila, Bucuresti, Universitatea de Medicina Southampton (boli respiratorii), la Spitalul Brompton, Londra, Serviciul de recuperare boli respiratorii Paderborn, la Clinica Nantes, Universitatea Navarra, Clinica San Miguel (alergologie) din Pamplona. Si-a sustinut teza de doctorat in domeniul medicine cu o tema de imunologie, in 1996. Autoare si coautoare a numeroase articole, cu indice Hirsch peste 9 si autoare la mai multe carti, capitole de carte in domeniul imunologiei si alergologiei. A introdus teste de provocare si imunoterapia specifica. Preda cursuri de imunologie si alergologie la studentii de la UMF “Iuliu Hatieganu” Cluj-Napoca, la anul 3 si 6 medicina generala, la medicina dentara, farmacie, nutritie si este responsabila de pregatirea medicilor rezidenti in specialitatea de Alergologie si Imunologie Clinica. Este investigator principal in numeroase studii clinice internationale privind bolile alergice (astm, rinita, soc anafilactic, urticarie). Participant la numeroase manifestarii de medicina, imunologie, alergologie, pediatrie, dermatologie regionale, nationale si internationale. A organizat “Scoala de Vara” 2007 la Cluj-Napoca, impreuna cu Academia Europeana de Alergologie si Imunologie Clinica (EAACI). A fost vicepresedinte (200-2006) si presedinte (2006-20017) al Societatii Nationale de Alergologie si Imunologie Clinica (SRAIC) , in prezent este \u201cfost-presedinte\u201d al SRAIC. Este membra la mai multe societati internationale de alergologie (EAACI, organizatia mondiala de Alergologie \u2013 WAO, la AAAAI, la ACAAI etc) si face parte din Comisiile de specialitate ale MS si Colegiului Medicilor. Are doi copii si trei nepoti.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Prof. Dr.\u00a0Deleanu Diana Universitatea de Medicin\u0103 \u0219i Farmacie”Iuliu Ha\u021bieganu”, Cluj NapocaReac\u021biile de hipersensibilitate la agen\u021bi biologici Autori: Diana Deleanu, Irena Nedelea Ultimul deceniu aduce, gra\u021bie terapiei imunomodulatoare, rezultate spectaculoase \u00een tratamentul \u021bintit al unor afec\u021biuni inflamatorii, autoimune, neoplazice. Utilizarea pe scar\u0103 larg\u0103 a agen\u021bilor biologici este grefat\u0103 \u00eens\u0103 de cre\u0219terea num\u0103rului de reac\u021bii adverse medicamentoase […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4414","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4414"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4414\/revisions"}],"predecessor-version":[{"id":6724,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4414\/revisions\/6724"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/strong><\/span><\/p>\n <\/strong><\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n Reac\u021biile de hipersensibilitate la agen\u021bi biologici <\/span> Ultimul deceniu aduce, gra\u021bie terapiei imunomodulatoare, rezultate spectaculoase \u00een tratamentul \u021bintit al unor afec\u021biuni inflamatorii, autoimune, neoplazice. Utilizarea pe scar\u0103 larg\u0103 a agen\u021bilor biologici este grefat\u0103 \u00eens\u0103 de cre\u0219terea num\u0103rului de reac\u021bii adverse medicamentoase mediate imunologic. Hyperreactivity Reactions to Biologics <\/span> In the last 10 years, due to the successful result of immunological therapies, many biologics are emerging as a significant therapeutic option for debilitating inflammatory and autoimmune conditions. Adverse reaction to biologics were reported due to increased number and large used of them. Scurt CV<\/span><\/p>\n A absolvit Facultatea de Medicina si Farmacie a Institutului de Medicina si Farmacie Cluj-Napoca (actuala Universitate de Medicina si Farmacie Iuliu Hatieganu) in 1983. Este medic primar de Medicina Interna si de Alergologie si Imunologie Clinica (din 1995). Este angajata la UMF Iuliu Hatieganu, disciplina de Imunologie si Alergologie (sef de disciplina) si la Institutul Regional de Gastroenterologie si Hepatologie (IRGH) \u201cProf. dr. Octavian Fodor\u201d, sectia Medicina Interna (sef de sectie) cu compartimente de Alergologie si de Imunologie. Conduce programul nationale pentru boli rare \u2013 imunodeficiente primare. [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> Prof. Dr.\u00a0Deleanu Diana Universitatea de Medicin\u0103 \u0219i Farmacie”Iuliu Ha\u021bieganu”, Cluj NapocaReac\u021biile de hipersensibilitate la agen\u021bi biologici Autori: Diana Deleanu, Irena Nedelea Ultimul deceniu aduce, gra\u021bie terapiei imunomodulatoare, rezultate spectaculoase \u00een tratamentul \u021bintit al unor afec\u021biuni inflamatorii, autoimune, neoplazice. Utilizarea pe scar\u0103 larg\u0103 a agen\u021bilor biologici este grefat\u0103 \u00eens\u0103 de cre\u0219terea num\u0103rului de reac\u021bii adverse medicamentoase […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4414","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4414"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4414\/revisions"}],"predecessor-version":[{"id":6724,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4414\/revisions\/6724"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Prof. Dr.\u00a0Deleanu Diana<\/strong><\/span>
Universitatea de Medicin\u0103 \u0219i Farmacie”Iuliu Ha\u021bieganu”, Cluj Napoca<\/strong><\/span><\/h4>\n
Autori: Diana Deleanu, Irena Nedelea<\/span><\/p>\n
Scopul lucr\u0103rii este prezentarea reac\u021biilor adverse la biologice.
Alergia medicamentoas\u0103 reprezint\u0103 reac\u021bia advers\u0103 imprevizibil\u0103 ce survine in urma administr\u0103rii unui medicament \u00eentr-o anumit\u0103 doz\u0103, tolerat\u0103 de subiec\u021bii normali produsa prin mecanism imunologic, IgE sau non-IgE mediat (prin IgG sau limfocite). Unul sau mai multe mecanisme imune pot concura la dezvoltarea reac\u021biilor alergice la medicamente.
Agent biologic este definit de ca un medicament ce contine una sau mai multe substante active produse de sau derivate dintr-o sursa biologica. Acestea include: vaccinurile, imunoterapiile, substantele biosimilare, terapia genica si celulele stem sau terapia tisulara. In inteles restrins, terapia biologica se refera la medicamentele bazate pe protein (de ex. Insulina, anticorpii monoclonali de tipul ixekizumab etc) Reactiile adverse fata de biologice se pot clasifica in 3 categorii: reacti induse de cytokine in concentratie mare (furtuna citokinelor); reactii de hipersensibilitate si in imunodeficiente secundare. Vom prezenta cu precadere reactiile de hipersensibilitate mediate imun. Reactiile de anafilaxie sunt cele mai alarmante, dar sunt putine. Exista posibilitatea desensibilizarii in cazul reactiilor mediate prin IgE. Si alte forme de reactii mediate imun se pot produce: boala serului.
In concluzie: Exista un risc scazut de reactii alergice la biologice. Unele dintre ele, mediate IgE pot beneficia de \u201edesensibilizare\u201d.<\/p>\n
Authors: Diana Deleanu, Irena Nedelea<\/span><\/p>\n
The aim of presentation is adverse events to biologics and their possible therapy.
Drug allergy is an imprevizible reaction after the administration of a biologic in normal dose (tolerated by the majority of subjects) and it is produced by an activation of immune system, either IgE-mediated, either non-IgE-mediated (activation of lymphocytes, or IgGs). One or more mechanism may play a role in hypersensitivity adverse reactions.
Biologics are defined as medication to contain one or more active substances from a biological source. They include: vaccines, immunotherapy, biosimilars, genic therapy, stem cells and tissue therapy. Usually, biologics include mainly drugs containing proteins (eg Insulin, Monoclonal Antibodies as ixekizumab etc). Adverse reactions of biologics may be classified in 3 groups: reaction induced by high amount of cytokine (cytokine storm); hypersensitivity reactions, and secondary immunodeficiency. Our presentations refer mainly to immune-mediated reactions. Anaphylactic reactions are most severe, but happily the are very few. It is possible to induce tolerance by \u201cdesensitization\u201d Other type of mediated-immune reaction may develop (eg serum sickness).
In conclusion: There is a low risk of allergioc reaction to biologics. In some cases it is possible to induce tolerance by \u201edesensititation\u201d<\/p>\n
Specializari la UMF Cluj-Napoca, UMF Carol Davila, Bucuresti, Universitatea de Medicina Southampton (boli respiratorii), la Spitalul Brompton, Londra, Serviciul de recuperare boli respiratorii Paderborn, la Clinica Nantes, Universitatea Navarra, Clinica San Miguel (alergologie) din Pamplona. Si-a sustinut teza de doctorat in domeniul medicine cu o tema de imunologie, in 1996. Autoare si coautoare a numeroase articole, cu indice Hirsch peste 9 si autoare la mai multe carti, capitole de carte in domeniul imunologiei si alergologiei. A introdus teste de provocare si imunoterapia specifica. Preda cursuri de imunologie si alergologie la studentii de la UMF “Iuliu Hatieganu” Cluj-Napoca, la anul 3 si 6 medicina generala, la medicina dentara, farmacie, nutritie si este responsabila de pregatirea medicilor rezidenti in specialitatea de Alergologie si Imunologie Clinica. Este investigator principal in numeroase studii clinice internationale privind bolile alergice (astm, rinita, soc anafilactic, urticarie). Participant la numeroase manifestarii de medicina, imunologie, alergologie, pediatrie, dermatologie regionale, nationale si internationale. A organizat “Scoala de Vara” 2007 la Cluj-Napoca, impreuna cu Academia Europeana de Alergologie si Imunologie Clinica (EAACI). A fost vicepresedinte (200-2006) si presedinte (2006-20017) al Societatii Nationale de Alergologie si Imunologie Clinica (SRAIC) , in prezent este \u201cfost-presedinte\u201d al SRAIC. Este membra la mai multe societati internationale de alergologie (EAACI, organizatia mondiala de Alergologie \u2013 WAO, la AAAAI, la ACAAI etc) si face parte din Comisiile de specialitate ale MS si Colegiului Medicilor. Are doi copii si trei nepoti.<\/p>\n<\/span><\/p>\n
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