Facultatea de Medicin\u0103 Dentar\u0103 U.M.F. \u201dCarol Davila\u201d Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.18″][et_pb_column type=”4_4″ _builder_version=”3.19.18″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Incontinentia pigmenti<\/span>
Autor:\u00a0Isabela S\u00e2rbu<\/span><\/p>\nIncontinentia pigmenti (IP) este o afec\u0163iune cu transmitere dominant\u0103 X-linkat\u0103 care, \u00een peste 95% dintre cazuri, afecteaz\u0103 nou-n\u0103scu\u0163i de sex feminin. Boala este \u00een general letal\u0103 la sexul masculin \u00eenc\u0103 din perioada intrauterin\u0103, excep\u0163ie f\u0103c\u00e2nd b\u0103ie\u0163ii cu sindrom Klinefelter (XXY) \u015fi cei cu mozaicism somatic. Este o boal\u0103 rar\u0103, cu o prevalen\u0163\u0103 de 1\/50 000 de cazuri \u00een popula\u0163ia general\u0103. Genodermatoza este complex\u0103, manifest\u0103rile cutanate fiind asociate cu un sindrom oculo-dento-cerebral, patogeneza sa fiind legat\u0103 de susceptibilitatea celulelor care prezint\u0103 muta\u0163ii ale unei gene situate \u00een regiunea Xq28 de pe cromozomul X fa\u0163\u0103 de apoptoza determinat\u0103 de factorul de necroza tumoral\u0103.
Din punct de vedere clinic, boala prezint\u0103 patru stadii de evolu\u0163ie: stadiul vezicular sau inflamator, stadiul verucos, stadiul de hiperpigmentare \u015fi stadiul de hipopigmentare. Aceste stadii se suprapun \u00eens\u0103 frecvent.
Prezent\u0103m cazul unui nou-n\u0103scut de sex feminin, rezultat dintr-o sarcin\u0103 cu evolu\u0163ie normal\u0103, care \u00eenc\u0103 de la na\u015ftere avea o erup\u0163ie alc\u0103tuit\u0103 ini\u0163ial din macule eritematoase, ulterior vezicule \u015fi bule, diseminate la nivelul trunchiului \u015fi membrelor. \u00cen a doua zi de via\u0163\u0103 pacienta a prezentat crize convulsive tonico-clonice generalizate tratate cu diazepam. La prezentarea \u00een clinica de dermatologie, la v\u00e2rsta de 14 zile, s-au observat macule de culoare maronie cu pattern reticular, precum \u015fi vezicule, bule \u015fi leziuni verucoase.
Prezent\u0103m un caz complex de IP \u00een care abordarea interdisciplinar\u0103 a pacientului cu implicarea medicului dermatolog, neurolog, oftalmolog, radiolog, pediatru dar \u015fi genetician, dentist \u015fi medicului de familie, este deosebit de important\u0103. De\u015fi medicul dermatolog are un rol central \u00een gestionarea cazurilor, prognosticul afec\u0163iunii este dependent de severitatea manifest\u0103rilor extracutanate.<\/p>\n
Incontinentia pigmenti<\/span>
Author:\u00a0Isabela S\u00e2rbu<\/span><\/p>\nIncontinentia pigmenti (IP) is an affliction inherited in an X-linked dominant pattern which, in more than 95% of cases, affects female new-borns. The disease is generally lethal in males since the intrauterine period, except in patients with Klinefelter syndrome (XXY) or somatic mosaicism. It is a rare disease, with an overall prevalence of 1\/50 000 cases. The genodermatosis is complex, the cutaneous manifestations being associated with an oculo-dental-cerebral syndrome, its pathogenesis being related with the susceptibility of the cells presenting mutations in a gene situated in the Xq28 region on chromosome X towards the apoptosis determined by the tumor necrosis factor.
Clinically, the disease presents four evolution stages: the vesicular or inflammatory stage, the verrucous stage, the hyperpigmentation stage and the hypopigmentation stage. These stages however often overlap.
We present the case of a female new-born from a normal pregnancy, who, since birth, presented an eruption consisting initially of erythematous patches and later in vesicles and bullae, disseminated on the trunk and limbs. In the second day of life the patient presented generalized tonic-clonic seizures which were treated with diazepam. At presentation in the dermatology clinic, at the age of 14 days, we observed brownish patches with a reticular pattern, as well as vesicles, bullae and verrucous lesions.
We present a complex case of IP in which the interdisciplinary team including the dermatologist, neurologist, ophthalmologist, radiologist, paediatrician, as well as geneticist, dentist and family doctor is very important. Even though the dermatologist plays a central role in managing the cases, the prognosis of the disease is related to the severity of the extracutaneous manifestations.<\/p>\n
Scurt CV<\/span><\/p>\nGrad didactic<\/strong>
Din anul 2016 \u2013 asistent universitar la disciplina dermatologie a Facult\u0103\u0163ii de Medicin\u0103 Dentar\u0103 U.M.F. \u201dCarol Davila\u201d Bucure\u015fti
Func\u0163ie<\/strong>
Asistent universitar la disciplina dermatologie, Facultatea de Medicin\u0103 Dentar\u0103 U.M.F. \u201dCarol Davila\u201d Bucure\u015fti
Medic specialist dermato-venerologie
Doctorand \u00een Medicin\u0103
Apartenen\u0163\u0103 la Societ\u0103\u0163i \u015etiin\u0163ifice<\/strong>
\u2022 Membru al Societ\u0103\u0163ii Rom\u00e2ne de Dermatologie
\u2022 Membru al Academiei Europene de Dermatologie \u015fi Venerologie EADV
\u2022 Membru al Academiei Europene de Dermato-oncologie EADO
\u2022 Membru al Academiei Europene de Alergologie \u015fi Imunologie Clinic\u0103 EAACI<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Asist. Univ. Dr. Isabela S\u00e2rbu Facultatea de Medicin\u0103 Dentar\u0103 U.M.F. \u201dCarol Davila\u201d Bucure\u015ftiIncontinentia pigmenti Autor:\u00a0Isabela S\u00e2rbu Incontinentia pigmenti (IP) este o afec\u0163iune cu transmitere dominant\u0103 X-linkat\u0103 care, \u00een peste 95% dintre cazuri, afecteaz\u0103 nou-n\u0103scu\u0163i de sex feminin. Boala este \u00een general letal\u0103 la sexul masculin \u00eenc\u0103 din perioada intrauterin\u0103, excep\u0163ie f\u0103c\u00e2nd b\u0103ie\u0163ii cu sindrom Klinefelter […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4426","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4426"}],"version-history":[{"count":9,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4426\/revisions"}],"predecessor-version":[{"id":4455,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4426\/revisions\/4455"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor:\u00a0Isabela S\u00e2rbu<\/span><\/p>\n
Incontinentia pigmenti (IP) este o afec\u0163iune cu transmitere dominant\u0103 X-linkat\u0103 care, \u00een peste 95% dintre cazuri, afecteaz\u0103 nou-n\u0103scu\u0163i de sex feminin. Boala este \u00een general letal\u0103 la sexul masculin \u00eenc\u0103 din perioada intrauterin\u0103, excep\u0163ie f\u0103c\u00e2nd b\u0103ie\u0163ii cu sindrom Klinefelter (XXY) \u015fi cei cu mozaicism somatic. Este o boal\u0103 rar\u0103, cu o prevalen\u0163\u0103 de 1\/50 000 de cazuri \u00een popula\u0163ia general\u0103. Genodermatoza este complex\u0103, manifest\u0103rile cutanate fiind asociate cu un sindrom oculo-dento-cerebral, patogeneza sa fiind legat\u0103 de susceptibilitatea celulelor care prezint\u0103 muta\u0163ii ale unei gene situate \u00een regiunea Xq28 de pe cromozomul X fa\u0163\u0103 de apoptoza determinat\u0103 de factorul de necroza tumoral\u0103.
Din punct de vedere clinic, boala prezint\u0103 patru stadii de evolu\u0163ie: stadiul vezicular sau inflamator, stadiul verucos, stadiul de hiperpigmentare \u015fi stadiul de hipopigmentare. Aceste stadii se suprapun \u00eens\u0103 frecvent.
Prezent\u0103m cazul unui nou-n\u0103scut de sex feminin, rezultat dintr-o sarcin\u0103 cu evolu\u0163ie normal\u0103, care \u00eenc\u0103 de la na\u015ftere avea o erup\u0163ie alc\u0103tuit\u0103 ini\u0163ial din macule eritematoase, ulterior vezicule \u015fi bule, diseminate la nivelul trunchiului \u015fi membrelor. \u00cen a doua zi de via\u0163\u0103 pacienta a prezentat crize convulsive tonico-clonice generalizate tratate cu diazepam. La prezentarea \u00een clinica de dermatologie, la v\u00e2rsta de 14 zile, s-au observat macule de culoare maronie cu pattern reticular, precum \u015fi vezicule, bule \u015fi leziuni verucoase.
Prezent\u0103m un caz complex de IP \u00een care abordarea interdisciplinar\u0103 a pacientului cu implicarea medicului dermatolog, neurolog, oftalmolog, radiolog, pediatru dar \u015fi genetician, dentist \u015fi medicului de familie, este deosebit de important\u0103. De\u015fi medicul dermatolog are un rol central \u00een gestionarea cazurilor, prognosticul afec\u0163iunii este dependent de severitatea manifest\u0103rilor extracutanate.<\/p>\n
Incontinentia pigmenti<\/span> Incontinentia pigmenti (IP) is an affliction inherited in an X-linked dominant pattern which, in more than 95% of cases, affects female new-borns. The disease is generally lethal in males since the intrauterine period, except in patients with Klinefelter syndrome (XXY) or somatic mosaicism. It is a rare disease, with an overall prevalence of 1\/50 000 cases. The genodermatosis is complex, the cutaneous manifestations being associated with an oculo-dental-cerebral syndrome, its pathogenesis being related with the susceptibility of the cells presenting mutations in a gene situated in the Xq28 region on chromosome X towards the apoptosis determined by the tumor necrosis factor. Scurt CV<\/span><\/p>\n Grad didactic<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> Asist. Univ. Dr. Isabela S\u00e2rbu Facultatea de Medicin\u0103 Dentar\u0103 U.M.F. \u201dCarol Davila\u201d Bucure\u015ftiIncontinentia pigmenti Autor:\u00a0Isabela S\u00e2rbu Incontinentia pigmenti (IP) este o afec\u0163iune cu transmitere dominant\u0103 X-linkat\u0103 care, \u00een peste 95% dintre cazuri, afecteaz\u0103 nou-n\u0103scu\u0163i de sex feminin. Boala este \u00een general letal\u0103 la sexul masculin \u00eenc\u0103 din perioada intrauterin\u0103, excep\u0163ie f\u0103c\u00e2nd b\u0103ie\u0163ii cu sindrom Klinefelter […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4426","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4426"}],"version-history":[{"count":9,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4426\/revisions"}],"predecessor-version":[{"id":4455,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4426\/revisions\/4455"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Author:\u00a0Isabela S\u00e2rbu<\/span><\/p>\n
Clinically, the disease presents four evolution stages: the vesicular or inflammatory stage, the verrucous stage, the hyperpigmentation stage and the hypopigmentation stage. These stages however often overlap.
We present the case of a female new-born from a normal pregnancy, who, since birth, presented an eruption consisting initially of erythematous patches and later in vesicles and bullae, disseminated on the trunk and limbs. In the second day of life the patient presented generalized tonic-clonic seizures which were treated with diazepam. At presentation in the dermatology clinic, at the age of 14 days, we observed brownish patches with a reticular pattern, as well as vesicles, bullae and verrucous lesions.
We present a complex case of IP in which the interdisciplinary team including the dermatologist, neurologist, ophthalmologist, radiologist, paediatrician, as well as geneticist, dentist and family doctor is very important. Even though the dermatologist plays a central role in managing the cases, the prognosis of the disease is related to the severity of the extracutaneous manifestations.<\/p>\n
Din anul 2016 \u2013 asistent universitar la disciplina dermatologie a Facult\u0103\u0163ii de Medicin\u0103 Dentar\u0103 U.M.F. \u201dCarol Davila\u201d Bucure\u015fti
Func\u0163ie<\/strong>
Asistent universitar la disciplina dermatologie, Facultatea de Medicin\u0103 Dentar\u0103 U.M.F. \u201dCarol Davila\u201d Bucure\u015fti
Medic specialist dermato-venerologie
Doctorand \u00een Medicin\u0103
Apartenen\u0163\u0103 la Societ\u0103\u0163i \u015etiin\u0163ifice<\/strong>
\u2022 Membru al Societ\u0103\u0163ii Rom\u00e2ne de Dermatologie
\u2022 Membru al Academiei Europene de Dermatologie \u015fi Venerologie EADV
\u2022 Membru al Academiei Europene de Dermato-oncologie EADO
\u2022 Membru al Academiei Europene de Alergologie \u015fi Imunologie Clinic\u0103 EAACI<\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"