<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\n\u015eef lucr. Dr Florea Laura<\/span><\/strong>
Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d Ia\u015fi<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.18″][et_pb_column type=”4_4″ _builder_version=”3.19.18″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Boala mixt\u0103 de \u021besut conjunctiv \u2013 o entitate distinct\u0103?<\/span>
Autor: Laura Florea<\/span><\/p>\nBoala mixt\u0103 de \u021besut conjunctiv (BMTC) este o entitate autoimun\u0103, distinct\u0103, ce prezint\u0103 manifest\u0103ri clinice caracteristice pentru lupus eritematos sistemic, sclerodermie sistemic\u0103, polimiozit\u0103 \u0219i poliartrit\u0103 reumatoid\u0103. BMTC este o boal\u0103 rar\u0103, mai frecvent\u0103 la femei cu v\u00e2rste \u00eentre 20-30 ani. Cauzele nu sunt bine cunoscute. Etiologia bolii este multifactorial\u0103 fiind implica\u021bi factori genetici, factori de mediu (expunerea la clorura de vinil \u0219i siliciu) \u0219i factori infec\u021bio\u0219i virali. Manifest\u0103rile BMTC sunt variate. Majoritatea pacien\u021bilor prezint\u0103 sindrom Raynaud, ulcere digitale, artralgii, artrite, degete tumefiate, edem al m\u00e2inilor, sclerodactilie sau acroscleroz\u0103, miozit\u0103. Se pot asocia hipomotilitatea esofagian\u0103, disfunc\u021bia pulmonar\u0103, rash, leucopenie, pleurezie, pericardit\u0103, hipertensiune arterial\u0103 pulmonar\u0103, meningit\u0103 aseptic\u0103, mielit\u0103, gangrena degetelor m\u00e2inilor \u0219i picioarelor, nevralgie de trigemen. Bilan\u021bul imunologic relev\u0103 titrul crescut al ANA cu aspect p\u0103tat in imunofluorescen\u021b\u0103, cu specificitate \u00eempotriva U1-RNP (ribonucleoproteine). Criteriile elaborate de Donato Alarcon Segovia const\u0103 \u00een titrul crescut al Ac antiU1RNP ( \u2265 1:1600) \u0219i cel pu\u021bin 3 dintre urm\u0103toarele: tumefierea m\u00e2inilor, sinovita, miozita confirmat\u0103 biologic sau histologic, sindromul Raynaud, acroscleroza cu sau f\u0103r\u0103 afectarea sclerodermic\u0103 proximal\u0103. Diagnosticul diferen\u021bial se face cu sindromul Overlap \u0219i boala nediferen\u021biata de \u021besut conjunctiv. Tratamentul vizeaz\u0103 controlul simptomelor \u0219i men\u021binerea func\u021biilor organelor vitale. Monitorizarea complica\u021biilor, ca hipertensiunea arterial\u0103 pulmonar\u0103 \u0219i a infec\u021biilor este important\u0103. Tratamentul trebuie individualizat pentru fiecare pacient, \u00een func\u021bie de atingerea de organ \u0219i de severitatea bolii. Unii pacien\u021bi necesit\u0103 tratament numai \u00een perioadele de activitate ale bolii, \u00een timp ce al\u021bii necesit\u0103 tratament continuu. Educarea pacientului asupra bolii \u0219i terapiei este esen\u021bial\u0103. Cheia succesului este abordarea multidisciplinar\u0103 cu implicarea tuturor specialit\u0103\u021bilor.<\/p>\n
\n
Mixed connective tissue disease: A disease entity?<\/span>
Author: Laura Florea<\/span><\/p>\n Mixed connective tissue disease (MCTD) is an autoimmune disorder that has features of other connective tissue diseases: systemic lupus erythematosus, scleroderma, polymyositis and rheumatoid arthritis. MCTD is a rare disease, occurring most often in women in their 20s and 30s. The causes of MCTD are not known. Genetic factors, exposure to certain viruses or chemicals such as polyvinyl chloride and silica are possible causes. Manifestations of MCTD can be various. Most patients experience severe Raynaud phenomenon, digital vascular infarcts and ulcerations, arthralgia, arthritis, swollen “sausage-like” fingers, sclerodactyly or acrosclerosis, and mild myositis. Other features can be: esophageal hypomotility, pulmonary dysfunction, rash, leukopenia, pleuritis, pericarditis, pulmonary hypertension, aseptic meningitis, myelitis, gangrene of fingers or toes, neuropathy affecting the trigeminal nerve in the face. High-titer speckled pattern fluorescent antinuclear antibody (FANA) is typical of MCTD. High concentrations in blood tests of a particular antibody called anti-U1-RNP (ribonucleoprotein) are detected. The Alarc\u00f3n-Segovia diagnostic criteria consist of a positive anti\u2013U1 RNP titer (>1:1600) and at least three of the following five clinical findings: hand edema, synovitis, biologically or histologically proven myositis, Raynaud phenomenon, acrosclerosis with or without proximal systemic sclerosis. Overlap syndrome and undifferentiated autoimmune rheumatic disease must differentiate from MTCD . The overall goal of therapy in MCTD is to control symptoms and to maintain function. Monitoring for development of complications, such as pulmonary hypertension or infection is important. Treatment for MCTD must be tailored to each particular patient, depending on the organs that are affected and how severe the condition is. Some patients may need treatment only during flare-ups, while others may require constant care. Education about MCTD and its treatment is essential. An interdisciplinary approach, which involves team members from different disciplines, is the key to success.<\/p>\n
Scurt CV<\/span><\/p>\nEste medic primar medicin\u0103 intern\u0103 \u015fi nefrologie, \u015fef de lucr\u0103ri la Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGr T Popa\u201d Ia\u015fi, doctor \u00een \u015ftiin\u0163e medicale \u015fi are competen\u0163\u0103 \u00een ecografie general\u0103. Este coordonator al Compartimentului de Medicin\u0103 Intern\u0103, Spital \u201cDr C I Parhon\u201d
A lucrat ca Chef de Clinique la Universitatea Paris VII Denis Diderot.
A ob\u0163inut Attestation de Formation Specialisee de Nephrologie \u00een Fran\u0163a (Faculte de Medicine Amiens) \u015fi Formation Investigateurs aux Essais Cliniques (Universite Paris VII Denis Diderot).
Este autor \u015fi coautor a numeroase c\u0103r\u0163i, capitole de carte \u015fi articole ap\u0103rute \u00een reviste na\u0163ionale \u015fi interna\u0163ionale.
Este membru al Societ\u0103\u0163ii Rom\u00e2ne de Nefrologie, Societ\u0103\u0163ii Rom\u00e2ne de Dermatologie \u015fi al Societ\u0103\u0163ii Europene de Dializ\u0103 \u015fi Transplant Renal (ERA-EDTA).
Domenii de interes: bolile autoimune, patologia cardio-vascular\u0103 \u00een popula\u021bia general\u0103 \u0219i \u00een boala cronic\u0103 de rinichi, hemodializa, dializa peritoneal\u0103.
\u00ce\u015fi desf\u0103\u015foar\u0103 activitatea \u00een Clinica de Medicin\u0103 Intern\u0103 – Nefrologie a Spitalului \u201eDr C I Parhon\u201d.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"\u015eef lucr. Dr Florea Laura Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d Ia\u015fiBoala mixt\u0103 de \u021besut conjunctiv \u2013 o entitate distinct\u0103? Autor: Laura Florea Boala mixt\u0103 de \u021besut conjunctiv (BMTC) este o entitate autoimun\u0103, distinct\u0103, ce prezint\u0103 manifest\u0103ri clinice caracteristice pentru lupus eritematos sistemic, sclerodermie sistemic\u0103, polimiozit\u0103 \u0219i poliartrit\u0103 reumatoid\u0103. BMTC este o boal\u0103 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4649","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4649"}],"version-history":[{"count":4,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4649\/revisions"}],"predecessor-version":[{"id":4666,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4649\/revisions\/4666"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/span><\/strong><\/h4>\n\u015eef lucr. Dr Florea Laura<\/span><\/strong>
Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d Ia\u015fi<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.18″][et_pb_column type=”4_4″ _builder_version=”3.19.18″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Boala mixt\u0103 de \u021besut conjunctiv \u2013 o entitate distinct\u0103?<\/span>
Autor: Laura Florea<\/span><\/p>\nBoala mixt\u0103 de \u021besut conjunctiv (BMTC) este o entitate autoimun\u0103, distinct\u0103, ce prezint\u0103 manifest\u0103ri clinice caracteristice pentru lupus eritematos sistemic, sclerodermie sistemic\u0103, polimiozit\u0103 \u0219i poliartrit\u0103 reumatoid\u0103. BMTC este o boal\u0103 rar\u0103, mai frecvent\u0103 la femei cu v\u00e2rste \u00eentre 20-30 ani. Cauzele nu sunt bine cunoscute. Etiologia bolii este multifactorial\u0103 fiind implica\u021bi factori genetici, factori de mediu (expunerea la clorura de vinil \u0219i siliciu) \u0219i factori infec\u021bio\u0219i virali. Manifest\u0103rile BMTC sunt variate. Majoritatea pacien\u021bilor prezint\u0103 sindrom Raynaud, ulcere digitale, artralgii, artrite, degete tumefiate, edem al m\u00e2inilor, sclerodactilie sau acroscleroz\u0103, miozit\u0103. Se pot asocia hipomotilitatea esofagian\u0103, disfunc\u021bia pulmonar\u0103, rash, leucopenie, pleurezie, pericardit\u0103, hipertensiune arterial\u0103 pulmonar\u0103, meningit\u0103 aseptic\u0103, mielit\u0103, gangrena degetelor m\u00e2inilor \u0219i picioarelor, nevralgie de trigemen. Bilan\u021bul imunologic relev\u0103 titrul crescut al ANA cu aspect p\u0103tat in imunofluorescen\u021b\u0103, cu specificitate \u00eempotriva U1-RNP (ribonucleoproteine). Criteriile elaborate de Donato Alarcon Segovia const\u0103 \u00een titrul crescut al Ac antiU1RNP ( \u2265 1:1600) \u0219i cel pu\u021bin 3 dintre urm\u0103toarele: tumefierea m\u00e2inilor, sinovita, miozita confirmat\u0103 biologic sau histologic, sindromul Raynaud, acroscleroza cu sau f\u0103r\u0103 afectarea sclerodermic\u0103 proximal\u0103. Diagnosticul diferen\u021bial se face cu sindromul Overlap \u0219i boala nediferen\u021biata de \u021besut conjunctiv. Tratamentul vizeaz\u0103 controlul simptomelor \u0219i men\u021binerea func\u021biilor organelor vitale. Monitorizarea complica\u021biilor, ca hipertensiunea arterial\u0103 pulmonar\u0103 \u0219i a infec\u021biilor este important\u0103. Tratamentul trebuie individualizat pentru fiecare pacient, \u00een func\u021bie de atingerea de organ \u0219i de severitatea bolii. Unii pacien\u021bi necesit\u0103 tratament numai \u00een perioadele de activitate ale bolii, \u00een timp ce al\u021bii necesit\u0103 tratament continuu. Educarea pacientului asupra bolii \u0219i terapiei este esen\u021bial\u0103. Cheia succesului este abordarea multidisciplinar\u0103 cu implicarea tuturor specialit\u0103\u021bilor.<\/p>\n
\n
Mixed connective tissue disease: A disease entity?<\/span>
Author: Laura Florea<\/span><\/p>\n Mixed connective tissue disease (MCTD) is an autoimmune disorder that has features of other connective tissue diseases: systemic lupus erythematosus, scleroderma, polymyositis and rheumatoid arthritis. MCTD is a rare disease, occurring most often in women in their 20s and 30s. The causes of MCTD are not known. Genetic factors, exposure to certain viruses or chemicals such as polyvinyl chloride and silica are possible causes. Manifestations of MCTD can be various. Most patients experience severe Raynaud phenomenon, digital vascular infarcts and ulcerations, arthralgia, arthritis, swollen “sausage-like” fingers, sclerodactyly or acrosclerosis, and mild myositis. Other features can be: esophageal hypomotility, pulmonary dysfunction, rash, leukopenia, pleuritis, pericarditis, pulmonary hypertension, aseptic meningitis, myelitis, gangrene of fingers or toes, neuropathy affecting the trigeminal nerve in the face. High-titer speckled pattern fluorescent antinuclear antibody (FANA) is typical of MCTD. High concentrations in blood tests of a particular antibody called anti-U1-RNP (ribonucleoprotein) are detected. The Alarc\u00f3n-Segovia diagnostic criteria consist of a positive anti\u2013U1 RNP titer (>1:1600) and at least three of the following five clinical findings: hand edema, synovitis, biologically or histologically proven myositis, Raynaud phenomenon, acrosclerosis with or without proximal systemic sclerosis. Overlap syndrome and undifferentiated autoimmune rheumatic disease must differentiate from MTCD . The overall goal of therapy in MCTD is to control symptoms and to maintain function. Monitoring for development of complications, such as pulmonary hypertension or infection is important. Treatment for MCTD must be tailored to each particular patient, depending on the organs that are affected and how severe the condition is. Some patients may need treatment only during flare-ups, while others may require constant care. Education about MCTD and its treatment is essential. An interdisciplinary approach, which involves team members from different disciplines, is the key to success.<\/p>\n
Scurt CV<\/span><\/p>\nEste medic primar medicin\u0103 intern\u0103 \u015fi nefrologie, \u015fef de lucr\u0103ri la Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGr T Popa\u201d Ia\u015fi, doctor \u00een \u015ftiin\u0163e medicale \u015fi are competen\u0163\u0103 \u00een ecografie general\u0103. Este coordonator al Compartimentului de Medicin\u0103 Intern\u0103, Spital \u201cDr C I Parhon\u201d
A lucrat ca Chef de Clinique la Universitatea Paris VII Denis Diderot.
A ob\u0163inut Attestation de Formation Specialisee de Nephrologie \u00een Fran\u0163a (Faculte de Medicine Amiens) \u015fi Formation Investigateurs aux Essais Cliniques (Universite Paris VII Denis Diderot).
Este autor \u015fi coautor a numeroase c\u0103r\u0163i, capitole de carte \u015fi articole ap\u0103rute \u00een reviste na\u0163ionale \u015fi interna\u0163ionale.
Este membru al Societ\u0103\u0163ii Rom\u00e2ne de Nefrologie, Societ\u0103\u0163ii Rom\u00e2ne de Dermatologie \u015fi al Societ\u0103\u0163ii Europene de Dializ\u0103 \u015fi Transplant Renal (ERA-EDTA).
Domenii de interes: bolile autoimune, patologia cardio-vascular\u0103 \u00een popula\u021bia general\u0103 \u0219i \u00een boala cronic\u0103 de rinichi, hemodializa, dializa peritoneal\u0103.
\u00ce\u015fi desf\u0103\u015foar\u0103 activitatea \u00een Clinica de Medicin\u0103 Intern\u0103 – Nefrologie a Spitalului \u201eDr C I Parhon\u201d.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"\u015eef lucr. Dr Florea Laura Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d Ia\u015fiBoala mixt\u0103 de \u021besut conjunctiv \u2013 o entitate distinct\u0103? Autor: Laura Florea Boala mixt\u0103 de \u021besut conjunctiv (BMTC) este o entitate autoimun\u0103, distinct\u0103, ce prezint\u0103 manifest\u0103ri clinice caracteristice pentru lupus eritematos sistemic, sclerodermie sistemic\u0103, polimiozit\u0103 \u0219i poliartrit\u0103 reumatoid\u0103. BMTC este o boal\u0103 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4649","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4649"}],"version-history":[{"count":4,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4649\/revisions"}],"predecessor-version":[{"id":4666,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4649\/revisions\/4666"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d Ia\u015fi<\/span><\/strong><\/h4>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.18″][et_pb_column type=”4_4″ _builder_version=”3.19.18″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Boala mixt\u0103 de \u021besut conjunctiv \u2013 o entitate distinct\u0103?<\/span> Boala mixt\u0103 de \u021besut conjunctiv (BMTC) este o entitate autoimun\u0103, distinct\u0103, ce prezint\u0103 manifest\u0103ri clinice caracteristice pentru lupus eritematos sistemic, sclerodermie sistemic\u0103, polimiozit\u0103 \u0219i poliartrit\u0103 reumatoid\u0103. BMTC este o boal\u0103 rar\u0103, mai frecvent\u0103 la femei cu v\u00e2rste \u00eentre 20-30 ani. Cauzele nu sunt bine cunoscute. Etiologia bolii este multifactorial\u0103 fiind implica\u021bi factori genetici, factori de mediu (expunerea la clorura de vinil \u0219i siliciu) \u0219i factori infec\u021bio\u0219i virali. Manifest\u0103rile BMTC sunt variate. Majoritatea pacien\u021bilor prezint\u0103 sindrom Raynaud, ulcere digitale, artralgii, artrite, degete tumefiate, edem al m\u00e2inilor, sclerodactilie sau acroscleroz\u0103, miozit\u0103. Se pot asocia hipomotilitatea esofagian\u0103, disfunc\u021bia pulmonar\u0103, rash, leucopenie, pleurezie, pericardit\u0103, hipertensiune arterial\u0103 pulmonar\u0103, meningit\u0103 aseptic\u0103, mielit\u0103, gangrena degetelor m\u00e2inilor \u0219i picioarelor, nevralgie de trigemen. Bilan\u021bul imunologic relev\u0103 titrul crescut al ANA cu aspect p\u0103tat in imunofluorescen\u021b\u0103, cu specificitate \u00eempotriva U1-RNP (ribonucleoproteine). Criteriile elaborate de Donato Alarcon Segovia const\u0103 \u00een titrul crescut al Ac antiU1RNP ( \u2265 1:1600) \u0219i cel pu\u021bin 3 dintre urm\u0103toarele: tumefierea m\u00e2inilor, sinovita, miozita confirmat\u0103 biologic sau histologic, sindromul Raynaud, acroscleroza cu sau f\u0103r\u0103 afectarea sclerodermic\u0103 proximal\u0103. Diagnosticul diferen\u021bial se face cu sindromul Overlap \u0219i boala nediferen\u021biata de \u021besut conjunctiv. Tratamentul vizeaz\u0103 controlul simptomelor \u0219i men\u021binerea func\u021biilor organelor vitale. Monitorizarea complica\u021biilor, ca hipertensiunea arterial\u0103 pulmonar\u0103 \u0219i a infec\u021biilor este important\u0103. Tratamentul trebuie individualizat pentru fiecare pacient, \u00een func\u021bie de atingerea de organ \u0219i de severitatea bolii. Unii pacien\u021bi necesit\u0103 tratament numai \u00een perioadele de activitate ale bolii, \u00een timp ce al\u021bii necesit\u0103 tratament continuu. Educarea pacientului asupra bolii \u0219i terapiei este esen\u021bial\u0103. Cheia succesului este abordarea multidisciplinar\u0103 cu implicarea tuturor specialit\u0103\u021bilor.<\/p>\n \n Mixed connective tissue disease: A disease entity?<\/span> Mixed connective tissue disease (MCTD) is an autoimmune disorder that has features of other connective tissue diseases: systemic lupus erythematosus, scleroderma, polymyositis and rheumatoid arthritis. MCTD is a rare disease, occurring most often in women in their 20s and 30s. The causes of MCTD are not known. Genetic factors, exposure to certain viruses or chemicals such as polyvinyl chloride and silica are possible causes. Manifestations of MCTD can be various. Most patients experience severe Raynaud phenomenon, digital vascular infarcts and ulcerations, arthralgia, arthritis, swollen “sausage-like” fingers, sclerodactyly or acrosclerosis, and mild myositis. Other features can be: esophageal hypomotility, pulmonary dysfunction, rash, leukopenia, pleuritis, pericarditis, pulmonary hypertension, aseptic meningitis, myelitis, gangrene of fingers or toes, neuropathy affecting the trigeminal nerve in the face. High-titer speckled pattern fluorescent antinuclear antibody (FANA) is typical of MCTD. High concentrations in blood tests of a particular antibody called anti-U1-RNP (ribonucleoprotein) are detected. The Alarc\u00f3n-Segovia diagnostic criteria consist of a positive anti\u2013U1 RNP titer (>1:1600) and at least three of the following five clinical findings: hand edema, synovitis, biologically or histologically proven myositis, Raynaud phenomenon, acrosclerosis with or without proximal systemic sclerosis. Overlap syndrome and undifferentiated autoimmune rheumatic disease must differentiate from MTCD . The overall goal of therapy in MCTD is to control symptoms and to maintain function. Monitoring for development of complications, such as pulmonary hypertension or infection is important. Treatment for MCTD must be tailored to each particular patient, depending on the organs that are affected and how severe the condition is. Some patients may need treatment only during flare-ups, while others may require constant care. Education about MCTD and its treatment is essential. An interdisciplinary approach, which involves team members from different disciplines, is the key to success.<\/p>\n Scurt CV<\/span><\/p>\n Este medic primar medicin\u0103 intern\u0103 \u015fi nefrologie, \u015fef de lucr\u0103ri la Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGr T Popa\u201d Ia\u015fi, doctor \u00een \u015ftiin\u0163e medicale \u015fi are competen\u0163\u0103 \u00een ecografie general\u0103. Este coordonator al Compartimentului de Medicin\u0103 Intern\u0103, Spital \u201cDr C I Parhon\u201d [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> \u015eef lucr. Dr Florea Laura Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d Ia\u015fiBoala mixt\u0103 de \u021besut conjunctiv \u2013 o entitate distinct\u0103? Autor: Laura Florea Boala mixt\u0103 de \u021besut conjunctiv (BMTC) este o entitate autoimun\u0103, distinct\u0103, ce prezint\u0103 manifest\u0103ri clinice caracteristice pentru lupus eritematos sistemic, sclerodermie sistemic\u0103, polimiozit\u0103 \u0219i poliartrit\u0103 reumatoid\u0103. BMTC este o boal\u0103 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4649","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4649"}],"version-history":[{"count":4,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4649\/revisions"}],"predecessor-version":[{"id":4666,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4649\/revisions\/4666"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Laura Florea<\/span><\/p>\n
Author: Laura Florea<\/span><\/p>\n
A lucrat ca Chef de Clinique la Universitatea Paris VII Denis Diderot.
A ob\u0163inut Attestation de Formation Specialisee de Nephrologie \u00een Fran\u0163a (Faculte de Medicine Amiens) \u015fi Formation Investigateurs aux Essais Cliniques (Universite Paris VII Denis Diderot).
Este autor \u015fi coautor a numeroase c\u0103r\u0163i, capitole de carte \u015fi articole ap\u0103rute \u00een reviste na\u0163ionale \u015fi interna\u0163ionale.
Este membru al Societ\u0103\u0163ii Rom\u00e2ne de Nefrologie, Societ\u0103\u0163ii Rom\u00e2ne de Dermatologie \u015fi al Societ\u0103\u0163ii Europene de Dializ\u0103 \u015fi Transplant Renal (ERA-EDTA).
Domenii de interes: bolile autoimune, patologia cardio-vascular\u0103 \u00een popula\u021bia general\u0103 \u0219i \u00een boala cronic\u0103 de rinichi, hemodializa, dializa peritoneal\u0103.
\u00ce\u015fi desf\u0103\u015foar\u0103 activitatea \u00een Clinica de Medicin\u0103 Intern\u0103 – Nefrologie a Spitalului \u201eDr C I Parhon\u201d.<\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"