<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nAsist. Univ. Dr. Jitaru Alexandra<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.18″][et_pb_column type=”4_4″ _builder_version=”3.19.18″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Spectrul manifest\u0103rilor cardiovasculare \u00een lupusul eritematos sistemic<\/span>
Autori: Alexandra Jitaru, Codrina Ancuta, Maria Magdalena Leon-Constantin, Alexandra Mastaleru, Florin Mitu<\/span><\/p>\nLupusul eritematos sistemic (LES), boal\u0103 autoimun\u0103 multifactorial\u0103 cu numeroase implica\u021bii organice, are ca substrat fiziopatologic o \u00eentreag\u0103 cascad\u0103 de fenomene inflamatorii ce implic\u0103 citokine \u0219i factori de cre\u0219tere, care determin\u0103 un turn-over celular accelerat, proliferare celular\u0103 \u0219i angiogenez\u0103, gener\u00e2nd astfel pierderea toleran\u021bei la self. Studiile arat\u0103 o prevalen\u021b\u0103 \u00eenalt\u0103 a factorilor de risc cardiovascular tradi\u021bionali (diabet zaharat, hipertensiune arterial\u0103, fumat, obezitate abdominal\u0103, hipercolesterolemie), dar care totu\u0219i nu explic\u0103 inciden\u021ba crescut\u0103 a evenimentelor ischemice asociate LES; astfel, se demonstreaz\u0103 implicarea direct\u0103 \u00een cre\u0219terea riscului cardiovascular a fenomenelor inflamatorii imun-mediate strict legate de boal\u0103. Comorbidit\u0103\u021bile cardiovasculare asociate LES cuprind componenta subclinic\u0103 (ateroscleroza subclinic\u0103, cuantificat\u0103 prin m\u0103surarea grosimii intime medii a carotidei \u0219i anomalii de perfuzie miocardic\u0103) \u0219i spectrul de manifest\u0103ri clinice reprezentat de boala coronarian\u0103, miocardita, pericardita \u0219i valvulopatii. Ghidurile actuale recomand\u0103 calcularea riscului cardiovascular prin multiplicare cu 1.5 a acestuia la pacien\u021bii cu boli autoimune altele dec\u00e2t poliartrita reumatoid\u0103 (inclusiv LES), \u00een func\u021bie de severitatea \u0219i\/sau activitatea bolii. Din punct de vedere al datelor statistice, studii recente eviden\u021biaz\u0103 faptul c\u0103 afectarea cardiovascular\u0103 reprezint\u0103 cea mai frecvent\u0103 cauz\u0103 de deces la pacien\u021bii cu o durata a bolii mai mare de 5 ani, aceasta survenind mult mai frecvent \u0219i mai precoce la pacien\u021bii cu LES comparativ cu popula\u021bia general\u0103. Tratamentul LES vizeaz\u0103 controlul adecvat al procesului inflamator imun-mediat \u0219i rec\u00e2\u0219tigarea toleran\u021bei la self, cu \u00eencetinirea implicit\u0103 a procesului aterosclerotic. Hidroxiclorochina, una dintre resursele terapeutice utilizate frecvent \u00een tratamentul LES, \u0219i-a demonstrat rolul protectiv cardiovascular \u00een numeroase studii, \u00een special prin ac\u021biunea sa \u00een stadiile subclinice ale afect\u0103rii cardiovasculare.<\/p>\n
Cardiovascular manifestations in systemic lupus erythematosus<\/span>
Authors: Alexandra Jitaru, Codrina Ancuta, Maria Magdalena Leon-Constantin, Alexandra Mastaleru, Florin Mitu<\/span><\/p>\nSystemic lupus erythematosus (SLE), a multifactorial autoimmune disease with many visceral implications, has as a complex pathobiology governed by a cascade of inflammatory events involving different cytokines and growth factors, leading to accelerated cellular turn-over, cell proliferation and angiogenesis, as well as loss of self-tolerance.
Various research papers already showed a high prevalence of traditional cardiovascular risk factors (e.g. diabetes, hypertension, smoking, abdominal obesity, hypercholesterolemia) in patients with SLE; however, these factors cannot entirely explain the increased incidence of ischemic events associated with SLE. Furthermore, a direct involvement of immune-mediated inflammatory phenomena strictly related to the disease are widely recognized to increase the cardiovascular risk in such patients.
The cardiovascular comorbidities associated with SLE include the subclinical atherosclerosis, quantified by measuring the carotid intima-media thickness and myocardial perfusion abnormalities, and the clinical manifestations represented by coronary disease, myocarditis, pericarditis as well as valvulopathy.
Current guidelines recommend to multiply by 1.5 the scores defining the cardiovascular risk in patients with autoimmune diseases other than rheumatoid arthritis (including SLE), depending on the severity and \/ or activity of the disease. From statistical point of view, recent studies highlighted the fact that cardiovascular damage is the most common cause of death in patients with a disease duration of more than 5 years, this occurring much more frequently and earlier in SLE patients compared to the general population.
SLE management classically aims to the proper control of the immune-mediated inflammatory process and the regaining of self-tolerance, with the implicit slow-down of the atherosclerotic process.
Hydroxychloroquine is commonly used in the treatment of SLE and has demonstrated its cardiovascular protective role in numerous studies, particularly by its action in the subclinical stages of cardiovascular disease.<\/p>\n
Scurt CV<\/span><\/p>\n\uf09f Asistent universitar \u00een cadrul disciplinei Semiologie Medical\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi
\uf09f Medic specialist Reumatologie
\uf09f Doctorand \u00een specialitatea Medicin\u0103 Intern\u0103
\uf09f Training \u00een ecografie musculo-scheletal\u0103 (Cluj-Napoca, Rom\u00e2nia, 2018-2019)
\uf09f Domenii de interes: boala cardiovascular\u0103 la pacien\u0163ii cu patologie reumatismal\u0103 imun-mediat\u0103, aplica\u0163iile ecografiei musculo-scheletale \u00een bolile inflamatorii reumatismale.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Asist. Univ. Dr. Jitaru Alexandra Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiSpectrul manifest\u0103rilor cardiovasculare \u00een lupusul eritematos sistemic Autori: Alexandra Jitaru, Codrina Ancuta, Maria Magdalena Leon-Constantin, Alexandra Mastaleru, Florin Mitu Lupusul eritematos sistemic (LES), boal\u0103 autoimun\u0103 multifactorial\u0103 cu numeroase implica\u021bii organice, are ca substrat fiziopatologic o \u00eentreag\u0103 cascad\u0103 de fenomene inflamatorii ce implic\u0103 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4804","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4804"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4804\/revisions"}],"predecessor-version":[{"id":4990,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4804\/revisions\/4990"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/strong><\/span><\/h4>\nAsist. Univ. Dr. Jitaru Alexandra<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.18″][et_pb_column type=”4_4″ _builder_version=”3.19.18″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Spectrul manifest\u0103rilor cardiovasculare \u00een lupusul eritematos sistemic<\/span>
Autori: Alexandra Jitaru, Codrina Ancuta, Maria Magdalena Leon-Constantin, Alexandra Mastaleru, Florin Mitu<\/span><\/p>\nLupusul eritematos sistemic (LES), boal\u0103 autoimun\u0103 multifactorial\u0103 cu numeroase implica\u021bii organice, are ca substrat fiziopatologic o \u00eentreag\u0103 cascad\u0103 de fenomene inflamatorii ce implic\u0103 citokine \u0219i factori de cre\u0219tere, care determin\u0103 un turn-over celular accelerat, proliferare celular\u0103 \u0219i angiogenez\u0103, gener\u00e2nd astfel pierderea toleran\u021bei la self. Studiile arat\u0103 o prevalen\u021b\u0103 \u00eenalt\u0103 a factorilor de risc cardiovascular tradi\u021bionali (diabet zaharat, hipertensiune arterial\u0103, fumat, obezitate abdominal\u0103, hipercolesterolemie), dar care totu\u0219i nu explic\u0103 inciden\u021ba crescut\u0103 a evenimentelor ischemice asociate LES; astfel, se demonstreaz\u0103 implicarea direct\u0103 \u00een cre\u0219terea riscului cardiovascular a fenomenelor inflamatorii imun-mediate strict legate de boal\u0103. Comorbidit\u0103\u021bile cardiovasculare asociate LES cuprind componenta subclinic\u0103 (ateroscleroza subclinic\u0103, cuantificat\u0103 prin m\u0103surarea grosimii intime medii a carotidei \u0219i anomalii de perfuzie miocardic\u0103) \u0219i spectrul de manifest\u0103ri clinice reprezentat de boala coronarian\u0103, miocardita, pericardita \u0219i valvulopatii. Ghidurile actuale recomand\u0103 calcularea riscului cardiovascular prin multiplicare cu 1.5 a acestuia la pacien\u021bii cu boli autoimune altele dec\u00e2t poliartrita reumatoid\u0103 (inclusiv LES), \u00een func\u021bie de severitatea \u0219i\/sau activitatea bolii. Din punct de vedere al datelor statistice, studii recente eviden\u021biaz\u0103 faptul c\u0103 afectarea cardiovascular\u0103 reprezint\u0103 cea mai frecvent\u0103 cauz\u0103 de deces la pacien\u021bii cu o durata a bolii mai mare de 5 ani, aceasta survenind mult mai frecvent \u0219i mai precoce la pacien\u021bii cu LES comparativ cu popula\u021bia general\u0103. Tratamentul LES vizeaz\u0103 controlul adecvat al procesului inflamator imun-mediat \u0219i rec\u00e2\u0219tigarea toleran\u021bei la self, cu \u00eencetinirea implicit\u0103 a procesului aterosclerotic. Hidroxiclorochina, una dintre resursele terapeutice utilizate frecvent \u00een tratamentul LES, \u0219i-a demonstrat rolul protectiv cardiovascular \u00een numeroase studii, \u00een special prin ac\u021biunea sa \u00een stadiile subclinice ale afect\u0103rii cardiovasculare.<\/p>\n
Cardiovascular manifestations in systemic lupus erythematosus<\/span>
Authors: Alexandra Jitaru, Codrina Ancuta, Maria Magdalena Leon-Constantin, Alexandra Mastaleru, Florin Mitu<\/span><\/p>\nSystemic lupus erythematosus (SLE), a multifactorial autoimmune disease with many visceral implications, has as a complex pathobiology governed by a cascade of inflammatory events involving different cytokines and growth factors, leading to accelerated cellular turn-over, cell proliferation and angiogenesis, as well as loss of self-tolerance.
Various research papers already showed a high prevalence of traditional cardiovascular risk factors (e.g. diabetes, hypertension, smoking, abdominal obesity, hypercholesterolemia) in patients with SLE; however, these factors cannot entirely explain the increased incidence of ischemic events associated with SLE. Furthermore, a direct involvement of immune-mediated inflammatory phenomena strictly related to the disease are widely recognized to increase the cardiovascular risk in such patients.
The cardiovascular comorbidities associated with SLE include the subclinical atherosclerosis, quantified by measuring the carotid intima-media thickness and myocardial perfusion abnormalities, and the clinical manifestations represented by coronary disease, myocarditis, pericarditis as well as valvulopathy.
Current guidelines recommend to multiply by 1.5 the scores defining the cardiovascular risk in patients with autoimmune diseases other than rheumatoid arthritis (including SLE), depending on the severity and \/ or activity of the disease. From statistical point of view, recent studies highlighted the fact that cardiovascular damage is the most common cause of death in patients with a disease duration of more than 5 years, this occurring much more frequently and earlier in SLE patients compared to the general population.
SLE management classically aims to the proper control of the immune-mediated inflammatory process and the regaining of self-tolerance, with the implicit slow-down of the atherosclerotic process.
Hydroxychloroquine is commonly used in the treatment of SLE and has demonstrated its cardiovascular protective role in numerous studies, particularly by its action in the subclinical stages of cardiovascular disease.<\/p>\n
Scurt CV<\/span><\/p>\n\uf09f Asistent universitar \u00een cadrul disciplinei Semiologie Medical\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi
\uf09f Medic specialist Reumatologie
\uf09f Doctorand \u00een specialitatea Medicin\u0103 Intern\u0103
\uf09f Training \u00een ecografie musculo-scheletal\u0103 (Cluj-Napoca, Rom\u00e2nia, 2018-2019)
\uf09f Domenii de interes: boala cardiovascular\u0103 la pacien\u0163ii cu patologie reumatismal\u0103 imun-mediat\u0103, aplica\u0163iile ecografiei musculo-scheletale \u00een bolile inflamatorii reumatismale.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Asist. Univ. Dr. Jitaru Alexandra Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiSpectrul manifest\u0103rilor cardiovasculare \u00een lupusul eritematos sistemic Autori: Alexandra Jitaru, Codrina Ancuta, Maria Magdalena Leon-Constantin, Alexandra Mastaleru, Florin Mitu Lupusul eritematos sistemic (LES), boal\u0103 autoimun\u0103 multifactorial\u0103 cu numeroase implica\u021bii organice, are ca substrat fiziopatologic o \u00eentreag\u0103 cascad\u0103 de fenomene inflamatorii ce implic\u0103 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4804","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4804"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4804\/revisions"}],"predecessor-version":[{"id":4990,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4804\/revisions\/4990"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.18″][et_pb_column type=”4_4″ _builder_version=”3.19.18″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Spectrul manifest\u0103rilor cardiovasculare \u00een lupusul eritematos sistemic<\/span> Lupusul eritematos sistemic (LES), boal\u0103 autoimun\u0103 multifactorial\u0103 cu numeroase implica\u021bii organice, are ca substrat fiziopatologic o \u00eentreag\u0103 cascad\u0103 de fenomene inflamatorii ce implic\u0103 citokine \u0219i factori de cre\u0219tere, care determin\u0103 un turn-over celular accelerat, proliferare celular\u0103 \u0219i angiogenez\u0103, gener\u00e2nd astfel pierderea toleran\u021bei la self. Studiile arat\u0103 o prevalen\u021b\u0103 \u00eenalt\u0103 a factorilor de risc cardiovascular tradi\u021bionali (diabet zaharat, hipertensiune arterial\u0103, fumat, obezitate abdominal\u0103, hipercolesterolemie), dar care totu\u0219i nu explic\u0103 inciden\u021ba crescut\u0103 a evenimentelor ischemice asociate LES; astfel, se demonstreaz\u0103 implicarea direct\u0103 \u00een cre\u0219terea riscului cardiovascular a fenomenelor inflamatorii imun-mediate strict legate de boal\u0103. Comorbidit\u0103\u021bile cardiovasculare asociate LES cuprind componenta subclinic\u0103 (ateroscleroza subclinic\u0103, cuantificat\u0103 prin m\u0103surarea grosimii intime medii a carotidei \u0219i anomalii de perfuzie miocardic\u0103) \u0219i spectrul de manifest\u0103ri clinice reprezentat de boala coronarian\u0103, miocardita, pericardita \u0219i valvulopatii. Ghidurile actuale recomand\u0103 calcularea riscului cardiovascular prin multiplicare cu 1.5 a acestuia la pacien\u021bii cu boli autoimune altele dec\u00e2t poliartrita reumatoid\u0103 (inclusiv LES), \u00een func\u021bie de severitatea \u0219i\/sau activitatea bolii. Din punct de vedere al datelor statistice, studii recente eviden\u021biaz\u0103 faptul c\u0103 afectarea cardiovascular\u0103 reprezint\u0103 cea mai frecvent\u0103 cauz\u0103 de deces la pacien\u021bii cu o durata a bolii mai mare de 5 ani, aceasta survenind mult mai frecvent \u0219i mai precoce la pacien\u021bii cu LES comparativ cu popula\u021bia general\u0103. Tratamentul LES vizeaz\u0103 controlul adecvat al procesului inflamator imun-mediat \u0219i rec\u00e2\u0219tigarea toleran\u021bei la self, cu \u00eencetinirea implicit\u0103 a procesului aterosclerotic. Hidroxiclorochina, una dintre resursele terapeutice utilizate frecvent \u00een tratamentul LES, \u0219i-a demonstrat rolul protectiv cardiovascular \u00een numeroase studii, \u00een special prin ac\u021biunea sa \u00een stadiile subclinice ale afect\u0103rii cardiovasculare.<\/p>\n Cardiovascular manifestations in systemic lupus erythematosus<\/span> Systemic lupus erythematosus (SLE), a multifactorial autoimmune disease with many visceral implications, has as a complex pathobiology governed by a cascade of inflammatory events involving different cytokines and growth factors, leading to accelerated cellular turn-over, cell proliferation and angiogenesis, as well as loss of self-tolerance. Scurt CV<\/span><\/p>\n \uf09f Asistent universitar \u00een cadrul disciplinei Semiologie Medical\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> Asist. Univ. Dr. Jitaru Alexandra Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiSpectrul manifest\u0103rilor cardiovasculare \u00een lupusul eritematos sistemic Autori: Alexandra Jitaru, Codrina Ancuta, Maria Magdalena Leon-Constantin, Alexandra Mastaleru, Florin Mitu Lupusul eritematos sistemic (LES), boal\u0103 autoimun\u0103 multifactorial\u0103 cu numeroase implica\u021bii organice, are ca substrat fiziopatologic o \u00eentreag\u0103 cascad\u0103 de fenomene inflamatorii ce implic\u0103 […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-4804","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=4804"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4804\/revisions"}],"predecessor-version":[{"id":4990,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/4804\/revisions\/4990"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=4804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Alexandra Jitaru, Codrina Ancuta, Maria Magdalena Leon-Constantin, Alexandra Mastaleru, Florin Mitu<\/span><\/p>\n
Authors: Alexandra Jitaru, Codrina Ancuta, Maria Magdalena Leon-Constantin, Alexandra Mastaleru, Florin Mitu<\/span><\/p>\n
Various research papers already showed a high prevalence of traditional cardiovascular risk factors (e.g. diabetes, hypertension, smoking, abdominal obesity, hypercholesterolemia) in patients with SLE; however, these factors cannot entirely explain the increased incidence of ischemic events associated with SLE. Furthermore, a direct involvement of immune-mediated inflammatory phenomena strictly related to the disease are widely recognized to increase the cardiovascular risk in such patients.
The cardiovascular comorbidities associated with SLE include the subclinical atherosclerosis, quantified by measuring the carotid intima-media thickness and myocardial perfusion abnormalities, and the clinical manifestations represented by coronary disease, myocarditis, pericarditis as well as valvulopathy.
Current guidelines recommend to multiply by 1.5 the scores defining the cardiovascular risk in patients with autoimmune diseases other than rheumatoid arthritis (including SLE), depending on the severity and \/ or activity of the disease. From statistical point of view, recent studies highlighted the fact that cardiovascular damage is the most common cause of death in patients with a disease duration of more than 5 years, this occurring much more frequently and earlier in SLE patients compared to the general population.
SLE management classically aims to the proper control of the immune-mediated inflammatory process and the regaining of self-tolerance, with the implicit slow-down of the atherosclerotic process.
Hydroxychloroquine is commonly used in the treatment of SLE and has demonstrated its cardiovascular protective role in numerous studies, particularly by its action in the subclinical stages of cardiovascular disease.<\/p>\n
\uf09f Medic specialist Reumatologie
\uf09f Doctorand \u00een specialitatea Medicin\u0103 Intern\u0103
\uf09f Training \u00een ecografie musculo-scheletal\u0103 (Cluj-Napoca, Rom\u00e2nia, 2018-2019)
\uf09f Domenii de interes: boala cardiovascular\u0103 la pacien\u0163ii cu patologie reumatismal\u0103 imun-mediat\u0103, aplica\u0163iile ecografiei musculo-scheletale \u00een bolile inflamatorii reumatismale.<\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"