<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nAssistant Professor Dragana Nikitovic, PhD, ERT\u00a0<\/span><\/strong>
Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.14″]The role of Hyaluronan and TLR4 in Keratinocyte Contact Senzitation<\/strong><\/span>
\nAUTHOR:\u00a0Dragana Nikitovic, PhD, ERT<\/span><\/p>\nAllergic contact dermatitis (ACD) is the most frequent among skin diseases and results upon skin contact with allergens. This particular type of allergy occurs after the mistaken response of the immune system resulting in sterile inflammation. The term \u201csterile\u201d refers to the type of inflammation caused chemically or by injury and not by pathogens. More accurately, contact allergens are low molecular weight chemicals (<1000kDa) the so-called haptens, unable to be recognized by the immune system due to their size. Thus, their absorption by the skin is followed by binding to a skin macromolecule, leading to the formation of a complete antigen. Subsequently, innate immune cells, likewise keratinocytes, cause maturation and migration of dendritic cells, which are in turn implicated at T-cells activation. Keratinocytes are important mediators in all phases of ACD progression. The extracellular matrix (ECM) is a complex network of molecules secreted by the cells, consisting of proteoglycans (PGs), glycosaminoglycans (GAGs), collagens and laminins. The ECM components participate in a variety of biological functions such as proliferation, adhesion, angiogenesis, cell motility, inflammation by activating specific signaling pathways, and finally mediating disease progression. Consequently, in all tissues inflammation, initialization and propagation can be supported by ECM-derived signals. Indeed, during ECM modification Damage Associated Molecular Patterns (DAMPs) are liberated namely, endogenous molecules that trigger and sustain inflammation. Skin exhibits high deposition of the glycosaminoglycan hyaluronan (HA) which under conditions of stress is degraded to Low molecular weight hyaluronan (LMWHA). Importantly, LMWHA has been characterized as DAMP and has been suggested to contribute to ACD through supporting keratinocyte sensitization. Toll like 4 (TLR4) is an innate immunity receptor implicated in ACD. Recent advances on contribution of TLR4 signaling in mediated by HA keratinocyte senzitation will be discussed.<\/p>\n
SHORT CV<\/span><\/p>\n<\/span>Dragana Nikitovic is an Assistant Professor at the School of Medicine, University of Crete (UOC) in Heraklion, Greece. She earned BSc in Biochemistry from the Faculty of Natural Sciences, University of Belgrade, Belgrade, Serbia in 1992, and earned a half-time PhD diploma in Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden in 1998 as well as Doctor of Medical Sciences degree (PhD) from the Medical School, UOC in 2008. Dr Nikitovic has carried out pre-doctoral research at Queen Mary and Westfield College, University of London, UK in 1993.<\/p>\nDr Nikitovic is co-author of 84 original publications or reviews and 5 book chapters. She has acted as Editor and Reviewer for numerous International Peer Journals and was member of congress organizing committees. Her research interest are the in the areas: Matrix Biology, Tumor Biology and Signal Transduction, Disease Markers, Molecular Targets, Inflammation, Biological Testing, Cytotoxicity. Emphasis is given to extracelluar matrix components signalling and especially to their implication in tumorigenesis and inflammation.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”on|on|on” _builder_version=”3.19.14″ disabled=”on”][et_pb_column type=”4_4″ _builder_version=”3.19.4″][et_pb_image src=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/02\/dragana.jpg” align=”center” _builder_version=”3.19.4″ border_radii=”on|100px|100px|100px|100px”][\/et_pb_image][et_pb_text _builder_version=”3.19.4″]<\/p>\n
Assistant Professor <\/strong>Dragana Nikitovic<\/strong>, PhD, ERT<\/strong>\u00a0 (Grecia)<\/span><\/p>\nPresent address: Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, Voutes PC 71003, Heraklion, Greece,<\/p>\n
Group Leader for Hyaluronan signaling in cancer, inflammation and cytotoxicity\u00a0<\/span><\/p>\nSHORT PRESENTATION \/ PROFILE (www.med.uoc.gr\/faculty\/nikitovic)<\/em><\/strong><\/p>\nDragana Nikitovic is an Assistant Professor at the School of Medicine, University of Crete (UOC) in Heraklion, Greece. She earned BSc in Biochemistry from the Faculty of Natural Sciences, University of Belgrade, Belgrade, Serbia in 1992, and earned a half-time PhD diploma in Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden in 1998 as well as Doctor of Medical Sciences degree (PhD) from the Medical School, UOC in 2008. Dr Nikitovic has carried out pre-doctoral research at Queen Mary and Westfield College, University of London, UK in 1993.<\/p>\n
Dr Nikitovic is co-author of 84 original publications or reviews and 5 book chapters. She has acted as Editor and Reviewer for numerous International Peer Journals and was member of congress organizing committees. Her research interest are the in the areas: <\/strong>Matrix Biology, Tumor Biology and Signal Transduction, Disease Markers, Molecular Targets, Inflammation, Biological Testing, Cytotoxicity. Emphasis is given to extracelluar matrix components signalling and especially to their implication in tumorigenesis and inflammation.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Assistant Professor Dragana Nikitovic, PhD, ERT\u00a0 Laboratory of Anatomy-Histology-Embryology, Medical School, University of CreteThe role of Hyaluronan and TLR4 in Keratinocyte Contact Senzitation AUTHOR:\u00a0Dragana Nikitovic, PhD, ERT Allergic contact dermatitis (ACD) is the most frequent among skin diseases and results upon skin contact with allergens. This particular type of allergy occurs after the mistaken response […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-761","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=761"}],"version-history":[{"count":12,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/761\/revisions"}],"predecessor-version":[{"id":5114,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/761\/revisions\/5114"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/span><\/strong><\/h4>\nAssistant Professor Dragana Nikitovic, PhD, ERT\u00a0<\/span><\/strong>
Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.14″]The role of Hyaluronan and TLR4 in Keratinocyte Contact Senzitation<\/strong><\/span>
\nAUTHOR:\u00a0Dragana Nikitovic, PhD, ERT<\/span><\/p>\nAllergic contact dermatitis (ACD) is the most frequent among skin diseases and results upon skin contact with allergens. This particular type of allergy occurs after the mistaken response of the immune system resulting in sterile inflammation. The term \u201csterile\u201d refers to the type of inflammation caused chemically or by injury and not by pathogens. More accurately, contact allergens are low molecular weight chemicals (<1000kDa) the so-called haptens, unable to be recognized by the immune system due to their size. Thus, their absorption by the skin is followed by binding to a skin macromolecule, leading to the formation of a complete antigen. Subsequently, innate immune cells, likewise keratinocytes, cause maturation and migration of dendritic cells, which are in turn implicated at T-cells activation. Keratinocytes are important mediators in all phases of ACD progression. The extracellular matrix (ECM) is a complex network of molecules secreted by the cells, consisting of proteoglycans (PGs), glycosaminoglycans (GAGs), collagens and laminins. The ECM components participate in a variety of biological functions such as proliferation, adhesion, angiogenesis, cell motility, inflammation by activating specific signaling pathways, and finally mediating disease progression. Consequently, in all tissues inflammation, initialization and propagation can be supported by ECM-derived signals. Indeed, during ECM modification Damage Associated Molecular Patterns (DAMPs) are liberated namely, endogenous molecules that trigger and sustain inflammation. Skin exhibits high deposition of the glycosaminoglycan hyaluronan (HA) which under conditions of stress is degraded to Low molecular weight hyaluronan (LMWHA). Importantly, LMWHA has been characterized as DAMP and has been suggested to contribute to ACD through supporting keratinocyte sensitization. Toll like 4 (TLR4) is an innate immunity receptor implicated in ACD. Recent advances on contribution of TLR4 signaling in mediated by HA keratinocyte senzitation will be discussed.<\/p>\n
SHORT CV<\/span><\/p>\n<\/span>Dragana Nikitovic is an Assistant Professor at the School of Medicine, University of Crete (UOC) in Heraklion, Greece. She earned BSc in Biochemistry from the Faculty of Natural Sciences, University of Belgrade, Belgrade, Serbia in 1992, and earned a half-time PhD diploma in Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden in 1998 as well as Doctor of Medical Sciences degree (PhD) from the Medical School, UOC in 2008. Dr Nikitovic has carried out pre-doctoral research at Queen Mary and Westfield College, University of London, UK in 1993.<\/p>\nDr Nikitovic is co-author of 84 original publications or reviews and 5 book chapters. She has acted as Editor and Reviewer for numerous International Peer Journals and was member of congress organizing committees. Her research interest are the in the areas: Matrix Biology, Tumor Biology and Signal Transduction, Disease Markers, Molecular Targets, Inflammation, Biological Testing, Cytotoxicity. Emphasis is given to extracelluar matrix components signalling and especially to their implication in tumorigenesis and inflammation.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”on|on|on” _builder_version=”3.19.14″ disabled=”on”][et_pb_column type=”4_4″ _builder_version=”3.19.4″][et_pb_image src=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/02\/dragana.jpg” align=”center” _builder_version=”3.19.4″ border_radii=”on|100px|100px|100px|100px”][\/et_pb_image][et_pb_text _builder_version=”3.19.4″]<\/p>\n
Assistant Professor <\/strong>Dragana Nikitovic<\/strong>, PhD, ERT<\/strong>\u00a0 (Grecia)<\/span><\/p>\nPresent address: Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, Voutes PC 71003, Heraklion, Greece,<\/p>\n
Group Leader for Hyaluronan signaling in cancer, inflammation and cytotoxicity\u00a0<\/span><\/p>\nSHORT PRESENTATION \/ PROFILE (www.med.uoc.gr\/faculty\/nikitovic)<\/em><\/strong><\/p>\nDragana Nikitovic is an Assistant Professor at the School of Medicine, University of Crete (UOC) in Heraklion, Greece. She earned BSc in Biochemistry from the Faculty of Natural Sciences, University of Belgrade, Belgrade, Serbia in 1992, and earned a half-time PhD diploma in Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden in 1998 as well as Doctor of Medical Sciences degree (PhD) from the Medical School, UOC in 2008. Dr Nikitovic has carried out pre-doctoral research at Queen Mary and Westfield College, University of London, UK in 1993.<\/p>\n
Dr Nikitovic is co-author of 84 original publications or reviews and 5 book chapters. She has acted as Editor and Reviewer for numerous International Peer Journals and was member of congress organizing committees. Her research interest are the in the areas: <\/strong>Matrix Biology, Tumor Biology and Signal Transduction, Disease Markers, Molecular Targets, Inflammation, Biological Testing, Cytotoxicity. Emphasis is given to extracelluar matrix components signalling and especially to their implication in tumorigenesis and inflammation.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Assistant Professor Dragana Nikitovic, PhD, ERT\u00a0 Laboratory of Anatomy-Histology-Embryology, Medical School, University of CreteThe role of Hyaluronan and TLR4 in Keratinocyte Contact Senzitation AUTHOR:\u00a0Dragana Nikitovic, PhD, ERT Allergic contact dermatitis (ACD) is the most frequent among skin diseases and results upon skin contact with allergens. This particular type of allergy occurs after the mistaken response […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-761","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=761"}],"version-history":[{"count":12,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/761\/revisions"}],"predecessor-version":[{"id":5114,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/761\/revisions\/5114"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete<\/span><\/strong><\/h4>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.14″]The role of Hyaluronan and TLR4 in Keratinocyte Contact Senzitation<\/strong><\/span> Allergic contact dermatitis (ACD) is the most frequent among skin diseases and results upon skin contact with allergens. This particular type of allergy occurs after the mistaken response of the immune system resulting in sterile inflammation. The term \u201csterile\u201d refers to the type of inflammation caused chemically or by injury and not by pathogens. More accurately, contact allergens are low molecular weight chemicals (<1000kDa) the so-called haptens, unable to be recognized by the immune system due to their size. Thus, their absorption by the skin is followed by binding to a skin macromolecule, leading to the formation of a complete antigen. Subsequently, innate immune cells, likewise keratinocytes, cause maturation and migration of dendritic cells, which are in turn implicated at T-cells activation. Keratinocytes are important mediators in all phases of ACD progression. The extracellular matrix (ECM) is a complex network of molecules secreted by the cells, consisting of proteoglycans (PGs), glycosaminoglycans (GAGs), collagens and laminins. The ECM components participate in a variety of biological functions such as proliferation, adhesion, angiogenesis, cell motility, inflammation by activating specific signaling pathways, and finally mediating disease progression. Consequently, in all tissues inflammation, initialization and propagation can be supported by ECM-derived signals. Indeed, during ECM modification Damage Associated Molecular Patterns (DAMPs) are liberated namely, endogenous molecules that trigger and sustain inflammation. Skin exhibits high deposition of the glycosaminoglycan hyaluronan (HA) which under conditions of stress is degraded to Low molecular weight hyaluronan (LMWHA). Importantly, LMWHA has been characterized as DAMP and has been suggested to contribute to ACD through supporting keratinocyte sensitization. Toll like 4 (TLR4) is an innate immunity receptor implicated in ACD. Recent advances on contribution of TLR4 signaling in mediated by HA keratinocyte senzitation will be discussed.<\/p>\n SHORT CV<\/span><\/p>\n <\/span>Dragana Nikitovic is an Assistant Professor at the School of Medicine, University of Crete (UOC) in Heraklion, Greece. She earned BSc in Biochemistry from the Faculty of Natural Sciences, University of Belgrade, Belgrade, Serbia in 1992, and earned a half-time PhD diploma in Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden in 1998 as well as Doctor of Medical Sciences degree (PhD) from the Medical School, UOC in 2008. Dr Nikitovic has carried out pre-doctoral research at Queen Mary and Westfield College, University of London, UK in 1993.<\/p>\n Dr Nikitovic is co-author of 84 original publications or reviews and 5 book chapters. She has acted as Editor and Reviewer for numerous International Peer Journals and was member of congress organizing committees. Her research interest are the in the areas: Matrix Biology, Tumor Biology and Signal Transduction, Disease Markers, Molecular Targets, Inflammation, Biological Testing, Cytotoxicity. Emphasis is given to extracelluar matrix components signalling and especially to their implication in tumorigenesis and inflammation.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”on|on|on” _builder_version=”3.19.14″ disabled=”on”][et_pb_column type=”4_4″ _builder_version=”3.19.4″][et_pb_image src=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/02\/dragana.jpg” align=”center” _builder_version=”3.19.4″ border_radii=”on|100px|100px|100px|100px”][\/et_pb_image][et_pb_text _builder_version=”3.19.4″]<\/p>\n Assistant Professor <\/strong>Dragana Nikitovic<\/strong>, PhD, ERT<\/strong>\u00a0 (Grecia)<\/span><\/p>\n Present address: Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, Voutes PC 71003, Heraklion, Greece,<\/p>\n Group Leader for Hyaluronan signaling in cancer, inflammation and cytotoxicity\u00a0<\/span><\/p>\n SHORT PRESENTATION \/ PROFILE (www.med.uoc.gr\/faculty\/nikitovic)<\/em><\/strong><\/p>\n Dragana Nikitovic is an Assistant Professor at the School of Medicine, University of Crete (UOC) in Heraklion, Greece. She earned BSc in Biochemistry from the Faculty of Natural Sciences, University of Belgrade, Belgrade, Serbia in 1992, and earned a half-time PhD diploma in Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden in 1998 as well as Doctor of Medical Sciences degree (PhD) from the Medical School, UOC in 2008. Dr Nikitovic has carried out pre-doctoral research at Queen Mary and Westfield College, University of London, UK in 1993.<\/p>\n Dr Nikitovic is co-author of 84 original publications or reviews and 5 book chapters. She has acted as Editor and Reviewer for numerous International Peer Journals and was member of congress organizing committees. Her research interest are the in the areas: <\/strong>Matrix Biology, Tumor Biology and Signal Transduction, Disease Markers, Molecular Targets, Inflammation, Biological Testing, Cytotoxicity. Emphasis is given to extracelluar matrix components signalling and especially to their implication in tumorigenesis and inflammation.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> Assistant Professor Dragana Nikitovic, PhD, ERT\u00a0 Laboratory of Anatomy-Histology-Embryology, Medical School, University of CreteThe role of Hyaluronan and TLR4 in Keratinocyte Contact Senzitation AUTHOR:\u00a0Dragana Nikitovic, PhD, ERT Allergic contact dermatitis (ACD) is the most frequent among skin diseases and results upon skin contact with allergens. This particular type of allergy occurs after the mistaken response […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-761","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=761"}],"version-history":[{"count":12,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/761\/revisions"}],"predecessor-version":[{"id":5114,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/761\/revisions\/5114"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nAUTHOR:\u00a0Dragana Nikitovic, PhD, ERT<\/span><\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"