<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nFarm. Docea Anca Oana<\/span><\/strong>
Universitatea de Medicin\u0103 \u015fi Farmacie Craiova<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Efectele dermatologice ale extractului de Centella asiatica de la utilizare tradi\u021bionala la dovezi \u0219tiin\u021bifice<\/span>
\nAutor: Anca Oana Docea<\/span><\/p>\nCentella asiatica este o plant\u0103 medicinal\u0103 utilizat\u0103 de sute de ani \u00een medicina tradi\u021bional\u0103 ca \u2018panaceu\u2019. Propriet\u0103\u021bile sale terapeutice sunt determinate de amestecul de acid mandecasic, acid asiatic, asiaticoside \u0219i madecasoside din compozi\u021bie. Pornind de la dovezile oferite de medicina tradi\u021bional\u0103, \u00een ultimii ani o serie de cercet\u0103tori au \u00eenceput s\u0103 studieze in vitro \u0219i in vivo efectele extractelor de centella asiatica \u00een procesul de vindecare a r\u0103nilor, a cicatricilor hipertrofice \u0219i a arsurilor. Alte studii au asociat utilizarea unguentelor cu extract de Centella asiatica cu un efect benefic \u00een tratarea formelor u\u0219oare spre moderate de dermatit\u0103 atopic\u0103. \u00cen ceea ce prive\u0219te mecanismul de ac\u021biune a extractului de Centella asiatica, studiile au ar\u0103tat c\u0103 acesta stimuleaz\u0103 proliferarea fibroblastelor \u0219i cre\u0219te sinteza de colagen \u0219i con\u021binutul de fibronectin\u0103 intracelular\u0103 \u0219i reduce faza inflamatorie a cicatricilor hipertrofice. Dovezile \u0219tiin\u021bifice au ar\u0103tat c\u0103 extractul de Centella asiatica poate fi utilizat cu succes \u00een diferite afec\u021biuni dermatologice cu efecte adverse minime.<\/p>\n
Centella asiatica effects in dermatology from traditional use to scientific proofs
\nAuthor: Anca Oana Docea<\/span><\/p>\nCentella asiatica is a medicinal plant used in traditional medicine as \u2018panacea\u2019 for hundreds of years. Its therapeutic properties are determined by the combination of mandecassic acid, asiatic acid, asiaticoside and madecasosside found in the extract. Starting from the knowledge of traditional medicine, in the last years many researchers started to study in vitro and in vivo Centella asiatica extract for its beneficial properties in healing process of wounds, hypertrophic scars and burns. Other studies showed that herbal ointment with Centella asiatica can have a positive effect in the treatment of mild-to moderate atopic dermatitis. Mechanistic approaches showed that Centella asiatica promotes fibroblast proliferation and increase the synthesis of collagen and intracellular fibronectin content and inhibits inflammatory phase of hypertrophic scars. Scientific proofs showed that Centella asiatica extracts are promising candidates for use in different dermatological disorders with minimum side effects. <\/span><\/span><\/p>\n
Scurt CV<\/span><\/p>\nPhD, ERT (European Register Toxicology), habilitated Professor
\nDepartment of Toxicology, University of Medicine and Pharmacy Craiova, Romania<\/p>\n
Dr. Anca Oana Docea, female, is pharmacist, specialist in Clinical Pharmacology and MSc in Pharmacology and Toxicology. From January 2018 she has the title of ERT (European Registered Toxicologist). She performed her PhD in \u201ePathogenic Implications of EGF and TGF growth factors as well as their receptors in gastric carcinomas\u201d. She specialised in vivo toxicological animal testing, neurobehavioral testing, biochemical and immunohistochemically analysis. In the last years her research has been focused on the nanotoxicology and the safety evaluation of amphiphilic poly-N-vinyl-2-pyrrolidone nanosized carriers and long term low dose toxicity studies simulating real life exposure. She specialized in clinical toxicology in Toxicology Department \u2013 Faculty of Medicine, Aristotle University of Thessaloniki, computational methods for the analysis of transcriptome datasets at King\u2019s College London, Faculty of Life Sciences & Medicine, Department of Medical & Molecular Genetics and in new models for evaluation of neurotoxicity of xenobiotics at Albert Einstein College of Medicine, Department of Molecular Pharmacology, New York, USA. Currently, she is Habilitated Lecturer Professor in the department of Toxicology, University of Medicine and Pharmacy Craiova, Faculty of Pharmacy. In the last 8 years she has published 38 articles indexed in Web of Science journals and has a h-index 15 (Clarivate Analytics). Dr. Docea wined in the last 3 years 12 prices from UEFISCDI (Executive Unit for Financing Higher Education, Research, Development and Innovation) for the published articles. She was leading 1 research project and 3 Research mobility projects funded by UEFISCDI.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"PhD, ERT (European Register Toxicology), habilitated ProfessorDepartment of Toxicology, University of Medicine and Pharmacy Craiova, Romania Dr. Anca Oana Docea, female, is pharmacist, specialist in Clinical Pharmacology and MSc in Pharmacology and Toxicology. From January 2018 she has the title of ERT (European Registered Toxicologist). She performed her PhD in \u201ePathogenic Implications of EGF and […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-865","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=865"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/865\/revisions"}],"predecessor-version":[{"id":4473,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/865\/revisions\/4473"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/span><\/strong><\/h4>\nFarm. Docea Anca Oana<\/span><\/strong>
Universitatea de Medicin\u0103 \u015fi Farmacie Craiova<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Efectele dermatologice ale extractului de Centella asiatica de la utilizare tradi\u021bionala la dovezi \u0219tiin\u021bifice<\/span>
\nAutor: Anca Oana Docea<\/span><\/p>\nCentella asiatica este o plant\u0103 medicinal\u0103 utilizat\u0103 de sute de ani \u00een medicina tradi\u021bional\u0103 ca \u2018panaceu\u2019. Propriet\u0103\u021bile sale terapeutice sunt determinate de amestecul de acid mandecasic, acid asiatic, asiaticoside \u0219i madecasoside din compozi\u021bie. Pornind de la dovezile oferite de medicina tradi\u021bional\u0103, \u00een ultimii ani o serie de cercet\u0103tori au \u00eenceput s\u0103 studieze in vitro \u0219i in vivo efectele extractelor de centella asiatica \u00een procesul de vindecare a r\u0103nilor, a cicatricilor hipertrofice \u0219i a arsurilor. Alte studii au asociat utilizarea unguentelor cu extract de Centella asiatica cu un efect benefic \u00een tratarea formelor u\u0219oare spre moderate de dermatit\u0103 atopic\u0103. \u00cen ceea ce prive\u0219te mecanismul de ac\u021biune a extractului de Centella asiatica, studiile au ar\u0103tat c\u0103 acesta stimuleaz\u0103 proliferarea fibroblastelor \u0219i cre\u0219te sinteza de colagen \u0219i con\u021binutul de fibronectin\u0103 intracelular\u0103 \u0219i reduce faza inflamatorie a cicatricilor hipertrofice. Dovezile \u0219tiin\u021bifice au ar\u0103tat c\u0103 extractul de Centella asiatica poate fi utilizat cu succes \u00een diferite afec\u021biuni dermatologice cu efecte adverse minime.<\/p>\n
Centella asiatica effects in dermatology from traditional use to scientific proofs
\nAuthor: Anca Oana Docea<\/span><\/p>\nCentella asiatica is a medicinal plant used in traditional medicine as \u2018panacea\u2019 for hundreds of years. Its therapeutic properties are determined by the combination of mandecassic acid, asiatic acid, asiaticoside and madecasosside found in the extract. Starting from the knowledge of traditional medicine, in the last years many researchers started to study in vitro and in vivo Centella asiatica extract for its beneficial properties in healing process of wounds, hypertrophic scars and burns. Other studies showed that herbal ointment with Centella asiatica can have a positive effect in the treatment of mild-to moderate atopic dermatitis. Mechanistic approaches showed that Centella asiatica promotes fibroblast proliferation and increase the synthesis of collagen and intracellular fibronectin content and inhibits inflammatory phase of hypertrophic scars. Scientific proofs showed that Centella asiatica extracts are promising candidates for use in different dermatological disorders with minimum side effects. <\/span><\/span><\/p>\n
Scurt CV<\/span><\/p>\nPhD, ERT (European Register Toxicology), habilitated Professor
\nDepartment of Toxicology, University of Medicine and Pharmacy Craiova, Romania<\/p>\n
Dr. Anca Oana Docea, female, is pharmacist, specialist in Clinical Pharmacology and MSc in Pharmacology and Toxicology. From January 2018 she has the title of ERT (European Registered Toxicologist). She performed her PhD in \u201ePathogenic Implications of EGF and TGF growth factors as well as their receptors in gastric carcinomas\u201d. She specialised in vivo toxicological animal testing, neurobehavioral testing, biochemical and immunohistochemically analysis. In the last years her research has been focused on the nanotoxicology and the safety evaluation of amphiphilic poly-N-vinyl-2-pyrrolidone nanosized carriers and long term low dose toxicity studies simulating real life exposure. She specialized in clinical toxicology in Toxicology Department \u2013 Faculty of Medicine, Aristotle University of Thessaloniki, computational methods for the analysis of transcriptome datasets at King\u2019s College London, Faculty of Life Sciences & Medicine, Department of Medical & Molecular Genetics and in new models for evaluation of neurotoxicity of xenobiotics at Albert Einstein College of Medicine, Department of Molecular Pharmacology, New York, USA. Currently, she is Habilitated Lecturer Professor in the department of Toxicology, University of Medicine and Pharmacy Craiova, Faculty of Pharmacy. In the last 8 years she has published 38 articles indexed in Web of Science journals and has a h-index 15 (Clarivate Analytics). Dr. Docea wined in the last 3 years 12 prices from UEFISCDI (Executive Unit for Financing Higher Education, Research, Development and Innovation) for the published articles. She was leading 1 research project and 3 Research mobility projects funded by UEFISCDI.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"PhD, ERT (European Register Toxicology), habilitated ProfessorDepartment of Toxicology, University of Medicine and Pharmacy Craiova, Romania Dr. Anca Oana Docea, female, is pharmacist, specialist in Clinical Pharmacology and MSc in Pharmacology and Toxicology. From January 2018 she has the title of ERT (European Registered Toxicologist). She performed her PhD in \u201ePathogenic Implications of EGF and […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-865","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=865"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/865\/revisions"}],"predecessor-version":[{"id":4473,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/865\/revisions\/4473"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Universitatea de Medicin\u0103 \u015fi Farmacie Craiova<\/span><\/strong><\/h4>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Efectele dermatologice ale extractului de Centella asiatica de la utilizare tradi\u021bionala la dovezi \u0219tiin\u021bifice<\/span> Centella asiatica este o plant\u0103 medicinal\u0103 utilizat\u0103 de sute de ani \u00een medicina tradi\u021bional\u0103 ca \u2018panaceu\u2019. Propriet\u0103\u021bile sale terapeutice sunt determinate de amestecul de acid mandecasic, acid asiatic, asiaticoside \u0219i madecasoside din compozi\u021bie. Pornind de la dovezile oferite de medicina tradi\u021bional\u0103, \u00een ultimii ani o serie de cercet\u0103tori au \u00eenceput s\u0103 studieze in vitro \u0219i in vivo efectele extractelor de centella asiatica \u00een procesul de vindecare a r\u0103nilor, a cicatricilor hipertrofice \u0219i a arsurilor. Alte studii au asociat utilizarea unguentelor cu extract de Centella asiatica cu un efect benefic \u00een tratarea formelor u\u0219oare spre moderate de dermatit\u0103 atopic\u0103. \u00cen ceea ce prive\u0219te mecanismul de ac\u021biune a extractului de Centella asiatica, studiile au ar\u0103tat c\u0103 acesta stimuleaz\u0103 proliferarea fibroblastelor \u0219i cre\u0219te sinteza de colagen \u0219i con\u021binutul de fibronectin\u0103 intracelular\u0103 \u0219i reduce faza inflamatorie a cicatricilor hipertrofice. Dovezile \u0219tiin\u021bifice au ar\u0103tat c\u0103 extractul de Centella asiatica poate fi utilizat cu succes \u00een diferite afec\u021biuni dermatologice cu efecte adverse minime.<\/p>\n Centella asiatica effects in dermatology from traditional use to scientific proofs Centella asiatica is a medicinal plant used in traditional medicine as \u2018panacea\u2019 for hundreds of years. Its therapeutic properties are determined by the combination of mandecassic acid, asiatic acid, asiaticoside and madecasosside found in the extract. Starting from the knowledge of traditional medicine, in the last years many researchers started to study in vitro and in vivo Centella asiatica extract for its beneficial properties in healing process of wounds, hypertrophic scars and burns. Other studies showed that herbal ointment with Centella asiatica can have a positive effect in the treatment of mild-to moderate atopic dermatitis. Mechanistic approaches showed that Centella asiatica promotes fibroblast proliferation and increase the synthesis of collagen and intracellular fibronectin content and inhibits inflammatory phase of hypertrophic scars. Scientific proofs showed that Centella asiatica extracts are promising candidates for use in different dermatological disorders with minimum side effects. <\/span><\/span><\/p>\n Scurt CV<\/span><\/p>\n PhD, ERT (European Register Toxicology), habilitated Professor Dr. Anca Oana Docea, female, is pharmacist, specialist in Clinical Pharmacology and MSc in Pharmacology and Toxicology. From January 2018 she has the title of ERT (European Registered Toxicologist). She performed her PhD in \u201ePathogenic Implications of EGF and TGF growth factors as well as their receptors in gastric carcinomas\u201d. She specialised in vivo toxicological animal testing, neurobehavioral testing, biochemical and immunohistochemically analysis. In the last years her research has been focused on the nanotoxicology and the safety evaluation of amphiphilic poly-N-vinyl-2-pyrrolidone nanosized carriers and long term low dose toxicity studies simulating real life exposure. She specialized in clinical toxicology in Toxicology Department \u2013 Faculty of Medicine, Aristotle University of Thessaloniki, computational methods for the analysis of transcriptome datasets at King\u2019s College London, Faculty of Life Sciences & Medicine, Department of Medical & Molecular Genetics and in new models for evaluation of neurotoxicity of xenobiotics at Albert Einstein College of Medicine, Department of Molecular Pharmacology, New York, USA. Currently, she is Habilitated Lecturer Professor in the department of Toxicology, University of Medicine and Pharmacy Craiova, Faculty of Pharmacy. In the last 8 years she has published 38 articles indexed in Web of Science journals and has a h-index 15 (Clarivate Analytics). Dr. Docea wined in the last 3 years 12 prices from UEFISCDI (Executive Unit for Financing Higher Education, Research, Development and Innovation) for the published articles. She was leading 1 research project and 3 Research mobility projects funded by UEFISCDI.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> PhD, ERT (European Register Toxicology), habilitated ProfessorDepartment of Toxicology, University of Medicine and Pharmacy Craiova, Romania Dr. Anca Oana Docea, female, is pharmacist, specialist in Clinical Pharmacology and MSc in Pharmacology and Toxicology. From January 2018 she has the title of ERT (European Registered Toxicologist). She performed her PhD in \u201ePathogenic Implications of EGF and […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-865","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=865"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/865\/revisions"}],"predecessor-version":[{"id":4473,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/865\/revisions\/4473"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nAutor: Anca Oana Docea<\/span><\/p>\n
\nAuthor: Anca Oana Docea<\/span><\/p>\n
\nDepartment of Toxicology, University of Medicine and Pharmacy Craiova, Romania<\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"