<\/strong><\/span><\/h5>\n<\/strong><\/span><\/h5>\n<\/strong><\/span><\/h5>\n<\/strong><\/span><\/h5>\nProf. Dr. B\u0103descu Magda Mariana<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa”, Ia\u015fi<\/strong><\/span><\/h5>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
Tegumentul: Oglind\u0103 a malignit\u0103\u021bii organelor interne<\/span>
Autori: Magda B\u0103descu, Manuela Ciocoiu, B.M. Diaconescu, Codru\u021ba B\u0103descu<\/span><\/p>\nIntroducere: Tegumentul se comport\u0103 ca o oglind\u0103 pentru diferite afec\u021biuni subiacente, \u00een special tumori maligne. Leziunea cutanat\u0103 poate fi uneori singurul simptom al bolii de baz\u0103.
Material \u015fi metod\u0103: C\u00e2teva studii diferite ce cuprind un total de 712 de pacien\u021bi cu tumori maligne interne, care au fost interna\u021bi pe o perioad\u0103 de 5 ani. Au fost examinate \u0219i diagnosticate toate metastazele cutanate.
Rezultate: Metastazele cutanate apar la 1% – 9% din to\u021bi pacien\u021bii cu cancer intern. Cele mai frecvente metastaze ale pielii dintr-o tumora primar\u0103 necunoscut\u0103 anterior provin din rinichi, pl\u0103m\u00e2ni, tiroid\u0103 sau ovar \u0219i sunt localizate cel mai frecvent (75%) la cap, g\u00e2t \u0219i trunchiul superior. Carcinoamele metastatice sunt, de obicei, diferen\u021biate de carcinoamele primare ale pielii datorit\u0103 tiparelor histologice tipice ale acestora. \u00cen cazul \u00een care distinc\u021bia dintre tumorile tegumentare metastatice \u0219i cele primare este dificil\u0103, este util\u0103 o varietate de panouri imunohistochimice de colorare. Pozitivitatea pentru citokeratin 7 (CK 7) (GCDFP), receptorul de estrogen (ER) \u0219i receptorul de progesteron (PR) indic\u0103 provenien\u021ba mamar\u0103, \u00een timp ce pozitivitatea factorului 1 de transcrip\u021bie tiroidian\u0103 (TTF-1) evoc\u0103 adenocarcinomul pulmonar ori tiroidian primar \u0219i nu este prezent \u00een tumorile cutanate primare. P63 este un marker pozitiv numai al tumorilor cutanate primare \u0219i negativ \u00een metastaze.
Concluzii: Metastazele cutanate reprezint\u0103 o oportunitate de a detecta un cancer poten\u021bial tratabil \u00eenainte de alte dovezi ale prezen\u021bei sale, de a modifica terapia dup\u0103 caz \u00een stadiul tumorii sau de a folosi leziunea cutanat\u0103 ca surs\u0103 de celule tumorale u\u0219or accesibile pentru terapie specific\u0103.<\/p>\n
Skin: A mirror of internal malignancy<\/span>
Authors: Magda B\u0103descu, Manuela Ciocoiu, B.M. Diaconescu, Codru\u021ba B\u0103descu<\/span><\/p>\nIntroduction: Tegument behaves like a mirror for various underlying conditions, especially malignant tumors. Skin lesion may sometimes be the only symptom of the underlying disease. Material and Method: Several different studies involving a total of 712 patients with internal malignant tumors who were hospitalized for a period of 5 years. All cutaneous metastases have been examined and diagnosed. Results: Cutaneous metastases occur in 1% – 9% of all patients with internal cancer. The most common skin metastases in a previously unknown primary tumor originate from the kidneys, lungs, thyroid or ovary, and are most commonly found (75%) in the head, neck, and upper trunk. Metastatic carcinomas are usually differentiated from the primary carcinomas of the skin due to their typical histological patterns. If the distinction between metastatic and primary skin tumors is difficult, a variety of immunohistochemical staining panels are useful. Positivity for cytokeratin 7 (CK 7) (GCDFP), estrogen receptor (ER) and progesterone receptor (PR) indicates mammary origin, while positivity of thyroid transcription factor (TTF-1) evokes primary adenocarcinoma or thyroid and is not present in primary skin tumors. P63 is a positive marker of only primary and negative tumors in metastases. Conclusions: Cutaneous metastases provide an opportunity to detect potentially treatable cancer before other evidence of its presence, to modify therapy as appropriate in the tumor stage, or to use cutaneous lesions as a source of tumor cells readily available for specific therapy.<\/p>\n
Scurt CV<\/span><\/p>\nProfesor Universitar
\u2022 Disciplina Fiziopatologie, Facultatea de Medicin\u0103, U.M.F. \u201eGrigore T. Popa\u201d Ia\u015fi
\u2022 Medic primar medicin\u0103 intern\u0103
\u2022 Membru a 15 societ\u0103\u0163i \u015ftiin\u0163ifice na\u0163ionale \u015fi interna\u0163ionale:
Autor a unui num\u0103r de 16 manuale didactice \u015fi a unui num\u0103r de 6 monografii, dintre care men\u0163ionez:
\u2022 Zincul, o speran\u0163\u0103 pentru diabetici (monografie) Magda B\u0103descu, Casa Editorial\u0103 “Demiurg” Ia\u015fi, 1997.
\u2022 Elemente Fiziopatologice de limbaj intercelular (Monografie), Manuela Ciocoiu, Magda B\u0103descu; Editura \u201cTerra Nostra\u201d, ISBN 973-85547-4-8, 2001.
\u2022 FIZIOPATOLOGIE. Insuficien\u0163a marilor sisteme func\u0163ionale, Manuela Ciocoiu, Magda B\u0103descu. Editura Junimea, Ia\u015fi, 2010, ISBN 978-973-37-1465-1
\u2022 Magda B\u0103descu, Manuela Ciocoiu, Lauren\u0163iu B\u0103descu. Natural polyphenols intake in experimental diabetes mellitus, LAP LAMBERT Academic Publishing 2012, ISBN-13: 978-3659211287
\u2022 Compendu de Fiziopatologie General\u0103; Magda B\u0103descu, Manuela Ciocoiu, Editura Vasiliana, ISBN 973-8148-23-5, Ia\u015fi, 2001.
\u2022 Compendu de Fiziopatologie Special\u0103; Magda B\u0103descu, Manuela Ciocoiu; Editura Vasiliana, ISBN 973-8148-32-4, Ia\u015fi, 2001.
\u2022 FIZIOPATOLOGIE SPECIAL\u0102, Editura \u201cGr. T. Popa\u201d, U.M.F. Ia\u015fi, 2011, coord. Magda B\u0103descu, ISBN 978-606-544-055-5
Activitatea \u015ftiin\u0163ific\u0103 se materializeaz\u0103 \u00een:
\u2022 31 lucr\u0103ri ISI publicate \u00een ultimii 10 ani
\u2022 66 lucr\u0103ri BDI publicate \u00een ultimii 10 ani
\u2022 37 lucr\u0103ri \u00een alte reviste, \u00een volumele unor conferin\u0163e cu ISBN sau ISSN
\u2022 11 programe de cercetare + 20 teze de doctorat finalizate si confirmate.
H-index Web of Science Core Collection = 7
Factor de impact cumulat (pentru toate articolele) = 34,28
Teme de cercetare de interes, cu aplicabilitate pentru studiile doctorale;
1. Patogenia complica\u021biilor diabetului zaharat precum \u0219i preven\u021bia \u0219i terapia acestora prin deriva\u021bi naturali (microelemente, polifenoli).
2. Posibilit\u0103\u021bi de limitare a complica\u021biilor hipertensiunii arteriale prin deriva\u021bi naturali.
3. Aspecte genetice \u0219i epigenetice \u00een diagnosticul \u0219i tratamentul cardiopatiei ischemice.
4. Aspecte celulare \u0219i moleculare \u00een etiopatogenia \u0219i terapia neoplazic\u0103.
5. Metode de diagnostic precoce \u0219i terapie \u00een bolile degenerative.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Scurt CV \u2022 Profesor Universitar \u2022 Disciplina Fiziopatologie, Facultatea de Medicin\u0103, U.M.F. \u201eGr.T.Popa\u201d Ia\u015fi\u2022 Medic primar medicin\u0103 intern\u0103\u2022 Membru a 15 societ\u0103\u0163i \u015ftiin\u0163ifice na\u0163ionale \u015fi interna\u0163ionale:Autor a unui num\u0103r de 16 manuale didactice \u015fi a unui num\u0103r de 6 monografii, dintre care men\u0163ionez:\u2022 Zincul, o speran\u0163\u0103 pentru diabetici (monografie) Magda B\u0103descu, Casa Editorial\u0103 “Demiurg” Ia\u015fi, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-877","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=877"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877\/revisions"}],"predecessor-version":[{"id":6720,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877\/revisions\/6720"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/strong><\/span><\/h5>\n<\/strong><\/span><\/h5>\nProf. Dr. B\u0103descu Magda Mariana<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa”, Ia\u015fi<\/strong><\/span><\/h5>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
Tegumentul: Oglind\u0103 a malignit\u0103\u021bii organelor interne<\/span>
Autori: Magda B\u0103descu, Manuela Ciocoiu, B.M. Diaconescu, Codru\u021ba B\u0103descu<\/span><\/p>\nIntroducere: Tegumentul se comport\u0103 ca o oglind\u0103 pentru diferite afec\u021biuni subiacente, \u00een special tumori maligne. Leziunea cutanat\u0103 poate fi uneori singurul simptom al bolii de baz\u0103.
Material \u015fi metod\u0103: C\u00e2teva studii diferite ce cuprind un total de 712 de pacien\u021bi cu tumori maligne interne, care au fost interna\u021bi pe o perioad\u0103 de 5 ani. Au fost examinate \u0219i diagnosticate toate metastazele cutanate.
Rezultate: Metastazele cutanate apar la 1% – 9% din to\u021bi pacien\u021bii cu cancer intern. Cele mai frecvente metastaze ale pielii dintr-o tumora primar\u0103 necunoscut\u0103 anterior provin din rinichi, pl\u0103m\u00e2ni, tiroid\u0103 sau ovar \u0219i sunt localizate cel mai frecvent (75%) la cap, g\u00e2t \u0219i trunchiul superior. Carcinoamele metastatice sunt, de obicei, diferen\u021biate de carcinoamele primare ale pielii datorit\u0103 tiparelor histologice tipice ale acestora. \u00cen cazul \u00een care distinc\u021bia dintre tumorile tegumentare metastatice \u0219i cele primare este dificil\u0103, este util\u0103 o varietate de panouri imunohistochimice de colorare. Pozitivitatea pentru citokeratin 7 (CK 7) (GCDFP), receptorul de estrogen (ER) \u0219i receptorul de progesteron (PR) indic\u0103 provenien\u021ba mamar\u0103, \u00een timp ce pozitivitatea factorului 1 de transcrip\u021bie tiroidian\u0103 (TTF-1) evoc\u0103 adenocarcinomul pulmonar ori tiroidian primar \u0219i nu este prezent \u00een tumorile cutanate primare. P63 este un marker pozitiv numai al tumorilor cutanate primare \u0219i negativ \u00een metastaze.
Concluzii: Metastazele cutanate reprezint\u0103 o oportunitate de a detecta un cancer poten\u021bial tratabil \u00eenainte de alte dovezi ale prezen\u021bei sale, de a modifica terapia dup\u0103 caz \u00een stadiul tumorii sau de a folosi leziunea cutanat\u0103 ca surs\u0103 de celule tumorale u\u0219or accesibile pentru terapie specific\u0103.<\/p>\n
Skin: A mirror of internal malignancy<\/span>
Authors: Magda B\u0103descu, Manuela Ciocoiu, B.M. Diaconescu, Codru\u021ba B\u0103descu<\/span><\/p>\nIntroduction: Tegument behaves like a mirror for various underlying conditions, especially malignant tumors. Skin lesion may sometimes be the only symptom of the underlying disease. Material and Method: Several different studies involving a total of 712 patients with internal malignant tumors who were hospitalized for a period of 5 years. All cutaneous metastases have been examined and diagnosed. Results: Cutaneous metastases occur in 1% – 9% of all patients with internal cancer. The most common skin metastases in a previously unknown primary tumor originate from the kidneys, lungs, thyroid or ovary, and are most commonly found (75%) in the head, neck, and upper trunk. Metastatic carcinomas are usually differentiated from the primary carcinomas of the skin due to their typical histological patterns. If the distinction between metastatic and primary skin tumors is difficult, a variety of immunohistochemical staining panels are useful. Positivity for cytokeratin 7 (CK 7) (GCDFP), estrogen receptor (ER) and progesterone receptor (PR) indicates mammary origin, while positivity of thyroid transcription factor (TTF-1) evokes primary adenocarcinoma or thyroid and is not present in primary skin tumors. P63 is a positive marker of only primary and negative tumors in metastases. Conclusions: Cutaneous metastases provide an opportunity to detect potentially treatable cancer before other evidence of its presence, to modify therapy as appropriate in the tumor stage, or to use cutaneous lesions as a source of tumor cells readily available for specific therapy.<\/p>\n
Scurt CV<\/span><\/p>\nProfesor Universitar
\u2022 Disciplina Fiziopatologie, Facultatea de Medicin\u0103, U.M.F. \u201eGrigore T. Popa\u201d Ia\u015fi
\u2022 Medic primar medicin\u0103 intern\u0103
\u2022 Membru a 15 societ\u0103\u0163i \u015ftiin\u0163ifice na\u0163ionale \u015fi interna\u0163ionale:
Autor a unui num\u0103r de 16 manuale didactice \u015fi a unui num\u0103r de 6 monografii, dintre care men\u0163ionez:
\u2022 Zincul, o speran\u0163\u0103 pentru diabetici (monografie) Magda B\u0103descu, Casa Editorial\u0103 “Demiurg” Ia\u015fi, 1997.
\u2022 Elemente Fiziopatologice de limbaj intercelular (Monografie), Manuela Ciocoiu, Magda B\u0103descu; Editura \u201cTerra Nostra\u201d, ISBN 973-85547-4-8, 2001.
\u2022 FIZIOPATOLOGIE. Insuficien\u0163a marilor sisteme func\u0163ionale, Manuela Ciocoiu, Magda B\u0103descu. Editura Junimea, Ia\u015fi, 2010, ISBN 978-973-37-1465-1
\u2022 Magda B\u0103descu, Manuela Ciocoiu, Lauren\u0163iu B\u0103descu. Natural polyphenols intake in experimental diabetes mellitus, LAP LAMBERT Academic Publishing 2012, ISBN-13: 978-3659211287
\u2022 Compendu de Fiziopatologie General\u0103; Magda B\u0103descu, Manuela Ciocoiu, Editura Vasiliana, ISBN 973-8148-23-5, Ia\u015fi, 2001.
\u2022 Compendu de Fiziopatologie Special\u0103; Magda B\u0103descu, Manuela Ciocoiu; Editura Vasiliana, ISBN 973-8148-32-4, Ia\u015fi, 2001.
\u2022 FIZIOPATOLOGIE SPECIAL\u0102, Editura \u201cGr. T. Popa\u201d, U.M.F. Ia\u015fi, 2011, coord. Magda B\u0103descu, ISBN 978-606-544-055-5
Activitatea \u015ftiin\u0163ific\u0103 se materializeaz\u0103 \u00een:
\u2022 31 lucr\u0103ri ISI publicate \u00een ultimii 10 ani
\u2022 66 lucr\u0103ri BDI publicate \u00een ultimii 10 ani
\u2022 37 lucr\u0103ri \u00een alte reviste, \u00een volumele unor conferin\u0163e cu ISBN sau ISSN
\u2022 11 programe de cercetare + 20 teze de doctorat finalizate si confirmate.
H-index Web of Science Core Collection = 7
Factor de impact cumulat (pentru toate articolele) = 34,28
Teme de cercetare de interes, cu aplicabilitate pentru studiile doctorale;
1. Patogenia complica\u021biilor diabetului zaharat precum \u0219i preven\u021bia \u0219i terapia acestora prin deriva\u021bi naturali (microelemente, polifenoli).
2. Posibilit\u0103\u021bi de limitare a complica\u021biilor hipertensiunii arteriale prin deriva\u021bi naturali.
3. Aspecte genetice \u0219i epigenetice \u00een diagnosticul \u0219i tratamentul cardiopatiei ischemice.
4. Aspecte celulare \u0219i moleculare \u00een etiopatogenia \u0219i terapia neoplazic\u0103.
5. Metode de diagnostic precoce \u0219i terapie \u00een bolile degenerative.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Scurt CV \u2022 Profesor Universitar \u2022 Disciplina Fiziopatologie, Facultatea de Medicin\u0103, U.M.F. \u201eGr.T.Popa\u201d Ia\u015fi\u2022 Medic primar medicin\u0103 intern\u0103\u2022 Membru a 15 societ\u0103\u0163i \u015ftiin\u0163ifice na\u0163ionale \u015fi interna\u0163ionale:Autor a unui num\u0103r de 16 manuale didactice \u015fi a unui num\u0103r de 6 monografii, dintre care men\u0163ionez:\u2022 Zincul, o speran\u0163\u0103 pentru diabetici (monografie) Magda B\u0103descu, Casa Editorial\u0103 “Demiurg” Ia\u015fi, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-877","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=877"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877\/revisions"}],"predecessor-version":[{"id":6720,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877\/revisions\/6720"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Prof. Dr. B\u0103descu Magda Mariana<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa”, Ia\u015fi<\/strong><\/span><\/h5>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n
Tegumentul: Oglind\u0103 a malignit\u0103\u021bii organelor interne<\/span>
Autori: Magda B\u0103descu, Manuela Ciocoiu, B.M. Diaconescu, Codru\u021ba B\u0103descu<\/span><\/p>\nIntroducere: Tegumentul se comport\u0103 ca o oglind\u0103 pentru diferite afec\u021biuni subiacente, \u00een special tumori maligne. Leziunea cutanat\u0103 poate fi uneori singurul simptom al bolii de baz\u0103.
Material \u015fi metod\u0103: C\u00e2teva studii diferite ce cuprind un total de 712 de pacien\u021bi cu tumori maligne interne, care au fost interna\u021bi pe o perioad\u0103 de 5 ani. Au fost examinate \u0219i diagnosticate toate metastazele cutanate.
Rezultate: Metastazele cutanate apar la 1% – 9% din to\u021bi pacien\u021bii cu cancer intern. Cele mai frecvente metastaze ale pielii dintr-o tumora primar\u0103 necunoscut\u0103 anterior provin din rinichi, pl\u0103m\u00e2ni, tiroid\u0103 sau ovar \u0219i sunt localizate cel mai frecvent (75%) la cap, g\u00e2t \u0219i trunchiul superior. Carcinoamele metastatice sunt, de obicei, diferen\u021biate de carcinoamele primare ale pielii datorit\u0103 tiparelor histologice tipice ale acestora. \u00cen cazul \u00een care distinc\u021bia dintre tumorile tegumentare metastatice \u0219i cele primare este dificil\u0103, este util\u0103 o varietate de panouri imunohistochimice de colorare. Pozitivitatea pentru citokeratin 7 (CK 7) (GCDFP), receptorul de estrogen (ER) \u0219i receptorul de progesteron (PR) indic\u0103 provenien\u021ba mamar\u0103, \u00een timp ce pozitivitatea factorului 1 de transcrip\u021bie tiroidian\u0103 (TTF-1) evoc\u0103 adenocarcinomul pulmonar ori tiroidian primar \u0219i nu este prezent \u00een tumorile cutanate primare. P63 este un marker pozitiv numai al tumorilor cutanate primare \u0219i negativ \u00een metastaze.
Concluzii: Metastazele cutanate reprezint\u0103 o oportunitate de a detecta un cancer poten\u021bial tratabil \u00eenainte de alte dovezi ale prezen\u021bei sale, de a modifica terapia dup\u0103 caz \u00een stadiul tumorii sau de a folosi leziunea cutanat\u0103 ca surs\u0103 de celule tumorale u\u0219or accesibile pentru terapie specific\u0103.<\/p>\n
Skin: A mirror of internal malignancy<\/span>
Authors: Magda B\u0103descu, Manuela Ciocoiu, B.M. Diaconescu, Codru\u021ba B\u0103descu<\/span><\/p>\nIntroduction: Tegument behaves like a mirror for various underlying conditions, especially malignant tumors. Skin lesion may sometimes be the only symptom of the underlying disease. Material and Method: Several different studies involving a total of 712 patients with internal malignant tumors who were hospitalized for a period of 5 years. All cutaneous metastases have been examined and diagnosed. Results: Cutaneous metastases occur in 1% – 9% of all patients with internal cancer. The most common skin metastases in a previously unknown primary tumor originate from the kidneys, lungs, thyroid or ovary, and are most commonly found (75%) in the head, neck, and upper trunk. Metastatic carcinomas are usually differentiated from the primary carcinomas of the skin due to their typical histological patterns. If the distinction between metastatic and primary skin tumors is difficult, a variety of immunohistochemical staining panels are useful. Positivity for cytokeratin 7 (CK 7) (GCDFP), estrogen receptor (ER) and progesterone receptor (PR) indicates mammary origin, while positivity of thyroid transcription factor (TTF-1) evokes primary adenocarcinoma or thyroid and is not present in primary skin tumors. P63 is a positive marker of only primary and negative tumors in metastases. Conclusions: Cutaneous metastases provide an opportunity to detect potentially treatable cancer before other evidence of its presence, to modify therapy as appropriate in the tumor stage, or to use cutaneous lesions as a source of tumor cells readily available for specific therapy.<\/p>\n
Scurt CV<\/span><\/p>\nProfesor Universitar
\u2022 Disciplina Fiziopatologie, Facultatea de Medicin\u0103, U.M.F. \u201eGrigore T. Popa\u201d Ia\u015fi
\u2022 Medic primar medicin\u0103 intern\u0103
\u2022 Membru a 15 societ\u0103\u0163i \u015ftiin\u0163ifice na\u0163ionale \u015fi interna\u0163ionale:
Autor a unui num\u0103r de 16 manuale didactice \u015fi a unui num\u0103r de 6 monografii, dintre care men\u0163ionez:
\u2022 Zincul, o speran\u0163\u0103 pentru diabetici (monografie) Magda B\u0103descu, Casa Editorial\u0103 “Demiurg” Ia\u015fi, 1997.
\u2022 Elemente Fiziopatologice de limbaj intercelular (Monografie), Manuela Ciocoiu, Magda B\u0103descu; Editura \u201cTerra Nostra\u201d, ISBN 973-85547-4-8, 2001.
\u2022 FIZIOPATOLOGIE. Insuficien\u0163a marilor sisteme func\u0163ionale, Manuela Ciocoiu, Magda B\u0103descu. Editura Junimea, Ia\u015fi, 2010, ISBN 978-973-37-1465-1
\u2022 Magda B\u0103descu, Manuela Ciocoiu, Lauren\u0163iu B\u0103descu. Natural polyphenols intake in experimental diabetes mellitus, LAP LAMBERT Academic Publishing 2012, ISBN-13: 978-3659211287
\u2022 Compendu de Fiziopatologie General\u0103; Magda B\u0103descu, Manuela Ciocoiu, Editura Vasiliana, ISBN 973-8148-23-5, Ia\u015fi, 2001.
\u2022 Compendu de Fiziopatologie Special\u0103; Magda B\u0103descu, Manuela Ciocoiu; Editura Vasiliana, ISBN 973-8148-32-4, Ia\u015fi, 2001.
\u2022 FIZIOPATOLOGIE SPECIAL\u0102, Editura \u201cGr. T. Popa\u201d, U.M.F. Ia\u015fi, 2011, coord. Magda B\u0103descu, ISBN 978-606-544-055-5
Activitatea \u015ftiin\u0163ific\u0103 se materializeaz\u0103 \u00een:
\u2022 31 lucr\u0103ri ISI publicate \u00een ultimii 10 ani
\u2022 66 lucr\u0103ri BDI publicate \u00een ultimii 10 ani
\u2022 37 lucr\u0103ri \u00een alte reviste, \u00een volumele unor conferin\u0163e cu ISBN sau ISSN
\u2022 11 programe de cercetare + 20 teze de doctorat finalizate si confirmate.
H-index Web of Science Core Collection = 7
Factor de impact cumulat (pentru toate articolele) = 34,28
Teme de cercetare de interes, cu aplicabilitate pentru studiile doctorale;
1. Patogenia complica\u021biilor diabetului zaharat precum \u0219i preven\u021bia \u0219i terapia acestora prin deriva\u021bi naturali (microelemente, polifenoli).
2. Posibilit\u0103\u021bi de limitare a complica\u021biilor hipertensiunii arteriale prin deriva\u021bi naturali.
3. Aspecte genetice \u0219i epigenetice \u00een diagnosticul \u0219i tratamentul cardiopatiei ischemice.
4. Aspecte celulare \u0219i moleculare \u00een etiopatogenia \u0219i terapia neoplazic\u0103.
5. Metode de diagnostic precoce \u0219i terapie \u00een bolile degenerative.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Scurt CV \u2022 Profesor Universitar \u2022 Disciplina Fiziopatologie, Facultatea de Medicin\u0103, U.M.F. \u201eGr.T.Popa\u201d Ia\u015fi\u2022 Medic primar medicin\u0103 intern\u0103\u2022 Membru a 15 societ\u0103\u0163i \u015ftiin\u0163ifice na\u0163ionale \u015fi interna\u0163ionale:Autor a unui num\u0103r de 16 manuale didactice \u015fi a unui num\u0103r de 6 monografii, dintre care men\u0163ionez:\u2022 Zincul, o speran\u0163\u0103 pentru diabetici (monografie) Magda B\u0103descu, Casa Editorial\u0103 “Demiurg” Ia\u015fi, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-877","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=877"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877\/revisions"}],"predecessor-version":[{"id":6720,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877\/revisions\/6720"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Magda B\u0103descu, Manuela Ciocoiu, B.M. Diaconescu, Codru\u021ba B\u0103descu<\/span><\/p>\n
Introducere: Tegumentul se comport\u0103 ca o oglind\u0103 pentru diferite afec\u021biuni subiacente, \u00een special tumori maligne. Leziunea cutanat\u0103 poate fi uneori singurul simptom al bolii de baz\u0103.
Material \u015fi metod\u0103: C\u00e2teva studii diferite ce cuprind un total de 712 de pacien\u021bi cu tumori maligne interne, care au fost interna\u021bi pe o perioad\u0103 de 5 ani. Au fost examinate \u0219i diagnosticate toate metastazele cutanate.
Rezultate: Metastazele cutanate apar la 1% – 9% din to\u021bi pacien\u021bii cu cancer intern. Cele mai frecvente metastaze ale pielii dintr-o tumora primar\u0103 necunoscut\u0103 anterior provin din rinichi, pl\u0103m\u00e2ni, tiroid\u0103 sau ovar \u0219i sunt localizate cel mai frecvent (75%) la cap, g\u00e2t \u0219i trunchiul superior. Carcinoamele metastatice sunt, de obicei, diferen\u021biate de carcinoamele primare ale pielii datorit\u0103 tiparelor histologice tipice ale acestora. \u00cen cazul \u00een care distinc\u021bia dintre tumorile tegumentare metastatice \u0219i cele primare este dificil\u0103, este util\u0103 o varietate de panouri imunohistochimice de colorare. Pozitivitatea pentru citokeratin 7 (CK 7) (GCDFP), receptorul de estrogen (ER) \u0219i receptorul de progesteron (PR) indic\u0103 provenien\u021ba mamar\u0103, \u00een timp ce pozitivitatea factorului 1 de transcrip\u021bie tiroidian\u0103 (TTF-1) evoc\u0103 adenocarcinomul pulmonar ori tiroidian primar \u0219i nu este prezent \u00een tumorile cutanate primare. P63 este un marker pozitiv numai al tumorilor cutanate primare \u0219i negativ \u00een metastaze.
Concluzii: Metastazele cutanate reprezint\u0103 o oportunitate de a detecta un cancer poten\u021bial tratabil \u00eenainte de alte dovezi ale prezen\u021bei sale, de a modifica terapia dup\u0103 caz \u00een stadiul tumorii sau de a folosi leziunea cutanat\u0103 ca surs\u0103 de celule tumorale u\u0219or accesibile pentru terapie specific\u0103.<\/p>\n
Skin: A mirror of internal malignancy<\/span> Introduction: Tegument behaves like a mirror for various underlying conditions, especially malignant tumors. Skin lesion may sometimes be the only symptom of the underlying disease. Material and Method: Several different studies involving a total of 712 patients with internal malignant tumors who were hospitalized for a period of 5 years. All cutaneous metastases have been examined and diagnosed. Results: Cutaneous metastases occur in 1% – 9% of all patients with internal cancer. The most common skin metastases in a previously unknown primary tumor originate from the kidneys, lungs, thyroid or ovary, and are most commonly found (75%) in the head, neck, and upper trunk. Metastatic carcinomas are usually differentiated from the primary carcinomas of the skin due to their typical histological patterns. If the distinction between metastatic and primary skin tumors is difficult, a variety of immunohistochemical staining panels are useful. Positivity for cytokeratin 7 (CK 7) (GCDFP), estrogen receptor (ER) and progesterone receptor (PR) indicates mammary origin, while positivity of thyroid transcription factor (TTF-1) evokes primary adenocarcinoma or thyroid and is not present in primary skin tumors. P63 is a positive marker of only primary and negative tumors in metastases. Conclusions: Cutaneous metastases provide an opportunity to detect potentially treatable cancer before other evidence of its presence, to modify therapy as appropriate in the tumor stage, or to use cutaneous lesions as a source of tumor cells readily available for specific therapy.<\/p>\n Scurt CV<\/span><\/p>\n Profesor Universitar [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false” column_structure=”3_5,2_5″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.27.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> Scurt CV \u2022 Profesor Universitar \u2022 Disciplina Fiziopatologie, Facultatea de Medicin\u0103, U.M.F. \u201eGr.T.Popa\u201d Ia\u015fi\u2022 Medic primar medicin\u0103 intern\u0103\u2022 Membru a 15 societ\u0103\u0163i \u015ftiin\u0163ifice na\u0163ionale \u015fi interna\u0163ionale:Autor a unui num\u0103r de 16 manuale didactice \u015fi a unui num\u0103r de 6 monografii, dintre care men\u0163ionez:\u2022 Zincul, o speran\u0163\u0103 pentru diabetici (monografie) Magda B\u0103descu, Casa Editorial\u0103 “Demiurg” Ia\u015fi, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-877","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=877"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877\/revisions"}],"predecessor-version":[{"id":6720,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/877\/revisions\/6720"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Authors: Magda B\u0103descu, Manuela Ciocoiu, B.M. Diaconescu, Codru\u021ba B\u0103descu<\/span><\/p>\n
\u2022 Disciplina Fiziopatologie, Facultatea de Medicin\u0103, U.M.F. \u201eGrigore T. Popa\u201d Ia\u015fi
\u2022 Medic primar medicin\u0103 intern\u0103
\u2022 Membru a 15 societ\u0103\u0163i \u015ftiin\u0163ifice na\u0163ionale \u015fi interna\u0163ionale:
Autor a unui num\u0103r de 16 manuale didactice \u015fi a unui num\u0103r de 6 monografii, dintre care men\u0163ionez:
\u2022 Zincul, o speran\u0163\u0103 pentru diabetici (monografie) Magda B\u0103descu, Casa Editorial\u0103 “Demiurg” Ia\u015fi, 1997.
\u2022 Elemente Fiziopatologice de limbaj intercelular (Monografie), Manuela Ciocoiu, Magda B\u0103descu; Editura \u201cTerra Nostra\u201d, ISBN 973-85547-4-8, 2001.
\u2022 FIZIOPATOLOGIE. Insuficien\u0163a marilor sisteme func\u0163ionale, Manuela Ciocoiu, Magda B\u0103descu. Editura Junimea, Ia\u015fi, 2010, ISBN 978-973-37-1465-1
\u2022 Magda B\u0103descu, Manuela Ciocoiu, Lauren\u0163iu B\u0103descu. Natural polyphenols intake in experimental diabetes mellitus, LAP LAMBERT Academic Publishing 2012, ISBN-13: 978-3659211287
\u2022 Compendu de Fiziopatologie General\u0103; Magda B\u0103descu, Manuela Ciocoiu, Editura Vasiliana, ISBN 973-8148-23-5, Ia\u015fi, 2001.
\u2022 Compendu de Fiziopatologie Special\u0103; Magda B\u0103descu, Manuela Ciocoiu; Editura Vasiliana, ISBN 973-8148-32-4, Ia\u015fi, 2001.
\u2022 FIZIOPATOLOGIE SPECIAL\u0102, Editura \u201cGr. T. Popa\u201d, U.M.F. Ia\u015fi, 2011, coord. Magda B\u0103descu, ISBN 978-606-544-055-5
Activitatea \u015ftiin\u0163ific\u0103 se materializeaz\u0103 \u00een:
\u2022 31 lucr\u0103ri ISI publicate \u00een ultimii 10 ani
\u2022 66 lucr\u0103ri BDI publicate \u00een ultimii 10 ani
\u2022 37 lucr\u0103ri \u00een alte reviste, \u00een volumele unor conferin\u0163e cu ISBN sau ISSN
\u2022 11 programe de cercetare + 20 teze de doctorat finalizate si confirmate.
H-index Web of Science Core Collection = 7
Factor de impact cumulat (pentru toate articolele) = 34,28
Teme de cercetare de interes, cu aplicabilitate pentru studiile doctorale;
1. Patogenia complica\u021biilor diabetului zaharat precum \u0219i preven\u021bia \u0219i terapia acestora prin deriva\u021bi naturali (microelemente, polifenoli).
2. Posibilit\u0103\u021bi de limitare a complica\u021biilor hipertensiunii arteriale prin deriva\u021bi naturali.
3. Aspecte genetice \u0219i epigenetice \u00een diagnosticul \u0219i tratamentul cardiopatiei ischemice.
4. Aspecte celulare \u0219i moleculare \u00een etiopatogenia \u0219i terapia neoplazic\u0103.
5. Metode de diagnostic precoce \u0219i terapie \u00een bolile degenerative.<\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"