<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nC.\u0218. I Dr. Benea Vasile<\/span><\/strong>
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Actualit\u0103\u021bi \u00een dermita atopic\u0103<\/span>
Autor: Vasile Benea<\/span><\/p>\nDermita atopic\u0103 este o dermatoz\u0103 cu evolu\u0163ie cronic\u0103, frecvent \u00eent\u00e2lnit\u0103 \u00een practica medical\u0103, afect\u00e2nd, \u00een \u021b\u0103rile dezvoltate, p\u00e2n\u0103 la 25 % dintre copii \u0219i p\u00e2n\u0103 la 10 dintre adul\u021bi. progresele ob\u021binute \u00een \u00een\u021belegerea mecanismelor etiopatogenice au condus la dezvoltarea unor noi terapii \u021bintite.
Etiopatogenia dermitei atopice este complex\u0103, implic\u00e2nd factori genetici, afectarea arhitecturii cutanate, tulbur\u0103ri ale r\u0103spunsului imun \u0219i modific\u0103ri ale microflorei cutanate. Muta\u021biile \u0219i polimorfismul genetic determin\u0103 tulbur\u0103ri ale func\u021biei de barier\u0103 cutanat\u0103 care au o importan\u021b\u0103 deosebit\u0103 \u00een dermita atopic\u0103. La adul\u021bii cu dermit\u0103 atopic\u0103, faza acut\u0103 se caracterizeaz\u0103 printr-un r\u0103spuns imun T helper 2\/T helper 22, cu implicarea limfocitelor T helper 17, \u00een timp ce \u00een faza cronic\u0103 se observ\u0103 o polarizare T helper 1; totu\u0219i, r\u0103spunsul T helper 2 are \u0219i el un rol important. La copii se pot eviden\u021bia o cantitate mai mare de cytokine induse de limfocitele T helper 17, precum \u0219i de peptide antimicrobiene. Tegumentele umane sunt colonizate de o varietate de microorganisme (microbiom) ce sunt influen\u021bate de factori ai organismului gazd\u0103 \u0219i din mediu; la atopici microbiomul este mai pu\u021bin divers, fiind dominat de Staphylococcus aureus.
Pacien\u021bii cu dermit\u0103 atopic\u0103 au un risc crescut de comorbidit\u0103\u021bi; acest risc este mai mare la cei cu forme severe de boal\u0103 \u0219i la fum\u0103tori.
Tratamentul standard actual al dermitei atopice este ghidat de severitatea inflama\u021biei cutanate \u0219i se bazeaz\u0103 pe tratamentul topic cu corticosteroizi sau inhibitori de calcineurin\u0103, terapia cu ultraviolete sau imunosupresoare sistemice. Un important pas \u00eenainte a fost reprezentat de introducerea, \u00een 2017, a tratamentului biologic cu dupilumab (care se leag\u0103 de subunitatea \u03b1 a receptorului pentru IL-4). De asemenea, se afl\u0103 \u00een studiu o serie de noi agen\u021bi terapeutici: inhibitori ai IL-13; inhibitori ai Janus-kinazei; inhibitori ai fosfodiesterazei-4; inhibitori ai TRPV1; inhibitori ai neurokininei-1; inhibitori ai limfocitelor T; inhibitori ai c\u0103ii leukotrienelor; noi antihistaminice; antagoni\u0219ti ai 5HT2B etc.<\/p>\n
What\u2019s new in atopic dermatitis?<\/span>
Author: Vasile Benea<\/span><\/p>\nAtopic dermatitis is a common inflammatory skin disease affecting up to 25% of children and up to 10% of adults in Western industrialized countries. With each year, more advances have been made in regard to understanding the pathophysiology of the disease and developing more targeted therapies.
Atopic dermatitis is a complex multifactorial disease encompassing defects in skin architecture, immune dysregulation, and skin flora changes. Gene polymorphisms and mutations are associated with defects of the epidermal barrier function and are crucial in patients. In adults, the acute phase is characterized by a strong T helper 2\/T helper 22 activation and the contribution of T helper 17 cells, whereas the chronic phase by a marked T helper 1 polarization, although the T helper 2 pathway had still an important role. More T helper 17-related cytokines and antimicrobial peptides were detectable in the skin of atopic dermatitis children than in the skin of adults. Human skin is densely colonized by a variety of natural flora (microbiome) influenced by the host and the surrounding environment. In atopic dermatitis (AD), the skin microbiome is dominated by Staphylococcus aureus and less diverse than in healthy skin.
There\u2019s a significantly increased risk for major comorbidities in adult patients with atopic dermatitis; the risk difference was predominantly found in patients with severe disease and among smokers.
The standard treatment of atopic dermatitis focuses on the severity of skin inflammation and consists of topical treatment with corticosteroids and calcineurin inhibitors, ultraviolet light or systemic immunosuppression. A new step forward was made with the introduction, in 2017, of dupilumab (which binds to the \u03b1-subunit of the IL-4 receptor, part of both the IL-4 and IL-13 receptor complex) in the treatment of adult atopic dermatitis. There are a lot of new agents in the pipeline: the interleukin 13 inhibitors; Janus kinase inhibitors; phosphodiesterase 4 inhibitors; TRPV1 (transient receptor potential cation channel subfamily V member 1) inhibitors; neurokinin 1 inhibitors; T-cell inhibitors; arachidonic acid, leukotriene, and prostaglandin inhibitors; 5HT2B antagonists; antihistamines, etc.<\/p>\n
<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103<\/strong>
Perioada<\/strong>
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:<\/strong>
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, \u015eoseaua Mihai Bravu 281, sector 3, 030303 Bucure\u015fti<\/p>\nEduca\u0163ie \u015fi formare<\/strong>
Perioada<\/strong>
Calificarea \/ diploma ob\u0163inut\u0103
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]![\"\"](\"https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Experien\u0163a profesional\u0103 Perioada Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti 2002 – 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti; 1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-936","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=936"}],"version-history":[{"count":9,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936\/revisions"}],"predecessor-version":[{"id":4801,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936\/revisions\/4801"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nC.\u0218. I Dr. Benea Vasile<\/span><\/strong>
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Actualit\u0103\u021bi \u00een dermita atopic\u0103<\/span>
Autor: Vasile Benea<\/span><\/p>\nDermita atopic\u0103 este o dermatoz\u0103 cu evolu\u0163ie cronic\u0103, frecvent \u00eent\u00e2lnit\u0103 \u00een practica medical\u0103, afect\u00e2nd, \u00een \u021b\u0103rile dezvoltate, p\u00e2n\u0103 la 25 % dintre copii \u0219i p\u00e2n\u0103 la 10 dintre adul\u021bi. progresele ob\u021binute \u00een \u00een\u021belegerea mecanismelor etiopatogenice au condus la dezvoltarea unor noi terapii \u021bintite.
Etiopatogenia dermitei atopice este complex\u0103, implic\u00e2nd factori genetici, afectarea arhitecturii cutanate, tulbur\u0103ri ale r\u0103spunsului imun \u0219i modific\u0103ri ale microflorei cutanate. Muta\u021biile \u0219i polimorfismul genetic determin\u0103 tulbur\u0103ri ale func\u021biei de barier\u0103 cutanat\u0103 care au o importan\u021b\u0103 deosebit\u0103 \u00een dermita atopic\u0103. La adul\u021bii cu dermit\u0103 atopic\u0103, faza acut\u0103 se caracterizeaz\u0103 printr-un r\u0103spuns imun T helper 2\/T helper 22, cu implicarea limfocitelor T helper 17, \u00een timp ce \u00een faza cronic\u0103 se observ\u0103 o polarizare T helper 1; totu\u0219i, r\u0103spunsul T helper 2 are \u0219i el un rol important. La copii se pot eviden\u021bia o cantitate mai mare de cytokine induse de limfocitele T helper 17, precum \u0219i de peptide antimicrobiene. Tegumentele umane sunt colonizate de o varietate de microorganisme (microbiom) ce sunt influen\u021bate de factori ai organismului gazd\u0103 \u0219i din mediu; la atopici microbiomul este mai pu\u021bin divers, fiind dominat de Staphylococcus aureus.
Pacien\u021bii cu dermit\u0103 atopic\u0103 au un risc crescut de comorbidit\u0103\u021bi; acest risc este mai mare la cei cu forme severe de boal\u0103 \u0219i la fum\u0103tori.
Tratamentul standard actual al dermitei atopice este ghidat de severitatea inflama\u021biei cutanate \u0219i se bazeaz\u0103 pe tratamentul topic cu corticosteroizi sau inhibitori de calcineurin\u0103, terapia cu ultraviolete sau imunosupresoare sistemice. Un important pas \u00eenainte a fost reprezentat de introducerea, \u00een 2017, a tratamentului biologic cu dupilumab (care se leag\u0103 de subunitatea \u03b1 a receptorului pentru IL-4). De asemenea, se afl\u0103 \u00een studiu o serie de noi agen\u021bi terapeutici: inhibitori ai IL-13; inhibitori ai Janus-kinazei; inhibitori ai fosfodiesterazei-4; inhibitori ai TRPV1; inhibitori ai neurokininei-1; inhibitori ai limfocitelor T; inhibitori ai c\u0103ii leukotrienelor; noi antihistaminice; antagoni\u0219ti ai 5HT2B etc.<\/p>\n
What\u2019s new in atopic dermatitis?<\/span>
Author: Vasile Benea<\/span><\/p>\nAtopic dermatitis is a common inflammatory skin disease affecting up to 25% of children and up to 10% of adults in Western industrialized countries. With each year, more advances have been made in regard to understanding the pathophysiology of the disease and developing more targeted therapies.
Atopic dermatitis is a complex multifactorial disease encompassing defects in skin architecture, immune dysregulation, and skin flora changes. Gene polymorphisms and mutations are associated with defects of the epidermal barrier function and are crucial in patients. In adults, the acute phase is characterized by a strong T helper 2\/T helper 22 activation and the contribution of T helper 17 cells, whereas the chronic phase by a marked T helper 1 polarization, although the T helper 2 pathway had still an important role. More T helper 17-related cytokines and antimicrobial peptides were detectable in the skin of atopic dermatitis children than in the skin of adults. Human skin is densely colonized by a variety of natural flora (microbiome) influenced by the host and the surrounding environment. In atopic dermatitis (AD), the skin microbiome is dominated by Staphylococcus aureus and less diverse than in healthy skin.
There\u2019s a significantly increased risk for major comorbidities in adult patients with atopic dermatitis; the risk difference was predominantly found in patients with severe disease and among smokers.
The standard treatment of atopic dermatitis focuses on the severity of skin inflammation and consists of topical treatment with corticosteroids and calcineurin inhibitors, ultraviolet light or systemic immunosuppression. A new step forward was made with the introduction, in 2017, of dupilumab (which binds to the \u03b1-subunit of the IL-4 receptor, part of both the IL-4 and IL-13 receptor complex) in the treatment of adult atopic dermatitis. There are a lot of new agents in the pipeline: the interleukin 13 inhibitors; Janus kinase inhibitors; phosphodiesterase 4 inhibitors; TRPV1 (transient receptor potential cation channel subfamily V member 1) inhibitors; neurokinin 1 inhibitors; T-cell inhibitors; arachidonic acid, leukotriene, and prostaglandin inhibitors; 5HT2B antagonists; antihistamines, etc.<\/p>\n
<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103<\/strong>
Perioada<\/strong>
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:<\/strong>
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, \u015eoseaua Mihai Bravu 281, sector 3, 030303 Bucure\u015fti<\/p>\nEduca\u0163ie \u015fi formare<\/strong>
Perioada<\/strong>
Calificarea \/ diploma ob\u0163inut\u0103
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Experien\u0163a profesional\u0103 Perioada Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti 2002 – 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti; 1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-936","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=936"}],"version-history":[{"count":9,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936\/revisions"}],"predecessor-version":[{"id":4801,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936\/revisions\/4801"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
C.\u0218. I Dr. Benea Vasile<\/span><\/strong>
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.14″][et_pb_column type=”4_4″ _builder_version=”3.19.14″][et_pb_text _builder_version=”3.19.18″]<\/p>\n
Actualit\u0103\u021bi \u00een dermita atopic\u0103<\/span>
Autor: Vasile Benea<\/span><\/p>\nDermita atopic\u0103 este o dermatoz\u0103 cu evolu\u0163ie cronic\u0103, frecvent \u00eent\u00e2lnit\u0103 \u00een practica medical\u0103, afect\u00e2nd, \u00een \u021b\u0103rile dezvoltate, p\u00e2n\u0103 la 25 % dintre copii \u0219i p\u00e2n\u0103 la 10 dintre adul\u021bi. progresele ob\u021binute \u00een \u00een\u021belegerea mecanismelor etiopatogenice au condus la dezvoltarea unor noi terapii \u021bintite.
Etiopatogenia dermitei atopice este complex\u0103, implic\u00e2nd factori genetici, afectarea arhitecturii cutanate, tulbur\u0103ri ale r\u0103spunsului imun \u0219i modific\u0103ri ale microflorei cutanate. Muta\u021biile \u0219i polimorfismul genetic determin\u0103 tulbur\u0103ri ale func\u021biei de barier\u0103 cutanat\u0103 care au o importan\u021b\u0103 deosebit\u0103 \u00een dermita atopic\u0103. La adul\u021bii cu dermit\u0103 atopic\u0103, faza acut\u0103 se caracterizeaz\u0103 printr-un r\u0103spuns imun T helper 2\/T helper 22, cu implicarea limfocitelor T helper 17, \u00een timp ce \u00een faza cronic\u0103 se observ\u0103 o polarizare T helper 1; totu\u0219i, r\u0103spunsul T helper 2 are \u0219i el un rol important. La copii se pot eviden\u021bia o cantitate mai mare de cytokine induse de limfocitele T helper 17, precum \u0219i de peptide antimicrobiene. Tegumentele umane sunt colonizate de o varietate de microorganisme (microbiom) ce sunt influen\u021bate de factori ai organismului gazd\u0103 \u0219i din mediu; la atopici microbiomul este mai pu\u021bin divers, fiind dominat de Staphylococcus aureus.
Pacien\u021bii cu dermit\u0103 atopic\u0103 au un risc crescut de comorbidit\u0103\u021bi; acest risc este mai mare la cei cu forme severe de boal\u0103 \u0219i la fum\u0103tori.
Tratamentul standard actual al dermitei atopice este ghidat de severitatea inflama\u021biei cutanate \u0219i se bazeaz\u0103 pe tratamentul topic cu corticosteroizi sau inhibitori de calcineurin\u0103, terapia cu ultraviolete sau imunosupresoare sistemice. Un important pas \u00eenainte a fost reprezentat de introducerea, \u00een 2017, a tratamentului biologic cu dupilumab (care se leag\u0103 de subunitatea \u03b1 a receptorului pentru IL-4). De asemenea, se afl\u0103 \u00een studiu o serie de noi agen\u021bi terapeutici: inhibitori ai IL-13; inhibitori ai Janus-kinazei; inhibitori ai fosfodiesterazei-4; inhibitori ai TRPV1; inhibitori ai neurokininei-1; inhibitori ai limfocitelor T; inhibitori ai c\u0103ii leukotrienelor; noi antihistaminice; antagoni\u0219ti ai 5HT2B etc.<\/p>\n
What\u2019s new in atopic dermatitis?<\/span>
Author: Vasile Benea<\/span><\/p>\nAtopic dermatitis is a common inflammatory skin disease affecting up to 25% of children and up to 10% of adults in Western industrialized countries. With each year, more advances have been made in regard to understanding the pathophysiology of the disease and developing more targeted therapies.
Atopic dermatitis is a complex multifactorial disease encompassing defects in skin architecture, immune dysregulation, and skin flora changes. Gene polymorphisms and mutations are associated with defects of the epidermal barrier function and are crucial in patients. In adults, the acute phase is characterized by a strong T helper 2\/T helper 22 activation and the contribution of T helper 17 cells, whereas the chronic phase by a marked T helper 1 polarization, although the T helper 2 pathway had still an important role. More T helper 17-related cytokines and antimicrobial peptides were detectable in the skin of atopic dermatitis children than in the skin of adults. Human skin is densely colonized by a variety of natural flora (microbiome) influenced by the host and the surrounding environment. In atopic dermatitis (AD), the skin microbiome is dominated by Staphylococcus aureus and less diverse than in healthy skin.
There\u2019s a significantly increased risk for major comorbidities in adult patients with atopic dermatitis; the risk difference was predominantly found in patients with severe disease and among smokers.
The standard treatment of atopic dermatitis focuses on the severity of skin inflammation and consists of topical treatment with corticosteroids and calcineurin inhibitors, ultraviolet light or systemic immunosuppression. A new step forward was made with the introduction, in 2017, of dupilumab (which binds to the \u03b1-subunit of the IL-4 receptor, part of both the IL-4 and IL-13 receptor complex) in the treatment of adult atopic dermatitis. There are a lot of new agents in the pipeline: the interleukin 13 inhibitors; Janus kinase inhibitors; phosphodiesterase 4 inhibitors; TRPV1 (transient receptor potential cation channel subfamily V member 1) inhibitors; neurokinin 1 inhibitors; T-cell inhibitors; arachidonic acid, leukotriene, and prostaglandin inhibitors; 5HT2B antagonists; antihistamines, etc.<\/p>\n
<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103<\/strong>
Perioada<\/strong>
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:<\/strong>
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, \u015eoseaua Mihai Bravu 281, sector 3, 030303 Bucure\u015fti<\/p>\nEduca\u0163ie \u015fi formare<\/strong>
Perioada<\/strong>
Calificarea \/ diploma ob\u0163inut\u0103
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"Experien\u0163a profesional\u0103 Perioada Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti 2002 – 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti; 1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-936","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=936"}],"version-history":[{"count":9,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936\/revisions"}],"predecessor-version":[{"id":4801,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936\/revisions\/4801"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Vasile Benea<\/span><\/p>\n
Dermita atopic\u0103 este o dermatoz\u0103 cu evolu\u0163ie cronic\u0103, frecvent \u00eent\u00e2lnit\u0103 \u00een practica medical\u0103, afect\u00e2nd, \u00een \u021b\u0103rile dezvoltate, p\u00e2n\u0103 la 25 % dintre copii \u0219i p\u00e2n\u0103 la 10 dintre adul\u021bi. progresele ob\u021binute \u00een \u00een\u021belegerea mecanismelor etiopatogenice au condus la dezvoltarea unor noi terapii \u021bintite.
Etiopatogenia dermitei atopice este complex\u0103, implic\u00e2nd factori genetici, afectarea arhitecturii cutanate, tulbur\u0103ri ale r\u0103spunsului imun \u0219i modific\u0103ri ale microflorei cutanate. Muta\u021biile \u0219i polimorfismul genetic determin\u0103 tulbur\u0103ri ale func\u021biei de barier\u0103 cutanat\u0103 care au o importan\u021b\u0103 deosebit\u0103 \u00een dermita atopic\u0103. La adul\u021bii cu dermit\u0103 atopic\u0103, faza acut\u0103 se caracterizeaz\u0103 printr-un r\u0103spuns imun T helper 2\/T helper 22, cu implicarea limfocitelor T helper 17, \u00een timp ce \u00een faza cronic\u0103 se observ\u0103 o polarizare T helper 1; totu\u0219i, r\u0103spunsul T helper 2 are \u0219i el un rol important. La copii se pot eviden\u021bia o cantitate mai mare de cytokine induse de limfocitele T helper 17, precum \u0219i de peptide antimicrobiene. Tegumentele umane sunt colonizate de o varietate de microorganisme (microbiom) ce sunt influen\u021bate de factori ai organismului gazd\u0103 \u0219i din mediu; la atopici microbiomul este mai pu\u021bin divers, fiind dominat de Staphylococcus aureus.
Pacien\u021bii cu dermit\u0103 atopic\u0103 au un risc crescut de comorbidit\u0103\u021bi; acest risc este mai mare la cei cu forme severe de boal\u0103 \u0219i la fum\u0103tori.
Tratamentul standard actual al dermitei atopice este ghidat de severitatea inflama\u021biei cutanate \u0219i se bazeaz\u0103 pe tratamentul topic cu corticosteroizi sau inhibitori de calcineurin\u0103, terapia cu ultraviolete sau imunosupresoare sistemice. Un important pas \u00eenainte a fost reprezentat de introducerea, \u00een 2017, a tratamentului biologic cu dupilumab (care se leag\u0103 de subunitatea \u03b1 a receptorului pentru IL-4). De asemenea, se afl\u0103 \u00een studiu o serie de noi agen\u021bi terapeutici: inhibitori ai IL-13; inhibitori ai Janus-kinazei; inhibitori ai fosfodiesterazei-4; inhibitori ai TRPV1; inhibitori ai neurokininei-1; inhibitori ai limfocitelor T; inhibitori ai c\u0103ii leukotrienelor; noi antihistaminice; antagoni\u0219ti ai 5HT2B etc.<\/p>\n
What\u2019s new in atopic dermatitis?<\/span> Atopic dermatitis is a common inflammatory skin disease affecting up to 25% of children and up to 10% of adults in Western industrialized countries. With each year, more advances have been made in regard to understanding the pathophysiology of the disease and developing more targeted therapies. <\/p>\n Scurt CV<\/span><\/p>\n Experien\u0163a profesional\u0103<\/strong> Educa\u0163ie \u015fi formare<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2019\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Contacteaz\u0103 operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”] <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> Experien\u0163a profesional\u0103 Perioada Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti 2002 – 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti; 1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"class_list":["post-936","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/comments?post=936"}],"version-history":[{"count":9,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936\/revisions"}],"predecessor-version":[{"id":4801,"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/pages\/936\/revisions\/4801"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2019\/wp-json\/wp\/v2\/media?parent=936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Author: Vasile Benea<\/span><\/p>\n
Atopic dermatitis is a complex multifactorial disease encompassing defects in skin architecture, immune dysregulation, and skin flora changes. Gene polymorphisms and mutations are associated with defects of the epidermal barrier function and are crucial in patients. In adults, the acute phase is characterized by a strong T helper 2\/T helper 22 activation and the contribution of T helper 17 cells, whereas the chronic phase by a marked T helper 1 polarization, although the T helper 2 pathway had still an important role. More T helper 17-related cytokines and antimicrobial peptides were detectable in the skin of atopic dermatitis children than in the skin of adults. Human skin is densely colonized by a variety of natural flora (microbiome) influenced by the host and the surrounding environment. In atopic dermatitis (AD), the skin microbiome is dominated by Staphylococcus aureus and less diverse than in healthy skin.
There\u2019s a significantly increased risk for major comorbidities in adult patients with atopic dermatitis; the risk difference was predominantly found in patients with severe disease and among smokers.
The standard treatment of atopic dermatitis focuses on the severity of skin inflammation and consists of topical treatment with corticosteroids and calcineurin inhibitors, ultraviolet light or systemic immunosuppression. A new step forward was made with the introduction, in 2017, of dupilumab (which binds to the \u03b1-subunit of the IL-4 receptor, part of both the IL-4 and IL-13 receptor complex) in the treatment of adult atopic dermatitis. There are a lot of new agents in the pipeline: the interleukin 13 inhibitors; Janus kinase inhibitors; phosphodiesterase 4 inhibitors; TRPV1 (transient receptor potential cation channel subfamily V member 1) inhibitors; neurokinin 1 inhibitors; T-cell inhibitors; arachidonic acid, leukotriene, and prostaglandin inhibitors; 5HT2B antagonists; antihistamines, etc.<\/p>\n
Perioada<\/strong>
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:<\/strong>
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, \u015eoseaua Mihai Bravu 281, sector 3, 030303 Bucure\u015fti<\/p>\n
Perioada<\/strong>
Calificarea \/ diploma ob\u0163inut\u0103
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n<\/span><\/p>\n
\nTel.: 0332.40.88.00-05<\/span>
\nE-mail: inscrieri@pdi.ro\/2019<\/a>
\n<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"