{"id":7459,"date":"2020-03-06T15:27:51","date_gmt":"2020-03-06T13:27:51","guid":{"rendered":"https:\/\/primaderma.ro\/?page_id=7459"},"modified":"2020-06-23T10:42:21","modified_gmt":"2020-06-23T08:42:21","slug":"prof-dr-ancuceanu-robert","status":"publish","type":"page","link":"https:\/\/pdi.ro\/2020\/prof-dr-ancuceanu-robert\/","title":{"rendered":"Prof. Dr. Ancuceanu Robert"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|off|off” _builder_version=”3.22″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#f0622a” top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” collapsed=”off”][et_pb_fullwidth_header title=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@” text_orientation=”right” header_image_url=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/05\/pdi_iulie_online.png” disabled_on=”on|on|off” _builder_version=”4.4.7″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”right” title_text_color=”#f0622a” title_font_size=”50px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” subhead_font=”||||||||” background_color=”rgba(239,145,107,0.54)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back.jpg” background_layout=”light” custom_margin=”0px||8px” custom_padding=”40px||40px||true” content_font_size_tablet=”” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row column_structure=”2_5,3_5″ _builder_version=”3.25″ locked=”off”][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/pdi.ro\/2020\/2019\/wp-content\/uploads\/2019\/02\/Robert-Ancuceanu.jpg” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ max_width=”25%” border_radii=”on|100px|100px|100px|100px”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″]<\/p>\n

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Prof. Dr. Ancuceanu Robert<\/strong><\/span>
U.M.F. “Carol Davila”, Bucure\u015fti<\/strong><\/span><\/h4>\n

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Psoriazisul indus medicamentos \u2013 certitudini \u0219i necunoscute<\/span>
Autori: R. Ancuceanu, Mihaela Dinu<\/span><\/p>\n

Introducere: Psoriazisul este o afec\u021biune inflamatorie complex\u0103, caracterizat\u0103 prin alterarea homeostaziei epidermice, manifestat\u0103 prin hiperpoliferare \u0219i tulbur\u0103ri ale diferen\u021bierii keratinocitelor. O serie de factori care pot declan\u0219a sau agrava psoriazisul au fost identifica\u021bi \u00een literatura medical\u0103, printre care \u0219i unele medicamente. Care sunt medicamentele care au fost asociate cu inducerea sau agravarea psoriazisului?
Materiale \u0219i metode: S-au analizat toate rezumatele caracteristicilor produsului (RCP) din \u201celectronic medicines compendium\u201d (https:\/\/www.medicines.org.uk\/emc\/) care con\u021bin termenul \u201epsoriazis\u201c \u0219i s-au identificat medicamentele pentru care exist\u0103 aten\u021bion\u0103ri, precau\u021bii sau contraindica\u021bii referitoare la posibila declan\u0219are sau agravare a afec\u021biunii. S-a realizat \u015fi o interogare computerizat\u0103 Medline \u00een acela\u0219i scop.
Rezultate \u0219i discu\u021bii: S-au identificat 47 de medicamente pentru care RCP-ul informeaz\u0103 asupra posibilit\u0103\u021bii de inducere sau agravare a psoriazisului. Cele mai mari clase terapeutice sunt reprezentate de beta-blocante (15 molecule), inhibitorii enzimei de conversie (6 molecule), interferoni (3 molecule) \u0219i un mic num\u0103r de \u015fapte anticorpi monoclonali (avelumab, cemiplimab, golimumab, ipilimumab, nivolumab, pembrolizumab, ustekinumab). Literatura \u0219tiin\u021bific\u0103 publicat\u0103 indic\u0103 mai multe alte medicamente care au fost asociate cu psoriazisul indus medicamentos, chiar dac\u0103 acestea nu sunt incluse \u00een RCP (de exemplu exist\u0103 cel pu\u021bin 14 rapoarte care asociaz\u0103 blocan\u021bii receptorilor angiotensinei cu psoriazisul, plus 89 de rapoarte identificate \u00een baza de date privind farmacovigilen\u021ba din Fran\u021ba). Alte medicamente al c\u0103ror RCP nu include informa\u021bii despre psoriazisul indus medicamentos, dar men\u021bionate \u00een literatur\u0103, includ sunitinib, sorafenib, panitumumab, cetuximab \u0219.a.
Concluzii: pentru medicul curant (\u0219i pentru pacien\u021bi) este important\u0103 cunoa\u0219terea (co)medica\u021biei care ar putea declan\u0219a sau agrava psoriazisul, iar informa\u021biile din RCP nu sunt \u00eentotdeauna suficiente.<\/p>\n

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Drug-induced psoriasis \u2013 certainties and unknowns<\/span>
Authors: R. Ancuceanu, Mihaela Dinu<\/span><\/p>\n

Introduction: Psoriasis is a complex, chronic inflammatory autoimmune disease, characterized by changes in epidermal homeostasis. A series of factors that can trigger or aggravate psoriasis have been identified in the medical literature, among which a number of medicinal products. What are the drugs associated with inducing or aggravating psoriasis?
Materials and methods: Summary of product characteristics (SmPCs) from the \u201celectronic medicines compendium\u201d (https:\/\/www.medicines.org.uk\/emc\/) containing the \u201epsoriasis\u201c term were analysed and the medicines for which there warnings and precautions are available referring to the possible triggering or aggravation of the disease. A Medline computerized search was performed for the same purpose.
Results and discussions: 47 medicinal products were identified for which the SmPC informs on the possibility of inducing or aggravating psoriasis. The largest therapeutic classes are represented by beta-blockers (15 molecules), ACE inhibitors (6 molecules), interferons (3 molecules), and seven monoclonal antibodies (avelumab, cemiplimab, golimumab, ipilimumab, nivolumab, pembrolizumab, ustekinumab). The published scientific literature indicates more medicinal products associated with drug induced psoriasis, although they are not included in the SmPC (for instance there are at least published 14 reports associating the angiotensin receptor blockers with psoriasis, plus 89 reports identified in the French pharmacovigilance databse). Other medicines for which the SmPC does not include drug induced psoriasis, but discussed in the literature, include sunitinib, sorafenib, panitumumab, cetuximab \u0219.a.
Conclusions: for the treating physician (and for the patients) it is important to know the (co)medications that could trigger or aggravate psoriasis, and the information from SmPC may not be always sufficient.<\/p>\n

Scurt CV<\/span><\/p>\n

Robert Ancuceanu este profesor \u00een cadrul Facult\u0103\u0163ii de Farmacie din Bucure\u015fti, unde pred\u0103 Biologie celular\u0103 \u0219i molecular\u0103 \u0219i Botanic\u0103 farmaceutic\u0103 \u0219i ocup\u0103 func\u021bia de prodecan pe probleme de \u00eenv\u0103\u021b\u0103m\u00e2nt universitar de licen\u021b\u0103 \u0219i master. Av\u00e2nd un doctorat \u00een farmacie, un masterat \u00een biostatistic\u0103 \u015fi licen\u0163\u0103 \u00een drept, a lucrat \u00een diferite domenii farmaceutice, de la cel academic la cel industrial \u015fi \u00een cadrul autorit\u0103\u0163ilor de reglementare. A fost director general al Direc\u0163iei Generale Farmaceutice \u015fi Aparatur\u0103 Medical\u0103 din Ministerul S\u0103n\u0103t\u0103\u0163ii \u015fi Vicepre\u015fedinte al Agen\u0163ie Na\u0163ionale a Medicamentului. A fost membru al Comitetului pentru Medicamente de Uz Uman (CHMP) \u015fi al Comitetului Pediatric (PDCO) \u015fi membru altern (supleant) al Comitetului pentru Medicamente pe baz\u0103 de Plante din cadrul Agen\u0163iei Europene a Medicamentului (EMA), precum \u015fi membru \u00een mai multe comitete sau grupuri de lucru din domeniul farmaceutic. A publicat 47 articole \u015ftiin\u0163ifice, este autor a dou\u0103 c\u0103r\u0163i \u015fi co-autor la alte patru. Pe l\u00e2ng\u0103 interesul s\u0103u larg pentru toate aspectele domeniului farmaceutic, Robert se consider\u0103 un renascentist \u00eent\u00e2rziat, fiind interesat \u015fi de drept, istorie, muzic\u0103, biostatistic\u0103, sociologie \u015fi literatur\u0103.<\/span><\/p>\n

Fig. 1<\/p>\n

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Contacteaz\u0103 operatorul PDI 2020<\/p>\n

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Operatorul PDI 2020<\/p>\n

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Adresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n

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Parteneri Media<\/p>\n

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Prof. Dr. Ancuceanu Robert U.M.F. “Carol Davila”, Bucure\u015ftiPsoriazisul indus medicamentos \u2013 certitudini \u0219i necunoscute Autori: R. Ancuceanu, Mihaela Dinu Introducere: Psoriazisul este o afec\u021biune inflamatorie complex\u0103, caracterizat\u0103 prin alterarea homeostaziei epidermice, manifestat\u0103 prin hiperpoliferare \u0219i tulbur\u0103ri ale diferen\u021bierii keratinocitelor. O serie de factori care pot declan\u0219a sau agrava psoriazisul au fost identifica\u021bi \u00een literatura medical\u0103, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7459","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7459"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7459\/revisions"}],"predecessor-version":[{"id":8390,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7459\/revisions\/8390"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}