<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nProf. Dr. Ciocoiu Manuela<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ locked=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.8″ hover_enabled=”0″]<\/p>\n
Influen\u0163a compu\u015filor polifenolici \u00een procesele fiziopatologice la nivelul pielii <\/span>
Autori: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\nPropriet\u0103\u021bile biologice ale polifenolilor includ propriet\u0103\u021bi antioxidante, antitumorale \u0219i efecte antiinflamatorii. Exist\u0103 o varietate de mecanisme poten\u021biale de ac\u021biune cum ar fi inhibarea enzimelor de replicare bacterian\u0103, inducerea apoptozei \u00een celulele tumorale, stimularea monocitelor\/macrofagelor pentru a produce citokine \u0219i stimularea mieloperoxidazei- iododependente a neutrofilelor.
Cunoa\u0219terea biodisponibilit\u0103\u021bii diverselor clase de polifenoli este esen\u021bial\u0103 \u00een \u00een\u021belegerea eficien\u021bei lor terapeutice. Activitatea metabolic\u0103 a polifenolilor depinde de activitatea intrinsec\u0103, de absorb\u021bia intestinal\u0103, de rata de metabolizare \u0219i de eliminare. Biodisponibilitatea sc\u0103zut\u0103 a majorit\u0103\u021bii polifenolilor, a condus la diverse asocieri de polifenoli \u0219i combina\u021bii de polifenoli cu vitamine \u0219i al\u021bi micronutrien\u021bi, care au fost selectate pentru a viza \u00een mod specific mecanismele celulare cheie, implicate \u00een carcinogeneza. Alte abord\u0103ri promi\u021b\u0103toare pentru cre\u0219terea biodisponibilit\u0103\u021bii compu\u015filor polifenolici \u00een studiile clinice includ utilizarea nanoparticulelor, lipozomilor, a complexelor fosfolipidice \u0219i a analogilor structurali.
Majoritatea combina\u021biilor de compu\u0219i naturali \u021bintesc mecanismele intracelulare de reglare ale carcinogenezei. S-a demonstrat lezarea \u021besutului conjunctiv ca un element comun implicat \u00een cre\u0219terea tumoral\u0103, invazie \u0219i metastazare. Rolul acestei bariere naturale anti-cancer este frecvent neglijat in abord\u0103rile terapeutice ale cancerului. Cu toate acestea, toate etapele metabolice critice \u00een cancer necesit\u0103 degradarea membranei bazale \u0219i a componentelor matricei extracelulare ca barier\u0103 fizic\u0103 care \u00eempiedic\u0103 cre\u0219terea, migrarea \u0219i invazia celulelor tumorale.
\u00cen concluzie, compu\u015fii polifenolici reprezint\u0103 o modalitate important\u0103 de tratament \u00een cancerul cutanat, lu\u00e2nd \u00een considerare utilizarea lor \u00een siguran\u0163\u0103. Datorit\u0103 abilit\u0103\u0163ii acestora de a modula multiple mecanisme biologice implicate \u00een ini\u0163ierea \u015fi progresia cancerului, compu\u015fii polifenolici ofer\u0103 nenum\u0103rate efecte terapeutice comparativ cu un singur compus.<\/p>\n
Influence of polyphenolic compounds on the pathophysiological processes in the skin<\/span>
Authors: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\nThe biological properties of polyphenols include antioxidant, anti-tumour and anti-inflammatory effects. There are a variety of potential mechanisms of action such as inhibition of bacterial replication enzymes, induction of apoptosis in tumour cells, stimulation of monocytes\/macrophages to produce cytokines, and iododependent myeloperoxidase stimulation of neutrophils.
Understanding the bioavailability of various classes of polyphenols is essential in understanding their therapeutic efficacy. The metabolic activity of polyphenols depends on the intrinsic activity, intestinal absorption, metabolism and elimination rate. The low bioavailability of most polyphenols has led to various combinations of polyphenols and combinations of polyphenols with vitamins and other micronutrients, which were selected to specifically target the key cellular mechanisms involved in carcinogenesis. Other promising approaches for increasing the bioavailability of polyphenolic compounds in clinical studies include the use of nanoparticles, liposomes, phospholipid complexes and structural analogues.
Most combinations of natural compounds target intracellular carcinogenesis regulation mechanisms. Damage to connective tissue has been shown to be a common element involved in tumour growth, invasion and metastasis. The role of this natural anti-cancer barrier is frequently overlooked in cancer therapy approaches. However, all critical metabolic stages in cancer require degradation of the base membrane and extracellular matrix components as a physical barrier that impedes growth, migration and invasion of tumour cells.
In conclusion, polyphenolic compounds are an important therapeutic option in skin cancer, considering their safe use. Because of their ability to modulate multiple biological mechanisms involved in cancer initiation and progression, polyphenolic compounds have countless therapeutic effects compared to a single compound.<\/p>\n
\u00a0Scurt CV<\/span><\/p>\nCoordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
![\"\"](\"https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiInfluen\u0163a compu\u015filor polifenolici \u00een procesele fiziopatologice la nivelul pielii Autori: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu Propriet\u0103\u021bile biologice ale polifenolilor includ propriet\u0103\u021bi antioxidante, antitumorale \u0219i efecte antiinflamatorii. Exist\u0103 o varietate de mecanisme poten\u021biale de ac\u021biune cum ar fi inhibarea enzimelor de replicare bacterian\u0103, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7501","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7501"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501\/revisions"}],"predecessor-version":[{"id":8406,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501\/revisions\/8406"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nProf. Dr. Ciocoiu Manuela<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ locked=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.8″ hover_enabled=”0″]<\/p>\n
Influen\u0163a compu\u015filor polifenolici \u00een procesele fiziopatologice la nivelul pielii <\/span>
Autori: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\nPropriet\u0103\u021bile biologice ale polifenolilor includ propriet\u0103\u021bi antioxidante, antitumorale \u0219i efecte antiinflamatorii. Exist\u0103 o varietate de mecanisme poten\u021biale de ac\u021biune cum ar fi inhibarea enzimelor de replicare bacterian\u0103, inducerea apoptozei \u00een celulele tumorale, stimularea monocitelor\/macrofagelor pentru a produce citokine \u0219i stimularea mieloperoxidazei- iododependente a neutrofilelor.
Cunoa\u0219terea biodisponibilit\u0103\u021bii diverselor clase de polifenoli este esen\u021bial\u0103 \u00een \u00een\u021belegerea eficien\u021bei lor terapeutice. Activitatea metabolic\u0103 a polifenolilor depinde de activitatea intrinsec\u0103, de absorb\u021bia intestinal\u0103, de rata de metabolizare \u0219i de eliminare. Biodisponibilitatea sc\u0103zut\u0103 a majorit\u0103\u021bii polifenolilor, a condus la diverse asocieri de polifenoli \u0219i combina\u021bii de polifenoli cu vitamine \u0219i al\u021bi micronutrien\u021bi, care au fost selectate pentru a viza \u00een mod specific mecanismele celulare cheie, implicate \u00een carcinogeneza. Alte abord\u0103ri promi\u021b\u0103toare pentru cre\u0219terea biodisponibilit\u0103\u021bii compu\u015filor polifenolici \u00een studiile clinice includ utilizarea nanoparticulelor, lipozomilor, a complexelor fosfolipidice \u0219i a analogilor structurali.
Majoritatea combina\u021biilor de compu\u0219i naturali \u021bintesc mecanismele intracelulare de reglare ale carcinogenezei. S-a demonstrat lezarea \u021besutului conjunctiv ca un element comun implicat \u00een cre\u0219terea tumoral\u0103, invazie \u0219i metastazare. Rolul acestei bariere naturale anti-cancer este frecvent neglijat in abord\u0103rile terapeutice ale cancerului. Cu toate acestea, toate etapele metabolice critice \u00een cancer necesit\u0103 degradarea membranei bazale \u0219i a componentelor matricei extracelulare ca barier\u0103 fizic\u0103 care \u00eempiedic\u0103 cre\u0219terea, migrarea \u0219i invazia celulelor tumorale.
\u00cen concluzie, compu\u015fii polifenolici reprezint\u0103 o modalitate important\u0103 de tratament \u00een cancerul cutanat, lu\u00e2nd \u00een considerare utilizarea lor \u00een siguran\u0163\u0103. Datorit\u0103 abilit\u0103\u0163ii acestora de a modula multiple mecanisme biologice implicate \u00een ini\u0163ierea \u015fi progresia cancerului, compu\u015fii polifenolici ofer\u0103 nenum\u0103rate efecte terapeutice comparativ cu un singur compus.<\/p>\n
Influence of polyphenolic compounds on the pathophysiological processes in the skin<\/span>
Authors: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\nThe biological properties of polyphenols include antioxidant, anti-tumour and anti-inflammatory effects. There are a variety of potential mechanisms of action such as inhibition of bacterial replication enzymes, induction of apoptosis in tumour cells, stimulation of monocytes\/macrophages to produce cytokines, and iododependent myeloperoxidase stimulation of neutrophils.
Understanding the bioavailability of various classes of polyphenols is essential in understanding their therapeutic efficacy. The metabolic activity of polyphenols depends on the intrinsic activity, intestinal absorption, metabolism and elimination rate. The low bioavailability of most polyphenols has led to various combinations of polyphenols and combinations of polyphenols with vitamins and other micronutrients, which were selected to specifically target the key cellular mechanisms involved in carcinogenesis. Other promising approaches for increasing the bioavailability of polyphenolic compounds in clinical studies include the use of nanoparticles, liposomes, phospholipid complexes and structural analogues.
Most combinations of natural compounds target intracellular carcinogenesis regulation mechanisms. Damage to connective tissue has been shown to be a common element involved in tumour growth, invasion and metastasis. The role of this natural anti-cancer barrier is frequently overlooked in cancer therapy approaches. However, all critical metabolic stages in cancer require degradation of the base membrane and extracellular matrix components as a physical barrier that impedes growth, migration and invasion of tumour cells.
In conclusion, polyphenolic compounds are an important therapeutic option in skin cancer, considering their safe use. Because of their ability to modulate multiple biological mechanisms involved in cancer initiation and progression, polyphenolic compounds have countless therapeutic effects compared to a single compound.<\/p>\n
\u00a0Scurt CV<\/span><\/p>\nCoordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n
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Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
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Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiInfluen\u0163a compu\u015filor polifenolici \u00een procesele fiziopatologice la nivelul pielii Autori: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu Propriet\u0103\u021bile biologice ale polifenolilor includ propriet\u0103\u021bi antioxidante, antitumorale \u0219i efecte antiinflamatorii. Exist\u0103 o varietate de mecanisme poten\u021biale de ac\u021biune cum ar fi inhibarea enzimelor de replicare bacterian\u0103, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7501","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7501"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501\/revisions"}],"predecessor-version":[{"id":8406,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501\/revisions\/8406"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Prof. Dr. Ciocoiu Manuela<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ locked=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.8″ hover_enabled=”0″]<\/p>\n
Influen\u0163a compu\u015filor polifenolici \u00een procesele fiziopatologice la nivelul pielii <\/span>
Autori: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\nPropriet\u0103\u021bile biologice ale polifenolilor includ propriet\u0103\u021bi antioxidante, antitumorale \u0219i efecte antiinflamatorii. Exist\u0103 o varietate de mecanisme poten\u021biale de ac\u021biune cum ar fi inhibarea enzimelor de replicare bacterian\u0103, inducerea apoptozei \u00een celulele tumorale, stimularea monocitelor\/macrofagelor pentru a produce citokine \u0219i stimularea mieloperoxidazei- iododependente a neutrofilelor.
Cunoa\u0219terea biodisponibilit\u0103\u021bii diverselor clase de polifenoli este esen\u021bial\u0103 \u00een \u00een\u021belegerea eficien\u021bei lor terapeutice. Activitatea metabolic\u0103 a polifenolilor depinde de activitatea intrinsec\u0103, de absorb\u021bia intestinal\u0103, de rata de metabolizare \u0219i de eliminare. Biodisponibilitatea sc\u0103zut\u0103 a majorit\u0103\u021bii polifenolilor, a condus la diverse asocieri de polifenoli \u0219i combina\u021bii de polifenoli cu vitamine \u0219i al\u021bi micronutrien\u021bi, care au fost selectate pentru a viza \u00een mod specific mecanismele celulare cheie, implicate \u00een carcinogeneza. Alte abord\u0103ri promi\u021b\u0103toare pentru cre\u0219terea biodisponibilit\u0103\u021bii compu\u015filor polifenolici \u00een studiile clinice includ utilizarea nanoparticulelor, lipozomilor, a complexelor fosfolipidice \u0219i a analogilor structurali.
Majoritatea combina\u021biilor de compu\u0219i naturali \u021bintesc mecanismele intracelulare de reglare ale carcinogenezei. S-a demonstrat lezarea \u021besutului conjunctiv ca un element comun implicat \u00een cre\u0219terea tumoral\u0103, invazie \u0219i metastazare. Rolul acestei bariere naturale anti-cancer este frecvent neglijat in abord\u0103rile terapeutice ale cancerului. Cu toate acestea, toate etapele metabolice critice \u00een cancer necesit\u0103 degradarea membranei bazale \u0219i a componentelor matricei extracelulare ca barier\u0103 fizic\u0103 care \u00eempiedic\u0103 cre\u0219terea, migrarea \u0219i invazia celulelor tumorale.
\u00cen concluzie, compu\u015fii polifenolici reprezint\u0103 o modalitate important\u0103 de tratament \u00een cancerul cutanat, lu\u00e2nd \u00een considerare utilizarea lor \u00een siguran\u0163\u0103. Datorit\u0103 abilit\u0103\u0163ii acestora de a modula multiple mecanisme biologice implicate \u00een ini\u0163ierea \u015fi progresia cancerului, compu\u015fii polifenolici ofer\u0103 nenum\u0103rate efecte terapeutice comparativ cu un singur compus.<\/p>\n
Influence of polyphenolic compounds on the pathophysiological processes in the skin<\/span>
Authors: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\nThe biological properties of polyphenols include antioxidant, anti-tumour and anti-inflammatory effects. There are a variety of potential mechanisms of action such as inhibition of bacterial replication enzymes, induction of apoptosis in tumour cells, stimulation of monocytes\/macrophages to produce cytokines, and iododependent myeloperoxidase stimulation of neutrophils.
Understanding the bioavailability of various classes of polyphenols is essential in understanding their therapeutic efficacy. The metabolic activity of polyphenols depends on the intrinsic activity, intestinal absorption, metabolism and elimination rate. The low bioavailability of most polyphenols has led to various combinations of polyphenols and combinations of polyphenols with vitamins and other micronutrients, which were selected to specifically target the key cellular mechanisms involved in carcinogenesis. Other promising approaches for increasing the bioavailability of polyphenolic compounds in clinical studies include the use of nanoparticles, liposomes, phospholipid complexes and structural analogues.
Most combinations of natural compounds target intracellular carcinogenesis regulation mechanisms. Damage to connective tissue has been shown to be a common element involved in tumour growth, invasion and metastasis. The role of this natural anti-cancer barrier is frequently overlooked in cancer therapy approaches. However, all critical metabolic stages in cancer require degradation of the base membrane and extracellular matrix components as a physical barrier that impedes growth, migration and invasion of tumour cells.
In conclusion, polyphenolic compounds are an important therapeutic option in skin cancer, considering their safe use. Because of their ability to modulate multiple biological mechanisms involved in cancer initiation and progression, polyphenolic compounds have countless therapeutic effects compared to a single compound.<\/p>\n
\u00a0Scurt CV<\/span><\/p>\nCoordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n
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Contacteaz\u0103 operatorul PDI 2020<\/p>\n
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Operatorul PDI 2020<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
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Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiInfluen\u0163a compu\u015filor polifenolici \u00een procesele fiziopatologice la nivelul pielii Autori: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu Propriet\u0103\u021bile biologice ale polifenolilor includ propriet\u0103\u021bi antioxidante, antitumorale \u0219i efecte antiinflamatorii. Exist\u0103 o varietate de mecanisme poten\u021biale de ac\u021biune cum ar fi inhibarea enzimelor de replicare bacterian\u0103, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7501","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7501"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501\/revisions"}],"predecessor-version":[{"id":8406,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501\/revisions\/8406"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\n
Propriet\u0103\u021bile biologice ale polifenolilor includ propriet\u0103\u021bi antioxidante, antitumorale \u0219i efecte antiinflamatorii. Exist\u0103 o varietate de mecanisme poten\u021biale de ac\u021biune cum ar fi inhibarea enzimelor de replicare bacterian\u0103, inducerea apoptozei \u00een celulele tumorale, stimularea monocitelor\/macrofagelor pentru a produce citokine \u0219i stimularea mieloperoxidazei- iododependente a neutrofilelor.
Cunoa\u0219terea biodisponibilit\u0103\u021bii diverselor clase de polifenoli este esen\u021bial\u0103 \u00een \u00een\u021belegerea eficien\u021bei lor terapeutice. Activitatea metabolic\u0103 a polifenolilor depinde de activitatea intrinsec\u0103, de absorb\u021bia intestinal\u0103, de rata de metabolizare \u0219i de eliminare. Biodisponibilitatea sc\u0103zut\u0103 a majorit\u0103\u021bii polifenolilor, a condus la diverse asocieri de polifenoli \u0219i combina\u021bii de polifenoli cu vitamine \u0219i al\u021bi micronutrien\u021bi, care au fost selectate pentru a viza \u00een mod specific mecanismele celulare cheie, implicate \u00een carcinogeneza. Alte abord\u0103ri promi\u021b\u0103toare pentru cre\u0219terea biodisponibilit\u0103\u021bii compu\u015filor polifenolici \u00een studiile clinice includ utilizarea nanoparticulelor, lipozomilor, a complexelor fosfolipidice \u0219i a analogilor structurali.
Majoritatea combina\u021biilor de compu\u0219i naturali \u021bintesc mecanismele intracelulare de reglare ale carcinogenezei. S-a demonstrat lezarea \u021besutului conjunctiv ca un element comun implicat \u00een cre\u0219terea tumoral\u0103, invazie \u0219i metastazare. Rolul acestei bariere naturale anti-cancer este frecvent neglijat in abord\u0103rile terapeutice ale cancerului. Cu toate acestea, toate etapele metabolice critice \u00een cancer necesit\u0103 degradarea membranei bazale \u0219i a componentelor matricei extracelulare ca barier\u0103 fizic\u0103 care \u00eempiedic\u0103 cre\u0219terea, migrarea \u0219i invazia celulelor tumorale.
\u00cen concluzie, compu\u015fii polifenolici reprezint\u0103 o modalitate important\u0103 de tratament \u00een cancerul cutanat, lu\u00e2nd \u00een considerare utilizarea lor \u00een siguran\u0163\u0103. Datorit\u0103 abilit\u0103\u0163ii acestora de a modula multiple mecanisme biologice implicate \u00een ini\u0163ierea \u015fi progresia cancerului, compu\u015fii polifenolici ofer\u0103 nenum\u0103rate efecte terapeutice comparativ cu un singur compus.<\/p>\n
Influence of polyphenolic compounds on the pathophysiological processes in the skin<\/span> The biological properties of polyphenols include antioxidant, anti-tumour and anti-inflammatory effects. There are a variety of potential mechanisms of action such as inhibition of bacterial replication enzymes, induction of apoptosis in tumour cells, stimulation of monocytes\/macrophages to produce cytokines, and iododependent myeloperoxidase stimulation of neutrophils. \u00a0Scurt CV<\/span><\/p>\n Coordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n Contacteaz\u0103 operatorul PDI 2020<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” 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A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.0.11″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiInfluen\u0163a compu\u015filor polifenolici \u00een procesele fiziopatologice la nivelul pielii Autori: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu Propriet\u0103\u021bile biologice ale polifenolilor includ propriet\u0103\u021bi antioxidante, antitumorale \u0219i efecte antiinflamatorii. Exist\u0103 o varietate de mecanisme poten\u021biale de ac\u021biune cum ar fi inhibarea enzimelor de replicare bacterian\u0103, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7501","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7501"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501\/revisions"}],"predecessor-version":[{"id":8406,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7501\/revisions\/8406"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Authors: Manuela Ciocoiu, Iuliana Hunea, Codru\u0163a B\u0103descu<\/span><\/p>\n
Understanding the bioavailability of various classes of polyphenols is essential in understanding their therapeutic efficacy. The metabolic activity of polyphenols depends on the intrinsic activity, intestinal absorption, metabolism and elimination rate. The low bioavailability of most polyphenols has led to various combinations of polyphenols and combinations of polyphenols with vitamins and other micronutrients, which were selected to specifically target the key cellular mechanisms involved in carcinogenesis. Other promising approaches for increasing the bioavailability of polyphenolic compounds in clinical studies include the use of nanoparticles, liposomes, phospholipid complexes and structural analogues.
Most combinations of natural compounds target intracellular carcinogenesis regulation mechanisms. Damage to connective tissue has been shown to be a common element involved in tumour growth, invasion and metastasis. The role of this natural anti-cancer barrier is frequently overlooked in cancer therapy approaches. However, all critical metabolic stages in cancer require degradation of the base membrane and extracellular matrix components as a physical barrier that impedes growth, migration and invasion of tumour cells.
In conclusion, polyphenolic compounds are an important therapeutic option in skin cancer, considering their safe use. Because of their ability to modulate multiple biological mechanisms involved in cancer initiation and progression, polyphenolic compounds have countless therapeutic effects compared to a single compound.<\/p>\n
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
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