<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nC.\u0218.I. Dr. Neagu Monica<\/strong><\/span>
Institutul Na\u0163ional \u201cVictor Babe\u015f\u201d, Bucure\u015fti<\/strong><\/span>
Spitalul Clinic \u201dColentina\u201d, Bucure\u015fti<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″]<\/p>\n
Aspecte imunologice in carcinomul spinocelular <\/span>
Autori: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac <\/span><\/p>\nCarcinomul spinocelular invaziv este un cancer comun in populatia Caucaziana (cSCC) in si reprezinta aproximativ 20% din toate cancerele cutanate. Etiopatogeneza cSCC este se pare multi-factoriala. Astfel, factori de mediu ca expunerea la radiatia ultravioleta, imbatranirea, sexul masculin, fumatul alaturi de o serie de factori genetici contribuie la aparitia cSCC. Conditii care induc imunosupresia, ca de exemplu infectia HIV, transplantul sau leukemia limfocitara cronica (CLL), favorizeaza aparitia cSCC. In pacientii imunosupresati, recidivele locoregionale au o incidenta crescuta, the riscul de metastaze in cSCC se dubleaza, si in consecinta evolutia clinica a pacientului este nefavorabila.
In procesul identificarii markerilor care pot monitoriza si predictiona recidiva cSCC am investigat o serie de marker imuni care ar putea sa ofere noi indicia privind evolutia clinica a pacientului.
La pacientii diagnosticati cu cSCC au fost analizate inainte si dupa operatia de excizare a tumorii populatiile de cellule immune circulante utilizand citometria in flux si IVD kit BD Multitest™ IMK Kit. Au fost analizate o serie de populatii immune circulante: limfocite T (CD3+), limfocite B (CD19+), subpopulatiile T helper (CD3+CD4+), T cytotoxic (CD3+CD8+), si limfocite natural killer (NK) (CD3\u2013CD16+ sau\/si CD56+). In toate cazurile investigate inainte de excizia tumorala limfocitele T CD3+ si subpopulatia CD4+ T au fost regasite in domeniul valorilor normale. Limfocitele T CD8+ care sustin functia citotoxica au fost gasite statistic semnificativ reduse fata de normal, ceea ce a dus la un raport CD4\/CD8 crescut. In pacientii cu cCSC limfocitele B (CD19+) circulante au valori scazute fata de normal in timp ce limfocitele NK sunt crescute. Acest mechanism compensatoriu intre aceste doua tipuri de populatii celulare a fost identificat de noi associate si altor tipuri de neoplazii. Putem concluziona ca celulele immune circulante pot fi utilizate ca elemente de monitorizare ale progresiei tumorale in acest tip de cancer cutanat.
Studiu finantat prin proiectele PN-III-P1-1.2-PCCDI-2017-0341\/2018, PN 19.21.01.01\/2019, EPITRAN COST ACTION 16120\/2018<\/p>\n
Immunological advances in cutaneous squamous cell carcinoma<\/span>
Authors: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac <\/span><\/p>\nInvasive cutaneous squamous cell carcinoma (cSCC) in Caucazian population is one of the most common cancers accounting for 20% of all cutaneous malignancies. cSCC etiopathogenesis has multi-factorial trait. Therefore, environmental factors like ultraviolet radiation exposure, advanced age, male sex, smoking along with genetic factors are contributing to the onset of cSCC. Immunosuppressive conditions, like HIV infection, transplant, or chronic lymphocytic leukemia (CLL), are immune-based favoring condition for cSCC. In immunosuppressed patients, locoregional recurrence has an increased incidence, the risk of metastatic cSCC doubles, hence the outcome for advanced disease is significantly worse.
In the quest to both monitor and predict the disease recurrence we have embarked in the search of various immune-related markers that can hint towards the clinical outcome of patients.
In cSCC patients before and after surgery peripheral blood was immediately tested for immune cell populations using flow citometry and the IVD kit BD Multitest™ IMK Kit. Within the test we have analyzed various immune cell circulatory populations: T lymphocytes (CD3+), B lymphocytes (CD19+), helper\/inducer T lymphocytes (CD3+CD4+), suppressor\/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) lymphocytes (CD3\u2013CD16+ and\/ or CD56+). For the investigated cases prior to the surgical resection total CD3+ T cells and CD4+ T cell sub-population were in the normal ranges. CD8+ T cells depicting cytotoxic lymphocytes are statistically reduced compared the normal values, thus leading to an increased ratio CD4\/CD8. In cCSC patients circulatory B lymphocytes (CD19+) have a decreased value while peripheral NK cells are increased. This immune compensatory process between these two types of cell populations has been reported by us in other neoplasias as well. We can conclude that peripheral immune cells can be useful for monitoring disease progression in these types of cancer.
Acknowledgement. PN-III-P1-1.2-PCCDI-2017-0341\/2018, PN 19.21.01.01\/2019, EPITRAN COST ACTION 16120\/2018<\/p>\n
Scurt CV<\/span><\/p>\nCS I, Profesor abilitat, \u015eef Laborator Imunologie, Institutul Na\u0163ional \u201cVictor Babes\u201d, Bucure\u015fti, Coordonator de Doctorat Facultatea de Biologie, Universitatea Bucure\u015fti, CS I \u00een colectivul de cercetare al Departamentului de Anatomie Patologic\u0103, Spitalul Clinic \u201dColentina\u201d, Bucure\u015fti.
1996 \u2013 Doctoratul \u00een Imunologie \u00een cotutel\u0103 cu Departamentul R&D Novartis, Ltd, Elvetia; din anul 2000 \u015eef de Laborator \u015fi din anul 2014 Profesor abilitat de Imunologie. \u00cen ultimii 5 ani a condus \u015fi participat \u00een peste 10 proiecte na\u0163ionale \u015fi 5 proiecte cu Fonduri structurale EU \u00een domeniul bio-medical, imunologie, proteomic\u0103, toxicologie. A fost membru \u00een echipe de cercetare interna\u0163ionale \u00een proiecte ERA-NET, FP7, Horizon2020. A condus proiecte interna\u0163ionale de cooperare bilateral\u0103 Rom\u00e2nia-China 511\/2011 cu Beijing Institute of Genomics, cooperare bilateral\u0103 Rom\u00e2nia-Grecia 7285\/02 cu University of Athens.
A fost director de proiect NATO SfP 982838\/2007 cu University of Tubingen. A fost membru al echipei de management pentru re\u0163eaua interna\u0163ional\u0103 COST Action D39, actualmente este membru al echipei de management pentru re\u0163elele interna\u0163ionale COST Action 16120\/2018 EPITRAN \u015fi COST Action 18125\/2019 AeroGels. Este co-inventator la 7 brevete de inven\u0163ie \u00een domeniul dermato-patologiei \u015fi dermato-oncologiei, brevete cu numeroase premii nterna\u0163ionale.
\u00cen perioada 2010-2013 a fost membru al Comisiei pentru Terapii Avansate \u2013 EMEA. Editor pentru c\u0103r\u0163i \u00een Edituri interna\u0163ionale, Editor pentru numere speciale \u00een reviste interna\u0163ionale Disease Markers, Journal of Immunology Research. Editor Asociat pentru Journal of Immunoassay and Immunochemistry. Evaluator pentru proiecte na\u0163ionale \u015fi interna\u0163ionale, evaluator la peste 50 de reviste interna\u0163ionale. Membru \u00een Editorial board pentru numeroase reviste interna\u0163ionale.
A publicat peste 100 de articole \u015ftiin\u0163ifice indexate ISI cu peste 1500 de cit\u0103ri, acumul\u00e2nd un Hirsch index de 17 (Clarivate), 21 (Google Academics).<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2020<\/p>\n
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![\"\"](\"https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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C.\u0218.I. Dr. Neagu Monica Institutul Na\u0163ional \u201cVictor Babe\u015f\u201d, Bucure\u015fti Spitalul Clinic \u201dColentina\u201d, Bucure\u015ftiAspecte imunologice in carcinomul spinocelular Autori: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac Carcinomul spinocelular invaziv este un cancer comun in populatia Caucaziana (cSCC) in si reprezinta aproximativ 20% din toate cancerele cutanate. Etiopatogeneza cSCC este se pare multi-factoriala. Astfel, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7583","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7583"}],"version-history":[{"count":4,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7583\/revisions"}],"predecessor-version":[{"id":8179,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7583\/revisions\/8179"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
C.\u0218.I. Dr. Neagu Monica<\/strong><\/span>
Institutul Na\u0163ional \u201cVictor Babe\u015f\u201d, Bucure\u015fti<\/strong><\/span>
Spitalul Clinic \u201dColentina\u201d, Bucure\u015fti<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″]<\/p>\n
Aspecte imunologice in carcinomul spinocelular <\/span>
Autori: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac <\/span><\/p>\nCarcinomul spinocelular invaziv este un cancer comun in populatia Caucaziana (cSCC) in si reprezinta aproximativ 20% din toate cancerele cutanate. Etiopatogeneza cSCC este se pare multi-factoriala. Astfel, factori de mediu ca expunerea la radiatia ultravioleta, imbatranirea, sexul masculin, fumatul alaturi de o serie de factori genetici contribuie la aparitia cSCC. Conditii care induc imunosupresia, ca de exemplu infectia HIV, transplantul sau leukemia limfocitara cronica (CLL), favorizeaza aparitia cSCC. In pacientii imunosupresati, recidivele locoregionale au o incidenta crescuta, the riscul de metastaze in cSCC se dubleaza, si in consecinta evolutia clinica a pacientului este nefavorabila.
In procesul identificarii markerilor care pot monitoriza si predictiona recidiva cSCC am investigat o serie de marker imuni care ar putea sa ofere noi indicia privind evolutia clinica a pacientului.
La pacientii diagnosticati cu cSCC au fost analizate inainte si dupa operatia de excizare a tumorii populatiile de cellule immune circulante utilizand citometria in flux si IVD kit BD Multitest™ IMK Kit. Au fost analizate o serie de populatii immune circulante: limfocite T (CD3+), limfocite B (CD19+), subpopulatiile T helper (CD3+CD4+), T cytotoxic (CD3+CD8+), si limfocite natural killer (NK) (CD3\u2013CD16+ sau\/si CD56+). In toate cazurile investigate inainte de excizia tumorala limfocitele T CD3+ si subpopulatia CD4+ T au fost regasite in domeniul valorilor normale. Limfocitele T CD8+ care sustin functia citotoxica au fost gasite statistic semnificativ reduse fata de normal, ceea ce a dus la un raport CD4\/CD8 crescut. In pacientii cu cCSC limfocitele B (CD19+) circulante au valori scazute fata de normal in timp ce limfocitele NK sunt crescute. Acest mechanism compensatoriu intre aceste doua tipuri de populatii celulare a fost identificat de noi associate si altor tipuri de neoplazii. Putem concluziona ca celulele immune circulante pot fi utilizate ca elemente de monitorizare ale progresiei tumorale in acest tip de cancer cutanat.
Studiu finantat prin proiectele PN-III-P1-1.2-PCCDI-2017-0341\/2018, PN 19.21.01.01\/2019, EPITRAN COST ACTION 16120\/2018<\/p>\n
Immunological advances in cutaneous squamous cell carcinoma<\/span>
Authors: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac <\/span><\/p>\nInvasive cutaneous squamous cell carcinoma (cSCC) in Caucazian population is one of the most common cancers accounting for 20% of all cutaneous malignancies. cSCC etiopathogenesis has multi-factorial trait. Therefore, environmental factors like ultraviolet radiation exposure, advanced age, male sex, smoking along with genetic factors are contributing to the onset of cSCC. Immunosuppressive conditions, like HIV infection, transplant, or chronic lymphocytic leukemia (CLL), are immune-based favoring condition for cSCC. In immunosuppressed patients, locoregional recurrence has an increased incidence, the risk of metastatic cSCC doubles, hence the outcome for advanced disease is significantly worse.
In the quest to both monitor and predict the disease recurrence we have embarked in the search of various immune-related markers that can hint towards the clinical outcome of patients.
In cSCC patients before and after surgery peripheral blood was immediately tested for immune cell populations using flow citometry and the IVD kit BD Multitest™ IMK Kit. Within the test we have analyzed various immune cell circulatory populations: T lymphocytes (CD3+), B lymphocytes (CD19+), helper\/inducer T lymphocytes (CD3+CD4+), suppressor\/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) lymphocytes (CD3\u2013CD16+ and\/ or CD56+). For the investigated cases prior to the surgical resection total CD3+ T cells and CD4+ T cell sub-population were in the normal ranges. CD8+ T cells depicting cytotoxic lymphocytes are statistically reduced compared the normal values, thus leading to an increased ratio CD4\/CD8. In cCSC patients circulatory B lymphocytes (CD19+) have a decreased value while peripheral NK cells are increased. This immune compensatory process between these two types of cell populations has been reported by us in other neoplasias as well. We can conclude that peripheral immune cells can be useful for monitoring disease progression in these types of cancer.
Acknowledgement. PN-III-P1-1.2-PCCDI-2017-0341\/2018, PN 19.21.01.01\/2019, EPITRAN COST ACTION 16120\/2018<\/p>\n
Scurt CV<\/span><\/p>\nCS I, Profesor abilitat, \u015eef Laborator Imunologie, Institutul Na\u0163ional \u201cVictor Babes\u201d, Bucure\u015fti, Coordonator de Doctorat Facultatea de Biologie, Universitatea Bucure\u015fti, CS I \u00een colectivul de cercetare al Departamentului de Anatomie Patologic\u0103, Spitalul Clinic \u201dColentina\u201d, Bucure\u015fti.
1996 \u2013 Doctoratul \u00een Imunologie \u00een cotutel\u0103 cu Departamentul R&D Novartis, Ltd, Elvetia; din anul 2000 \u015eef de Laborator \u015fi din anul 2014 Profesor abilitat de Imunologie. \u00cen ultimii 5 ani a condus \u015fi participat \u00een peste 10 proiecte na\u0163ionale \u015fi 5 proiecte cu Fonduri structurale EU \u00een domeniul bio-medical, imunologie, proteomic\u0103, toxicologie. A fost membru \u00een echipe de cercetare interna\u0163ionale \u00een proiecte ERA-NET, FP7, Horizon2020. A condus proiecte interna\u0163ionale de cooperare bilateral\u0103 Rom\u00e2nia-China 511\/2011 cu Beijing Institute of Genomics, cooperare bilateral\u0103 Rom\u00e2nia-Grecia 7285\/02 cu University of Athens.
A fost director de proiect NATO SfP 982838\/2007 cu University of Tubingen. A fost membru al echipei de management pentru re\u0163eaua interna\u0163ional\u0103 COST Action D39, actualmente este membru al echipei de management pentru re\u0163elele interna\u0163ionale COST Action 16120\/2018 EPITRAN \u015fi COST Action 18125\/2019 AeroGels. Este co-inventator la 7 brevete de inven\u0163ie \u00een domeniul dermato-patologiei \u015fi dermato-oncologiei, brevete cu numeroase premii nterna\u0163ionale.
\u00cen perioada 2010-2013 a fost membru al Comisiei pentru Terapii Avansate \u2013 EMEA. Editor pentru c\u0103r\u0163i \u00een Edituri interna\u0163ionale, Editor pentru numere speciale \u00een reviste interna\u0163ionale Disease Markers, Journal of Immunology Research. Editor Asociat pentru Journal of Immunoassay and Immunochemistry. Evaluator pentru proiecte na\u0163ionale \u015fi interna\u0163ionale, evaluator la peste 50 de reviste interna\u0163ionale. Membru \u00een Editorial board pentru numeroase reviste interna\u0163ionale.
A publicat peste 100 de articole \u015ftiin\u0163ifice indexate ISI cu peste 1500 de cit\u0103ri, acumul\u00e2nd un Hirsch index de 17 (Clarivate), 21 (Google Academics).<\/p>\n
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Contacteaz\u0103 operatorul PDI 2020<\/p>\n
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Operatorul PDI 2020<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
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C.\u0218.I. Dr. Neagu Monica Institutul Na\u0163ional \u201cVictor Babe\u015f\u201d, Bucure\u015fti Spitalul Clinic \u201dColentina\u201d, Bucure\u015ftiAspecte imunologice in carcinomul spinocelular Autori: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac Carcinomul spinocelular invaziv este un cancer comun in populatia Caucaziana (cSCC) in si reprezinta aproximativ 20% din toate cancerele cutanate. Etiopatogeneza cSCC este se pare multi-factoriala. Astfel, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7583","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7583"}],"version-history":[{"count":4,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7583\/revisions"}],"predecessor-version":[{"id":8179,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7583\/revisions\/8179"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac <\/span><\/p>\n
Carcinomul spinocelular invaziv este un cancer comun in populatia Caucaziana (cSCC) in si reprezinta aproximativ 20% din toate cancerele cutanate. Etiopatogeneza cSCC este se pare multi-factoriala. Astfel, factori de mediu ca expunerea la radiatia ultravioleta, imbatranirea, sexul masculin, fumatul alaturi de o serie de factori genetici contribuie la aparitia cSCC. Conditii care induc imunosupresia, ca de exemplu infectia HIV, transplantul sau leukemia limfocitara cronica (CLL), favorizeaza aparitia cSCC. In pacientii imunosupresati, recidivele locoregionale au o incidenta crescuta, the riscul de metastaze in cSCC se dubleaza, si in consecinta evolutia clinica a pacientului este nefavorabila.
In procesul identificarii markerilor care pot monitoriza si predictiona recidiva cSCC am investigat o serie de marker imuni care ar putea sa ofere noi indicia privind evolutia clinica a pacientului.
La pacientii diagnosticati cu cSCC au fost analizate inainte si dupa operatia de excizare a tumorii populatiile de cellule immune circulante utilizand citometria in flux si IVD kit BD Multitest™ IMK Kit. Au fost analizate o serie de populatii immune circulante: limfocite T (CD3+), limfocite B (CD19+), subpopulatiile T helper (CD3+CD4+), T cytotoxic (CD3+CD8+), si limfocite natural killer (NK) (CD3\u2013CD16+ sau\/si CD56+). In toate cazurile investigate inainte de excizia tumorala limfocitele T CD3+ si subpopulatia CD4+ T au fost regasite in domeniul valorilor normale. Limfocitele T CD8+ care sustin functia citotoxica au fost gasite statistic semnificativ reduse fata de normal, ceea ce a dus la un raport CD4\/CD8 crescut. In pacientii cu cCSC limfocitele B (CD19+) circulante au valori scazute fata de normal in timp ce limfocitele NK sunt crescute. Acest mechanism compensatoriu intre aceste doua tipuri de populatii celulare a fost identificat de noi associate si altor tipuri de neoplazii. Putem concluziona ca celulele immune circulante pot fi utilizate ca elemente de monitorizare ale progresiei tumorale in acest tip de cancer cutanat.
Studiu finantat prin proiectele PN-III-P1-1.2-PCCDI-2017-0341\/2018, PN 19.21.01.01\/2019, EPITRAN COST ACTION 16120\/2018<\/p>\n
Immunological advances in cutaneous squamous cell carcinoma<\/span> Invasive cutaneous squamous cell carcinoma (cSCC) in Caucazian population is one of the most common cancers accounting for 20% of all cutaneous malignancies. cSCC etiopathogenesis has multi-factorial trait. Therefore, environmental factors like ultraviolet radiation exposure, advanced age, male sex, smoking along with genetic factors are contributing to the onset of cSCC. Immunosuppressive conditions, like HIV infection, transplant, or chronic lymphocytic leukemia (CLL), are immune-based favoring condition for cSCC. In immunosuppressed patients, locoregional recurrence has an increased incidence, the risk of metastatic cSCC doubles, hence the outcome for advanced disease is significantly worse. Scurt CV<\/span><\/p>\n CS I, Profesor abilitat, \u015eef Laborator Imunologie, Institutul Na\u0163ional \u201cVictor Babes\u201d, Bucure\u015fti, Coordonator de Doctorat Facultatea de Biologie, Universitatea Bucure\u015fti, CS I \u00een colectivul de cercetare al Departamentului de Anatomie Patologic\u0103, Spitalul Clinic \u201dColentina\u201d, Bucure\u015fti. [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n Contacteaz\u0103 operatorul PDI 2020<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2020<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.0.11″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" C.\u0218.I. Dr. Neagu Monica Institutul Na\u0163ional \u201cVictor Babe\u015f\u201d, Bucure\u015fti Spitalul Clinic \u201dColentina\u201d, Bucure\u015ftiAspecte imunologice in carcinomul spinocelular Autori: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac Carcinomul spinocelular invaziv este un cancer comun in populatia Caucaziana (cSCC) in si reprezinta aproximativ 20% din toate cancerele cutanate. Etiopatogeneza cSCC este se pare multi-factoriala. Astfel, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7583","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7583"}],"version-history":[{"count":4,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7583\/revisions"}],"predecessor-version":[{"id":8179,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7583\/revisions\/8179"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Authors: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac <\/span><\/p>\n
In the quest to both monitor and predict the disease recurrence we have embarked in the search of various immune-related markers that can hint towards the clinical outcome of patients.
In cSCC patients before and after surgery peripheral blood was immediately tested for immune cell populations using flow citometry and the IVD kit BD Multitest™ IMK Kit. Within the test we have analyzed various immune cell circulatory populations: T lymphocytes (CD3+), B lymphocytes (CD19+), helper\/inducer T lymphocytes (CD3+CD4+), suppressor\/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) lymphocytes (CD3\u2013CD16+ and\/ or CD56+). For the investigated cases prior to the surgical resection total CD3+ T cells and CD4+ T cell sub-population were in the normal ranges. CD8+ T cells depicting cytotoxic lymphocytes are statistically reduced compared the normal values, thus leading to an increased ratio CD4\/CD8. In cCSC patients circulatory B lymphocytes (CD19+) have a decreased value while peripheral NK cells are increased. This immune compensatory process between these two types of cell populations has been reported by us in other neoplasias as well. We can conclude that peripheral immune cells can be useful for monitoring disease progression in these types of cancer.
Acknowledgement. PN-III-P1-1.2-PCCDI-2017-0341\/2018, PN 19.21.01.01\/2019, EPITRAN COST ACTION 16120\/2018<\/p>\n
1996 \u2013 Doctoratul \u00een Imunologie \u00een cotutel\u0103 cu Departamentul R&D Novartis, Ltd, Elvetia; din anul 2000 \u015eef de Laborator \u015fi din anul 2014 Profesor abilitat de Imunologie. \u00cen ultimii 5 ani a condus \u015fi participat \u00een peste 10 proiecte na\u0163ionale \u015fi 5 proiecte cu Fonduri structurale EU \u00een domeniul bio-medical, imunologie, proteomic\u0103, toxicologie. A fost membru \u00een echipe de cercetare interna\u0163ionale \u00een proiecte ERA-NET, FP7, Horizon2020. A condus proiecte interna\u0163ionale de cooperare bilateral\u0103 Rom\u00e2nia-China 511\/2011 cu Beijing Institute of Genomics, cooperare bilateral\u0103 Rom\u00e2nia-Grecia 7285\/02 cu University of Athens.
A fost director de proiect NATO SfP 982838\/2007 cu University of Tubingen. A fost membru al echipei de management pentru re\u0163eaua interna\u0163ional\u0103 COST Action D39, actualmente este membru al echipei de management pentru re\u0163elele interna\u0163ionale COST Action 16120\/2018 EPITRAN \u015fi COST Action 18125\/2019 AeroGels. Este co-inventator la 7 brevete de inven\u0163ie \u00een domeniul dermato-patologiei \u015fi dermato-oncologiei, brevete cu numeroase premii nterna\u0163ionale.
\u00cen perioada 2010-2013 a fost membru al Comisiei pentru Terapii Avansate \u2013 EMEA. Editor pentru c\u0103r\u0163i \u00een Edituri interna\u0163ionale, Editor pentru numere speciale \u00een reviste interna\u0163ionale Disease Markers, Journal of Immunology Research. Editor Asociat pentru Journal of Immunoassay and Immunochemistry. Evaluator pentru proiecte na\u0163ionale \u015fi interna\u0163ionale, evaluator la peste 50 de reviste interna\u0163ionale. Membru \u00een Editorial board pentru numeroase reviste interna\u0163ionale.
A publicat peste 100 de articole \u015ftiin\u0163ifice indexate ISI cu peste 1500 de cit\u0103ri, acumul\u00e2nd un Hirsch index de 17 (Clarivate), 21 (Google Academics).<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n