<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nProf. Dr. C\u0103runtu Constantin<\/strong><\/span>
\n U.M.F. “Carol Davila”, Bucure\u015fti<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ locked=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.0″]<\/p>\n
Cancerul cutanat \u015fi factorii neuro-endocrini \u2013 o nou\u0103 fa\u0163et\u0103 a unei vechi istorii<\/span>
Autori: Constantin C\u0103runtu, Mihai Lupu, Daniel Boda, Ana C\u0103runtu, Sabina Zurac, Carolina Constantin, Monica Neagu<\/span><\/p>\nCancerul de piele este cea mai frecvent\u0103 form\u0103 de neoplazie, cu o inciden\u021b\u0103 \u00een cre\u0219tere la nivel mondial. Exist\u0103 diferite tipuri de cancer de piele, care exprim\u0103 un comportament distructiv sau invaziv, unele dintre ele cu risc semnificativ de metastazare. De aici, interesul extraordinar pentru cercet\u0103ri privind mecanismele celulare \u0219i moleculare implicate \u00een dezvoltarea \u0219i evolu\u021bia cancerului de piele.
O posibil\u0103 leg\u0103tur\u0103 \u00eentre cancer \u0219i factorii nervo\u0219i a fost sugerat\u0103 \u00eenc\u0103 din primul sfert al secolului XX. Cu toate acestea, numai \u00een ultimii ani, tot mai multe studii au \u00eenceput s\u0103 dezv\u0103luie impactul semnificativ asupra cancerului de piele al neuropeptidelor, neurohormonilor \u0219i neurotransmi\u021b\u0103torilor. Ace\u0219ti factori neuro-endocrini pot activa mecanisme de modulare direct\u0103 asupra capacit\u0103\u021bii de proliferare sau metastazare a celulelor tumorale. De asemenea, pot activa c\u0103i indirecte care implic\u0103 micromediul tumoral, r\u0103spunsul imun sau procesele inflamatorii ale pielii cu un efect puternic asupra evolu\u021biei \u0219i prognosticului bolii.
Aprofundarea studiilor \u00een acest domeniu poate deschide noi perspective \u00een cercetarea cancerului de piele care s\u0103 conduc\u0103 la descoperirea de noi poten\u021biali markeri de diagnostic \u0219i prognostic, precum \u0219i de noi \u021binte terapeutice \u00een dermato-oncologie.<\/p>\n
<\/p>\n
Skin cancer and neuro-endocrine factors – a new twist to an old story<\/span>
Authors: Constantin C\u0103runtu, Mihai Lupu, Daniel Boda, Ana C\u0103runtu, Sabina Zurac, Carolina Constantin, Monica Neagu<\/span><\/p>\nSkin cancer is the most common form of malignancy, with a worldwide increasing incidence. There are various types of skin cancer, expressing destructive or invasive behavior, some of them with significant risk of metastases. Hence, the tremendous interest in research regarding the cellular and molecular mechanisms of skin cancer development and progression.
A possible link between cancer and nervous factors has been suggested as early as the first quarter of 20th century. However, only in the last years, more and more studies have started to unveil the significant impact on skin cancer of neuropeptides, neurohormones and neurotransmitters. These neuro-endocrine factors can activate direct modulatory mechanisms on proliferation or metastasis capacity of tumor cells. They can also activate indirect pathways involving tumor microenvironment, immune responses or skin inflammation with a strong effect on evolution and prognosis of the disease.
Further study may open new perspectives in skin cancer research, leading to discovery of new potential diagnostic and prognostic markers as well as new therapeutic targets in dermato-oncology.<\/p>\n
Scurt CV<\/span><\/p>\nProfessor of Physiology at \u201cCarol Davila\u201d University of Medicine and Pharmacy in Bucharest.
Dermatologist at “Prof. N.C. Paulescu” National Institute of Diabetes in Bucharest.
Trained in in vivo confocal microscopy, cellular and molecular biology techniques, and molecular imaging techniques.
Member of International Dermoscopy Society, International League of Dermatological Societies, International Union of Physiological Sciences.
Research interest: in vivo confocal microscopy, dermatooncology, inflammatory skin diseases, neurogenic inflammation, psychodermatology, neuroendocrinology of the skin<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
![\"\"](\"https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
[\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.0.11″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Prof. Dr. C\u0103runtu Constantin U.M.F. “Carol Davila”, Bucure\u015ftiCancerul cutanat \u015fi factorii neuro-endocrini \u2013 o nou\u0103 fa\u0163et\u0103 a unei vechi istorii Autori: Constantin C\u0103runtu, Mihai Lupu, Daniel Boda, Ana C\u0103runtu, Sabina Zurac, Carolina Constantin, Monica Neagu Cancerul de piele este cea mai frecvent\u0103 form\u0103 de neoplazie, cu o inciden\u021b\u0103 \u00een cre\u0219tere la nivel mondial. Exist\u0103 diferite […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7908","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7908"}],"version-history":[{"count":4,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7908\/revisions"}],"predecessor-version":[{"id":8162,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7908\/revisions\/8162"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Prof. Dr. C\u0103runtu Constantin<\/strong><\/span>
\n U.M.F. “Carol Davila”, Bucure\u015fti<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ locked=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.0″]<\/p>\n
Cancerul cutanat \u015fi factorii neuro-endocrini \u2013 o nou\u0103 fa\u0163et\u0103 a unei vechi istorii<\/span>
Autori: Constantin C\u0103runtu, Mihai Lupu, Daniel Boda, Ana C\u0103runtu, Sabina Zurac, Carolina Constantin, Monica Neagu<\/span><\/p>\nCancerul de piele este cea mai frecvent\u0103 form\u0103 de neoplazie, cu o inciden\u021b\u0103 \u00een cre\u0219tere la nivel mondial. Exist\u0103 diferite tipuri de cancer de piele, care exprim\u0103 un comportament distructiv sau invaziv, unele dintre ele cu risc semnificativ de metastazare. De aici, interesul extraordinar pentru cercet\u0103ri privind mecanismele celulare \u0219i moleculare implicate \u00een dezvoltarea \u0219i evolu\u021bia cancerului de piele.
O posibil\u0103 leg\u0103tur\u0103 \u00eentre cancer \u0219i factorii nervo\u0219i a fost sugerat\u0103 \u00eenc\u0103 din primul sfert al secolului XX. Cu toate acestea, numai \u00een ultimii ani, tot mai multe studii au \u00eenceput s\u0103 dezv\u0103luie impactul semnificativ asupra cancerului de piele al neuropeptidelor, neurohormonilor \u0219i neurotransmi\u021b\u0103torilor. Ace\u0219ti factori neuro-endocrini pot activa mecanisme de modulare direct\u0103 asupra capacit\u0103\u021bii de proliferare sau metastazare a celulelor tumorale. De asemenea, pot activa c\u0103i indirecte care implic\u0103 micromediul tumoral, r\u0103spunsul imun sau procesele inflamatorii ale pielii cu un efect puternic asupra evolu\u021biei \u0219i prognosticului bolii.
Aprofundarea studiilor \u00een acest domeniu poate deschide noi perspective \u00een cercetarea cancerului de piele care s\u0103 conduc\u0103 la descoperirea de noi poten\u021biali markeri de diagnostic \u0219i prognostic, precum \u0219i de noi \u021binte terapeutice \u00een dermato-oncologie.<\/p>\n
<\/p>\n
Skin cancer and neuro-endocrine factors – a new twist to an old story<\/span>
Authors: Constantin C\u0103runtu, Mihai Lupu, Daniel Boda, Ana C\u0103runtu, Sabina Zurac, Carolina Constantin, Monica Neagu<\/span><\/p>\nSkin cancer is the most common form of malignancy, with a worldwide increasing incidence. There are various types of skin cancer, expressing destructive or invasive behavior, some of them with significant risk of metastases. Hence, the tremendous interest in research regarding the cellular and molecular mechanisms of skin cancer development and progression.
A possible link between cancer and nervous factors has been suggested as early as the first quarter of 20th century. However, only in the last years, more and more studies have started to unveil the significant impact on skin cancer of neuropeptides, neurohormones and neurotransmitters. These neuro-endocrine factors can activate direct modulatory mechanisms on proliferation or metastasis capacity of tumor cells. They can also activate indirect pathways involving tumor microenvironment, immune responses or skin inflammation with a strong effect on evolution and prognosis of the disease.
Further study may open new perspectives in skin cancer research, leading to discovery of new potential diagnostic and prognostic markers as well as new therapeutic targets in dermato-oncology.<\/p>\n
Scurt CV<\/span><\/p>\nProfessor of Physiology at \u201cCarol Davila\u201d University of Medicine and Pharmacy in Bucharest.
Dermatologist at “Prof. N.C. Paulescu” National Institute of Diabetes in Bucharest.
Trained in in vivo confocal microscopy, cellular and molecular biology techniques, and molecular imaging techniques.
Member of International Dermoscopy Society, International League of Dermatological Societies, International Union of Physiological Sciences.
Research interest: in vivo confocal microscopy, dermatooncology, inflammatory skin diseases, neurogenic inflammation, psychodermatology, neuroendocrinology of the skin<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
[\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.0.11″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Prof. Dr. C\u0103runtu Constantin U.M.F. “Carol Davila”, Bucure\u015ftiCancerul cutanat \u015fi factorii neuro-endocrini \u2013 o nou\u0103 fa\u0163et\u0103 a unei vechi istorii Autori: Constantin C\u0103runtu, Mihai Lupu, Daniel Boda, Ana C\u0103runtu, Sabina Zurac, Carolina Constantin, Monica Neagu Cancerul de piele este cea mai frecvent\u0103 form\u0103 de neoplazie, cu o inciden\u021b\u0103 \u00een cre\u0219tere la nivel mondial. Exist\u0103 diferite […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7908","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7908"}],"version-history":[{"count":4,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7908\/revisions"}],"predecessor-version":[{"id":8162,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7908\/revisions\/8162"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Constantin C\u0103runtu, Mihai Lupu, Daniel Boda, Ana C\u0103runtu, Sabina Zurac, Carolina Constantin, Monica Neagu<\/span><\/p>\n
Cancerul de piele este cea mai frecvent\u0103 form\u0103 de neoplazie, cu o inciden\u021b\u0103 \u00een cre\u0219tere la nivel mondial. Exist\u0103 diferite tipuri de cancer de piele, care exprim\u0103 un comportament distructiv sau invaziv, unele dintre ele cu risc semnificativ de metastazare. De aici, interesul extraordinar pentru cercet\u0103ri privind mecanismele celulare \u0219i moleculare implicate \u00een dezvoltarea \u0219i evolu\u021bia cancerului de piele.
O posibil\u0103 leg\u0103tur\u0103 \u00eentre cancer \u0219i factorii nervo\u0219i a fost sugerat\u0103 \u00eenc\u0103 din primul sfert al secolului XX. Cu toate acestea, numai \u00een ultimii ani, tot mai multe studii au \u00eenceput s\u0103 dezv\u0103luie impactul semnificativ asupra cancerului de piele al neuropeptidelor, neurohormonilor \u0219i neurotransmi\u021b\u0103torilor. Ace\u0219ti factori neuro-endocrini pot activa mecanisme de modulare direct\u0103 asupra capacit\u0103\u021bii de proliferare sau metastazare a celulelor tumorale. De asemenea, pot activa c\u0103i indirecte care implic\u0103 micromediul tumoral, r\u0103spunsul imun sau procesele inflamatorii ale pielii cu un efect puternic asupra evolu\u021biei \u0219i prognosticului bolii.
Aprofundarea studiilor \u00een acest domeniu poate deschide noi perspective \u00een cercetarea cancerului de piele care s\u0103 conduc\u0103 la descoperirea de noi poten\u021biali markeri de diagnostic \u0219i prognostic, precum \u0219i de noi \u021binte terapeutice \u00een dermato-oncologie.<\/p>\n
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Skin cancer and neuro-endocrine factors – a new twist to an old story<\/span> Skin cancer is the most common form of malignancy, with a worldwide increasing incidence. There are various types of skin cancer, expressing destructive or invasive behavior, some of them with significant risk of metastases. Hence, the tremendous interest in research regarding the cellular and molecular mechanisms of skin cancer development and progression. Scurt CV<\/span><\/p>\n Professor of Physiology at \u201cCarol Davila\u201d University of Medicine and Pharmacy in Bucharest. 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Exist\u0103 diferite […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7908","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7908"}],"version-history":[{"count":4,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7908\/revisions"}],"predecessor-version":[{"id":8162,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7908\/revisions\/8162"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Authors: Constantin C\u0103runtu, Mihai Lupu, Daniel Boda, Ana C\u0103runtu, Sabina Zurac, Carolina Constantin, Monica Neagu<\/span><\/p>\n
A possible link between cancer and nervous factors has been suggested as early as the first quarter of 20th century. However, only in the last years, more and more studies have started to unveil the significant impact on skin cancer of neuropeptides, neurohormones and neurotransmitters. These neuro-endocrine factors can activate direct modulatory mechanisms on proliferation or metastasis capacity of tumor cells. They can also activate indirect pathways involving tumor microenvironment, immune responses or skin inflammation with a strong effect on evolution and prognosis of the disease.
Further study may open new perspectives in skin cancer research, leading to discovery of new potential diagnostic and prognostic markers as well as new therapeutic targets in dermato-oncology.<\/p>\n
Dermatologist at “Prof. N.C. Paulescu” National Institute of Diabetes in Bucharest.
Trained in in vivo confocal microscopy, cellular and molecular biology techniques, and molecular imaging techniques.
Member of International Dermoscopy Society, International League of Dermatological Societies, International Union of Physiological Sciences.
Research interest: in vivo confocal microscopy, dermatooncology, inflammatory skin diseases, neurogenic inflammation, psychodermatology, neuroendocrinology of the skin<\/span><\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n