<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nConf. Dr. Opri\u015f-Belinski Daniela<\/span><\/strong>
Spitalul Clinic “Sf\u00e2nta Maria”, U.M.F. “Carol Davila” Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.7″ hover_enabled=”0″]<\/p>\n
Nout\u0103\u0163i \u00een lupusul eritematos sistemic: Criteriile de clasificare ACR\/EULAR 2019 \u015fi o compara\u0163ie cu criteriile anterioare<\/span>
Autor: Daniela Opri\u015f-Belinski<\/span><\/p>\nLupusul eritematos sistemic (LES) este o boal\u00e3 inflamatorie cronic\u00e3 caracterizeaz\u00e3 prin pierderea toleran\u0163ei la self \u015fi existen\u0163a fenomenelor autoimune. Apari\u0163ia de autoanticorpi determin\u00e3 distrugeri celulare \u015fi tisulare prin reac\u0163ia de citotoxicitate sau prin apari\u0163ia de complexe imune circulante. Toate acestea induc o heterogenitate marcat\u00e3 a manifest\u00e3rilor clinice \u015fi paraclinice fapt care asociaz\u0103 necesitatea existen\u0163ei unor criterii de clasificare validate cu sensibilitate \u015fi specificitate foarte \u00eenalte.
\nDe-a lungul timpului au existat mai multe criterii de clasificare, dintre care s-au remarcat criteriile ACR din 1982 revizuite \u00een 1997, apoi criteriile SLICC din 2012 \u015fi, ultimile ap\u0103rute, criteriile societ\u0103\u0163ilor american\u0103 \u015fi european\u0103 de reumatologie \u201cACR\/EULAR 2019\u201d. La fel ca \u015fi celelalte dou\u0103 criterii anterioare \u015fi \u00een cazul acestora din urm\u0103 exist\u0103 un sistem pe baz\u0103 de scor care evalueaz\u0103 at\u00e2t modific\u0103rile clinice \u00eenalt sugestive c\u00e2t \u015fi pe cele de laborator. Fiecare dintre elementele incluse \u00een cele 7 grupe de manifest\u0103ri clinice, hematologice \u015fi histologice (nefrita lupic\u0103) \u015fi 3 imunologice c\u00e2nt\u0103re\u015fte diferit (scor de la 2 la 10). Remarc\u0103m fa\u0163\u0103 de precedentele introducerea manifest\u0103rilor constitu\u0163ionale (febra), rezultatului la punc\u0163ia biopsie renal\u0103 dar \u015f\u00ee men\u0163inerea hipocomplementemiei, introdus\u0103 pentru prima data \u00een criteriile SLICC. Un pacient poate fi clasificat ca \u015fi LES numai dac\u0103 anticorpii anti nucleari sunt pozitivi (criteriu obligatoriu) \u015fi scorul cumulativ total este mai mare sau egal cu 10 puncte. Evaluarea cohortei de validare a acestor noi criterii a dus la o sensibilitate de 96,1% \u015fi o specificitate de 93,4%.\n<\/p>\n
What\u2019s new in systemic lupus: European League Against Rheumatism\/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus<\/span>
Author: Daniela Opri\u015f-Belinski<\/span><\/p>\nSystemic lupus erythematosus (SLE) is a chronic inflammatory disease characterised by loss of self-tolerance and autoimmune manifestations. The appearance of autoantibodies produces tissue damage by both cytotoxicity reaction and type 3 immune complex reaction. Due to the marked heterogenicity of clinical and paraclinical features, the necessity of high specificity and sensibility classification criteria is very high.
\nSince 1982, with the first ACR criteria that were revised in 1997, we had SLICC criteria in 2012 and now, the new joint American and European EULAR\/ACR criteria. It uses a more complex scoring system that evaluates high suggestive clinical and paraclinical features. Every element that is included in the seven clinical, hematological, histological (lupus nephritis) and in the three immunologic domains is differently weighted according to importance (from 2 to 10). As compared to previous criteria we remark the inclusion of constitutional manifestations (fever) and the positive renal biopsy. Low complement levels, that were first introduced in SLICC, were preserved. Patients accumulating \u226510 points are classified, but only if anti-nuclear antibodies are positive (obligatory entry criterion). In the validation cohort, the new criteria had a sensitivity of 96.1% and specificity of 93.4%.\n<\/p>\n
Scurt CV<\/span><\/p>\nDr. Daniela Opris-Belinski a absolvit \u00een anul 2000 Universitatea de Medicin\u0103 \u0219i Farmacie Carol Davila din Bucure\u0219ti. Este medic primar medicin\u0103 intern\u0103 \u015fi reumatologie. Din anul 2015, dup\u0103 parcurgerea prin concurs a anterioarelor trepte ierarhice, a devenit conferentiar la aceea\u0219i universitate.
\nInteresele sale de cercetare includ \u00een special bolile inflamatorii reumatologice artrita reumatoid\u0103, lupusul eritematos sistemic, sindromul Sj\u0151gen \u0219i c\u00e2teva forme de vasculit\u0103.
\nEste autor \u015fi co-autor a peste 100 de lucr\u0103ri de specialitate publicate \u00een reviste na\u0163ionale \u015fi interna\u0163ionale. A publicat \u015fi coordonat mai multe c\u0103r\u0163i dar \u015fi capitole de carte.
\nA fost investigator principal \u015fi subinvestigator \u00een studii clinice interna\u021bionale de faz\u0103 a II-a \u0219i a III-a \u00een domeniul reumatologiei \u0219i, de asemenea, coordonatorul rom\u00e2n al unui grant interna\u0163ional Horizon 2020.
\nDr. Opris-Belinski este membru al Consiliului Editorial al Jurnalului Rom\u00e2n de Reumatologie, al mai multor reviste interna\u0163ionale, membru activ al Societ\u0103\u021bii Rom\u00e2ne de Reumatologie, Societ\u0103\u021bii Rom\u00e2ne de Medicin\u0103 Intern\u0103 \u0219i al mai multor societ\u0103\u021bi interna\u021bionale.\n<\/p>\n
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Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2020<\/p>\n
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![\"\"](\"https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Dr. Opri\u015f-Belinski DanielaSpitalul Clinic “Sf\u00e2nta Maria”, U.M.F. “Carol Davila” Bucure\u015ftiNout\u0103\u0163i \u00een lupusul eritematos sistemic: Criteriile de clasificare ACR\/EULAR 2019 \u015fi o compara\u0163ie cu criteriile anterioare Autor: Daniela Opri\u015f-Belinski Lupusul eritematos sistemic (LES) este o boal\u00e3 inflamatorie cronic\u00e3 caracterizeaz\u00e3 prin pierderea toleran\u0163ei la self \u015fi existen\u0163a fenomenelor autoimune. Apari\u0163ia de autoanticorpi determin\u00e3 distrugeri celulare \u015fi […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7977","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7977"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7977\/revisions"}],"predecessor-version":[{"id":8186,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7977\/revisions\/8186"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Conf. Dr. Opri\u015f-Belinski Daniela<\/span><\/strong>
Spitalul Clinic “Sf\u00e2nta Maria”, U.M.F. “Carol Davila” Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.7″ hover_enabled=”0″]<\/p>\n
Nout\u0103\u0163i \u00een lupusul eritematos sistemic: Criteriile de clasificare ACR\/EULAR 2019 \u015fi o compara\u0163ie cu criteriile anterioare<\/span>
Autor: Daniela Opri\u015f-Belinski<\/span><\/p>\nLupusul eritematos sistemic (LES) este o boal\u00e3 inflamatorie cronic\u00e3 caracterizeaz\u00e3 prin pierderea toleran\u0163ei la self \u015fi existen\u0163a fenomenelor autoimune. Apari\u0163ia de autoanticorpi determin\u00e3 distrugeri celulare \u015fi tisulare prin reac\u0163ia de citotoxicitate sau prin apari\u0163ia de complexe imune circulante. Toate acestea induc o heterogenitate marcat\u00e3 a manifest\u00e3rilor clinice \u015fi paraclinice fapt care asociaz\u0103 necesitatea existen\u0163ei unor criterii de clasificare validate cu sensibilitate \u015fi specificitate foarte \u00eenalte.
\nDe-a lungul timpului au existat mai multe criterii de clasificare, dintre care s-au remarcat criteriile ACR din 1982 revizuite \u00een 1997, apoi criteriile SLICC din 2012 \u015fi, ultimile ap\u0103rute, criteriile societ\u0103\u0163ilor american\u0103 \u015fi european\u0103 de reumatologie \u201cACR\/EULAR 2019\u201d. La fel ca \u015fi celelalte dou\u0103 criterii anterioare \u015fi \u00een cazul acestora din urm\u0103 exist\u0103 un sistem pe baz\u0103 de scor care evalueaz\u0103 at\u00e2t modific\u0103rile clinice \u00eenalt sugestive c\u00e2t \u015fi pe cele de laborator. Fiecare dintre elementele incluse \u00een cele 7 grupe de manifest\u0103ri clinice, hematologice \u015fi histologice (nefrita lupic\u0103) \u015fi 3 imunologice c\u00e2nt\u0103re\u015fte diferit (scor de la 2 la 10). Remarc\u0103m fa\u0163\u0103 de precedentele introducerea manifest\u0103rilor constitu\u0163ionale (febra), rezultatului la punc\u0163ia biopsie renal\u0103 dar \u015f\u00ee men\u0163inerea hipocomplementemiei, introdus\u0103 pentru prima data \u00een criteriile SLICC. Un pacient poate fi clasificat ca \u015fi LES numai dac\u0103 anticorpii anti nucleari sunt pozitivi (criteriu obligatoriu) \u015fi scorul cumulativ total este mai mare sau egal cu 10 puncte. Evaluarea cohortei de validare a acestor noi criterii a dus la o sensibilitate de 96,1% \u015fi o specificitate de 93,4%.\n<\/p>\n
What\u2019s new in systemic lupus: European League Against Rheumatism\/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus<\/span>
Author: Daniela Opri\u015f-Belinski<\/span><\/p>\nSystemic lupus erythematosus (SLE) is a chronic inflammatory disease characterised by loss of self-tolerance and autoimmune manifestations. The appearance of autoantibodies produces tissue damage by both cytotoxicity reaction and type 3 immune complex reaction. Due to the marked heterogenicity of clinical and paraclinical features, the necessity of high specificity and sensibility classification criteria is very high.
\nSince 1982, with the first ACR criteria that were revised in 1997, we had SLICC criteria in 2012 and now, the new joint American and European EULAR\/ACR criteria. It uses a more complex scoring system that evaluates high suggestive clinical and paraclinical features. Every element that is included in the seven clinical, hematological, histological (lupus nephritis) and in the three immunologic domains is differently weighted according to importance (from 2 to 10). As compared to previous criteria we remark the inclusion of constitutional manifestations (fever) and the positive renal biopsy. Low complement levels, that were first introduced in SLICC, were preserved. Patients accumulating \u226510 points are classified, but only if anti-nuclear antibodies are positive (obligatory entry criterion). In the validation cohort, the new criteria had a sensitivity of 96.1% and specificity of 93.4%.\n<\/p>\n
Scurt CV<\/span><\/p>\nDr. Daniela Opris-Belinski a absolvit \u00een anul 2000 Universitatea de Medicin\u0103 \u0219i Farmacie Carol Davila din Bucure\u0219ti. Este medic primar medicin\u0103 intern\u0103 \u015fi reumatologie. Din anul 2015, dup\u0103 parcurgerea prin concurs a anterioarelor trepte ierarhice, a devenit conferentiar la aceea\u0219i universitate.
\nInteresele sale de cercetare includ \u00een special bolile inflamatorii reumatologice artrita reumatoid\u0103, lupusul eritematos sistemic, sindromul Sj\u0151gen \u0219i c\u00e2teva forme de vasculit\u0103.
\nEste autor \u015fi co-autor a peste 100 de lucr\u0103ri de specialitate publicate \u00een reviste na\u0163ionale \u015fi interna\u0163ionale. A publicat \u015fi coordonat mai multe c\u0103r\u0163i dar \u015fi capitole de carte.
\nA fost investigator principal \u015fi subinvestigator \u00een studii clinice interna\u021bionale de faz\u0103 a II-a \u0219i a III-a \u00een domeniul reumatologiei \u0219i, de asemenea, coordonatorul rom\u00e2n al unui grant interna\u0163ional Horizon 2020.
\nDr. Opris-Belinski este membru al Consiliului Editorial al Jurnalului Rom\u00e2n de Reumatologie, al mai multor reviste interna\u0163ionale, membru activ al Societ\u0103\u021bii Rom\u00e2ne de Reumatologie, Societ\u0103\u021bii Rom\u00e2ne de Medicin\u0103 Intern\u0103 \u0219i al mai multor societ\u0103\u021bi interna\u021bionale.\n<\/p>\n
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Contacteaz\u0103 operatorul PDI 2020<\/p>\n
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Operatorul PDI 2020<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
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Parteneri Media<\/p>\n
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Conf. Dr. Opri\u015f-Belinski DanielaSpitalul Clinic “Sf\u00e2nta Maria”, U.M.F. “Carol Davila” Bucure\u015ftiNout\u0103\u0163i \u00een lupusul eritematos sistemic: Criteriile de clasificare ACR\/EULAR 2019 \u015fi o compara\u0163ie cu criteriile anterioare Autor: Daniela Opri\u015f-Belinski Lupusul eritematos sistemic (LES) este o boal\u00e3 inflamatorie cronic\u00e3 caracterizeaz\u00e3 prin pierderea toleran\u0163ei la self \u015fi existen\u0163a fenomenelor autoimune. Apari\u0163ia de autoanticorpi determin\u00e3 distrugeri celulare \u015fi […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7977","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7977"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7977\/revisions"}],"predecessor-version":[{"id":8186,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7977\/revisions\/8186"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Daniela Opri\u015f-Belinski<\/span><\/p>\n
Lupusul eritematos sistemic (LES) este o boal\u00e3 inflamatorie cronic\u00e3 caracterizeaz\u00e3 prin pierderea toleran\u0163ei la self \u015fi existen\u0163a fenomenelor autoimune. Apari\u0163ia de autoanticorpi determin\u00e3 distrugeri celulare \u015fi tisulare prin reac\u0163ia de citotoxicitate sau prin apari\u0163ia de complexe imune circulante. Toate acestea induc o heterogenitate marcat\u00e3 a manifest\u00e3rilor clinice \u015fi paraclinice fapt care asociaz\u0103 necesitatea existen\u0163ei unor criterii de clasificare validate cu sensibilitate \u015fi specificitate foarte \u00eenalte.
\nDe-a lungul timpului au existat mai multe criterii de clasificare, dintre care s-au remarcat criteriile ACR din 1982 revizuite \u00een 1997, apoi criteriile SLICC din 2012 \u015fi, ultimile ap\u0103rute, criteriile societ\u0103\u0163ilor american\u0103 \u015fi european\u0103 de reumatologie \u201cACR\/EULAR 2019\u201d. La fel ca \u015fi celelalte dou\u0103 criterii anterioare \u015fi \u00een cazul acestora din urm\u0103 exist\u0103 un sistem pe baz\u0103 de scor care evalueaz\u0103 at\u00e2t modific\u0103rile clinice \u00eenalt sugestive c\u00e2t \u015fi pe cele de laborator. Fiecare dintre elementele incluse \u00een cele 7 grupe de manifest\u0103ri clinice, hematologice \u015fi histologice (nefrita lupic\u0103) \u015fi 3 imunologice c\u00e2nt\u0103re\u015fte diferit (scor de la 2 la 10). Remarc\u0103m fa\u0163\u0103 de precedentele introducerea manifest\u0103rilor constitu\u0163ionale (febra), rezultatului la punc\u0163ia biopsie renal\u0103 dar \u015f\u00ee men\u0163inerea hipocomplementemiei, introdus\u0103 pentru prima data \u00een criteriile SLICC. Un pacient poate fi clasificat ca \u015fi LES numai dac\u0103 anticorpii anti nucleari sunt pozitivi (criteriu obligatoriu) \u015fi scorul cumulativ total este mai mare sau egal cu 10 puncte. Evaluarea cohortei de validare a acestor noi criterii a dus la o sensibilitate de 96,1% \u015fi o specificitate de 93,4%.\n<\/p>\n
What\u2019s new in systemic lupus: European League Against Rheumatism\/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus<\/span> Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterised by loss of self-tolerance and autoimmune manifestations. The appearance of autoantibodies produces tissue damage by both cytotoxicity reaction and type 3 immune complex reaction. Due to the marked heterogenicity of clinical and paraclinical features, the necessity of high specificity and sensibility classification criteria is very high. Scurt CV<\/span><\/p>\n Dr. Daniela Opris-Belinski a absolvit \u00een anul 2000 Universitatea de Medicin\u0103 \u0219i Farmacie Carol Davila din Bucure\u0219ti. Este medic primar medicin\u0103 intern\u0103 \u015fi reumatologie. Din anul 2015, dup\u0103 parcurgerea prin concurs a anterioarelor trepte ierarhice, a devenit conferentiar la aceea\u0219i universitate. [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n Contacteaz\u0103 operatorul PDI 2020<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2020<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.0.11″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Conf. Dr. Opri\u015f-Belinski DanielaSpitalul Clinic “Sf\u00e2nta Maria”, U.M.F. “Carol Davila” Bucure\u015ftiNout\u0103\u0163i \u00een lupusul eritematos sistemic: Criteriile de clasificare ACR\/EULAR 2019 \u015fi o compara\u0163ie cu criteriile anterioare Autor: Daniela Opri\u015f-Belinski Lupusul eritematos sistemic (LES) este o boal\u00e3 inflamatorie cronic\u00e3 caracterizeaz\u00e3 prin pierderea toleran\u0163ei la self \u015fi existen\u0163a fenomenelor autoimune. Apari\u0163ia de autoanticorpi determin\u00e3 distrugeri celulare \u015fi […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7977","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7977","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7977"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7977\/revisions"}],"predecessor-version":[{"id":8186,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7977\/revisions\/8186"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7977"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Author: Daniela Opri\u015f-Belinski<\/span><\/p>\n
\nSince 1982, with the first ACR criteria that were revised in 1997, we had SLICC criteria in 2012 and now, the new joint American and European EULAR\/ACR criteria. It uses a more complex scoring system that evaluates high suggestive clinical and paraclinical features. Every element that is included in the seven clinical, hematological, histological (lupus nephritis) and in the three immunologic domains is differently weighted according to importance (from 2 to 10). As compared to previous criteria we remark the inclusion of constitutional manifestations (fever) and the positive renal biopsy. Low complement levels, that were first introduced in SLICC, were preserved. Patients accumulating \u226510 points are classified, but only if anti-nuclear antibodies are positive (obligatory entry criterion). In the validation cohort, the new criteria had a sensitivity of 96.1% and specificity of 93.4%.\n<\/p>\n
\nInteresele sale de cercetare includ \u00een special bolile inflamatorii reumatologice artrita reumatoid\u0103, lupusul eritematos sistemic, sindromul Sj\u0151gen \u0219i c\u00e2teva forme de vasculit\u0103.
\nEste autor \u015fi co-autor a peste 100 de lucr\u0103ri de specialitate publicate \u00een reviste na\u0163ionale \u015fi interna\u0163ionale. A publicat \u015fi coordonat mai multe c\u0103r\u0163i dar \u015fi capitole de carte.
\nA fost investigator principal \u015fi subinvestigator \u00een studii clinice interna\u021bionale de faz\u0103 a II-a \u0219i a III-a \u00een domeniul reumatologiei \u0219i, de asemenea, coordonatorul rom\u00e2n al unui grant interna\u0163ional Horizon 2020.
\nDr. Opris-Belinski este membru al Consiliului Editorial al Jurnalului Rom\u00e2n de Reumatologie, al mai multor reviste interna\u0163ionale, membru activ al Societ\u0103\u021bii Rom\u00e2ne de Reumatologie, Societ\u0103\u021bii Rom\u00e2ne de Medicin\u0103 Intern\u0103 \u0219i al mai multor societ\u0103\u021bi interna\u021bionale.\n<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n