<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nDr. Ungureanu Gabriela<\/span><\/strong>
\n Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.7″ hover_enabled=”0″]<\/p>\n
Angioedemul ereditar \u2013 o provocare medical\u0103<\/span>
Autor: Gabriela Ungureanu <\/span><\/p>\nAEE este o boal\u0103 genetic\u0103 rar\u0103, cu poten\u021bial letal, cu transmitere autozomal dominant\u0103 indus\u0103 prin deficit enzimatic de C1INH, caracterizat\u0103 prin episoade recurente de angioedem (f\u0103r\u0103 urticarie), cu caracter de durere \u0219i arsur\u0103, manifestat la nivel cutanat \u0219i al mucoaselor.
Clinic, se poate identifica edem la nivelul extremit\u0103\u021bilor (membre, facial, OGE), atacuri abdominale acute \u0219i manifest\u0103ri respiratorii cu dificultate la \u00eenghi\u021bit, respirat, amenin\u021batoare de via\u021b\u0103 ce necesit\u0103 intuba\u021bie orotraheal\u0103.
Diagnosticul clinic necesit\u0103 o anamnez\u0103 familial\u0103 \u0219i personal\u0103 am\u0103nun\u021bit\u0103, teste serologice pentru determinare C1INH \u0219i C4 \u0219i test genetic F-XII.
Terapeutic, AEE nu r\u0103spunde la antihistaminice, corticoterapie sistemic\u0219 sau adrenalin\u0103. AEE r\u0103spunde la concentrate C1INH, C1INH recombinant, blocant al receptorului de bradikinin\u0103 \u0219i blocan\u021bi de kalicrein\u0103, deorece este un angiodem mediat de bradikinin\u0103 \u0219i nu de histamin\u0103.<\/p>\n
Hereditery angioedema \u201cHAE\u201d \u2013 a medical challenge<\/span>
Author: Gabriela Ungureanu <\/span><\/p>\nHeredetery angioedema is a rare genetic condition caused by mutation in the SERPING 1 gene.This condition is inherited in an autosomal dominant pattern. HAE is a disorder characterized by recurrent episodes of severe swelling \u2013 angioedema under the skin and lining of the gut and lung. Minor trauma or stress may trigger an attack.
The most commons areas of the body to develop swelling are the limbs, face, intestinal tract and airway. Itchiness does not tipically. If the intestinal truct is affected occur abdominal pain and vomiting, nausea and diarrhea. Swelling in the airway constrict breathing and lead to life threatening obstruction of the airway, and could be deadly. Simptomps of HAE typically begin in childhood and worsen during the puberty.
Mutation in the SERPING 1 induse HAE Type I \u2013 lead to reduced levels of C1Inhibitor in the blood, while Type II result in the normal production of C1Inhibitor that function is abnormally. Mutation in the F XII gene are associated with some case of HAE Type III. This mutation result in the production of F XII with increased activity. As a result, more bradykinine is generated, and blood vessel becomes more leaky, wich leads to sudden episodes of swelling.
Treatement :
\u2022 antihistamines and corticosteroid that treat allergies don\u2019t work well for this disease.
\u2022 treat or prevent attack with: – BERINERT, CINRYZE \u2013 C1 esteraze inhibitor;
– RUCONEST \u2013 conestalalfa recombined;
– FIRAZYR \u2013 icatibant \u2013 bradikynin receptor blocker;
– KALBITOR \u2013 ecallantinde \u2013 kalicrein blocker;
– TAKHZYRO – lanadelumab.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u021ba:<\/strong>
2014 – Prezent – Manager clinica \u201dNew Medical\u201d Bac\u0103u \u2013 Clinica alergologie\u2013imunologie clinic\u0103
2004 – Prezent \u2013 Coordonator compartiment alergologie\u2013imunologie clinic\u0103, Sec\u021bia dermato\u2013venerice , Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u
2019 – Specialist dermato\u2013venerice
2009 – Medic primar alergologie imunologie clinic\u0103
2004 – Medic specialist alergologie imunologie clinic\u0103
1999 – 2004 – Rezident alergologie imunologie clinic\u0103 Spital Clinic \u201cNicolae Malaxa\u201d Bucure\u0219ti, U.M.F. \u201cCarol Davila\u201d
1996 – 1999 \u2013 Serviciu de Ambulan\u021b\u0103 Jude\u021bean Bac\u0103u
1990 – 1996 \u2013 U.M.F. \u201cGrigore T. Popa\u201c Ia\u0219i \u2013 Medic Generalist<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
Membru Societatea Rom\u00e2n\u0103 Dermatologie
Membru Societatea Rom\u00e2n\u0103 de Alergologie Imunologie Clinic\u0103
Membru Academia European\u0103 de Alergologie Imunologie Clinic\u0103
Membru Asocia\u021bia Dermatologilor din Moldova<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
![\"\"](\"https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
[\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.0.11″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Dr. Ungureanu Gabriela Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103uAngioedemul ereditar \u2013 o provocare medical\u0103 Autor: Gabriela Ungureanu AEE este o boal\u0103 genetic\u0103 rar\u0103, cu poten\u021bial letal, cu transmitere autozomal dominant\u0103 indus\u0103 prin deficit enzimatic de C1INH, caracterizat\u0103 prin episoade recurente de angioedem (f\u0103r\u0103 urticarie), cu caracter de durere \u0219i arsur\u0103, manifestat la nivel cutanat \u0219i al […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7995","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7995"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7995\/revisions"}],"predecessor-version":[{"id":8217,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7995\/revisions\/8217"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Dr. Ungureanu Gabriela<\/span><\/strong>
\n Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.7″ hover_enabled=”0″]<\/p>\n
Angioedemul ereditar \u2013 o provocare medical\u0103<\/span>
Autor: Gabriela Ungureanu <\/span><\/p>\nAEE este o boal\u0103 genetic\u0103 rar\u0103, cu poten\u021bial letal, cu transmitere autozomal dominant\u0103 indus\u0103 prin deficit enzimatic de C1INH, caracterizat\u0103 prin episoade recurente de angioedem (f\u0103r\u0103 urticarie), cu caracter de durere \u0219i arsur\u0103, manifestat la nivel cutanat \u0219i al mucoaselor.
Clinic, se poate identifica edem la nivelul extremit\u0103\u021bilor (membre, facial, OGE), atacuri abdominale acute \u0219i manifest\u0103ri respiratorii cu dificultate la \u00eenghi\u021bit, respirat, amenin\u021batoare de via\u021b\u0103 ce necesit\u0103 intuba\u021bie orotraheal\u0103.
Diagnosticul clinic necesit\u0103 o anamnez\u0103 familial\u0103 \u0219i personal\u0103 am\u0103nun\u021bit\u0103, teste serologice pentru determinare C1INH \u0219i C4 \u0219i test genetic F-XII.
Terapeutic, AEE nu r\u0103spunde la antihistaminice, corticoterapie sistemic\u0219 sau adrenalin\u0103. AEE r\u0103spunde la concentrate C1INH, C1INH recombinant, blocant al receptorului de bradikinin\u0103 \u0219i blocan\u021bi de kalicrein\u0103, deorece este un angiodem mediat de bradikinin\u0103 \u0219i nu de histamin\u0103.<\/p>\n
Hereditery angioedema \u201cHAE\u201d \u2013 a medical challenge<\/span>
Author: Gabriela Ungureanu <\/span><\/p>\nHeredetery angioedema is a rare genetic condition caused by mutation in the SERPING 1 gene.This condition is inherited in an autosomal dominant pattern. HAE is a disorder characterized by recurrent episodes of severe swelling \u2013 angioedema under the skin and lining of the gut and lung. Minor trauma or stress may trigger an attack.
The most commons areas of the body to develop swelling are the limbs, face, intestinal tract and airway. Itchiness does not tipically. If the intestinal truct is affected occur abdominal pain and vomiting, nausea and diarrhea. Swelling in the airway constrict breathing and lead to life threatening obstruction of the airway, and could be deadly. Simptomps of HAE typically begin in childhood and worsen during the puberty.
Mutation in the SERPING 1 induse HAE Type I \u2013 lead to reduced levels of C1Inhibitor in the blood, while Type II result in the normal production of C1Inhibitor that function is abnormally. Mutation in the F XII gene are associated with some case of HAE Type III. This mutation result in the production of F XII with increased activity. As a result, more bradykinine is generated, and blood vessel becomes more leaky, wich leads to sudden episodes of swelling.
Treatement :
\u2022 antihistamines and corticosteroid that treat allergies don\u2019t work well for this disease.
\u2022 treat or prevent attack with: – BERINERT, CINRYZE \u2013 C1 esteraze inhibitor;
– RUCONEST \u2013 conestalalfa recombined;
– FIRAZYR \u2013 icatibant \u2013 bradikynin receptor blocker;
– KALBITOR \u2013 ecallantinde \u2013 kalicrein blocker;
– TAKHZYRO – lanadelumab.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u021ba:<\/strong>
2014 – Prezent – Manager clinica \u201dNew Medical\u201d Bac\u0103u \u2013 Clinica alergologie\u2013imunologie clinic\u0103
2004 – Prezent \u2013 Coordonator compartiment alergologie\u2013imunologie clinic\u0103, Sec\u021bia dermato\u2013venerice , Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u
2019 – Specialist dermato\u2013venerice
2009 – Medic primar alergologie imunologie clinic\u0103
2004 – Medic specialist alergologie imunologie clinic\u0103
1999 – 2004 – Rezident alergologie imunologie clinic\u0103 Spital Clinic \u201cNicolae Malaxa\u201d Bucure\u0219ti, U.M.F. \u201cCarol Davila\u201d
1996 – 1999 \u2013 Serviciu de Ambulan\u021b\u0103 Jude\u021bean Bac\u0103u
1990 – 1996 \u2013 U.M.F. \u201cGrigore T. Popa\u201c Ia\u0219i \u2013 Medic Generalist<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
Membru Societatea Rom\u00e2n\u0103 Dermatologie
Membru Societatea Rom\u00e2n\u0103 de Alergologie Imunologie Clinic\u0103
Membru Academia European\u0103 de Alergologie Imunologie Clinic\u0103
Membru Asocia\u021bia Dermatologilor din Moldova<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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Dr. Ungureanu Gabriela Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103uAngioedemul ereditar \u2013 o provocare medical\u0103 Autor: Gabriela Ungureanu AEE este o boal\u0103 genetic\u0103 rar\u0103, cu poten\u021bial letal, cu transmitere autozomal dominant\u0103 indus\u0103 prin deficit enzimatic de C1INH, caracterizat\u0103 prin episoade recurente de angioedem (f\u0103r\u0103 urticarie), cu caracter de durere \u0219i arsur\u0103, manifestat la nivel cutanat \u0219i al […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7995","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=7995"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7995\/revisions"}],"predecessor-version":[{"id":8217,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/7995\/revisions\/8217"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=7995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Gabriela Ungureanu <\/span><\/p>\n
AEE este o boal\u0103 genetic\u0103 rar\u0103, cu poten\u021bial letal, cu transmitere autozomal dominant\u0103 indus\u0103 prin deficit enzimatic de C1INH, caracterizat\u0103 prin episoade recurente de angioedem (f\u0103r\u0103 urticarie), cu caracter de durere \u0219i arsur\u0103, manifestat la nivel cutanat \u0219i al mucoaselor.
Clinic, se poate identifica edem la nivelul extremit\u0103\u021bilor (membre, facial, OGE), atacuri abdominale acute \u0219i manifest\u0103ri respiratorii cu dificultate la \u00eenghi\u021bit, respirat, amenin\u021batoare de via\u021b\u0103 ce necesit\u0103 intuba\u021bie orotraheal\u0103.
Diagnosticul clinic necesit\u0103 o anamnez\u0103 familial\u0103 \u0219i personal\u0103 am\u0103nun\u021bit\u0103, teste serologice pentru determinare C1INH \u0219i C4 \u0219i test genetic F-XII.
Terapeutic, AEE nu r\u0103spunde la antihistaminice, corticoterapie sistemic\u0219 sau adrenalin\u0103. AEE r\u0103spunde la concentrate C1INH, C1INH recombinant, blocant al receptorului de bradikinin\u0103 \u0219i blocan\u021bi de kalicrein\u0103, deorece este un angiodem mediat de bradikinin\u0103 \u0219i nu de histamin\u0103.<\/p>\n
Hereditery angioedema \u201cHAE\u201d \u2013 a medical challenge<\/span> Heredetery angioedema is a rare genetic condition caused by mutation in the SERPING 1 gene.This condition is inherited in an autosomal dominant pattern. HAE is a disorder characterized by recurrent episodes of severe swelling \u2013 angioedema under the skin and lining of the gut and lung. Minor trauma or stress may trigger an attack. 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Author: Gabriela Ungureanu <\/span><\/p>\n
The most commons areas of the body to develop swelling are the limbs, face, intestinal tract and airway. Itchiness does not tipically. If the intestinal truct is affected occur abdominal pain and vomiting, nausea and diarrhea. Swelling in the airway constrict breathing and lead to life threatening obstruction of the airway, and could be deadly. Simptomps of HAE typically begin in childhood and worsen during the puberty.
Mutation in the SERPING 1 induse HAE Type I \u2013 lead to reduced levels of C1Inhibitor in the blood, while Type II result in the normal production of C1Inhibitor that function is abnormally. Mutation in the F XII gene are associated with some case of HAE Type III. This mutation result in the production of F XII with increased activity. As a result, more bradykinine is generated, and blood vessel becomes more leaky, wich leads to sudden episodes of swelling.
Treatement :
\u2022 antihistamines and corticosteroid that treat allergies don\u2019t work well for this disease.
\u2022 treat or prevent attack with: – BERINERT, CINRYZE \u2013 C1 esteraze inhibitor;
– RUCONEST \u2013 conestalalfa recombined;
– FIRAZYR \u2013 icatibant \u2013 bradikynin receptor blocker;
– KALBITOR \u2013 ecallantinde \u2013 kalicrein blocker;
– TAKHZYRO – lanadelumab.<\/p>\n
2014 – Prezent – Manager clinica \u201dNew Medical\u201d Bac\u0103u \u2013 Clinica alergologie\u2013imunologie clinic\u0103
2004 – Prezent \u2013 Coordonator compartiment alergologie\u2013imunologie clinic\u0103, Sec\u021bia dermato\u2013venerice , Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u
2019 – Specialist dermato\u2013venerice
2009 – Medic primar alergologie imunologie clinic\u0103
2004 – Medic specialist alergologie imunologie clinic\u0103
1999 – 2004 – Rezident alergologie imunologie clinic\u0103 Spital Clinic \u201cNicolae Malaxa\u201d Bucure\u0219ti, U.M.F. \u201cCarol Davila\u201d
1996 – 1999 \u2013 Serviciu de Ambulan\u021b\u0103 Jude\u021bean Bac\u0103u
1990 – 1996 \u2013 U.M.F. \u201cGrigore T. Popa\u201c Ia\u0219i \u2013 Medic Generalist<\/p>\n
Membru Societatea Rom\u00e2n\u0103 Dermatologie
Membru Societatea Rom\u00e2n\u0103 de Alergologie Imunologie Clinic\u0103
Membru Academia European\u0103 de Alergologie Imunologie Clinic\u0103
Membru Asocia\u021bia Dermatologilor din Moldova<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n