<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nConf. Univ. Dr. Onofrei Viviana<\/span><\/strong>
\nUniversitatea de Medicin\u0103 \u0219i Farmacie \u201dGrigore T. Popa\u201d, Ia\u0219i
\nSpitalul Jude\u021bean Clinic de Urgen\u021be, Sec\u021bia Cardiologie, Ia\u0219i, Rom\u00e2nia<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.7″ hover_enabled=”0″]<\/p>\n
Manifest\u0103ri cardiovasculare \u00een lupusul eritematos sistemic: actualizare critic\u0103<\/span>
Autor: Viviana Onofrei<\/span><\/p>\nIntroducere: Acest subiect interdisciplinar este de actualitate av\u00e2nd \u00een vedere morbi-mortalitatea semnificativ\u0103 prin boli CV \u00een LES. \u00cen\u021belegerea patogenezei evenimentelor CV este foarte important\u0103, dar problema este incomplet elucidat\u0103.
Material \u0219i metod\u0103: Pornind de la revizuirea sistematic\u0103 a literaturii recente \u0219i experien\u021ba noastr\u0103 clinic\u0103, expunerea subliniaz\u0103 aspecte noi legate de fiziopatologie, noi biomarkeri moleculari, rolul metodelor imagistice de evaluare a aterosclerozei, tratamente poten\u021biale pentru bolile CV \u00een LES.
Rezultate: Bolile CV au inciden\u021b\u0103 propor\u021bional crescut\u0103 \u00een LES comparativ cu popula\u021bia general\u0103, tind s\u0103 fie clinic silen\u021bioase pentru o perioad\u0103 lung\u0103 de timp, dar sunt poten\u021bial fatale. Exist\u0103 multiple rezultate contradictorii referitoare la factorii de risc \u00een LES. Al\u021bi factori lega\u021bi de boal\u0103 ca injuria endotelial\u0103, inflama\u021bia cronic\u0103, adaptarea r\u0103spunsului imun, efectul protector\/nociv al diferitelor tipuri de medica\u021bie, ar putea fi mai importan\u021bi dec\u00e2t factorii conven\u021bionali de risc pentru ateroscleroz\u0103. Date recente demonstreaz\u0103 c\u0103 injuria tisular\u0103 este mai degrab\u0103 cauza complica\u021biilor CV dec\u00e2t inflama\u021bia. Este incomplet cunoscut dac\u0103 LES posed\u0103 un risc general crescut de boli CV sau bolile CV reprezint\u0103 un fenotip \u00eent\u00e2lnit la anumite subgrupuri de pacien\u021bi.
Concluzii: LES are o patogenez\u0103 multifactorial\u0103 \u0219i o rela\u021bie intricat\u0103 cu bolile CV. Nivelul actual al cercet\u0103rii fundamentale este incomplet. Este o nevoie stringent\u0103 de studii prospective care s\u0103 transpun\u0103 informa\u021biile \u00een modalit\u0103\u021bi eficiente de abordare terapeutic\u0103.<\/p>\n
Cardiovascular manifestations in systemic lupus erythematosus: a critical up-date<\/span>
Author: Viviana Onofrei<\/span><\/p>\nIntroduction: This interdisciplinary topic is up to date because of the significant morbi-mortality related to the CV involvement in SLE. Understanding the pathogenesis of CV events is very important but it is incompletely understood.
Material and method: Based on the systematic review of recent literature and our clinical experience, the topic highlights the modern aspects on the physiopathology, new molecular biomarkers, imaging methods of atherosclerosis assessment, and the potential treatments of CV disease in SLE.
Results: CV disease have a proportionally higher incidence in SLE compared to general populations, tend to be clinically silent for long periods, but are potentially fatal. There are several conflicting results regarding lupus-related risk factors. Other disease-related factors may be more important than conventional atherosclerotic risk factors, namely, the endothelial damage, chronic inflammation, adaptive immune responses and the protective\/harmful effect of several drugs. There are also recent findings which argue that tissue injury rather than inflammation may be the cause of CV complications in SLE. It is incompletely defined whether SLE have a general elevated risk of CV disease or CV disease is a phenotype occurring in some subgroups of patients.
Conclusions: SLE has a multifactorial pathogenesis and an intricate relationship with CV disease. The current state of fundamental research remains incomplete. There is a great need for prospective studies to translate the information into effective approaches of treatment.<\/p>\n
Scurt CV<\/span><\/p>\nAbsolvent\u0103 a Facult\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie \u201dGrigore T. Popa\u201d Ia\u015fi, promo\u021bia 1991<\/p>\n
Experien\u0163a profesional\u0103:<\/strong>
Conferen\u021biar universitar, Disciplina Medicin\u0103 Intern\u0103 (Cardiologie), Facultatea de Medicin\u0103, U.M.F. \u201cGrigore T. Popa\u201d Ia\u0219i
Activitate didactic\u0103 curicular\u0103 \u0219i extracuricular\u0103 continu\u0103 din 1996
Medic primar cardiologie \u0219i medicin\u0103 intern\u0103 la Clinica de Cardiologie, USTACC, Spitalul Jude\u021bean Clinic de Urgen\u021be \u201cSf. Spiridon\u201d Ia\u0219i
Doctor \u00een \u0219tiin\u021be medicale, teza de doctorat \u201dDisfunc\u021bia endotelial\u0103 \u00een hipertensiunea arterial\u0103\u201d, 2006
Competen\u021be \u00een Ecocardiografie General\u0103 \u0219i Ultrasonografie General\u0103
Masterat “Bazele nutri\u0163iei clinice”, 2011<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
Membr\u0103 \u00een Societatea Rom\u00e2n\u0103 de Cardiologie
Membr\u0103 \u00een Societatea European\u0103 de Cardiologie
Membr\u0103 \u00een Societatea European\u0103 de Hipertensiune
Membr\u0103 \u00een American Heart Association\/American College of Cardiology)<\/p>\nDistinc\u021bii:<\/strong>
European Hypertension Specialist
Diplom\u0103 de excelen\u021b\u0103 din partea Societ\u0103\u021bii Rom\u00e2ne de Hipertensiune
Fellow of European Society of Cardiology<\/p>\nDomenii de interes \u015ftiin\u0163ific:<\/strong>
Afectarea cardiovascular\u0103 \u00een patologia medical\u0103, hipertensiunea arterial\u0103, disfunc\u0163ia endotelial\u0103 \u015fi rigiditatea arterial\u0103, insuficien\u0163a cardiac\u0103, bolile vasculare, boli metabolice.
Implicare activ\u0103 \u00een activitatea de cercetare \u0219tiin\u021bific\u0103 (granturi de cercetare \u0219tiin\u021bific\u0103, coinvestigator \u00een studii clinice multicentrice interna\u021bionale, colaborator \u00een registre na\u021bionale \u0219i europene de specialitate)
Metode de investiga\u0163ie sau tratament originale introduse \u00een premier\u0103 na\u021bional\u0103 (studiul comparativ \u015fi integrat al disfunc\u0163iei endoteliale \u00een hipertensiunea arterial\u0103 prin metoda Complior \u015fi ecografie vascular\u0103 (2001), tromboliza ghidat\u0103 pe cateter \u00een trombozele venoase profunde (echipa Prof. Dr. Datcu \u2013 2004)
Editor de c\u0103r\u021bi de specialitate cu colectiv na\u021bional, manuale, peste 100 lucr\u0103ri \u0219tiin\u021bifice \u00een reviste ISI \u0219i BDI<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
![\"\"](\"https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ. Dr. Onofrei Viviana Universitatea de Medicin\u0103 \u0219i Farmacie \u201dGrigore T. Popa\u201d, Ia\u0219i Spitalul Jude\u021bean Clinic de Urgen\u021be, Sec\u021bia Cardiologie, Ia\u0219i, Rom\u00e2niaManifest\u0103ri cardiovasculare \u00een lupusul eritematos sistemic: actualizare critic\u0103 Autor: Viviana Onofrei Introducere: Acest subiect interdisciplinar este de actualitate av\u00e2nd \u00een vedere morbi-mortalitatea semnificativ\u0103 prin boli CV \u00een LES. \u00cen\u021belegerea patogenezei evenimentelor CV este […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8086","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=8086"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8086\/revisions"}],"predecessor-version":[{"id":8224,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8086\/revisions\/8224"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=8086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Conf. Univ. Dr. Onofrei Viviana<\/span><\/strong>
\nUniversitatea de Medicin\u0103 \u0219i Farmacie \u201dGrigore T. Popa\u201d, Ia\u0219i
\nSpitalul Jude\u021bean Clinic de Urgen\u021be, Sec\u021bia Cardiologie, Ia\u0219i, Rom\u00e2nia<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.7″ hover_enabled=”0″]<\/p>\n
Manifest\u0103ri cardiovasculare \u00een lupusul eritematos sistemic: actualizare critic\u0103<\/span>
Autor: Viviana Onofrei<\/span><\/p>\nIntroducere: Acest subiect interdisciplinar este de actualitate av\u00e2nd \u00een vedere morbi-mortalitatea semnificativ\u0103 prin boli CV \u00een LES. \u00cen\u021belegerea patogenezei evenimentelor CV este foarte important\u0103, dar problema este incomplet elucidat\u0103.
Material \u0219i metod\u0103: Pornind de la revizuirea sistematic\u0103 a literaturii recente \u0219i experien\u021ba noastr\u0103 clinic\u0103, expunerea subliniaz\u0103 aspecte noi legate de fiziopatologie, noi biomarkeri moleculari, rolul metodelor imagistice de evaluare a aterosclerozei, tratamente poten\u021biale pentru bolile CV \u00een LES.
Rezultate: Bolile CV au inciden\u021b\u0103 propor\u021bional crescut\u0103 \u00een LES comparativ cu popula\u021bia general\u0103, tind s\u0103 fie clinic silen\u021bioase pentru o perioad\u0103 lung\u0103 de timp, dar sunt poten\u021bial fatale. Exist\u0103 multiple rezultate contradictorii referitoare la factorii de risc \u00een LES. Al\u021bi factori lega\u021bi de boal\u0103 ca injuria endotelial\u0103, inflama\u021bia cronic\u0103, adaptarea r\u0103spunsului imun, efectul protector\/nociv al diferitelor tipuri de medica\u021bie, ar putea fi mai importan\u021bi dec\u00e2t factorii conven\u021bionali de risc pentru ateroscleroz\u0103. Date recente demonstreaz\u0103 c\u0103 injuria tisular\u0103 este mai degrab\u0103 cauza complica\u021biilor CV dec\u00e2t inflama\u021bia. Este incomplet cunoscut dac\u0103 LES posed\u0103 un risc general crescut de boli CV sau bolile CV reprezint\u0103 un fenotip \u00eent\u00e2lnit la anumite subgrupuri de pacien\u021bi.
Concluzii: LES are o patogenez\u0103 multifactorial\u0103 \u0219i o rela\u021bie intricat\u0103 cu bolile CV. Nivelul actual al cercet\u0103rii fundamentale este incomplet. Este o nevoie stringent\u0103 de studii prospective care s\u0103 transpun\u0103 informa\u021biile \u00een modalit\u0103\u021bi eficiente de abordare terapeutic\u0103.<\/p>\n
Cardiovascular manifestations in systemic lupus erythematosus: a critical up-date<\/span>
Author: Viviana Onofrei<\/span><\/p>\nIntroduction: This interdisciplinary topic is up to date because of the significant morbi-mortality related to the CV involvement in SLE. Understanding the pathogenesis of CV events is very important but it is incompletely understood.
Material and method: Based on the systematic review of recent literature and our clinical experience, the topic highlights the modern aspects on the physiopathology, new molecular biomarkers, imaging methods of atherosclerosis assessment, and the potential treatments of CV disease in SLE.
Results: CV disease have a proportionally higher incidence in SLE compared to general populations, tend to be clinically silent for long periods, but are potentially fatal. There are several conflicting results regarding lupus-related risk factors. Other disease-related factors may be more important than conventional atherosclerotic risk factors, namely, the endothelial damage, chronic inflammation, adaptive immune responses and the protective\/harmful effect of several drugs. There are also recent findings which argue that tissue injury rather than inflammation may be the cause of CV complications in SLE. It is incompletely defined whether SLE have a general elevated risk of CV disease or CV disease is a phenotype occurring in some subgroups of patients.
Conclusions: SLE has a multifactorial pathogenesis and an intricate relationship with CV disease. The current state of fundamental research remains incomplete. There is a great need for prospective studies to translate the information into effective approaches of treatment.<\/p>\n
Scurt CV<\/span><\/p>\nAbsolvent\u0103 a Facult\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie \u201dGrigore T. Popa\u201d Ia\u015fi, promo\u021bia 1991<\/p>\n
Experien\u0163a profesional\u0103:<\/strong>
Conferen\u021biar universitar, Disciplina Medicin\u0103 Intern\u0103 (Cardiologie), Facultatea de Medicin\u0103, U.M.F. \u201cGrigore T. Popa\u201d Ia\u0219i
Activitate didactic\u0103 curicular\u0103 \u0219i extracuricular\u0103 continu\u0103 din 1996
Medic primar cardiologie \u0219i medicin\u0103 intern\u0103 la Clinica de Cardiologie, USTACC, Spitalul Jude\u021bean Clinic de Urgen\u021be \u201cSf. Spiridon\u201d Ia\u0219i
Doctor \u00een \u0219tiin\u021be medicale, teza de doctorat \u201dDisfunc\u021bia endotelial\u0103 \u00een hipertensiunea arterial\u0103\u201d, 2006
Competen\u021be \u00een Ecocardiografie General\u0103 \u0219i Ultrasonografie General\u0103
Masterat “Bazele nutri\u0163iei clinice”, 2011<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
Membr\u0103 \u00een Societatea Rom\u00e2n\u0103 de Cardiologie
Membr\u0103 \u00een Societatea European\u0103 de Cardiologie
Membr\u0103 \u00een Societatea European\u0103 de Hipertensiune
Membr\u0103 \u00een American Heart Association\/American College of Cardiology)<\/p>\nDistinc\u021bii:<\/strong>
European Hypertension Specialist
Diplom\u0103 de excelen\u021b\u0103 din partea Societ\u0103\u021bii Rom\u00e2ne de Hipertensiune
Fellow of European Society of Cardiology<\/p>\nDomenii de interes \u015ftiin\u0163ific:<\/strong>
Afectarea cardiovascular\u0103 \u00een patologia medical\u0103, hipertensiunea arterial\u0103, disfunc\u0163ia endotelial\u0103 \u015fi rigiditatea arterial\u0103, insuficien\u0163a cardiac\u0103, bolile vasculare, boli metabolice.
Implicare activ\u0103 \u00een activitatea de cercetare \u0219tiin\u021bific\u0103 (granturi de cercetare \u0219tiin\u021bific\u0103, coinvestigator \u00een studii clinice multicentrice interna\u021bionale, colaborator \u00een registre na\u021bionale \u0219i europene de specialitate)
Metode de investiga\u0163ie sau tratament originale introduse \u00een premier\u0103 na\u021bional\u0103 (studiul comparativ \u015fi integrat al disfunc\u0163iei endoteliale \u00een hipertensiunea arterial\u0103 prin metoda Complior \u015fi ecografie vascular\u0103 (2001), tromboliza ghidat\u0103 pe cateter \u00een trombozele venoase profunde (echipa Prof. Dr. Datcu \u2013 2004)
Editor de c\u0103r\u021bi de specialitate cu colectiv na\u021bional, manuale, peste 100 lucr\u0103ri \u0219tiin\u021bifice \u00een reviste ISI \u0219i BDI<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2020<\/p>\n
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Operatorul PDI 2020<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ. Dr. Onofrei Viviana Universitatea de Medicin\u0103 \u0219i Farmacie \u201dGrigore T. Popa\u201d, Ia\u0219i Spitalul Jude\u021bean Clinic de Urgen\u021be, Sec\u021bia Cardiologie, Ia\u0219i, Rom\u00e2niaManifest\u0103ri cardiovasculare \u00een lupusul eritematos sistemic: actualizare critic\u0103 Autor: Viviana Onofrei Introducere: Acest subiect interdisciplinar este de actualitate av\u00e2nd \u00een vedere morbi-mortalitatea semnificativ\u0103 prin boli CV \u00een LES. \u00cen\u021belegerea patogenezei evenimentelor CV este […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8086","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=8086"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8086\/revisions"}],"predecessor-version":[{"id":8224,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8086\/revisions\/8224"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=8086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Viviana Onofrei<\/span><\/p>\n
Introducere: Acest subiect interdisciplinar este de actualitate av\u00e2nd \u00een vedere morbi-mortalitatea semnificativ\u0103 prin boli CV \u00een LES. \u00cen\u021belegerea patogenezei evenimentelor CV este foarte important\u0103, dar problema este incomplet elucidat\u0103.
Material \u0219i metod\u0103: Pornind de la revizuirea sistematic\u0103 a literaturii recente \u0219i experien\u021ba noastr\u0103 clinic\u0103, expunerea subliniaz\u0103 aspecte noi legate de fiziopatologie, noi biomarkeri moleculari, rolul metodelor imagistice de evaluare a aterosclerozei, tratamente poten\u021biale pentru bolile CV \u00een LES.
Rezultate: Bolile CV au inciden\u021b\u0103 propor\u021bional crescut\u0103 \u00een LES comparativ cu popula\u021bia general\u0103, tind s\u0103 fie clinic silen\u021bioase pentru o perioad\u0103 lung\u0103 de timp, dar sunt poten\u021bial fatale. Exist\u0103 multiple rezultate contradictorii referitoare la factorii de risc \u00een LES. Al\u021bi factori lega\u021bi de boal\u0103 ca injuria endotelial\u0103, inflama\u021bia cronic\u0103, adaptarea r\u0103spunsului imun, efectul protector\/nociv al diferitelor tipuri de medica\u021bie, ar putea fi mai importan\u021bi dec\u00e2t factorii conven\u021bionali de risc pentru ateroscleroz\u0103. Date recente demonstreaz\u0103 c\u0103 injuria tisular\u0103 este mai degrab\u0103 cauza complica\u021biilor CV dec\u00e2t inflama\u021bia. Este incomplet cunoscut dac\u0103 LES posed\u0103 un risc general crescut de boli CV sau bolile CV reprezint\u0103 un fenotip \u00eent\u00e2lnit la anumite subgrupuri de pacien\u021bi.
Concluzii: LES are o patogenez\u0103 multifactorial\u0103 \u0219i o rela\u021bie intricat\u0103 cu bolile CV. Nivelul actual al cercet\u0103rii fundamentale este incomplet. Este o nevoie stringent\u0103 de studii prospective care s\u0103 transpun\u0103 informa\u021biile \u00een modalit\u0103\u021bi eficiente de abordare terapeutic\u0103.<\/p>\n
Cardiovascular manifestations in systemic lupus erythematosus: a critical up-date<\/span> Introduction: This interdisciplinary topic is up to date because of the significant morbi-mortality related to the CV involvement in SLE. Understanding the pathogenesis of CV events is very important but it is incompletely understood. Scurt CV<\/span><\/p>\n Absolvent\u0103 a Facult\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie \u201dGrigore T. Popa\u201d Ia\u015fi, promo\u021bia 1991<\/p>\n Experien\u0163a profesional\u0103:<\/strong> Apartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong> Distinc\u021bii:<\/strong> Domenii de interes \u015ftiin\u0163ific:<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n Contacteaz\u0103 operatorul PDI 2020<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” 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button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2020<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.0.11″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Conf. Univ. Dr. Onofrei Viviana Universitatea de Medicin\u0103 \u0219i Farmacie \u201dGrigore T. Popa\u201d, Ia\u0219i Spitalul Jude\u021bean Clinic de Urgen\u021be, Sec\u021bia Cardiologie, Ia\u0219i, Rom\u00e2niaManifest\u0103ri cardiovasculare \u00een lupusul eritematos sistemic: actualizare critic\u0103 Autor: Viviana Onofrei Introducere: Acest subiect interdisciplinar este de actualitate av\u00e2nd \u00een vedere morbi-mortalitatea semnificativ\u0103 prin boli CV \u00een LES. \u00cen\u021belegerea patogenezei evenimentelor CV este […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8086","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=8086"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8086\/revisions"}],"predecessor-version":[{"id":8224,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8086\/revisions\/8224"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=8086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Author: Viviana Onofrei<\/span><\/p>\n
Material and method: Based on the systematic review of recent literature and our clinical experience, the topic highlights the modern aspects on the physiopathology, new molecular biomarkers, imaging methods of atherosclerosis assessment, and the potential treatments of CV disease in SLE.
Results: CV disease have a proportionally higher incidence in SLE compared to general populations, tend to be clinically silent for long periods, but are potentially fatal. There are several conflicting results regarding lupus-related risk factors. Other disease-related factors may be more important than conventional atherosclerotic risk factors, namely, the endothelial damage, chronic inflammation, adaptive immune responses and the protective\/harmful effect of several drugs. There are also recent findings which argue that tissue injury rather than inflammation may be the cause of CV complications in SLE. It is incompletely defined whether SLE have a general elevated risk of CV disease or CV disease is a phenotype occurring in some subgroups of patients.
Conclusions: SLE has a multifactorial pathogenesis and an intricate relationship with CV disease. The current state of fundamental research remains incomplete. There is a great need for prospective studies to translate the information into effective approaches of treatment.<\/p>\n
Conferen\u021biar universitar, Disciplina Medicin\u0103 Intern\u0103 (Cardiologie), Facultatea de Medicin\u0103, U.M.F. \u201cGrigore T. Popa\u201d Ia\u0219i
Activitate didactic\u0103 curicular\u0103 \u0219i extracuricular\u0103 continu\u0103 din 1996
Medic primar cardiologie \u0219i medicin\u0103 intern\u0103 la Clinica de Cardiologie, USTACC, Spitalul Jude\u021bean Clinic de Urgen\u021be \u201cSf. Spiridon\u201d Ia\u0219i
Doctor \u00een \u0219tiin\u021be medicale, teza de doctorat \u201dDisfunc\u021bia endotelial\u0103 \u00een hipertensiunea arterial\u0103\u201d, 2006
Competen\u021be \u00een Ecocardiografie General\u0103 \u0219i Ultrasonografie General\u0103
Masterat “Bazele nutri\u0163iei clinice”, 2011<\/p>\n
Membr\u0103 \u00een Societatea Rom\u00e2n\u0103 de Cardiologie
Membr\u0103 \u00een Societatea European\u0103 de Cardiologie
Membr\u0103 \u00een Societatea European\u0103 de Hipertensiune
Membr\u0103 \u00een American Heart Association\/American College of Cardiology)<\/p>\n
European Hypertension Specialist
Diplom\u0103 de excelen\u021b\u0103 din partea Societ\u0103\u021bii Rom\u00e2ne de Hipertensiune
Fellow of European Society of Cardiology<\/p>\n
Afectarea cardiovascular\u0103 \u00een patologia medical\u0103, hipertensiunea arterial\u0103, disfunc\u0163ia endotelial\u0103 \u015fi rigiditatea arterial\u0103, insuficien\u0163a cardiac\u0103, bolile vasculare, boli metabolice.
Implicare activ\u0103 \u00een activitatea de cercetare \u0219tiin\u021bific\u0103 (granturi de cercetare \u0219tiin\u021bific\u0103, coinvestigator \u00een studii clinice multicentrice interna\u021bionale, colaborator \u00een registre na\u021bionale \u0219i europene de specialitate)
Metode de investiga\u0163ie sau tratament originale introduse \u00een premier\u0103 na\u021bional\u0103 (studiul comparativ \u015fi integrat al disfunc\u0163iei endoteliale \u00een hipertensiunea arterial\u0103 prin metoda Complior \u015fi ecografie vascular\u0103 (2001), tromboliza ghidat\u0103 pe cateter \u00een trombozele venoase profunde (echipa Prof. Dr. Datcu \u2013 2004)
Editor de c\u0103r\u021bi de specialitate cu colectiv na\u021bional, manuale, peste 100 lucr\u0103ri \u0219tiin\u021bifice \u00een reviste ISI \u0219i BDI<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n