<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nC.\u0218. gr. I Dr. Benea Vasile<\/span><\/strong>
\nSpitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.8″]<\/p>\n
Actualit\u0103\u0163i terapeutice \u00een angioedemul ereditar<\/span>
Autor: Vasile Benea<\/span><\/p>\nAngioedemul ereditar (HAE) este o afec\u0163iune rar\u0103, transmis\u0103 autozomal dominant, determinat\u0103 de un deficit par\u0163ial de inhibitor de C1 esteraz\u0103 (C1-INH). S-au descris trei variante de HAE; \u00een timp ce tipurile I \u015fi II exist\u0103 un deficit cantitativ \u015fi\/sau func\u0163ional de C1-INH (care rezult\u0103 din muta\u0163ii heterogene la nivelul SERPING1, gena ce codific\u0103 C1-INH, localizat\u0103 \u00een regiunea cromozomiala 11q12-q13.1.), tipul III este caracterizat prin valori normale ale C1-INH \u015fi este determinat de muta\u0163ii ale genelor factorului XII, angiopoietinei-1 sau plasminogenului. Nivelul redus al C1-INH determin\u0103 o activitate local\u0103 crescut\u0103 a bradikininei care contribuie la apari\u021bia \u0219i dezvoltarea angioedemului.
Diagnosticul precoce al HAE reprezint\u0103 premiza pentru un management corect. Cele mai utilizate teste diagnostice sunt reprezentate de dozarea complementului, inclusiv a frac\u021biunii C4 \u015fi a C1-INH (func\u021bional \u0219i cantitativ).
Tratamentul HAE const\u0103 \u00een profilaxia pe termen scurt \u015fi \u00eendelungat \u015fi \u00een managementul episoadelor acute. Este important\u0103 evitarea factorilor declan\u015fatori. Baza profilaxiei a fost reprezentat\u0103 de terapia cu androgeni atenua\u0163i (danazolul, stanozololul); agen\u0163ii antifibrinolitici (acidul tranexamic \u015fi acidul epsilon-aminocaproic) sunt terapii alternative. Recent FDA a aprobat C1-INH pentru profilaxia HAE. Ca profilaxie pe termen scurt \u00eenainte de interven\u0163iile chirurgicale se poate administra concentrat de C1-INH sau danazol. Tratamentul de elec\u0163ie \u00een cazul atacurilor acute este reprezentat de concentratul de C1-INH. Sunt disponibile \u015fi un C1-INH recombinant \u015fi un derivat nanofiltrat din plasm\u0103. Icatibant (un inhibitor al receptorului BK-2), ecalantid \u0219i lanadelumab (inhibitori ai kalicreinei) au fost de cur\u00e2nd aproba\u021bi pentru tratamentul HAE.<\/p>\n
Hereditary angioedema: an update<\/span>
Author: Vasile Benea<\/span><\/p>\nHereditary angioedema (HAE) is a rare autosomal dominant disorder caused by partial deficiency of C1 esterase inhibitor (C1-INH). Three variants of HAE have been described; whereas types I and II are characterized by quantitative and\/or functional C1-INH (that result from heterogeneous mutations in SERPING1, the C1-INH gene located in the chromosomal region 11q12\u2013q13.1.), type III is characterized by normal complement levels and may be caused by mutations in the factor XII gene, in the angiopoietin-1 gene or in the plasminogen gene. Low C1-INH concentration results in increased bradykinin local activity which contributes to angioedema.
Early diagnosis of HAE is an absolute prerequisite for correct management. Complement studies, including C4 and C1- INH (both antigenic and functional) are the most commonly used tests in the diagnosis of HAE.
Treatment of hereditary angioedema consists of the short and long-term prophylaxis and the management of acute episodes. Avoidance of triggers is important. The mainstay of prophylaxis has been attenuated androgen therapy (such as danazol and stanozolol); antifibrinolytic agents, such as tranexamic acid and epsilon-aminocaproic acid, are alternative therapies. Recently, a Cl-INH was approved by the FDA for HAE prophylaxis. As short-term prophylaxis before surgical procedures, C1-INH concentrate or danazol can be administered before the procedure. Plasma-derived C1-INH concentrate represents the drug of choice in the acute attacks. A recombinant C1-INH and a plasma-derived nanofiltered C1-INH are available. Icatibant, a BK-2 receptor inhibitor; ecallantide and lanadelumab, kallikrein inhibitors have recently been licensed for the treatment of acute HAE attacks.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103:<\/strong>
Perioada:
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, \u015eoseaua Mihai Bravu 281, sector 3, 030303 Bucure\u015fti
Educa\u0163ie \u015fi formare:<\/strong>
Perioada:
Calificarea \/ diploma ob\u0163inut\u0103:
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
![\"\"](\"https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
[\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.0.11″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
C.\u0218. gr. I Dr. Benea Vasile Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015ftiActualit\u0103\u0163i terapeutice \u00een angioedemul ereditar Autor: Vasile Benea Angioedemul ereditar (HAE) este o afec\u0163iune rar\u0103, transmis\u0103 autozomal dominant, determinat\u0103 de un deficit par\u0163ial de inhibitor de C1 esteraz\u0103 (C1-INH). S-au descris trei variante de HAE; \u00een timp ce tipurile I […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8447","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=8447"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8447\/revisions"}],"predecessor-version":[{"id":8455,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8447\/revisions\/8455"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=8447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
C.\u0218. gr. I Dr. Benea Vasile<\/span><\/strong>
\nSpitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.8″]<\/p>\n
Actualit\u0103\u0163i terapeutice \u00een angioedemul ereditar<\/span>
Autor: Vasile Benea<\/span><\/p>\nAngioedemul ereditar (HAE) este o afec\u0163iune rar\u0103, transmis\u0103 autozomal dominant, determinat\u0103 de un deficit par\u0163ial de inhibitor de C1 esteraz\u0103 (C1-INH). S-au descris trei variante de HAE; \u00een timp ce tipurile I \u015fi II exist\u0103 un deficit cantitativ \u015fi\/sau func\u0163ional de C1-INH (care rezult\u0103 din muta\u0163ii heterogene la nivelul SERPING1, gena ce codific\u0103 C1-INH, localizat\u0103 \u00een regiunea cromozomiala 11q12-q13.1.), tipul III este caracterizat prin valori normale ale C1-INH \u015fi este determinat de muta\u0163ii ale genelor factorului XII, angiopoietinei-1 sau plasminogenului. Nivelul redus al C1-INH determin\u0103 o activitate local\u0103 crescut\u0103 a bradikininei care contribuie la apari\u021bia \u0219i dezvoltarea angioedemului.
Diagnosticul precoce al HAE reprezint\u0103 premiza pentru un management corect. Cele mai utilizate teste diagnostice sunt reprezentate de dozarea complementului, inclusiv a frac\u021biunii C4 \u015fi a C1-INH (func\u021bional \u0219i cantitativ).
Tratamentul HAE const\u0103 \u00een profilaxia pe termen scurt \u015fi \u00eendelungat \u015fi \u00een managementul episoadelor acute. Este important\u0103 evitarea factorilor declan\u015fatori. Baza profilaxiei a fost reprezentat\u0103 de terapia cu androgeni atenua\u0163i (danazolul, stanozololul); agen\u0163ii antifibrinolitici (acidul tranexamic \u015fi acidul epsilon-aminocaproic) sunt terapii alternative. Recent FDA a aprobat C1-INH pentru profilaxia HAE. Ca profilaxie pe termen scurt \u00eenainte de interven\u0163iile chirurgicale se poate administra concentrat de C1-INH sau danazol. Tratamentul de elec\u0163ie \u00een cazul atacurilor acute este reprezentat de concentratul de C1-INH. Sunt disponibile \u015fi un C1-INH recombinant \u015fi un derivat nanofiltrat din plasm\u0103. Icatibant (un inhibitor al receptorului BK-2), ecalantid \u0219i lanadelumab (inhibitori ai kalicreinei) au fost de cur\u00e2nd aproba\u021bi pentru tratamentul HAE.<\/p>\n
Hereditary angioedema: an update<\/span>
Author: Vasile Benea<\/span><\/p>\nHereditary angioedema (HAE) is a rare autosomal dominant disorder caused by partial deficiency of C1 esterase inhibitor (C1-INH). Three variants of HAE have been described; whereas types I and II are characterized by quantitative and\/or functional C1-INH (that result from heterogeneous mutations in SERPING1, the C1-INH gene located in the chromosomal region 11q12\u2013q13.1.), type III is characterized by normal complement levels and may be caused by mutations in the factor XII gene, in the angiopoietin-1 gene or in the plasminogen gene. Low C1-INH concentration results in increased bradykinin local activity which contributes to angioedema.
Early diagnosis of HAE is an absolute prerequisite for correct management. Complement studies, including C4 and C1- INH (both antigenic and functional) are the most commonly used tests in the diagnosis of HAE.
Treatment of hereditary angioedema consists of the short and long-term prophylaxis and the management of acute episodes. Avoidance of triggers is important. The mainstay of prophylaxis has been attenuated androgen therapy (such as danazol and stanozolol); antifibrinolytic agents, such as tranexamic acid and epsilon-aminocaproic acid, are alternative therapies. Recently, a Cl-INH was approved by the FDA for HAE prophylaxis. As short-term prophylaxis before surgical procedures, C1-INH concentrate or danazol can be administered before the procedure. Plasma-derived C1-INH concentrate represents the drug of choice in the acute attacks. A recombinant C1-INH and a plasma-derived nanofiltered C1-INH are available. Icatibant, a BK-2 receptor inhibitor; ecallantide and lanadelumab, kallikrein inhibitors have recently been licensed for the treatment of acute HAE attacks.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103:<\/strong>
Perioada:
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, \u015eoseaua Mihai Bravu 281, sector 3, 030303 Bucure\u015fti
Educa\u0163ie \u015fi formare:<\/strong>
Perioada:
Calificarea \/ diploma ob\u0163inut\u0103:
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2020<\/p>\n
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Operatorul PDI 2020<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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C.\u0218. gr. I Dr. Benea Vasile Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015ftiActualit\u0103\u0163i terapeutice \u00een angioedemul ereditar Autor: Vasile Benea Angioedemul ereditar (HAE) este o afec\u0163iune rar\u0103, transmis\u0103 autozomal dominant, determinat\u0103 de un deficit par\u0163ial de inhibitor de C1 esteraz\u0103 (C1-INH). S-au descris trei variante de HAE; \u00een timp ce tipurile I […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8447","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=8447"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8447\/revisions"}],"predecessor-version":[{"id":8455,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8447\/revisions\/8455"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=8447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Vasile Benea<\/span><\/p>\n
Angioedemul ereditar (HAE) este o afec\u0163iune rar\u0103, transmis\u0103 autozomal dominant, determinat\u0103 de un deficit par\u0163ial de inhibitor de C1 esteraz\u0103 (C1-INH). S-au descris trei variante de HAE; \u00een timp ce tipurile I \u015fi II exist\u0103 un deficit cantitativ \u015fi\/sau func\u0163ional de C1-INH (care rezult\u0103 din muta\u0163ii heterogene la nivelul SERPING1, gena ce codific\u0103 C1-INH, localizat\u0103 \u00een regiunea cromozomiala 11q12-q13.1.), tipul III este caracterizat prin valori normale ale C1-INH \u015fi este determinat de muta\u0163ii ale genelor factorului XII, angiopoietinei-1 sau plasminogenului. Nivelul redus al C1-INH determin\u0103 o activitate local\u0103 crescut\u0103 a bradikininei care contribuie la apari\u021bia \u0219i dezvoltarea angioedemului.
Diagnosticul precoce al HAE reprezint\u0103 premiza pentru un management corect. Cele mai utilizate teste diagnostice sunt reprezentate de dozarea complementului, inclusiv a frac\u021biunii C4 \u015fi a C1-INH (func\u021bional \u0219i cantitativ).
Tratamentul HAE const\u0103 \u00een profilaxia pe termen scurt \u015fi \u00eendelungat \u015fi \u00een managementul episoadelor acute. Este important\u0103 evitarea factorilor declan\u015fatori. Baza profilaxiei a fost reprezentat\u0103 de terapia cu androgeni atenua\u0163i (danazolul, stanozololul); agen\u0163ii antifibrinolitici (acidul tranexamic \u015fi acidul epsilon-aminocaproic) sunt terapii alternative. Recent FDA a aprobat C1-INH pentru profilaxia HAE. Ca profilaxie pe termen scurt \u00eenainte de interven\u0163iile chirurgicale se poate administra concentrat de C1-INH sau danazol. Tratamentul de elec\u0163ie \u00een cazul atacurilor acute este reprezentat de concentratul de C1-INH. Sunt disponibile \u015fi un C1-INH recombinant \u015fi un derivat nanofiltrat din plasm\u0103. Icatibant (un inhibitor al receptorului BK-2), ecalantid \u0219i lanadelumab (inhibitori ai kalicreinei) au fost de cur\u00e2nd aproba\u021bi pentru tratamentul HAE.<\/p>\n
Hereditary angioedema: an update<\/span> Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by partial deficiency of C1 esterase inhibitor (C1-INH). Three variants of HAE have been described; whereas types I and II are characterized by quantitative and\/or functional C1-INH (that result from heterogeneous mutations in SERPING1, the C1-INH gene located in the chromosomal region 11q12\u2013q13.1.), type III is characterized by normal complement levels and may be caused by mutations in the factor XII gene, in the angiopoietin-1 gene or in the plasminogen gene. Low C1-INH concentration results in increased bradykinin local activity which contributes to angioedema. Scurt CV<\/span><\/p>\n Experien\u0163a profesional\u0103:<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n Contacteaz\u0103 operatorul PDI 2020<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” 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button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2020<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.0.11″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" C.\u0218. gr. I Dr. Benea Vasile Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015ftiActualit\u0103\u0163i terapeutice \u00een angioedemul ereditar Autor: Vasile Benea Angioedemul ereditar (HAE) este o afec\u0163iune rar\u0103, transmis\u0103 autozomal dominant, determinat\u0103 de un deficit par\u0163ial de inhibitor de C1 esteraz\u0103 (C1-INH). S-au descris trei variante de HAE; \u00een timp ce tipurile I […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8447","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=8447"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8447\/revisions"}],"predecessor-version":[{"id":8455,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8447\/revisions\/8455"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=8447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Author: Vasile Benea<\/span><\/p>\n
Early diagnosis of HAE is an absolute prerequisite for correct management. Complement studies, including C4 and C1- INH (both antigenic and functional) are the most commonly used tests in the diagnosis of HAE.
Treatment of hereditary angioedema consists of the short and long-term prophylaxis and the management of acute episodes. Avoidance of triggers is important. The mainstay of prophylaxis has been attenuated androgen therapy (such as danazol and stanozolol); antifibrinolytic agents, such as tranexamic acid and epsilon-aminocaproic acid, are alternative therapies. Recently, a Cl-INH was approved by the FDA for HAE prophylaxis. As short-term prophylaxis before surgical procedures, C1-INH concentrate or danazol can be administered before the procedure. Plasma-derived C1-INH concentrate represents the drug of choice in the acute attacks. A recombinant C1-INH and a plasma-derived nanofiltered C1-INH are available. Icatibant, a BK-2 receptor inhibitor; ecallantide and lanadelumab, kallikrein inhibitors have recently been licensed for the treatment of acute HAE attacks.<\/p>\n
Perioada:
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, \u015eoseaua Mihai Bravu 281, sector 3, 030303 Bucure\u015fti
Educa\u0163ie \u015fi formare:<\/strong>
Perioada:
Calificarea \/ diploma ob\u0163inut\u0103:
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n