{"id":8649,"date":"2020-07-09T09:56:44","date_gmt":"2020-07-09T07:56:44","guid":{"rendered":"https:\/\/primaderma.ro\/?page_id=8649"},"modified":"2020-07-09T09:56:44","modified_gmt":"2020-07-09T07:56:44","slug":"sef-lucr-dr-badescu-aida-corina","status":"publish","type":"page","link":"https:\/\/pdi.ro\/2020\/sef-lucr-dr-badescu-aida-corina\/","title":{"rendered":"\u015eef lucr. Dr. B\u0103descu Aida Corina"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; disabled_on=&#8221;on|off|off&#8221; _builder_version=&#8221;3.22&#8243; custom_margin=&#8221;||&#8221; custom_padding=&#8221;15px||29px&#8221; top_divider_style=&#8221;waves2&#8243; top_divider_color=&#8221;#f0622a&#8221; top_divider_flip=&#8221;horizontal|vertical&#8221; bottom_divider_style=&#8221;waves2&#8243; bottom_divider_color=&#8221;#fcdedb&#8221; bottom_divider_height=&#8221;105px&#8221; bottom_divider_flip=&#8221;vertical&#8221; collapsed=&#8221;off&#8221;][et_pb_fullwidth_header title=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@&#8221; text_orientation=&#8221;right&#8221; header_image_url=&#8221;https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/05\/pdi_iulie_online.png&#8221; disabled_on=&#8221;on|on|off&#8221; _builder_version=&#8221;4.4.7&#8243; _dynamic_attributes=&#8221;title&#8221; title_font=&#8221;Kaushan Script||||||||&#8221; title_text_align=&#8221;right&#8221; title_text_color=&#8221;#f0622a&#8221; title_font_size=&#8221;50px&#8221; content_font=&#8221;|600||on|||||&#8221; content_text_align=&#8221;center&#8221; content_text_color=&#8221;#686766&#8243; content_font_size=&#8221;15px&#8221; subhead_font=&#8221;||||||||&#8221; background_color=&#8221;rgba(239,145,107,0.54)&#8221; background_image=&#8221;https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back.jpg&#8221; background_layout=&#8221;light&#8221; custom_margin=&#8221;0px||8px&#8221; custom_padding=&#8221;40px||40px||true&#8221; content_font_size_tablet=&#8221;&#8221; content_font_size_phone=&#8221;15px&#8221; content_font_size_last_edited=&#8221;on|desktop&#8221;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;3.25&#8243; locked=&#8221;off&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/Badescu-Aida.png&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.4.8&#8243; max_width=&#8221;32%&#8221; hover_enabled=&#8221;0&#8243; border_radii=&#8221;on|100px|100px|100px|100px&#8221; title_text=&#8221;Badescu-Aida&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243;]<\/p>\n<h5><span style=\"color: #ff6600;\"><strong><\/strong><\/span><\/h5>\n<h5><span style=\"color: #ff6600;\"><strong><\/strong><\/span><\/h5>\n<h5><span style=\"color: #ff6600;\"><strong><\/strong><\/span><\/h5>\n<h5><span style=\"color: #ff6600;\"><strong><\/strong><\/span><\/h5>\n<h5><span style=\"color: #ff6600;\"><strong><\/strong><\/span><\/h5>\n<h5><span style=\"color: #ff6600;\"><strong>\u015eef lucr. Dr. B\u0103descu Aida Corina<\/strong><\/span><br \/><span style=\"color: #ff6600;\"><strong> Universitatea de Medicin\u0103 \u015fi Farmacie &#8220;Grigore T. Popa&#8221;, Ia\u015fi<\/strong><\/span><\/h5>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.25&#8243; locked=&#8221;off&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.4.8&#8243; hover_enabled=&#8221;0&#8243;]<\/p>\n<p><!--<\/p>\n\n\n\n\n<p style=\"text-align: justify;\"><span style=\"color: #ff6600;\">Efectul antitumoral al unor peptide citotoxice antimicrobiene, cu aplicabilitate \u00een neoplaziile tegumentului<\/span>\n\n\n<span style=\"color: #ff6600;\"> Autori: Magda B\u0103descu, Manuela Ciocoiu, Daniela Jitaru, B.M. Diaconescu, Maria Cristina Vl\u0103deanu, Iris Bararu-Bojan, Carmen Anton, Codru\u021ba B\u0103descu<\/span><\/p>\n\n\n\n\n<p style=\"text-align: justify;\">Introducere: Cancerul este cea mai frecvent\u0103 cauz\u0103 a mortalit\u0103\u021bii umane la nivel mondial. Terapiile anticancer, cum ar fi chimioterapia \u0219i radia\u021biile, sunt asociate cu efecte secundare severe. Multe studii au ar\u0103tat c\u0103 unele peptidele antimicrobiene prezint\u0103 un spectru larg de activitate citotoxic\u0103 \u00eempotriva celulelor canceroase.\n\n\nMaterial \u0219i metod\u0103: \u00cen acest studiu in vitro, am evaluat poten\u021bialul tumoricid al magaininei, cecropinei A \u0219i B, dermaseptinei \u0219i lycotoxinei asupra liniilor de celule tumorale: MDA-MB-231 (adenocarcinomul mamar) \u0219i M14K (mezoteliom uman) precum \u0219i asupra unei linii de keratinocite normale.\n\n\nRezultate: Am analizat efectele acestor peptide cationice asupra viabilit\u0103\u021bii, citotoxicit\u0103\u021bii \u0219i prolifer\u0103rii celulelor din liniile celulare tumorale \u0219i keratinocite. Studiul de viabilitate a fost realizat folosind anexin\u0103 \u0219i 7-AAD (7-amino-actinomicin\u0103 D), pentru detectarea \u0219i m\u0103surarea apoptozei prin tehnica citometriei \u00een flux. Peptidele utilizate de noi sunt citolitice (antimicrobiene) \u0219i pot distruge integritatea membranei cu pierderea con\u021binutului celular \u0219i moartea celulelor. Rezultatele studiului nostru au relevat faptul c\u0103 efectele citotoxice ale peptidelor, asupra celulelor tumorale, depind de concentra\u021bia lor. Eficien\u021ba lor este maxim\u0103 la concentra\u021bii de 120 \u00b5M dar persist\u0103 \u0219i la concentra\u021bii de 60 \u00b5M. Efectele au fost nesemnificative la concentra\u021bii de 30 \u00b5M.. Peptidele studiate nu au avut efect citotoxic asupra keratinocitelor normale.\n\n\nConcluzii: Intensitatea efectului tumoricid depinde at\u00e2t de natura peptidului utilizat \u015fi de concentra\u0163ia acestuia \u00een mediul de via\u0163\u0103 al celulelor, c\u00e2t \u015fi de tipul de linie celular\u0103 utilizat\u0103. Ele ar putea reprezenta o alternativ\u0103 terapeutic\u0103 asupra tumorilor maligne de piele.<\/p>\n\n\n\n\n<p><span style=\"color: #ff6600;\">Antitumoral effect of some antimicrobial cytotoxic peptides, as a novel therapy against skin cancers<\/span>\n\n\n<span style=\"color: #ff6600;\">Authors: Magda B\u0103descu, Manuela Ciocoiu, Daniela Jitaru, B.M. Diaconescu, Maria Cristina Vl\u0103deanu, Iris Bararu-Bojan, Carmen Anton, Codru\u021ba B\u0103descu<\/span><\/p>\n\n\n\n\n<p style=\"text-align: justify;\">Introduction: Cancer is the most common cause of human mortality worldwide. Anticancer therapies, such as chemotherapy and radiation, are associated with severe side effects. Many studies have shown that some antimicrobial peptides have a cytotoxic activity against cancer cells.\n\n\nMaterial and method: In this study, we evaluated the tumoricidal potential of magainin and cecropines (A and B) on tumor cell lines: MDA-MB-231 (breast adenocarcinoma) and M14K (human mesothelioma) as well as a normal keratinocyte lines.\n\n\nResults: We analyzed the effects of these cationic peptides on viability, cytotoxicity and cell proliferation in tumor and keratinocyte cell lines. The feasibility study was performed using annexin and 7-AAD (7-amino-actinomycin D), for the detection and measurement of apoptosis by flow cytometry. The peptides used by us are cytolytic (antimicrobial) effect and can destroy the integrity of the membrane with loss of cell content and cell death. The results of our study revealed that the cytotoxic effects of peptides on tumor cells depend on their concentration. Their efficiency is maximum at concentrations of 120 \u00b5M but it persists at concentrations of 60 \u00b5M. The effects were insignificant at concentrations of 30 \u00b5M. The studied peptides had no cytotoxic effect on normal keratinocytes line.\n\n\nConclusions: The intensity of the tumoricidal effect depends both on the nature of the peptide used and its concentration in the cell life environment, as well as on the type of tumoral cell line used. They could be a therapeutic alternative for malignant skin tumors.<\/p>\n\n\n\n\n<p>--><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #ff6600;\">Scurt CV<\/span><\/p>\n<p style=\"text-align: justify;\">Medic primar Medicin\u0103 de Laborator &#8211; Laboratorul de Biologie Molecular\u0103 a Spitalului de Boli Infec\u0163ioase \u201dSf. Parascheva\u201d Ia\u015fi<br \/> Medic primar Microbiologie Medical\u0103<br \/> Doctor \u00een \u015ftiin\u0163e medicale \u2013 specialitatea Dermatovenerologie<\/p>\n<p style=\"text-align: justify;\"><strong>Membru \u00een societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong><br \/> European Society for Clinical Microbiology and Infectious Disease<br \/> Societatea Rom\u00e2n\u0103 de Microbiologie<br \/> Societatea Rom\u00e2n\u0103 de Imunologie<br \/> Societatea Rom\u00e2n\u0103 de Micologie \u0219i Micotoxicologie<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.22&#8243; background_color=&#8221;rgba(117,194,33,0.23)&#8221; background_image=&#8221;https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png&#8221; background_blend=&#8221;luminosity&#8221; custom_padding=&#8221;54px|0px|0|0px|false|false&#8221; top_divider_style=&#8221;waves2&#8243; top_divider_color=&#8221;#ffffff&#8221; 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text_font_size_tablet=&#8221;&#8221; text_font_size_phone=&#8221;&#8221; text_font_size_last_edited=&#8221;on|desktop&#8221;]<\/p>\n<p>Contacteaz\u0103 operatorul PDI 2020<\/p>\n<p>[\/et_pb_text][et_pb_contact_form email=&#8221;contact@primaderma.ro\/2019&#8243; submit_button_text=&#8221;Trimite mesajul&#8221; _builder_version=&#8221;3.19.4&#8243; title_font=&#8221;||||||||&#8221;][et_pb_contact_field field_id=&#8221;Name&#8221; field_title=&#8221;Nume&#8221; _builder_version=&#8221;3.18.9&#8243; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;off&#8221; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; 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button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;off&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.0.11&#8243; text_font=&#8221;Kaushan Script||||||||&#8221; text_text_color=&#8221;#f0622a&#8221; text_font_size=&#8221;30px&#8221; header_font=&#8221;||||||||&#8221; background_layout=&#8221;dark&#8221;]<\/p>\n<p>Operatorul PDI 2020<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.0.11&#8243; text_font=&#8221;||||||||&#8221;]<\/p>\n<p><span><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/pdi.ro\/2020\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\" width=\"151\" height=\"33\" alt=\"\" class=\"wp-image-774 alignleft size-full\" \/><\/span><\/p>\n<p><span><\/span><\/p>\n<p><span><\/span><\/p>\n<p><span>Adresa: Str. A. Panu nr. 13, Iasi<\/span><br \/> <span>Tel.: 0332.40.88.00-05<\/span><br \/> <span>E-mail: <a href=\"mailto:inscrieri@primaderma.ro\" target=\"_blank\" rel=\"noopener noreferrer\">inscrieri@primaderma.ro<\/a><br \/> <\/span><span>Website:\u00a0<\/span><a href=\"http:\/\/www.eventernet.ro\/\" target=\"Blank\" rel=\"noopener noreferrer\">www.eventernet.ro<\/a><\/p>\n<p>[\/et_pb_text][et_pb_text disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.0.11&#8243; text_font=&#8221;Kaushan Script||||||||&#8221; text_text_color=&#8221;#f0622a&#8221; text_font_size=&#8221;30px&#8221; header_font=&#8221;||||||||&#8221; background_layout=&#8221;dark&#8221; locked=&#8221;off&#8221;]<\/p>\n<p>Parteneri Media<\/p>\n<p>[\/et_pb_text][et_pb_gallery gallery_ids=&#8221;7203,7204,7232,7231&#8243; fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.0.11&#8243; transform_scale=&#8221;86%|86%&#8221; max_width=&#8221;63%&#8221; auto=&#8221;on&#8221; auto_speed=&#8221;3500&#8243; hover_transition_duration=&#8221;100ms&#8221; hover_transition_delay=&#8221;50ms&#8221; hover_transition_speed_curve=&#8221;ease-in-out&#8221; locked=&#8221;off&#8221;][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u015eef lucr. Dr. B\u0103descu Aida Corina Universitatea de Medicin\u0103 \u015fi Farmacie &#8220;Grigore T. Popa&#8221;, Ia\u015fi Scurt CV Medic primar Medicin\u0103 de Laborator &#8211; Laboratorul de Biologie Molecular\u0103 a Spitalului de Boli Infec\u0163ioase \u201dSf. Parascheva\u201d Ia\u015fi Medic primar Microbiologie Medical\u0103 Doctor \u00een \u015ftiin\u0163e medicale \u2013 specialitatea Dermatovenerologie Membru \u00een societ\u0103\u0163i \u015ftiin\u0163ifice: European Society for Clinical Microbiology [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8649","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/comments?post=8649"}],"version-history":[{"count":3,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8649\/revisions"}],"predecessor-version":[{"id":8654,"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/pages\/8649\/revisions\/8654"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2020\/wp-json\/wp\/v2\/media?parent=8649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}