{"id":10630,"date":"2021-07-17T16:22:14","date_gmt":"2021-07-17T14:22:14","guid":{"rendered":"https:\/\/primaderma.ro\/?page_id=10630"},"modified":"2021-07-17T16:37:15","modified_gmt":"2021-07-17T14:37:15","slug":"dr-roxana-bilibau","status":"publish","type":"page","link":"https:\/\/pdi.ro\/2021\/dr-roxana-bilibau\/","title":{"rendered":"Dr. Roxana Bilib\u0103u"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|off|off” _builder_version=”3.22″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#f0622a” top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” global_module=”9062″ collapsed=”off”][et_pb_fullwidth_header title=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@” text_orientation=”right” header_image_url=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_logo_header_int_600x300px.png” disabled_on=”on|on|off” _builder_version=”4.9.4″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”right” title_text_color=”#f0622a” title_font_size=”50px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” subhead_font=”||||||||” background_color=”#ef916b” background_image=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”luminosity” background_layout=”light” custom_margin=”0px||8px” custom_padding=”40px||40px||true” content_font_size_tablet=”” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”3.25″][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/07\/Bilibou.jpg” title_text=”Bilibou” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.9.7″ max_width=”31%” hover_enabled=”0″ border_radii=”on|100px|100px|100px|100px” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.7″ hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n

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Dr. Roxana Bilib\u0103u<\/span><\/strong>
Departamentul de Dermatologie, Spitalul CF Ia\u0219i<\/span><\/strong><\/h4>\n

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Ce este nou \u00een terapia biologic\u0103?
Noi orizonturi terapeutice pentru pacien\u021bii cu dermatit\u0103 atopic\u0103<\/span><\/p>\n

Autori: Roxana Bilib\u0103u3, Mihaela-Paula Toader2, Diana Stefania D\u00eerzu3, Alina Elena Sp\u00eenu3, Andreea Corina Dr\u0103goi3, Anastasia Vicovan3, \u0218tefana Maria Cap\u0219a3, Andreea Tucaliuc3, Isabela Alexandra Fartu\u0219nic3, Catalina Cojocaru3, C\u0103t\u0103lina Elena Br\u0103ni\u0219teanu4, Mirela M\u0103r\u0103nduc\u01031, Mirela Andrese Porumb1, M. Glod4, Daciana-Elena Br\u0103ni\u0219teanu1
1Departamentul de Dermatologie, Universitatea de Medicin\u0103 \u0219i Farmacie \u201cGrigore T. Popa\u201d Ia\u0219i
2Departamentul de Dermatologie Oral\u0103, Universitatea de Medicin\u0103 \u0219i Farmacie \u201cGrigore T. Popa\u201d Ia\u0219i
3Departamentul de Dermatologie, Spitalul CF Ia\u0219i
4Departamentul de Chirurgie, Universitatea de Medicin\u0103 \u0219i Farmacie \u201cGrigore T. Popa\u201d Ia\u0219i<\/p>\n

Cuvinte cheie: atopie, dermatit\u0103, terapie biologic\u0103, dupilumab<\/p>\n

Dermatita atopic\u0103 este o dermatoz\u0103 inflamatorie cronic\u0103, recurent\u0103, pruriginoas\u0103, caracterizat\u0103 printr-un r\u0103spuns imun mediat de limfocitele T helper 2, ce apare la persoanele cu antecedente personale sau familiale de atopie. Progresele recente realizate \u00een \u00een\u021belegerea patogenezei dermatitei atopice au determinat extinderea op\u021biunilor terapeutice, culmin\u00e2nd cu aprobarea recent\u0103 a Dupilumabului pentru tratamentul pacien\u021bilor ce sufer\u0103 de dermatit\u0103 atopic\u0103 forma moderat\u0103 p\u00e2n\u0103 la sever\u0103. Dupilumabul este un anticorp monoclonal, antagonist al subunit\u0103\u021bii \u03b1 al receptorului IL-4 care inhib\u0103 semnalizarea IL-4 \u0219i IL-13 prin blocarea subunit\u0103\u021bii IL-4\u03b1, comun\u0103 pentru cele dou\u0103 citokine. Blocarea IL-4\/13 este eficient\u0103 \u00een reducerea r\u0103spunsului inflamator de tip Th2 prin sc\u0103derea r\u0103spunsurilor induse de IL-4 \u0219i IL-13, inclusiv eliberea de citokine proinflamatorii, chemokine \u0219i IgE. Aprobarea Dupilumabului pentru tratamentul dermatitei atopice forma moderat-sever\u0103, inclusiv pentru copiii de peste 6 ani, aduce speran\u021b\u0103 \u0219i bucurie. Prezent\u0103m experien\u021ba Clinicii de Dermatologie a Spitalului Clinic CF Ia\u0219i prin cazul unui pacient \u00een v\u00e2rsta de 18 ani, cunoscut cu dermatit\u0103 atopic\u0103 de la v\u00e2rsta de 2 ani, cu multiple rec\u0103deri \u0219i perioade de remisiune \u0219i cu o calitate a vie\u021bii sever afectat\u0103.<\/p>\n

What’s new in biological therapy?
New therapeutic horizons for patients with atopic dermatitis<\/span><\/p>\n

Authors: Roxana Bilib\u0103u3, Mihaela-Paula Toader2, Diana Stefania D\u00eerzu3, Alina Elena Sp\u00eenu3, Andreea Corina Dr\u0103goi3, Anastasia Vicovan3, \u0218tefana Maria Cap\u0219a3, Andreea Tucaliuc3, Isabela Alexandra Fartu\u0219nic3, Catalina Cojocaru3, C\u0103t\u0103lina Elena Br\u0103ni\u0219teanu4, Mirela M\u0103r\u0103nduc\u01031, Mirela Andrese Porumb1, M. Glod4, Daciana-Elena Br\u0103ni\u0219teanu1<\/p>\n

1Department of Dermatology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania
2Department of Oral Dermatology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania
3Department of Dermatology, \u201cRailway Clinical Hospital\u201d, 700506 Iasi, Romania
4\u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania Department of Surgery, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania<\/p>\n

Keywords: atopic, dermatitis, biological therapy, dupilumab<\/p>\n

Atopic dermatitis is a chronic, recurrent, pruritic inflammatory dermatosis, characterized by an immune response mediated by T helper 2 lymphocytes, which occurs in patients with a personal or family history of atopy. Recent studies in understanding the pathogenesis of atopic dermatitis have led to an expansion of therapeutic options, culminating in the recent approval of Dupilumab for the treatment of patients with moderate to severe atopic dermatitis. Dupilumab is a monoclonal antibody, antagonist of the \u03b1 subunit of the IL-4 receptor that inhibits IL-4 and IL-13 by blocking the IL-4\u03b1 subunit, common to the two cytokines. Blockade of IL-4\/13 is effective in reducing the Th2-type inflammatory response by decreasing IL-4 and IL-13-induced responses, including the release of proinflammatory cytokines, chemokines, and IgE.
The approval of Dupilumab for the treatment of moderate-severe atopic dermatitis, including children over 6 years, brings hope and joy. We present the case of an 18-year-old patient, known with atopic dermatitis from the age of 2, with multiple relapses and remission periods and a severely affected quality of life.<\/p>\n

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Contacteaz\u0103 operatorul PDI 2021<\/p>\n

[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2021\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.9.4″ title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n

Operatorul PDI 2021<\/p>\n

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\"\"<\/span><\/p>\n

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Adresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n

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Parteneri Media<\/p>\n

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Dr. Roxana Bilib\u0103uDepartamentul de Dermatologie, Spitalul CF Ia\u0219iCe este nou \u00een terapia biologic\u0103?Noi orizonturi terapeutice pentru pacien\u021bii cu dermatit\u0103 atopic\u0103 Autori: Roxana Bilib\u0103u3, Mihaela-Paula Toader2, Diana Stefania D\u00eerzu3, Alina Elena Sp\u00eenu3, Andreea Corina Dr\u0103goi3, Anastasia Vicovan3, \u0218tefana Maria Cap\u0219a3, Andreea Tucaliuc3, Isabela Alexandra Fartu\u0219nic3, Catalina Cojocaru3, C\u0103t\u0103lina Elena Br\u0103ni\u0219teanu4, Mirela M\u0103r\u0103nduc\u01031, Mirela Andrese Porumb1, M. […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-10630","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/10630","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=10630"}],"version-history":[{"count":2,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/10630\/revisions"}],"predecessor-version":[{"id":10632,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/10630\/revisions\/10632"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=10630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}