<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nAsist. Univ. Dr. Pintea Irena<\/span><\/strong>
Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj-Napoca<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.7″]<\/p>\n
Terapia substitutiv\u0103 cu imunoglobuline \u00een imunodeficien\u021bele primare umorale. Registrul de imunodeficien\u021b\u0103 primar\u0103 al departamentului de alergologie \u0219i imunologie, IRGH “Profesor Doctor Octavian Fodor”<\/span>
Autori: Irena Pintea1,2, Carmen Teodora Dobrican1,2 , Adriana Muntean1,2 , Diana Deleanu1,2,3<\/span>
1Disciplina Alergologie \u0219i Imunologie, Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu\u201d, Cluj-Napoca, Rom\u00e2nia
2Ambulatorul de Alergologie, Institutul Regional de Gastroenterologie \u0219i Hepatologie “Profesor Doctor Octavian Fodor\u201d Cluj-Napoca, Rom\u00e2nia
3Sec\u021bia Medicin\u0103 Intern\u0103, Institutul Regional de Gastroenterologie \u0219i Hepatologie “Profesor Doctor Octavian Fodor\u201d Cluj-Napoca, Rom\u00e2nia<\/p>\nCuvinte cheie: imunodeficien\u021be primare, tratament substitutiv, imunoglobuline<\/p>\n
Introducere: Imunodeficien\u021bele primare cuprind un grup heterogen de afec\u021biuni caracterizate prin func\u021bionarea deficitar\u0103 sau chiar absent\u0103 a unuia sau a mai multor componente ale sistemului imun \u0219i care predispun la infec\u021bii frecvente \u0219i severe, autoimunitate, alterarea homeostaziei imune, boli autoinflamatorii, boli limfoproliferative \u0219i neoplazii. Conform estim\u0103rilor globale, \u00eentre 70% \u0219i 90% din imunodeficien\u021bele primare r\u0103m\u00e2n nediagnosticate sau sunt diagnosticate tardiv.
Material \u0219i metod\u0103: Lucrarea de fa\u021b\u0103 discut\u0103 modalit\u0103\u021bile actuale de tratament substitutiv cu imunoglobuline \u00een imunodeficien\u021bele primare \u0219i expune experien\u021ba Departamentului de Alergologie \u0219i Imunologie al IRGH Profesor Doctor Octavian Fodor, Cluj-Napoca privind pacien\u021bii cu imunodeficien\u021be primare inclu\u0219i \u00een Programul Na\u021bional de Boli Rare.
Rezultate: Registrul include un numar de 60 de pacien\u021bi cu imunodeficien\u021b\u0103 primar\u0103, cu v\u00e2rste cuprinse \u00eentre 25 \u0219i 77 de ani, dintre care 62.26% sunt de sex feminin. Afec\u021biunile alergice au fost documentate la 22,9% dintre pacien\u021bi, iar 19,67% au afec\u021biuni autoimune concomitente. 66% dintre pacien\u021bi urmeaz\u0103 tratament substitutiv intravenos (IGIV), iar 34% terapie de substitu\u021bie subcutanat\u0103 (IGSC). Dintre ace\u0219tia, 1,66% sufer\u0103 de agamaglobulinemie X-linkat\u0103 Bruton, 15% au deficit selectiv de subclase de IgG, iar 83,34% au imunodeficien\u021b\u0103 comun\u0103 variabil\u0103. La 90% dintre pacien\u021bii cu tratament substitutiv subcutanat s-a f\u0103cut conversia de la terapia cu IGIV, iar la 10% s-a ini\u021biat SCIG de la momentul diagnosticului\/lu\u0103rii \u00een eviden\u021b\u0103 \u00een departamentul nostru.
Concluzii: Imunodeficien\u021bele Primare au o prevalen\u021b\u0103 mai \u00eenalt\u0103 dec\u00e2t cea raportat\u0103. Diagnosticul precoce \u0219i instituirea tratamentului adecvat sunt esen\u021biale pentru evolu\u021bia bolii. Terapia de substitu\u021bie cu imunoglobuline este cheia de bolt\u0103 a tratamentului imunodeficien\u021belor primare.<\/p>\n
Immunoglobulin replacement therapy in humoral primary immunodeficiency. Professor Doctor Octavian Fodor righ primary immunodeficiency registry<\/span>
Autori: Irena Pintea1,2, Carmen Teodora Dobrican1,2, Adriana Muntean1,2, Diana Deleanu1,2,3<\/span>
1Allergy and Immunology Discipline, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Cluj-Napoca, Romania
2Allergology Ambulatory, \u201cProfesor Doctor Octavian Fodor\u201d Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
3Internal Medicine Department, \u201cProfesor Doctor Octavian Fodor\u201d Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania<\/p>\nKeywords: primary immunodeficiency, immunoglobulin, replacement therapy<\/p>\n
Introduction: Primary immunodeficiencies encompass a heterogeneous group of diseases that result from defects in immune system development and\/or function and evolve with frequent and severe infections, autoimmunity, impaired immune homeostasis, autoinflammatory diseases, lymphoproliferative diseases and neoplasia. According to global estimates, between 70% and 90% of primary immunodeficiencies remain undiagnosed or are diagnosed late.
Material and method: This paper discusses the current options of immunoglobulin replacement therapy in primary immunodeficiencies and presents the experience of the Department of Allergology and Immunology of Professor Doctor Octavian Fodor RIGH, Cluj-Napoca, in patients with primary immunodeficiencies included in the National Rare Diseases Program.
Results: The registry includes a number of 60 patients with primary immunodeficiency, aged between 25 and 77 years, of which 62.26% are female. Allergic conditions have been documented in 22.9% of patients, and 19.67% have concomitant autoimmune diseases. 66% of patients receive intravenous replacement therapy (IVIG) and 34% subcutaneous replacement therapy (IGSC). Of these, 1.66% suffer from Bruton X-linked agamaglobulinemia, 15% have selective deficiency of IgG subclasses, and 83.34% have variable common immunodeficiency. In 90% of patients with subcutaneous replacement therapy, the conversion from IVIG therapy was made, and in 10% SCIG was initiated from the moment of diagnosis \/ registration in our department.
Conclusions: Primary immunodeficiencies have a higher prevalence than reported. Early diagnosis and appropriate treatment are essential for the evolution of the disease. Immunoglobulin replacement therapy is the keystone of the treatment of primary immunodeficiencies.<\/p>\n
Scurt CV<\/p>\n
Grad didactic: <\/strong>
Asistent Universitar<\/p>\nFunc\u0163ie: <\/strong>
Medic specialist<\/p>\nLoc de munc\u0103: <\/strong>
Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Institutul Regional de Gastroenterologie si Hepatologie Profesor Doctor Octavian Fodor, Cluj-Napoca<\/p>\nSpecializ\u0103ri:<\/strong>
Alergologie si Imunologie Clinica<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
Membru Societatea Romana de Alergologie si Imunologie Clinica, membru EEACI<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2021<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2021\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.9.4″ title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2021<\/p>\n
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![\"\"](\"https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
[\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,9252,9464,10156,10157″ fullwidth=”on” _builder_version=”4.9.7″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Asist. Univ. Dr. Pintea Irena Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj-NapocaTerapia substitutiv\u0103 cu imunoglobuline \u00een imunodeficien\u021bele primare umorale. Registrul de imunodeficien\u021b\u0103 primar\u0103 al departamentului de alergologie \u0219i imunologie, IRGH “Profesor Doctor Octavian Fodor”Autori: Irena Pintea1,2, Carmen Teodora Dobrican1,2 , Adriana Muntean1,2 , Diana Deleanu1,2,31Disciplina Alergologie \u0219i Imunologie, Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7592","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/7592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=7592"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/7592\/revisions"}],"predecessor-version":[{"id":10525,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/7592\/revisions\/10525"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=7592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Asist. Univ. Dr. Pintea Irena<\/span><\/strong>
Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj-Napoca<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.7″]<\/p>\n
Terapia substitutiv\u0103 cu imunoglobuline \u00een imunodeficien\u021bele primare umorale. Registrul de imunodeficien\u021b\u0103 primar\u0103 al departamentului de alergologie \u0219i imunologie, IRGH “Profesor Doctor Octavian Fodor”<\/span>
Autori: Irena Pintea1,2, Carmen Teodora Dobrican1,2 , Adriana Muntean1,2 , Diana Deleanu1,2,3<\/span>
1Disciplina Alergologie \u0219i Imunologie, Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu\u201d, Cluj-Napoca, Rom\u00e2nia
2Ambulatorul de Alergologie, Institutul Regional de Gastroenterologie \u0219i Hepatologie “Profesor Doctor Octavian Fodor\u201d Cluj-Napoca, Rom\u00e2nia
3Sec\u021bia Medicin\u0103 Intern\u0103, Institutul Regional de Gastroenterologie \u0219i Hepatologie “Profesor Doctor Octavian Fodor\u201d Cluj-Napoca, Rom\u00e2nia<\/p>\nCuvinte cheie: imunodeficien\u021be primare, tratament substitutiv, imunoglobuline<\/p>\n
Introducere: Imunodeficien\u021bele primare cuprind un grup heterogen de afec\u021biuni caracterizate prin func\u021bionarea deficitar\u0103 sau chiar absent\u0103 a unuia sau a mai multor componente ale sistemului imun \u0219i care predispun la infec\u021bii frecvente \u0219i severe, autoimunitate, alterarea homeostaziei imune, boli autoinflamatorii, boli limfoproliferative \u0219i neoplazii. Conform estim\u0103rilor globale, \u00eentre 70% \u0219i 90% din imunodeficien\u021bele primare r\u0103m\u00e2n nediagnosticate sau sunt diagnosticate tardiv.
Material \u0219i metod\u0103: Lucrarea de fa\u021b\u0103 discut\u0103 modalit\u0103\u021bile actuale de tratament substitutiv cu imunoglobuline \u00een imunodeficien\u021bele primare \u0219i expune experien\u021ba Departamentului de Alergologie \u0219i Imunologie al IRGH Profesor Doctor Octavian Fodor, Cluj-Napoca privind pacien\u021bii cu imunodeficien\u021be primare inclu\u0219i \u00een Programul Na\u021bional de Boli Rare.
Rezultate: Registrul include un numar de 60 de pacien\u021bi cu imunodeficien\u021b\u0103 primar\u0103, cu v\u00e2rste cuprinse \u00eentre 25 \u0219i 77 de ani, dintre care 62.26% sunt de sex feminin. Afec\u021biunile alergice au fost documentate la 22,9% dintre pacien\u021bi, iar 19,67% au afec\u021biuni autoimune concomitente. 66% dintre pacien\u021bi urmeaz\u0103 tratament substitutiv intravenos (IGIV), iar 34% terapie de substitu\u021bie subcutanat\u0103 (IGSC). Dintre ace\u0219tia, 1,66% sufer\u0103 de agamaglobulinemie X-linkat\u0103 Bruton, 15% au deficit selectiv de subclase de IgG, iar 83,34% au imunodeficien\u021b\u0103 comun\u0103 variabil\u0103. La 90% dintre pacien\u021bii cu tratament substitutiv subcutanat s-a f\u0103cut conversia de la terapia cu IGIV, iar la 10% s-a ini\u021biat SCIG de la momentul diagnosticului\/lu\u0103rii \u00een eviden\u021b\u0103 \u00een departamentul nostru.
Concluzii: Imunodeficien\u021bele Primare au o prevalen\u021b\u0103 mai \u00eenalt\u0103 dec\u00e2t cea raportat\u0103. Diagnosticul precoce \u0219i instituirea tratamentului adecvat sunt esen\u021biale pentru evolu\u021bia bolii. Terapia de substitu\u021bie cu imunoglobuline este cheia de bolt\u0103 a tratamentului imunodeficien\u021belor primare.<\/p>\n
Immunoglobulin replacement therapy in humoral primary immunodeficiency. Professor Doctor Octavian Fodor righ primary immunodeficiency registry<\/span>
Autori: Irena Pintea1,2, Carmen Teodora Dobrican1,2, Adriana Muntean1,2, Diana Deleanu1,2,3<\/span>
1Allergy and Immunology Discipline, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Cluj-Napoca, Romania
2Allergology Ambulatory, \u201cProfesor Doctor Octavian Fodor\u201d Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
3Internal Medicine Department, \u201cProfesor Doctor Octavian Fodor\u201d Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania<\/p>\nKeywords: primary immunodeficiency, immunoglobulin, replacement therapy<\/p>\n
Introduction: Primary immunodeficiencies encompass a heterogeneous group of diseases that result from defects in immune system development and\/or function and evolve with frequent and severe infections, autoimmunity, impaired immune homeostasis, autoinflammatory diseases, lymphoproliferative diseases and neoplasia. According to global estimates, between 70% and 90% of primary immunodeficiencies remain undiagnosed or are diagnosed late.
Material and method: This paper discusses the current options of immunoglobulin replacement therapy in primary immunodeficiencies and presents the experience of the Department of Allergology and Immunology of Professor Doctor Octavian Fodor RIGH, Cluj-Napoca, in patients with primary immunodeficiencies included in the National Rare Diseases Program.
Results: The registry includes a number of 60 patients with primary immunodeficiency, aged between 25 and 77 years, of which 62.26% are female. Allergic conditions have been documented in 22.9% of patients, and 19.67% have concomitant autoimmune diseases. 66% of patients receive intravenous replacement therapy (IVIG) and 34% subcutaneous replacement therapy (IGSC). Of these, 1.66% suffer from Bruton X-linked agamaglobulinemia, 15% have selective deficiency of IgG subclasses, and 83.34% have variable common immunodeficiency. In 90% of patients with subcutaneous replacement therapy, the conversion from IVIG therapy was made, and in 10% SCIG was initiated from the moment of diagnosis \/ registration in our department.
Conclusions: Primary immunodeficiencies have a higher prevalence than reported. Early diagnosis and appropriate treatment are essential for the evolution of the disease. Immunoglobulin replacement therapy is the keystone of the treatment of primary immunodeficiencies.<\/p>\n
Scurt CV<\/p>\n
Grad didactic: <\/strong>
Asistent Universitar<\/p>\nFunc\u0163ie: <\/strong>
Medic specialist<\/p>\nLoc de munc\u0103: <\/strong>
Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Institutul Regional de Gastroenterologie si Hepatologie Profesor Doctor Octavian Fodor, Cluj-Napoca<\/p>\nSpecializ\u0103ri:<\/strong>
Alergologie si Imunologie Clinica<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
Membru Societatea Romana de Alergologie si Imunologie Clinica, membru EEACI<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2021<\/p>\n
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Operatorul PDI 2021<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
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Asist. Univ. Dr. Pintea Irena Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj-NapocaTerapia substitutiv\u0103 cu imunoglobuline \u00een imunodeficien\u021bele primare umorale. Registrul de imunodeficien\u021b\u0103 primar\u0103 al departamentului de alergologie \u0219i imunologie, IRGH “Profesor Doctor Octavian Fodor”Autori: Irena Pintea1,2, Carmen Teodora Dobrican1,2 , Adriana Muntean1,2 , Diana Deleanu1,2,31Disciplina Alergologie \u0219i Imunologie, Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7592","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/7592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=7592"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/7592\/revisions"}],"predecessor-version":[{"id":10525,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/7592\/revisions\/10525"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=7592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Irena Pintea1,2, Carmen Teodora Dobrican1,2 , Adriana Muntean1,2 , Diana Deleanu1,2,3<\/span>
1Disciplina Alergologie \u0219i Imunologie, Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu\u201d, Cluj-Napoca, Rom\u00e2nia
2Ambulatorul de Alergologie, Institutul Regional de Gastroenterologie \u0219i Hepatologie “Profesor Doctor Octavian Fodor\u201d Cluj-Napoca, Rom\u00e2nia
3Sec\u021bia Medicin\u0103 Intern\u0103, Institutul Regional de Gastroenterologie \u0219i Hepatologie “Profesor Doctor Octavian Fodor\u201d Cluj-Napoca, Rom\u00e2nia<\/p>\n
Cuvinte cheie: imunodeficien\u021be primare, tratament substitutiv, imunoglobuline<\/p>\n
Introducere: Imunodeficien\u021bele primare cuprind un grup heterogen de afec\u021biuni caracterizate prin func\u021bionarea deficitar\u0103 sau chiar absent\u0103 a unuia sau a mai multor componente ale sistemului imun \u0219i care predispun la infec\u021bii frecvente \u0219i severe, autoimunitate, alterarea homeostaziei imune, boli autoinflamatorii, boli limfoproliferative \u0219i neoplazii. Conform estim\u0103rilor globale, \u00eentre 70% \u0219i 90% din imunodeficien\u021bele primare r\u0103m\u00e2n nediagnosticate sau sunt diagnosticate tardiv.
Material \u0219i metod\u0103: Lucrarea de fa\u021b\u0103 discut\u0103 modalit\u0103\u021bile actuale de tratament substitutiv cu imunoglobuline \u00een imunodeficien\u021bele primare \u0219i expune experien\u021ba Departamentului de Alergologie \u0219i Imunologie al IRGH Profesor Doctor Octavian Fodor, Cluj-Napoca privind pacien\u021bii cu imunodeficien\u021be primare inclu\u0219i \u00een Programul Na\u021bional de Boli Rare.
Rezultate: Registrul include un numar de 60 de pacien\u021bi cu imunodeficien\u021b\u0103 primar\u0103, cu v\u00e2rste cuprinse \u00eentre 25 \u0219i 77 de ani, dintre care 62.26% sunt de sex feminin. Afec\u021biunile alergice au fost documentate la 22,9% dintre pacien\u021bi, iar 19,67% au afec\u021biuni autoimune concomitente. 66% dintre pacien\u021bi urmeaz\u0103 tratament substitutiv intravenos (IGIV), iar 34% terapie de substitu\u021bie subcutanat\u0103 (IGSC). Dintre ace\u0219tia, 1,66% sufer\u0103 de agamaglobulinemie X-linkat\u0103 Bruton, 15% au deficit selectiv de subclase de IgG, iar 83,34% au imunodeficien\u021b\u0103 comun\u0103 variabil\u0103. La 90% dintre pacien\u021bii cu tratament substitutiv subcutanat s-a f\u0103cut conversia de la terapia cu IGIV, iar la 10% s-a ini\u021biat SCIG de la momentul diagnosticului\/lu\u0103rii \u00een eviden\u021b\u0103 \u00een departamentul nostru.
Concluzii: Imunodeficien\u021bele Primare au o prevalen\u021b\u0103 mai \u00eenalt\u0103 dec\u00e2t cea raportat\u0103. Diagnosticul precoce \u0219i instituirea tratamentului adecvat sunt esen\u021biale pentru evolu\u021bia bolii. Terapia de substitu\u021bie cu imunoglobuline este cheia de bolt\u0103 a tratamentului imunodeficien\u021belor primare.<\/p>\n
Immunoglobulin replacement therapy in humoral primary immunodeficiency. Professor Doctor Octavian Fodor righ primary immunodeficiency registry<\/span> Keywords: primary immunodeficiency, immunoglobulin, replacement therapy<\/p>\n Introduction: Primary immunodeficiencies encompass a heterogeneous group of diseases that result from defects in immune system development and\/or function and evolve with frequent and severe infections, autoimmunity, impaired immune homeostasis, autoinflammatory diseases, lymphoproliferative diseases and neoplasia. According to global estimates, between 70% and 90% of primary immunodeficiencies remain undiagnosed or are diagnosed late. Scurt CV<\/p>\n Grad didactic: <\/strong> Func\u0163ie: <\/strong> Loc de munc\u0103: <\/strong> Specializ\u0103ri:<\/strong> Apartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all”][et_pb_row column_structure=”3_5,2_5″ 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button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2021<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,9252,9464,10156,10157″ fullwidth=”on” _builder_version=”4.9.7″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Asist. Univ. Dr. Pintea Irena Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj-NapocaTerapia substitutiv\u0103 cu imunoglobuline \u00een imunodeficien\u021bele primare umorale. Registrul de imunodeficien\u021b\u0103 primar\u0103 al departamentului de alergologie \u0219i imunologie, IRGH “Profesor Doctor Octavian Fodor”Autori: Irena Pintea1,2, Carmen Teodora Dobrican1,2 , Adriana Muntean1,2 , Diana Deleanu1,2,31Disciplina Alergologie \u0219i Imunologie, Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7592","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/7592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=7592"}],"version-history":[{"count":8,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/7592\/revisions"}],"predecessor-version":[{"id":10525,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/7592\/revisions\/10525"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=7592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Irena Pintea1,2, Carmen Teodora Dobrican1,2, Adriana Muntean1,2, Diana Deleanu1,2,3<\/span>
1Allergy and Immunology Discipline, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Cluj-Napoca, Romania
2Allergology Ambulatory, \u201cProfesor Doctor Octavian Fodor\u201d Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania
3Internal Medicine Department, \u201cProfesor Doctor Octavian Fodor\u201d Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania<\/p>\n
Material and method: This paper discusses the current options of immunoglobulin replacement therapy in primary immunodeficiencies and presents the experience of the Department of Allergology and Immunology of Professor Doctor Octavian Fodor RIGH, Cluj-Napoca, in patients with primary immunodeficiencies included in the National Rare Diseases Program.
Results: The registry includes a number of 60 patients with primary immunodeficiency, aged between 25 and 77 years, of which 62.26% are female. Allergic conditions have been documented in 22.9% of patients, and 19.67% have concomitant autoimmune diseases. 66% of patients receive intravenous replacement therapy (IVIG) and 34% subcutaneous replacement therapy (IGSC). Of these, 1.66% suffer from Bruton X-linked agamaglobulinemia, 15% have selective deficiency of IgG subclasses, and 83.34% have variable common immunodeficiency. In 90% of patients with subcutaneous replacement therapy, the conversion from IVIG therapy was made, and in 10% SCIG was initiated from the moment of diagnosis \/ registration in our department.
Conclusions: Primary immunodeficiencies have a higher prevalence than reported. Early diagnosis and appropriate treatment are essential for the evolution of the disease. Immunoglobulin replacement therapy is the keystone of the treatment of primary immunodeficiencies.<\/p>\n
Asistent Universitar<\/p>\n
Medic specialist<\/p>\n
Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca, Institutul Regional de Gastroenterologie si Hepatologie Profesor Doctor Octavian Fodor, Cluj-Napoca<\/p>\n
Alergologie si Imunologie Clinica<\/p>\n
Membru Societatea Romana de Alergologie si Imunologie Clinica, membru EEACI<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n