<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nConf. Univ. Dr. Gabriela Stoleriu<\/span><\/strong>
\nFacultatea de Medicin\u0103 \u015fi Farmacie, Universitatea \u201dDun\u0103rea de Jos\u201d, Gala\u0163i<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.7″ hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n
Manifest\u0103ri cutanate ale imunoterapiei bazate pe anticorpi monoclonali<\/span>
Autori: Gabriela Stoleriu1, Smaranda \u0162arean2, A. Oan\u0163\u01033<\/span><\/p>\n1 Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
2 Centrul Medical Topmed, T\u00e2rgu Mure\u015f, Rom\u00e2nia
3 Dermamed, Bra\u015fov, Rom\u00e2nia<\/p>\n
Cuvinte cheie: melanom malign metastatic, anticorpi monoclonali, exantem, vitiligo, keratoze<\/p>\n
Melanomul malign este o tumor\u0103 a melanocitelor sau a celulelor dezvoltate din melanocite, cu o inciden\u021b\u0103 anual\u0103 crescut\u0103 \u00een ultimele decenii. Dac\u0103 formele diagnosticate \u00eentr-un stadiu pu\u0163in avansat au prognostic bun \u015fi se pot vindeca doar prin excizie chirurgical\u0103, formele avansate \u015fi \u00eendeosebi formele metastatice au prognostic nefavorabil. Arsenalul terapeutic al melanomului nerezecabil sau metastatic const\u0103 \u00een: terapia \u0163intit\u0103 pentru tumori care poart\u0103 o muta\u0163ie activatoare a BRAF \u00een pozi\u0163ia V600 (molecule anti-BRAF: vemurafenib, dabrafenib \u015fi molecule anti-MEK: CI-1040, selumetinib, trametinib, cobimetinib), imunoterapia bazat\u0103 pe anticorpi monoclonali anti-CTLA4 (ipilimumab) \u015fi anti-PD1 (nivolumab \u015fi pembrolizumab), chimioterapia citotoxic\u0103 (dacarbazina, fotemustina, temozolomida +\/- platine \u015fi taxoizi). Imunoterapia cu inhibitori ai punctelor de control (anticorpi anti-PD1) \u00een melanomul metastatic permite o supravie\u0163uire medie global\u0103 superioar\u0103, pembrolizumab duc\u00e2nd la regresia tumorilor \u015fi cre\u015fterea ratei de supravie\u0163uire. Reac\u0163iile adverse ale pembrolizumabului pot fi severe. Dermatitele, pruritul, enterocolitele \u015fi hepatitele sunt cele mai frecvente. Mai pu\u0163in obi\u015fnuite sunt hipofizitele, uveitele, neuropatiile \u015fi sindromul Guillain-Barre. Moleculele au un profil de toleran\u0163\u0103 foarte diferit, iar efectele secundare trebuie prevenite \u015fi gestionate \u00eentr-o manier\u0103 adaptat\u0103 \u00eenainte de optimizarea complian\u0163ei tratamentului \u015fi eficien\u0163ei acestuia. Se impune o comunicare interdisciplinar\u0103 mai ales pentru pacien\u0163ii care necesit\u0103 tratament sistemic.<\/p>\n
Skin manifestations of immune checkpoint inhibitors<\/span>
Autori: Gabriela Stoleriu1, Smaranda \u0162arean2, A. Oan\u0163\u01033<\/span><\/p>\nMedical Clinical Department, Faculty of Medicine and Pharmacy,”Dun\u0103rea de Jos” University of Gala\u0163i, Romania
2Topmed Medical Center, T\u00e2rgu Mure\u015f, Romania
3Dermamed, Brasov, Romania<\/p>\n
Keywords: malignant melanoma, checkpoint inhibitors, exanthema, vitiligo, keratoses<\/p>\n
Malignant melanoma is a tumor of melanocytes or cells developed from melanocytes, with an increased annual incidence in recent decades. If the forms diagnosed at an advanced stage have a good prognosis and can be cured only by surgical excision, the advanced forms and especially the metastatic forms have an unfavorable prognosis. The therapeutic arsenal of unresectable or metastatic melanoma consists of: targeted therapy for tumors bearing a BRAF activating mutation at V600 (anti-BRAF molecules: vemurafenib, dabrafenib and anti-MEK molecules: CI-1040, selumetinib, trametinib, cobimetinib), immunotherapy based on anti-CTLA4 (ipilimumab) and anti-PD1 monoclonal antibodies (nivolumab and pembrolizumab), cytotoxic chemotherapy (dacarbazine, fotemustine, temozolomide +\/- platinum and taxoids). Immunotherapy with immune checkpoint inhibitors (anti-PD1 antibodies) in metastatic melanoma allows a higher overall mean survival, pembrolizumab leading to tumor regression and increased survival. Side effects of pembrolizumab can be severe. Dermatitis, pruritus, enterocolitis and hepatitis are the most common. Less common are pituitary, uveitis, neuropathy and Guillain-Barre syndrome. Molecules have a very different tolerance profile, and side effects must be prevented and managed in an appropriate manner before optimizing treatment compliance and its effectiveness. Interdisciplinary communication is required especially for patients requiring systemic treatment.<\/p>\n
Infec\u0163ii fungice cutanate profunde<\/span>
Autori: Gabriela Stoleriu1, Florina Mihaela Filip Ciubotaru2, Nicu\u0163a Manolache3, Daciana Br\u0103ni\u015fteanu4<\/span><\/p>\n1Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
2Disciplina Medicin\u0103 de Familie Adul\u021bi, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
3Departamentul \u015etiin\u0163e Farmaceutice, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
4Disciplina Dermatologie, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia<\/p>\n
Cuvinte cheie: aspergiloza, criptococoza, histoplasmoza, micetom, micoze profunde<\/p>\n
Infec\u021biile fungice cutanate profunde afecteaz\u0103 adesea persoane cu ocupa\u0163ii particulare (agricultori, fermieri, lucr\u0103tori \u00een cauciuc, v\u00e2n\u0103tori, cresc\u0103tori de porumbei, lucr\u0103tori pe \u0219antierele de construc\u021bii, \u00eentre\u0163inerea sistemelor de ventila\u021bie contaminate, exploratori), din anumite arii geografice (Africa de Sud, America Central\u0103, America de Sud, Argentina, Australia de Vest, provinciile canadiene din jurul Marilor Lacuri, China, India, Olanda, Orientul Mijlociu, v\u0103ile din jurul r\u00e2urilor Mississippi \u0219i Ohio, zonele cu clim\u0103 temperat\u0103, pe\u015fteri cu lilieci), \u015fi, chiar dac\u0103 sunt rar \u00eent\u00e2lnite \u00een Rom\u00e2nia, trebuie cunoscute datorit\u0103 turismului \u015fi emigr\u0103rii unui procent \u00eensemnat de rom\u00e2ni care se re\u00eentorc \u00een \u0163ar\u0103 \u00een vacan\u0163e. Aceste infec\u0163ii micotice se instaleaz\u0103 frecvent la pacien\u021bi cu imunodeficien\u0163\u0103 (SIDA, imunodeficien\u021ba primar\u0103, st\u0103ri imunosupresive induse de medicamente, v\u00e2rstele extreme), dar pot ap\u0103rea \u0219i la persoane imunocompetente. Morbiditatea \u0219i mortalitatea sunt legate de agentul etiologic, localizarea, durata \u0219i amploarea infec\u021biei. Fiecare dintre dintre micozele profunde (sporotricoza, aspergiloza, criptococoza, histoplasmoza, blastomicoza, mucormicoza, paracoccidioidomicoza, lobomicoza, ficomicoza, feohifomicoza, micetomul) implic\u0103 discu\u021bii asupra diagnosticelor diferen\u021biale \u0219i asupra posibilit\u0103\u021bilor examenelor de laborator care pot confirma supozi\u021bia de diagnostic. Este necesar consultul interdisciplinar (dermatologie, boli infec\u021bioase, pneumoftiziologie, neurologie, chirurgie plastic\u0103 etc.) pentru un diagnostic corect \u015fi complet, pentru instituirea c\u00e2t mai rapid\u0103 a terapiei corespunz\u0103toare (antifungice, chirurgie, \u00eengrijirea imunodeficien\u0163ei). Prognosticul este excelent dac\u0103 tratamentul este efectuat la timp \u0219i corespunz\u0103tor, dar infec\u0163iile netratate \u0219i diseminate au o rat\u0103 de mortalitate de aproape 100%. Profilaxia const\u0103 din prevenirea \u0219i tratamentul infec\u021biilor oportuniste la pacien\u021bii imunodeficien\u0163i, informarea corect\u0103 a celor care c\u0103l\u0103toresc \u00een zonele endemice.<\/p>\n
Deep skin fungal infections<\/span>
Autori: Gabriela Stoleriu1, Florina Mihaela Filip Ciubotaru2, Nicu\u0163a Manolache3, Daciana Br\u0103ni\u015fteanu4<\/span><\/p>\n1Department of Clinical Medicine, Faculty of Medicine and Pharmacy, Lower Danube University of Galati, Romania
2Discipline Family Medicine Adults, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
3Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, Dun\u0103rea de Jos University of Galati, Romania
4Dermatology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania<\/p>\n
Keywords: aspergillosis, cryptococcosis, histoplasmosis, mycetoma, deep mycoses<\/p>\n
Deep skin fungal infections often affect people with special occupations (farmers, rubber workers, hunters, pigeon breeders, construction site workers, maintenance of contaminated ventilation systems, explorers), from certain geographical areas (South Africa, America Central, South America, Argentina, Western Australia, the Canadian provinces around the Great Lakes, China, India, the Netherlands, the Middle East, the valleys around the Mississippi and Ohio rivers, temperate areas, bat caves), and even they are rarely found in Romania, they must be known due to tourism and emigration of a significant percentage of Romanians who return to the country on vacation. These fungal infections are common in patients with immunodeficiency (AIDS, primary immunodeficiency, drug-induced immunosuppressive conditions, extreme ages), but can also occur in immunocompetent individuals. Morbidity and mortality are related to the etiological agent, the location, duration and extent of the infection. Each of the deep mycoses (sporotrichosis, aspergillosis, cryptococcosis, histoplasmosis, blastomycosis, mucormycosis, paracoccidioidomycosis, lobomycosis, phycomycosis, pheohifomycosis, mycetoma) involves discussions of differential diagnoses and the possibilities of laboratory examinations. It is necessary the interdisciplinary consultation (dermatology, infectious diseases, pneumophthisiology, neurology, plastic surgery, etc.) for a correct and complete diagnosis, for the appropriate therapy (antifungal, surgery, immunodeficiency care). The prognosis is excellent if the treatment is performed on time and properly, but untreated and disseminated infections have a mortality rate of almost 100%. Prophylaxis consists of the prevention and treatment of opportunistic infections in immunocompromised patients and the correct information of those who travel to endemic areas.<\/p>\n
Simpozion Roche-Posay: Toleriane Ultra – abordare eficient\u0103 \u00een managementul pielii intolerante, alergice \u0219i sensibile<\/span>
Speaker: Gabriela Stoleriu<\/span><\/p>\nProcesele biologice care antreneaz\u0103 deshidratarea pielii sunt complexe \u0219i includ o serie de factori care determin\u0103 deficien\u021be ale unor proteine \u0219i enzime responsabile de degradarea structurii cutanate, perturb\u0103ri ale func\u0163iilor celulare \u0219i ale echilibrului hidrolipidic. Coexisten\u021ba multiplilor factori favorizan\u0163i externi \u0219i interni influen\u0163eaz\u0103 sinergic modul \u00een care pielea reac\u021bioneaz\u0103, determin\u0103 frecvent imposibilitatea refacerii naturale a barierei tegumentare.
Unul din motivele de \u00eengrijorare la nivel local \u0219i mondial este reprezentat de cre\u0219terea num\u0103rului de persoane cu piele sensibil\u0103, \u00een special \u00een contextul epidemiologic actual.
Prin formularea sa unic\u0103, bogat\u0103 \u00een Ap\u0103 termal\u0103 La Roche-Posay, Niacinamid\u0103 \u0219i Neurosensin\u0103, gama TOLERIANE ULTRA \u0219i-a dovedit eficacitatea \u00een hidratarea, calmarea \u0219i redarea confortului pielii intolerante, alergice \u0219i sensibile.
Managementul acestei afec\u021biuni devine astfel un pilon important \u00een cre\u0219terea calit\u0103\u021bii vie\u021bii pacien\u021bilor, TOLERIANE ULTRA fiind parte integrant\u0103 din solu\u021bia terapeutic\u0103.<\/p>\n
Simpozion Roche-Posay: Toleriane Ultra – efficient approach in the management of intolerant, allergic and sensitive skin<\/span>
Speaker: Gabriela Stoleriu<\/span><\/p>\nThe biological processes that cause skin dehydration are complex and include several factors that cause deficiencies in proteins and enzymes responsible for the degradation of cutaneous structure, disorders of cellular function and hydrolipid balance. The coexistence of multiple external and internal factors influences the way the skin reacts, frequently causes the impossibility of natural restoration of skin barrier.
One of the local and global concerns is the growing number of people with sensitive skin, especially in the existent epidemiologic context.
By its unique formulation, rich in La Roche-Posay Thermal Water, Niacinamide and Neurosensin, TOLERIANE ULTRA range has proven its effectiveness in hydrating, smoothing and restoring the comfort of intolerant, allergic and sensitive skin.
The management of this pathology becomes an important step in increasing patients\u2019 quality of life, TOLERIANE ULTRA being the inner part of the therapeutic solution.<\/p>\n
Scurt CV<\/span><\/p>\n\n- Medic primar dermatovenerologie<\/li>\n
- Doctor \u00een medicin\u0103<\/li>\n
- Atestat \u00een dermato-cosmetologie<\/li>\n
- Formator \u00een dermato-cosmetologie (Lector)<\/li>\n<\/ul>\n
Colabor\u0103ri:<\/em>
Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 \u201dSf. Spiridon\u201d, Ia\u0219i
Derma Clinique, Ia\u0219i<\/p>\nAfiliere profesional\u0103:<\/em><\/p>\n\n- Societatea Rom\u00e2n\u0103 de Dermatologie (SRD)<\/li>\n
- \u00a0Societatea de Medici \u0219i Naturali\u0219ti \u2013 Ia\u015fi (SMN)<\/li>\n
- Asocia\u0163ia Dermatologilor din Moldova (ADEM)<\/li>\n
- Societatea Rom\u00e2n\u0103 de Dermato-Oncologie (SRDO)<\/li>\n
- Asocia\u021bia Rom\u00e2n\u0103 de Imuno-Dermatologie (ARID)<\/li>\n
- European Academy of Dermato-Venerology (EADV)<\/li>\n
- International Dermoscopy Society (IDS)<\/li>\n
- World Academy of Medical Sciences (WAMS)<\/li>\n
- American Academy of Dermatology (AAD)<\/li>\n<\/ul>\n
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Contacteaz\u0103 operatorul PDI 2021<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2021\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.9.4″ title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2021<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
![\"\"](\"https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ. Dr. Gabriela Stoleriu Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea \u201dDun\u0103rea de Jos\u201d, Gala\u0163iManifest\u0103ri cutanate ale imunoterapiei bazate pe anticorpi monoclonaliAutori: Gabriela Stoleriu1, Smaranda \u0162arean2, A. Oan\u0163\u01033 1 Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia2 Centrul Medical Topmed, T\u00e2rgu Mure\u015f, Rom\u00e2nia3 Dermamed, Bra\u015fov, Rom\u00e2nia Cuvinte cheie: […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8124","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=8124"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8124\/revisions"}],"predecessor-version":[{"id":10200,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8124\/revisions\/10200"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=8124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Conf. Univ. Dr. Gabriela Stoleriu<\/span><\/strong>
\nFacultatea de Medicin\u0103 \u015fi Farmacie, Universitatea \u201dDun\u0103rea de Jos\u201d, Gala\u0163i<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.7″ hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n
Manifest\u0103ri cutanate ale imunoterapiei bazate pe anticorpi monoclonali<\/span>
Autori: Gabriela Stoleriu1, Smaranda \u0162arean2, A. Oan\u0163\u01033<\/span><\/p>\n1 Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
2 Centrul Medical Topmed, T\u00e2rgu Mure\u015f, Rom\u00e2nia
3 Dermamed, Bra\u015fov, Rom\u00e2nia<\/p>\n
Cuvinte cheie: melanom malign metastatic, anticorpi monoclonali, exantem, vitiligo, keratoze<\/p>\n
Melanomul malign este o tumor\u0103 a melanocitelor sau a celulelor dezvoltate din melanocite, cu o inciden\u021b\u0103 anual\u0103 crescut\u0103 \u00een ultimele decenii. Dac\u0103 formele diagnosticate \u00eentr-un stadiu pu\u0163in avansat au prognostic bun \u015fi se pot vindeca doar prin excizie chirurgical\u0103, formele avansate \u015fi \u00eendeosebi formele metastatice au prognostic nefavorabil. Arsenalul terapeutic al melanomului nerezecabil sau metastatic const\u0103 \u00een: terapia \u0163intit\u0103 pentru tumori care poart\u0103 o muta\u0163ie activatoare a BRAF \u00een pozi\u0163ia V600 (molecule anti-BRAF: vemurafenib, dabrafenib \u015fi molecule anti-MEK: CI-1040, selumetinib, trametinib, cobimetinib), imunoterapia bazat\u0103 pe anticorpi monoclonali anti-CTLA4 (ipilimumab) \u015fi anti-PD1 (nivolumab \u015fi pembrolizumab), chimioterapia citotoxic\u0103 (dacarbazina, fotemustina, temozolomida +\/- platine \u015fi taxoizi). Imunoterapia cu inhibitori ai punctelor de control (anticorpi anti-PD1) \u00een melanomul metastatic permite o supravie\u0163uire medie global\u0103 superioar\u0103, pembrolizumab duc\u00e2nd la regresia tumorilor \u015fi cre\u015fterea ratei de supravie\u0163uire. Reac\u0163iile adverse ale pembrolizumabului pot fi severe. Dermatitele, pruritul, enterocolitele \u015fi hepatitele sunt cele mai frecvente. Mai pu\u0163in obi\u015fnuite sunt hipofizitele, uveitele, neuropatiile \u015fi sindromul Guillain-Barre. Moleculele au un profil de toleran\u0163\u0103 foarte diferit, iar efectele secundare trebuie prevenite \u015fi gestionate \u00eentr-o manier\u0103 adaptat\u0103 \u00eenainte de optimizarea complian\u0163ei tratamentului \u015fi eficien\u0163ei acestuia. Se impune o comunicare interdisciplinar\u0103 mai ales pentru pacien\u0163ii care necesit\u0103 tratament sistemic.<\/p>\n
Skin manifestations of immune checkpoint inhibitors<\/span>
Autori: Gabriela Stoleriu1, Smaranda \u0162arean2, A. Oan\u0163\u01033<\/span><\/p>\nMedical Clinical Department, Faculty of Medicine and Pharmacy,”Dun\u0103rea de Jos” University of Gala\u0163i, Romania
2Topmed Medical Center, T\u00e2rgu Mure\u015f, Romania
3Dermamed, Brasov, Romania<\/p>\n
Keywords: malignant melanoma, checkpoint inhibitors, exanthema, vitiligo, keratoses<\/p>\n
Malignant melanoma is a tumor of melanocytes or cells developed from melanocytes, with an increased annual incidence in recent decades. If the forms diagnosed at an advanced stage have a good prognosis and can be cured only by surgical excision, the advanced forms and especially the metastatic forms have an unfavorable prognosis. The therapeutic arsenal of unresectable or metastatic melanoma consists of: targeted therapy for tumors bearing a BRAF activating mutation at V600 (anti-BRAF molecules: vemurafenib, dabrafenib and anti-MEK molecules: CI-1040, selumetinib, trametinib, cobimetinib), immunotherapy based on anti-CTLA4 (ipilimumab) and anti-PD1 monoclonal antibodies (nivolumab and pembrolizumab), cytotoxic chemotherapy (dacarbazine, fotemustine, temozolomide +\/- platinum and taxoids). Immunotherapy with immune checkpoint inhibitors (anti-PD1 antibodies) in metastatic melanoma allows a higher overall mean survival, pembrolizumab leading to tumor regression and increased survival. Side effects of pembrolizumab can be severe. Dermatitis, pruritus, enterocolitis and hepatitis are the most common. Less common are pituitary, uveitis, neuropathy and Guillain-Barre syndrome. Molecules have a very different tolerance profile, and side effects must be prevented and managed in an appropriate manner before optimizing treatment compliance and its effectiveness. Interdisciplinary communication is required especially for patients requiring systemic treatment.<\/p>\n
Infec\u0163ii fungice cutanate profunde<\/span>
Autori: Gabriela Stoleriu1, Florina Mihaela Filip Ciubotaru2, Nicu\u0163a Manolache3, Daciana Br\u0103ni\u015fteanu4<\/span><\/p>\n1Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
2Disciplina Medicin\u0103 de Familie Adul\u021bi, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
3Departamentul \u015etiin\u0163e Farmaceutice, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
4Disciplina Dermatologie, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia<\/p>\n
Cuvinte cheie: aspergiloza, criptococoza, histoplasmoza, micetom, micoze profunde<\/p>\n
Infec\u021biile fungice cutanate profunde afecteaz\u0103 adesea persoane cu ocupa\u0163ii particulare (agricultori, fermieri, lucr\u0103tori \u00een cauciuc, v\u00e2n\u0103tori, cresc\u0103tori de porumbei, lucr\u0103tori pe \u0219antierele de construc\u021bii, \u00eentre\u0163inerea sistemelor de ventila\u021bie contaminate, exploratori), din anumite arii geografice (Africa de Sud, America Central\u0103, America de Sud, Argentina, Australia de Vest, provinciile canadiene din jurul Marilor Lacuri, China, India, Olanda, Orientul Mijlociu, v\u0103ile din jurul r\u00e2urilor Mississippi \u0219i Ohio, zonele cu clim\u0103 temperat\u0103, pe\u015fteri cu lilieci), \u015fi, chiar dac\u0103 sunt rar \u00eent\u00e2lnite \u00een Rom\u00e2nia, trebuie cunoscute datorit\u0103 turismului \u015fi emigr\u0103rii unui procent \u00eensemnat de rom\u00e2ni care se re\u00eentorc \u00een \u0163ar\u0103 \u00een vacan\u0163e. Aceste infec\u0163ii micotice se instaleaz\u0103 frecvent la pacien\u021bi cu imunodeficien\u0163\u0103 (SIDA, imunodeficien\u021ba primar\u0103, st\u0103ri imunosupresive induse de medicamente, v\u00e2rstele extreme), dar pot ap\u0103rea \u0219i la persoane imunocompetente. Morbiditatea \u0219i mortalitatea sunt legate de agentul etiologic, localizarea, durata \u0219i amploarea infec\u021biei. Fiecare dintre dintre micozele profunde (sporotricoza, aspergiloza, criptococoza, histoplasmoza, blastomicoza, mucormicoza, paracoccidioidomicoza, lobomicoza, ficomicoza, feohifomicoza, micetomul) implic\u0103 discu\u021bii asupra diagnosticelor diferen\u021biale \u0219i asupra posibilit\u0103\u021bilor examenelor de laborator care pot confirma supozi\u021bia de diagnostic. Este necesar consultul interdisciplinar (dermatologie, boli infec\u021bioase, pneumoftiziologie, neurologie, chirurgie plastic\u0103 etc.) pentru un diagnostic corect \u015fi complet, pentru instituirea c\u00e2t mai rapid\u0103 a terapiei corespunz\u0103toare (antifungice, chirurgie, \u00eengrijirea imunodeficien\u0163ei). Prognosticul este excelent dac\u0103 tratamentul este efectuat la timp \u0219i corespunz\u0103tor, dar infec\u0163iile netratate \u0219i diseminate au o rat\u0103 de mortalitate de aproape 100%. Profilaxia const\u0103 din prevenirea \u0219i tratamentul infec\u021biilor oportuniste la pacien\u021bii imunodeficien\u0163i, informarea corect\u0103 a celor care c\u0103l\u0103toresc \u00een zonele endemice.<\/p>\n
Deep skin fungal infections<\/span>
Autori: Gabriela Stoleriu1, Florina Mihaela Filip Ciubotaru2, Nicu\u0163a Manolache3, Daciana Br\u0103ni\u015fteanu4<\/span><\/p>\n1Department of Clinical Medicine, Faculty of Medicine and Pharmacy, Lower Danube University of Galati, Romania
2Discipline Family Medicine Adults, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
3Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, Dun\u0103rea de Jos University of Galati, Romania
4Dermatology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania<\/p>\n
Keywords: aspergillosis, cryptococcosis, histoplasmosis, mycetoma, deep mycoses<\/p>\n
Deep skin fungal infections often affect people with special occupations (farmers, rubber workers, hunters, pigeon breeders, construction site workers, maintenance of contaminated ventilation systems, explorers), from certain geographical areas (South Africa, America Central, South America, Argentina, Western Australia, the Canadian provinces around the Great Lakes, China, India, the Netherlands, the Middle East, the valleys around the Mississippi and Ohio rivers, temperate areas, bat caves), and even they are rarely found in Romania, they must be known due to tourism and emigration of a significant percentage of Romanians who return to the country on vacation. These fungal infections are common in patients with immunodeficiency (AIDS, primary immunodeficiency, drug-induced immunosuppressive conditions, extreme ages), but can also occur in immunocompetent individuals. Morbidity and mortality are related to the etiological agent, the location, duration and extent of the infection. Each of the deep mycoses (sporotrichosis, aspergillosis, cryptococcosis, histoplasmosis, blastomycosis, mucormycosis, paracoccidioidomycosis, lobomycosis, phycomycosis, pheohifomycosis, mycetoma) involves discussions of differential diagnoses and the possibilities of laboratory examinations. It is necessary the interdisciplinary consultation (dermatology, infectious diseases, pneumophthisiology, neurology, plastic surgery, etc.) for a correct and complete diagnosis, for the appropriate therapy (antifungal, surgery, immunodeficiency care). The prognosis is excellent if the treatment is performed on time and properly, but untreated and disseminated infections have a mortality rate of almost 100%. Prophylaxis consists of the prevention and treatment of opportunistic infections in immunocompromised patients and the correct information of those who travel to endemic areas.<\/p>\n
Simpozion Roche-Posay: Toleriane Ultra – abordare eficient\u0103 \u00een managementul pielii intolerante, alergice \u0219i sensibile<\/span>
Speaker: Gabriela Stoleriu<\/span><\/p>\nProcesele biologice care antreneaz\u0103 deshidratarea pielii sunt complexe \u0219i includ o serie de factori care determin\u0103 deficien\u021be ale unor proteine \u0219i enzime responsabile de degradarea structurii cutanate, perturb\u0103ri ale func\u0163iilor celulare \u0219i ale echilibrului hidrolipidic. Coexisten\u021ba multiplilor factori favorizan\u0163i externi \u0219i interni influen\u0163eaz\u0103 sinergic modul \u00een care pielea reac\u021bioneaz\u0103, determin\u0103 frecvent imposibilitatea refacerii naturale a barierei tegumentare.
Unul din motivele de \u00eengrijorare la nivel local \u0219i mondial este reprezentat de cre\u0219terea num\u0103rului de persoane cu piele sensibil\u0103, \u00een special \u00een contextul epidemiologic actual.
Prin formularea sa unic\u0103, bogat\u0103 \u00een Ap\u0103 termal\u0103 La Roche-Posay, Niacinamid\u0103 \u0219i Neurosensin\u0103, gama TOLERIANE ULTRA \u0219i-a dovedit eficacitatea \u00een hidratarea, calmarea \u0219i redarea confortului pielii intolerante, alergice \u0219i sensibile.
Managementul acestei afec\u021biuni devine astfel un pilon important \u00een cre\u0219terea calit\u0103\u021bii vie\u021bii pacien\u021bilor, TOLERIANE ULTRA fiind parte integrant\u0103 din solu\u021bia terapeutic\u0103.<\/p>\n
Simpozion Roche-Posay: Toleriane Ultra – efficient approach in the management of intolerant, allergic and sensitive skin<\/span>
Speaker: Gabriela Stoleriu<\/span><\/p>\nThe biological processes that cause skin dehydration are complex and include several factors that cause deficiencies in proteins and enzymes responsible for the degradation of cutaneous structure, disorders of cellular function and hydrolipid balance. The coexistence of multiple external and internal factors influences the way the skin reacts, frequently causes the impossibility of natural restoration of skin barrier.
One of the local and global concerns is the growing number of people with sensitive skin, especially in the existent epidemiologic context.
By its unique formulation, rich in La Roche-Posay Thermal Water, Niacinamide and Neurosensin, TOLERIANE ULTRA range has proven its effectiveness in hydrating, smoothing and restoring the comfort of intolerant, allergic and sensitive skin.
The management of this pathology becomes an important step in increasing patients\u2019 quality of life, TOLERIANE ULTRA being the inner part of the therapeutic solution.<\/p>\n
Scurt CV<\/span><\/p>\n\n- Medic primar dermatovenerologie<\/li>\n
- Doctor \u00een medicin\u0103<\/li>\n
- Atestat \u00een dermato-cosmetologie<\/li>\n
- Formator \u00een dermato-cosmetologie (Lector)<\/li>\n<\/ul>\n
Colabor\u0103ri:<\/em>
Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 \u201dSf. Spiridon\u201d, Ia\u0219i
Derma Clinique, Ia\u0219i<\/p>\nAfiliere profesional\u0103:<\/em><\/p>\n\n- Societatea Rom\u00e2n\u0103 de Dermatologie (SRD)<\/li>\n
- \u00a0Societatea de Medici \u0219i Naturali\u0219ti \u2013 Ia\u015fi (SMN)<\/li>\n
- Asocia\u0163ia Dermatologilor din Moldova (ADEM)<\/li>\n
- Societatea Rom\u00e2n\u0103 de Dermato-Oncologie (SRDO)<\/li>\n
- Asocia\u021bia Rom\u00e2n\u0103 de Imuno-Dermatologie (ARID)<\/li>\n
- European Academy of Dermato-Venerology (EADV)<\/li>\n
- International Dermoscopy Society (IDS)<\/li>\n
- World Academy of Medical Sciences (WAMS)<\/li>\n
- American Academy of Dermatology (AAD)<\/li>\n<\/ul>\n
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Contacteaz\u0103 operatorul PDI 2021<\/p>\n
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Operatorul PDI 2021<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ. Dr. Gabriela Stoleriu Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea \u201dDun\u0103rea de Jos\u201d, Gala\u0163iManifest\u0103ri cutanate ale imunoterapiei bazate pe anticorpi monoclonaliAutori: Gabriela Stoleriu1, Smaranda \u0162arean2, A. Oan\u0163\u01033 1 Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia2 Centrul Medical Topmed, T\u00e2rgu Mure\u015f, Rom\u00e2nia3 Dermamed, Bra\u015fov, Rom\u00e2nia Cuvinte cheie: […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8124","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=8124"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8124\/revisions"}],"predecessor-version":[{"id":10200,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8124\/revisions\/10200"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=8124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Gabriela Stoleriu1, Smaranda \u0162arean2, A. Oan\u0163\u01033<\/span><\/p>\n
1 Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
2 Centrul Medical Topmed, T\u00e2rgu Mure\u015f, Rom\u00e2nia
3 Dermamed, Bra\u015fov, Rom\u00e2nia<\/p>\n
Cuvinte cheie: melanom malign metastatic, anticorpi monoclonali, exantem, vitiligo, keratoze<\/p>\n
Melanomul malign este o tumor\u0103 a melanocitelor sau a celulelor dezvoltate din melanocite, cu o inciden\u021b\u0103 anual\u0103 crescut\u0103 \u00een ultimele decenii. Dac\u0103 formele diagnosticate \u00eentr-un stadiu pu\u0163in avansat au prognostic bun \u015fi se pot vindeca doar prin excizie chirurgical\u0103, formele avansate \u015fi \u00eendeosebi formele metastatice au prognostic nefavorabil. Arsenalul terapeutic al melanomului nerezecabil sau metastatic const\u0103 \u00een: terapia \u0163intit\u0103 pentru tumori care poart\u0103 o muta\u0163ie activatoare a BRAF \u00een pozi\u0163ia V600 (molecule anti-BRAF: vemurafenib, dabrafenib \u015fi molecule anti-MEK: CI-1040, selumetinib, trametinib, cobimetinib), imunoterapia bazat\u0103 pe anticorpi monoclonali anti-CTLA4 (ipilimumab) \u015fi anti-PD1 (nivolumab \u015fi pembrolizumab), chimioterapia citotoxic\u0103 (dacarbazina, fotemustina, temozolomida +\/- platine \u015fi taxoizi). Imunoterapia cu inhibitori ai punctelor de control (anticorpi anti-PD1) \u00een melanomul metastatic permite o supravie\u0163uire medie global\u0103 superioar\u0103, pembrolizumab duc\u00e2nd la regresia tumorilor \u015fi cre\u015fterea ratei de supravie\u0163uire. Reac\u0163iile adverse ale pembrolizumabului pot fi severe. Dermatitele, pruritul, enterocolitele \u015fi hepatitele sunt cele mai frecvente. Mai pu\u0163in obi\u015fnuite sunt hipofizitele, uveitele, neuropatiile \u015fi sindromul Guillain-Barre. Moleculele au un profil de toleran\u0163\u0103 foarte diferit, iar efectele secundare trebuie prevenite \u015fi gestionate \u00eentr-o manier\u0103 adaptat\u0103 \u00eenainte de optimizarea complian\u0163ei tratamentului \u015fi eficien\u0163ei acestuia. Se impune o comunicare interdisciplinar\u0103 mai ales pentru pacien\u0163ii care necesit\u0103 tratament sistemic.<\/p>\n
Skin manifestations of immune checkpoint inhibitors<\/span> Medical Clinical Department, Faculty of Medicine and Pharmacy,”Dun\u0103rea de Jos” University of Gala\u0163i, Romania Keywords: malignant melanoma, checkpoint inhibitors, exanthema, vitiligo, keratoses<\/p>\n Malignant melanoma is a tumor of melanocytes or cells developed from melanocytes, with an increased annual incidence in recent decades. If the forms diagnosed at an advanced stage have a good prognosis and can be cured only by surgical excision, the advanced forms and especially the metastatic forms have an unfavorable prognosis. The therapeutic arsenal of unresectable or metastatic melanoma consists of: targeted therapy for tumors bearing a BRAF activating mutation at V600 (anti-BRAF molecules: vemurafenib, dabrafenib and anti-MEK molecules: CI-1040, selumetinib, trametinib, cobimetinib), immunotherapy based on anti-CTLA4 (ipilimumab) and anti-PD1 monoclonal antibodies (nivolumab and pembrolizumab), cytotoxic chemotherapy (dacarbazine, fotemustine, temozolomide +\/- platinum and taxoids). Immunotherapy with immune checkpoint inhibitors (anti-PD1 antibodies) in metastatic melanoma allows a higher overall mean survival, pembrolizumab leading to tumor regression and increased survival. Side effects of pembrolizumab can be severe. Dermatitis, pruritus, enterocolitis and hepatitis are the most common. Less common are pituitary, uveitis, neuropathy and Guillain-Barre syndrome. Molecules have a very different tolerance profile, and side effects must be prevented and managed in an appropriate manner before optimizing treatment compliance and its effectiveness. Interdisciplinary communication is required especially for patients requiring systemic treatment.<\/p>\n Infec\u0163ii fungice cutanate profunde<\/span> 1Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia Cuvinte cheie: aspergiloza, criptococoza, histoplasmoza, micetom, micoze profunde<\/p>\n Infec\u021biile fungice cutanate profunde afecteaz\u0103 adesea persoane cu ocupa\u0163ii particulare (agricultori, fermieri, lucr\u0103tori \u00een cauciuc, v\u00e2n\u0103tori, cresc\u0103tori de porumbei, lucr\u0103tori pe \u0219antierele de construc\u021bii, \u00eentre\u0163inerea sistemelor de ventila\u021bie contaminate, exploratori), din anumite arii geografice (Africa de Sud, America Central\u0103, America de Sud, Argentina, Australia de Vest, provinciile canadiene din jurul Marilor Lacuri, China, India, Olanda, Orientul Mijlociu, v\u0103ile din jurul r\u00e2urilor Mississippi \u0219i Ohio, zonele cu clim\u0103 temperat\u0103, pe\u015fteri cu lilieci), \u015fi, chiar dac\u0103 sunt rar \u00eent\u00e2lnite \u00een Rom\u00e2nia, trebuie cunoscute datorit\u0103 turismului \u015fi emigr\u0103rii unui procent \u00eensemnat de rom\u00e2ni care se re\u00eentorc \u00een \u0163ar\u0103 \u00een vacan\u0163e. Aceste infec\u0163ii micotice se instaleaz\u0103 frecvent la pacien\u021bi cu imunodeficien\u0163\u0103 (SIDA, imunodeficien\u021ba primar\u0103, st\u0103ri imunosupresive induse de medicamente, v\u00e2rstele extreme), dar pot ap\u0103rea \u0219i la persoane imunocompetente. Morbiditatea \u0219i mortalitatea sunt legate de agentul etiologic, localizarea, durata \u0219i amploarea infec\u021biei. Fiecare dintre dintre micozele profunde (sporotricoza, aspergiloza, criptococoza, histoplasmoza, blastomicoza, mucormicoza, paracoccidioidomicoza, lobomicoza, ficomicoza, feohifomicoza, micetomul) implic\u0103 discu\u021bii asupra diagnosticelor diferen\u021biale \u0219i asupra posibilit\u0103\u021bilor examenelor de laborator care pot confirma supozi\u021bia de diagnostic. Este necesar consultul interdisciplinar (dermatologie, boli infec\u021bioase, pneumoftiziologie, neurologie, chirurgie plastic\u0103 etc.) pentru un diagnostic corect \u015fi complet, pentru instituirea c\u00e2t mai rapid\u0103 a terapiei corespunz\u0103toare (antifungice, chirurgie, \u00eengrijirea imunodeficien\u0163ei). Prognosticul este excelent dac\u0103 tratamentul este efectuat la timp \u0219i corespunz\u0103tor, dar infec\u0163iile netratate \u0219i diseminate au o rat\u0103 de mortalitate de aproape 100%. Profilaxia const\u0103 din prevenirea \u0219i tratamentul infec\u021biilor oportuniste la pacien\u021bii imunodeficien\u0163i, informarea corect\u0103 a celor care c\u0103l\u0103toresc \u00een zonele endemice.<\/p>\n Deep skin fungal infections<\/span> 1Department of Clinical Medicine, Faculty of Medicine and Pharmacy, Lower Danube University of Galati, Romania Keywords: aspergillosis, cryptococcosis, histoplasmosis, mycetoma, deep mycoses<\/p>\n Deep skin fungal infections often affect people with special occupations (farmers, rubber workers, hunters, pigeon breeders, construction site workers, maintenance of contaminated ventilation systems, explorers), from certain geographical areas (South Africa, America Central, South America, Argentina, Western Australia, the Canadian provinces around the Great Lakes, China, India, the Netherlands, the Middle East, the valleys around the Mississippi and Ohio rivers, temperate areas, bat caves), and even they are rarely found in Romania, they must be known due to tourism and emigration of a significant percentage of Romanians who return to the country on vacation. These fungal infections are common in patients with immunodeficiency (AIDS, primary immunodeficiency, drug-induced immunosuppressive conditions, extreme ages), but can also occur in immunocompetent individuals. Morbidity and mortality are related to the etiological agent, the location, duration and extent of the infection. Each of the deep mycoses (sporotrichosis, aspergillosis, cryptococcosis, histoplasmosis, blastomycosis, mucormycosis, paracoccidioidomycosis, lobomycosis, phycomycosis, pheohifomycosis, mycetoma) involves discussions of differential diagnoses and the possibilities of laboratory examinations. It is necessary the interdisciplinary consultation (dermatology, infectious diseases, pneumophthisiology, neurology, plastic surgery, etc.) for a correct and complete diagnosis, for the appropriate therapy (antifungal, surgery, immunodeficiency care). The prognosis is excellent if the treatment is performed on time and properly, but untreated and disseminated infections have a mortality rate of almost 100%. Prophylaxis consists of the prevention and treatment of opportunistic infections in immunocompromised patients and the correct information of those who travel to endemic areas.<\/p>\n Simpozion Roche-Posay: Toleriane Ultra – abordare eficient\u0103 \u00een managementul pielii intolerante, alergice \u0219i sensibile<\/span> Procesele biologice care antreneaz\u0103 deshidratarea pielii sunt complexe \u0219i includ o serie de factori care determin\u0103 deficien\u021be ale unor proteine \u0219i enzime responsabile de degradarea structurii cutanate, perturb\u0103ri ale func\u0163iilor celulare \u0219i ale echilibrului hidrolipidic. Coexisten\u021ba multiplilor factori favorizan\u0163i externi \u0219i interni influen\u0163eaz\u0103 sinergic modul \u00een care pielea reac\u021bioneaz\u0103, determin\u0103 frecvent imposibilitatea refacerii naturale a barierei tegumentare. Simpozion Roche-Posay: Toleriane Ultra – efficient approach in the management of intolerant, allergic and sensitive skin<\/span> The biological processes that cause skin dehydration are complex and include several factors that cause deficiencies in proteins and enzymes responsible for the degradation of cutaneous structure, disorders of cellular function and hydrolipid balance. The coexistence of multiple external and internal factors influences the way the skin reacts, frequently causes the impossibility of natural restoration of skin barrier. Scurt CV<\/span><\/p>\n Colabor\u0103ri:<\/em> Afiliere profesional\u0103:<\/em><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ 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A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,9252,9464,10156,10157″ fullwidth=”on” _builder_version=”4.9.7″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Conf. Univ. Dr. Gabriela Stoleriu Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea \u201dDun\u0103rea de Jos\u201d, Gala\u0163iManifest\u0103ri cutanate ale imunoterapiei bazate pe anticorpi monoclonaliAutori: Gabriela Stoleriu1, Smaranda \u0162arean2, A. Oan\u0163\u01033 1 Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia2 Centrul Medical Topmed, T\u00e2rgu Mure\u015f, Rom\u00e2nia3 Dermamed, Bra\u015fov, Rom\u00e2nia Cuvinte cheie: […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8124","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=8124"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8124\/revisions"}],"predecessor-version":[{"id":10200,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8124\/revisions\/10200"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=8124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Gabriela Stoleriu1, Smaranda \u0162arean2, A. Oan\u0163\u01033<\/span><\/p>\n
2Topmed Medical Center, T\u00e2rgu Mure\u015f, Romania
3Dermamed, Brasov, Romania<\/p>\n
Autori: Gabriela Stoleriu1, Florina Mihaela Filip Ciubotaru2, Nicu\u0163a Manolache3, Daciana Br\u0103ni\u015fteanu4<\/span><\/p>\n
2Disciplina Medicin\u0103 de Familie Adul\u021bi, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
3Departamentul \u015etiin\u0163e Farmaceutice, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
4Disciplina Dermatologie, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia<\/p>\n
Autori: Gabriela Stoleriu1, Florina Mihaela Filip Ciubotaru2, Nicu\u0163a Manolache3, Daciana Br\u0103ni\u015fteanu4<\/span><\/p>\n
2Discipline Family Medicine Adults, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
3Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, Dun\u0103rea de Jos University of Galati, Romania
4Dermatology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania<\/p>\n
Speaker: Gabriela Stoleriu<\/span><\/p>\n
Unul din motivele de \u00eengrijorare la nivel local \u0219i mondial este reprezentat de cre\u0219terea num\u0103rului de persoane cu piele sensibil\u0103, \u00een special \u00een contextul epidemiologic actual.
Prin formularea sa unic\u0103, bogat\u0103 \u00een Ap\u0103 termal\u0103 La Roche-Posay, Niacinamid\u0103 \u0219i Neurosensin\u0103, gama TOLERIANE ULTRA \u0219i-a dovedit eficacitatea \u00een hidratarea, calmarea \u0219i redarea confortului pielii intolerante, alergice \u0219i sensibile.
Managementul acestei afec\u021biuni devine astfel un pilon important \u00een cre\u0219terea calit\u0103\u021bii vie\u021bii pacien\u021bilor, TOLERIANE ULTRA fiind parte integrant\u0103 din solu\u021bia terapeutic\u0103.<\/p>\n
Speaker: Gabriela Stoleriu<\/span><\/p>\n
One of the local and global concerns is the growing number of people with sensitive skin, especially in the existent epidemiologic context.
By its unique formulation, rich in La Roche-Posay Thermal Water, Niacinamide and Neurosensin, TOLERIANE ULTRA range has proven its effectiveness in hydrating, smoothing and restoring the comfort of intolerant, allergic and sensitive skin.
The management of this pathology becomes an important step in increasing patients\u2019 quality of life, TOLERIANE ULTRA being the inner part of the therapeutic solution.<\/p>\n\n
Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 \u201dSf. Spiridon\u201d, Ia\u0219i
Derma Clinique, Ia\u0219i<\/p>\n\n
<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n