{"id":8335,"date":"2020-06-17T11:44:26","date_gmt":"2020-06-17T09:44:26","guid":{"rendered":"https:\/\/primaderma.ro\/?page_id=8335"},"modified":"2021-07-07T11:50:02","modified_gmt":"2021-07-07T09:50:02","slug":"asist-univ-dr-radu-antonia","status":"publish","type":"page","link":"https:\/\/pdi.ro\/2021\/asist-univ-dr-radu-antonia\/","title":{"rendered":"Asist. Univ. Dr. Radu Antonia"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|off|off” _builder_version=”3.22″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#f0622a” top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” collapsed=”off” global_module=”9062″][et_pb_fullwidth_header title=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@” text_orientation=”right” header_image_url=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_logo_header_int_600x300px.png” disabled_on=”on|on|off” _builder_version=”4.9.4″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”right” title_text_color=”#f0622a” title_font_size=”50px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” subhead_font=”||||||||” background_color=”#ef916b” background_image=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”luminosity” background_layout=”light” custom_margin=”0px||8px” custom_padding=”40px||40px||true” content_font_size_tablet=”” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ locked=”off”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”3.25″][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2020\/06\/Radu-Antonia.png” title_text=”Radu Antonia” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.4.8″ max_width=”31%” border_radii=”on|100px|100px|100px|100px”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.4.8″]<\/p>\n

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Asist. Univ. Dr. Radu Antonia<\/span><\/strong>
Universitatea de Medicin\u0103 \u015fi Farmacie din Craiova<\/span><\/strong><\/h4>\n

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Studiul imunohistochimic comparativ al CD 117 \u00een leziunile melanocitare<\/span>
Autori: Antonia Radu1, Cornelia Bejenaru1, I \u0162olea2, LE Bejenaru3, Gabriela Stoleriu4, Daciana Elena Br\u0103ni\u015fteanu5<\/span>
1Departamentul de Botanic\u0103 Farmaceutic\u0103, Universitatea de Medicin\u0103 \u0219i Farmacie Craiova
2Departamentul de Dermatologie, Universitatea de Medicin\u0103 \u0219i Farmacie Craiova
3Departmentul de Farmacognozie \u0219i Fitoterapie, Universitatea de Medicin\u0103 \u0219i Farmacie Craiova
4Departamentul Clinic, Universitatea de Medicin\u0103 \u0219i Farmacie “Dun\u0103rea de Jos” Gala\u021bi
5Departamentul de Dermatologie, Universitatea de Medicin\u0103 \u0219i Farmacie “Grigore T. Popa” Ia\u015fi, Rom\u00e2nia<\/p>\n

Cuvinte cheie: melanom, CD 117, imunohistochimie, tumorigeneza, inhibitori de tirozin kinaza<\/p>\n

Scopul acestui studiu a fost evaluarea imunohistochimic\u0103 comparativ\u0103 a lui CD 117, biomarkerul care evalueaz\u0103 at\u00e2t progresia, c\u00e2t \u0219i prognosticul tumoral, \u00een diferite leziuni melanocitare, pentru a eviden\u021bia importan\u021ba acestui biomarker \u00een melanomul malign (MM). Studiul a fost f\u0103cut pe 55 de cazuri, reprezentate de un grup de control, care a inclus 10 cazuri de nevi, c\u00e2t \u0219i de un grup de studiu, care con\u021binea 35 de cazuri de melanom primar \u0219i 10 metastaze. CD 117 este extrem de implicat \u00een procesul de tumorigenez\u0103 al tumorilor cutanate, fiind nedetectabil din punct de vedere imunohistochimic \u00een leziunile benigne, dar intens exprimat \u00een leziunile displazice \u0219i \u00een zonele de melanom in situ. \u00cen melanoamele invazive, expresia lui CD 117 tinde s\u0103 descreasc\u0103 odat\u0103 cu progresia neoplaziei \u0219i intrarea \u00een faza tumorigenic\u0103, de cre\u0219tere vertical\u0103, fiind mai sc\u0103zut\u0103 \u00een componen\u021ba dermic\u0103 profund\u0103 a tumorilor \u0219i in melanoamele nodulare. Pentru a elimina barierele epidermice \u0219i a ca\u0219tiga un avantaj proliferativ pentru a permite tranzi\u021bia c\u0103tre faza de cre\u0219tere vertical\u0103, se pare c\u0103 MM ar trebui s\u0103 piard\u0103 expresia lui CD117. Metastazele cutanate exprim\u0103 CD 117 la un nivel comparabil cu tumorile lor primare, suger\u00e2nd ca alte mecanisme intervin direct \u00een procesul de metastaz\u0103, nu doar pierderea expresiei CD 117. Supraexpresia CD 117 \u00een leziunile melanocitare cutanate se coreleaz\u0103 semnificativ cu intensitatea crescut\u0103 a imunocoloratiei, suger\u00e2nd c\u0103 evaluarea imunohistochimic\u0103 a lui CD 117 poate deveni o bun\u0103 metod\u0103 pentru screening-ul pacien\u021bilor, care ar putea beneficia de o terapie personalizat\u0103 cu inhibitori de tirozin kinaz\u0103.<\/p>\n

Comparative immunohistochemical evaluation of CD 117 in melanocytic lesions<\/span>
Autori: Antonia Radu1, Cornelia Bejenaru1, I \u0162olea2, LE Bejenaru3, Gabriela Stoleriu4, Daciana Elena Br\u0103ni\u015fteanu5<\/span>
1Pharmaceutical Botany Department, University of Medicine and Pharmacy Craiova
2Dermatology Department, University of Medicine and Pharmacy Craiova
3Department of Pharmacognosy and Phytotherapy, University of Medicine and Pharmacy Craiova
4Clinical Department, Faculty of Medicine and Pharmacy, “Dun\u0103rea de Jos” University Galati
5Dermatology Department, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy Iasi, Romania<\/p>\n

Keywords: melanoma, CD 117, immunohistochemistry, tumorigenesis, tyrosine kinase inhibitors<\/p>\n

The aim of this research was to do a comparative immunohistochemical evaluation of CD 117, the biomarker that evaluates both tumor progression and prognosis, in different melanocytic lesions, to emphasize the significance of this biomarker in malignant melanoma (MM). The study was performed on 55 cases, represented by a control group, which included 10 cases of nevi, as well as a study group consisting of 35 cases of primary MM and 10 metastases. CD 117 is massively involved in the process of tumorigenesis of cutaneous malignancies, being immunohistochemically undetectable in benign neural lesions, but densely expressed in dysplastic lesions and in situ melanoma areas. In invasive cutaneous MMs, CD 117 expression tends to decrease as neoplasia progresses and goes into the tumorigenic, vertical growth phase, being lower in the profound dermal component of tumors and in nodular MMs. To eliminate the epidermal barriers and gain a proliferative advantage to allow the transition to the vertical growth phase, it seems that MM should lose expression of CD 117. Cutaneous metastases express CD 117 at a level comparable to their primary tumors, suggesting that other mechanisms interfere directly with the metastasis process and not loss of CD 117 expression by itself. CD 117 overexpression in cutaneous melanocytic lesions correlates significantly with increased immunostaining intensity, suggesting that the immunohistochemical evaluation of CD 117 may be a good method for screening patients, who could benefit from a personalized therapy with tyrosine kinase inhibitors.<\/p>\n

Scurt CV<\/span><\/p>\n

Profesia, titlul \u015ftiin\u0163ific: farmacist, doctor \u00een medicin\u0103, asistent universitar UMF Craiova, jurist<\/p>\n

Studii:<\/strong>
Universitare:<\/em>
▪ Facultatea de Drept \u015fi \u015etiin\u0163e Administrative, Universitatea din Craiova: 2012
▪ Facultatea de Farmacie, Universitatea de Medicin\u0103 \u015fi Farmacie din Craiova: 2013
Postuniversitare:<\/em>
\u2013 Specialitate “Drept Privat\u201d, Facultatea de Drept \u015fi \u015etiin\u0163e Administrative, Universitatea din Craiova: 2013
\u2013 Specialitate “Farmacologie \u015fi Toxicologie\u201d, Facultatea de Farmacie, U.M.F. din Craiova: 2014<\/p>\n

Realiz\u0103ri \u015ftiin\u0163ifice \u015fi profesionale:<\/strong>
Experien\u0163\u0103 profesional\u0103:<\/em>
2013-prezent: Farmacist Diriginte, SC Izvorul Tamaduirii Biovita SRL
2018-prezent: Asistent Universitar Dr., disciplina Botanica Farmaceutica, Facultatea de Farmacie, U.M.F. Craiova
Activitate \u015ftiin\u0163ific\u0103:<\/em>
Doctorat – UMF Craiova:
▪ Titlul tezei de doctorat: “Studiul parametrilor clinico-morfologici \u015fi al markerilor imunohistochimici cu implica\u0163ii tumorigenice, prognostice \u015fi terapeutice \u00een melanomul malign cutanat\u201d, sub conducerea Prof. Univ. Dr. Anica Dricu;
▪ Confirmarea titlului de doctor \u00een domeniul Medicin\u0103: Ord. M.E.N. nr. 3356\/21.03.2018.
Proiecte de cercetare:<\/em>
2014-2015: POSDRU\/159\/1.5\/S\/133377, titlu: “Probleme de diagnostic \u00een melanomul malign \u2013 implica\u021bii terapeutice”
2016-2017: UMF Craiova, titlu: “Evaluarea in vitro a efectului acidului salicilic asupra tumorilor cerebrale”
Lucr\u0103ri in extenso publicate \u00een reviste cotate ISI Web of Science sau indexate BDI: 13
Articole publicate \u00een rezumat \u00een volumele unor manifest\u0103ri \u015ftiin\u0163ifice cu ISBN sau ISSN: 27
\u00a0Membru al unor societ\u0103\u0163i \u015ftiin\u0163ifice la nivel national:<\/em>
▪ Societatea de \u015etiin\u0163e Farmaceutice din Rom\u00e2nia
▪ Societatea Rom\u00e2n\u0103 de Istoria Farmaciei
▪ Societatea Rom\u00e2n\u0103 de Biologie Celular\u0103
▪ Societatea Rom\u00e2n\u0103 de Biochimie \u015fi Biologie Molecular\u0103
▪ Societatea Rom\u00e2n\u0103 de Dermatologie<\/p>\n

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Asist. Univ. Dr. Radu AntoniaUniversitatea de Medicin\u0103 \u015fi Farmacie din CraiovaStudiul imunohistochimic comparativ al CD 117 \u00een leziunile melanocitareAutori: Antonia Radu1, Cornelia Bejenaru1, I \u0162olea2, LE Bejenaru3, Gabriela Stoleriu4, Daciana Elena Br\u0103ni\u015fteanu51Departamentul de Botanic\u0103 Farmaceutic\u0103, Universitatea de Medicin\u0103 \u0219i Farmacie Craiova2Departamentul de Dermatologie, Universitatea de Medicin\u0103 \u0219i Farmacie Craiova3Departmentul de Farmacognozie \u0219i Fitoterapie, Universitatea de […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-8335","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=8335"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8335\/revisions"}],"predecessor-version":[{"id":10081,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/8335\/revisions\/10081"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=8335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}