<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nConf. Univ. Dr. Anca Oana Docea<\/strong><\/span>
Departamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia<\/p>\n<\/strong><\/span><\/h4>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ locked=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.7″ hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n
Nanoparticulele de argint stabilizate cu etilen glicol ca nou\u0103 op\u021biune pentru tratamentul infec\u021biilor antibacteriene \u00een vindecarea r\u0103nilor: o evaluare toxicologic\u0103<\/span>
Autori: Anca Oana Docea1, Laurentiu Mogoanta2, Daniela Calina3<\/span><\/p>\n1Departamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia
2 Departamentul de histologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia
3Departamentul de Farmacie Clinic\u0103, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia
<\/span><\/p>\nDezvoltarea bacteriilor cu rezisten\u021b\u0103 multipl\u0103 reprezint\u0103 o mare provocare pentru tratamentul infec\u021biilor cutanate \u0219i vindecarea r\u0103nilor. Noi alternative pentru antibioticele standard sunt studiate intens pentru a reduce inciden\u021ba rezisten\u021bei bacteriilor \u0219i pentru a cre\u0219te r\u0103spunsul terapeutic. Nanoparticulele de argint (AgNPs) sunt studiate pe larg pentru capacitatea lor de a trata infec\u021biile bacteriene, fungice \u0219i virale, \u00eempreun\u0103 cu capacitatea lor de a promova vindecarea r\u0103nilor. Avantajul utiliz\u0103rii nanoparticulelor de argint este legat de costul redus, eficacitatea ridicat\u0103 \u0219i toxicitatea sc\u0103zut\u0103. In acest studiu am sintetizat nanoparticule de argint stabilizate cu etilen glicol (EG) printr-o reac\u021bie simpl\u0103 de reducere a azotatului de argint \u00eentr-o solu\u021bie alcalin\u0103 de EG \u0219i hidroxid de sodiu. Toxicitatea subcronic\u0103 a AgNPs a fost testat\u0103 pe patruzeci de \u0219obolani CD-SD de 12 s\u0103pt\u0103m\u00e2ni (20 de masculi\u0219i 20 de femele). Animalele au fost \u00eemp\u0103r\u021bite \u00een 4 grupuri de c\u00e2te 10 \u0219obolani per grup (5 femele \u0219i 5 masculi) \u0219i expuse timp de 28 de zile intraperitoneal la 0 mg\/kgc; 1 mg\/kgc Ag-EG, 2 mg\/kgc Ag-EG si respectiv, 4 mg\/kgc Ag-EG. Ag-EG NPs au prezentat o toxicitate sc\u0103zut\u0103 la dozele maxime testate de 4 mg\/kgc administrate intraperitoneal. Argintul s-a acumulat mai ales \u00een ficat \u0219i splin\u0103 \u0219i cantitati infima au fost detectate \u00een inim\u0103, pl\u0103m\u00e2ni, rinichi \u0219i creier. Nu s-au observat modific\u0103ri histopatologice \u00een organele de acumulare. \u00cen concluzie, nanoparticule de argint stabilizate cu etilen glicol sunt considerate o op\u021biune sigur\u0103 pentru tratamentul r\u0103nilor de la nivelul pielii si mucoaselor, chiar dac\u0103 sunt absorbite \u00een circula\u021bia sistemic\u0103.<\/p>\n
Ethylene glycol silver nanoparticles as a new option for the treatment of antibacterial infections in wound healing: a toxicological evaluation<\/span>
Autori: Anca Oana Docea1, Laurentiu Mogoanta2, Daniela Calina3<\/span><\/p>\n1Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
2 Department of Histology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
3 Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
<\/span><\/p>\nThe development of multiple resistance bacteria poses a big challenge for the treatment of several skin infections and wound healing. New alternatives for standard antibiotics have been tried to decrease the incidence of bacteria resistance and to increase the therapeutical response. Silver nanoparticles (AgNPs) are extensively studied for their ability to treat bacterial, fungal and viral infections along with their ability to promote wound healing. The advantage of using silver nanoparticles is related to low cost, high efficacy and low toxicity. In this study we synthesized ethylene glycol (EG) silver nanoparticles through a simple reduction reaction of silver nitrate in an alkaline solution of EG and sodium hydroxide. The sub-chronic toxicity of AgNPs was tested on forty 12-week CD-SD rats (20 males and 20 females). Animals were divided into 4 groups of 10 rats per group (5 females and 5 males) and exposed for 28 days intraperitoneally at 0 mg\/body weight; 1 mg \/kg body weight Ag-EG, 2 mg\/kg body weight Ag-EG, 4 mg\/kg of Ag-EG body. AgNPs functionalized with EG showed low toxicity at the maximum tested doses of 4 mg\/kg body weight administered intraperitoneally. The silver was accumulated especially in the liver and spleen and in low levels in the heart, lung, kidney and brain. No histopathological changes have been observed in the organs of accumulation. In conclusion, ethylene glycol silver nanoparticles are considered a safe option for the treatment of wound healing, even if they are absorbed in the systemic circulation.<\/p>\n
Scurt CV<\/span><\/p>\nAnca Oana Docea este conferen\u021biar universitar cu abilitare \u00een Farmacie \u00een cadrul Facult\u0103\u021bii de Farmacie, Universitatea de Medicina si Farmacie din Craiova, unde pred\u0103 Toxicologie \u0219i reprezentanta Rom\u00e2niei \u00een Comitetul Pentru Evaluarea Riscurilor din cadrul Agentiei Europene pentru Produse Chimice (ECHA). Este farmacist specialist Farmacie Clinic\u0103, de\u021bine un masterat \u00een Farmacologie \u0219i Toxicologie, titlul de Toxicolog recunoscut la nivel European (ERT \u2013 European Registered Toxicologist) \u0219i titlul de doctor \u00een Medicin\u0103. S-a specializat \u00een test\u0103rile toxicologice pe animale, test\u0103rile neurocognitive in vivo \u0219i analize biochimice \u0219i imunohistochimice. A urmat specializ\u0103ri de toxicologie clinic\u0103 la Universitatea Aristotle din Thessaloniki, Grecia \u0219i Universitatea din Granada, Spania, specializare \u00een metode de analiz\u0103 a bazelor de date transcriptomice la King\u2019s College London \u0219i specializare \u00een noi modele in vivo \u0219i in vitro de evaluare a neurotoxicit\u0103\u021bii xenobioticelor la Albert Einstein College of Medicine, New York, USA.
\u00cen prezent este editor asociat pentru Toxicology Reports Journal (ELSEVIER) \u0219i guest-editor pentru o serie de edi\u021bii speciale \u00een cadrul Toxicology Reports journal (ELSEVIER), Food and Chemical Toxicology (ELSEVIER), Frontiers in Pharmacology (Frontiers), Medicina (MDPI), Life (MDPI). A publicat peste 110 de articole \u0219tiin\u021bifice (dintre care 103 indexate ISI Clarivate), 2 c\u0103r\u021bi cu profil didactic \u0219i 5 capitole de carte de specialitate \u00een edituri interna\u021bionale, recunoa\u0219terea na\u021bional \u0219i interna\u021bional\u0103 fiind redat\u0103 printr-un H-index de 28 (Web of Science, Clarivate Analytics).
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Contacteaz\u0103 operatorul PDI 2021<\/p>\n
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Operatorul PDI 2021<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ. Dr. Anca Oana DoceaDepartamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia Nanoparticulele de argint stabilizate cu etilen glicol ca nou\u0103 op\u021biune pentru tratamentul infec\u021biilor antibacteriene \u00een vindecarea r\u0103nilor: o evaluare toxicologic\u0103 Autori: Anca Oana Docea1, Laurentiu Mogoanta2, Daniela Calina3 1Departamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-9734","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9734","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=9734"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9734\/revisions"}],"predecessor-version":[{"id":9746,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9734\/revisions\/9746"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=9734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Conf. Univ. Dr. Anca Oana Docea<\/strong><\/span>
Departamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia<\/p>\n<\/strong><\/span><\/h4>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ locked=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.7″ hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n
Nanoparticulele de argint stabilizate cu etilen glicol ca nou\u0103 op\u021biune pentru tratamentul infec\u021biilor antibacteriene \u00een vindecarea r\u0103nilor: o evaluare toxicologic\u0103<\/span>
Autori: Anca Oana Docea1, Laurentiu Mogoanta2, Daniela Calina3<\/span><\/p>\n1Departamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia
2 Departamentul de histologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia
3Departamentul de Farmacie Clinic\u0103, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia
<\/span><\/p>\nDezvoltarea bacteriilor cu rezisten\u021b\u0103 multipl\u0103 reprezint\u0103 o mare provocare pentru tratamentul infec\u021biilor cutanate \u0219i vindecarea r\u0103nilor. Noi alternative pentru antibioticele standard sunt studiate intens pentru a reduce inciden\u021ba rezisten\u021bei bacteriilor \u0219i pentru a cre\u0219te r\u0103spunsul terapeutic. Nanoparticulele de argint (AgNPs) sunt studiate pe larg pentru capacitatea lor de a trata infec\u021biile bacteriene, fungice \u0219i virale, \u00eempreun\u0103 cu capacitatea lor de a promova vindecarea r\u0103nilor. Avantajul utiliz\u0103rii nanoparticulelor de argint este legat de costul redus, eficacitatea ridicat\u0103 \u0219i toxicitatea sc\u0103zut\u0103. In acest studiu am sintetizat nanoparticule de argint stabilizate cu etilen glicol (EG) printr-o reac\u021bie simpl\u0103 de reducere a azotatului de argint \u00eentr-o solu\u021bie alcalin\u0103 de EG \u0219i hidroxid de sodiu. Toxicitatea subcronic\u0103 a AgNPs a fost testat\u0103 pe patruzeci de \u0219obolani CD-SD de 12 s\u0103pt\u0103m\u00e2ni (20 de masculi\u0219i 20 de femele). Animalele au fost \u00eemp\u0103r\u021bite \u00een 4 grupuri de c\u00e2te 10 \u0219obolani per grup (5 femele \u0219i 5 masculi) \u0219i expuse timp de 28 de zile intraperitoneal la 0 mg\/kgc; 1 mg\/kgc Ag-EG, 2 mg\/kgc Ag-EG si respectiv, 4 mg\/kgc Ag-EG. Ag-EG NPs au prezentat o toxicitate sc\u0103zut\u0103 la dozele maxime testate de 4 mg\/kgc administrate intraperitoneal. Argintul s-a acumulat mai ales \u00een ficat \u0219i splin\u0103 \u0219i cantitati infima au fost detectate \u00een inim\u0103, pl\u0103m\u00e2ni, rinichi \u0219i creier. Nu s-au observat modific\u0103ri histopatologice \u00een organele de acumulare. \u00cen concluzie, nanoparticule de argint stabilizate cu etilen glicol sunt considerate o op\u021biune sigur\u0103 pentru tratamentul r\u0103nilor de la nivelul pielii si mucoaselor, chiar dac\u0103 sunt absorbite \u00een circula\u021bia sistemic\u0103.<\/p>\n
Ethylene glycol silver nanoparticles as a new option for the treatment of antibacterial infections in wound healing: a toxicological evaluation<\/span>
Autori: Anca Oana Docea1, Laurentiu Mogoanta2, Daniela Calina3<\/span><\/p>\n1Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
2 Department of Histology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
3 Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
<\/span><\/p>\nThe development of multiple resistance bacteria poses a big challenge for the treatment of several skin infections and wound healing. New alternatives for standard antibiotics have been tried to decrease the incidence of bacteria resistance and to increase the therapeutical response. Silver nanoparticles (AgNPs) are extensively studied for their ability to treat bacterial, fungal and viral infections along with their ability to promote wound healing. The advantage of using silver nanoparticles is related to low cost, high efficacy and low toxicity. In this study we synthesized ethylene glycol (EG) silver nanoparticles through a simple reduction reaction of silver nitrate in an alkaline solution of EG and sodium hydroxide. The sub-chronic toxicity of AgNPs was tested on forty 12-week CD-SD rats (20 males and 20 females). Animals were divided into 4 groups of 10 rats per group (5 females and 5 males) and exposed for 28 days intraperitoneally at 0 mg\/body weight; 1 mg \/kg body weight Ag-EG, 2 mg\/kg body weight Ag-EG, 4 mg\/kg of Ag-EG body. AgNPs functionalized with EG showed low toxicity at the maximum tested doses of 4 mg\/kg body weight administered intraperitoneally. The silver was accumulated especially in the liver and spleen and in low levels in the heart, lung, kidney and brain. No histopathological changes have been observed in the organs of accumulation. In conclusion, ethylene glycol silver nanoparticles are considered a safe option for the treatment of wound healing, even if they are absorbed in the systemic circulation.<\/p>\n
Scurt CV<\/span><\/p>\nAnca Oana Docea este conferen\u021biar universitar cu abilitare \u00een Farmacie \u00een cadrul Facult\u0103\u021bii de Farmacie, Universitatea de Medicina si Farmacie din Craiova, unde pred\u0103 Toxicologie \u0219i reprezentanta Rom\u00e2niei \u00een Comitetul Pentru Evaluarea Riscurilor din cadrul Agentiei Europene pentru Produse Chimice (ECHA). Este farmacist specialist Farmacie Clinic\u0103, de\u021bine un masterat \u00een Farmacologie \u0219i Toxicologie, titlul de Toxicolog recunoscut la nivel European (ERT \u2013 European Registered Toxicologist) \u0219i titlul de doctor \u00een Medicin\u0103. S-a specializat \u00een test\u0103rile toxicologice pe animale, test\u0103rile neurocognitive in vivo \u0219i analize biochimice \u0219i imunohistochimice. A urmat specializ\u0103ri de toxicologie clinic\u0103 la Universitatea Aristotle din Thessaloniki, Grecia \u0219i Universitatea din Granada, Spania, specializare \u00een metode de analiz\u0103 a bazelor de date transcriptomice la King\u2019s College London \u0219i specializare \u00een noi modele in vivo \u0219i in vitro de evaluare a neurotoxicit\u0103\u021bii xenobioticelor la Albert Einstein College of Medicine, New York, USA.
\u00cen prezent este editor asociat pentru Toxicology Reports Journal (ELSEVIER) \u0219i guest-editor pentru o serie de edi\u021bii speciale \u00een cadrul Toxicology Reports journal (ELSEVIER), Food and Chemical Toxicology (ELSEVIER), Frontiers in Pharmacology (Frontiers), Medicina (MDPI), Life (MDPI). A publicat peste 110 de articole \u0219tiin\u021bifice (dintre care 103 indexate ISI Clarivate), 2 c\u0103r\u021bi cu profil didactic \u0219i 5 capitole de carte de specialitate \u00een edituri interna\u021bionale, recunoa\u0219terea na\u021bional \u0219i interna\u021bional\u0103 fiind redat\u0103 printr-un H-index de 28 (Web of Science, Clarivate Analytics).
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Contacteaz\u0103 operatorul PDI 2021<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2021\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.9.4″ title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2021<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ. Dr. Anca Oana DoceaDepartamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia Nanoparticulele de argint stabilizate cu etilen glicol ca nou\u0103 op\u021biune pentru tratamentul infec\u021biilor antibacteriene \u00een vindecarea r\u0103nilor: o evaluare toxicologic\u0103 Autori: Anca Oana Docea1, Laurentiu Mogoanta2, Daniela Calina3 1Departamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-9734","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9734","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=9734"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9734\/revisions"}],"predecessor-version":[{"id":9746,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9734\/revisions\/9746"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=9734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Anca Oana Docea1, Laurentiu Mogoanta2, Daniela Calina3<\/span><\/p>\n
1Departamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia Dezvoltarea bacteriilor cu rezisten\u021b\u0103 multipl\u0103 reprezint\u0103 o mare provocare pentru tratamentul infec\u021biilor cutanate \u0219i vindecarea r\u0103nilor. Noi alternative pentru antibioticele standard sunt studiate intens pentru a reduce inciden\u021ba rezisten\u021bei bacteriilor \u0219i pentru a cre\u0219te r\u0103spunsul terapeutic. Nanoparticulele de argint (AgNPs) sunt studiate pe larg pentru capacitatea lor de a trata infec\u021biile bacteriene, fungice \u0219i virale, \u00eempreun\u0103 cu capacitatea lor de a promova vindecarea r\u0103nilor. Avantajul utiliz\u0103rii nanoparticulelor de argint este legat de costul redus, eficacitatea ridicat\u0103 \u0219i toxicitatea sc\u0103zut\u0103. In acest studiu am sintetizat nanoparticule de argint stabilizate cu etilen glicol (EG) printr-o reac\u021bie simpl\u0103 de reducere a azotatului de argint \u00eentr-o solu\u021bie alcalin\u0103 de EG \u0219i hidroxid de sodiu. Toxicitatea subcronic\u0103 a AgNPs a fost testat\u0103 pe patruzeci de \u0219obolani CD-SD de 12 s\u0103pt\u0103m\u00e2ni (20 de masculi\u0219i 20 de femele). Animalele au fost \u00eemp\u0103r\u021bite \u00een 4 grupuri de c\u00e2te 10 \u0219obolani per grup (5 femele \u0219i 5 masculi) \u0219i expuse timp de 28 de zile intraperitoneal la 0 mg\/kgc; 1 mg\/kgc Ag-EG, 2 mg\/kgc Ag-EG si respectiv, 4 mg\/kgc Ag-EG. Ag-EG NPs au prezentat o toxicitate sc\u0103zut\u0103 la dozele maxime testate de 4 mg\/kgc administrate intraperitoneal. Argintul s-a acumulat mai ales \u00een ficat \u0219i splin\u0103 \u0219i cantitati infima au fost detectate \u00een inim\u0103, pl\u0103m\u00e2ni, rinichi \u0219i creier. Nu s-au observat modific\u0103ri histopatologice \u00een organele de acumulare. \u00cen concluzie, nanoparticule de argint stabilizate cu etilen glicol sunt considerate o op\u021biune sigur\u0103 pentru tratamentul r\u0103nilor de la nivelul pielii si mucoaselor, chiar dac\u0103 sunt absorbite \u00een circula\u021bia sistemic\u0103.<\/p>\n Ethylene glycol silver nanoparticles as a new option for the treatment of antibacterial infections in wound healing: a toxicological evaluation<\/span> 1Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania The development of multiple resistance bacteria poses a big challenge for the treatment of several skin infections and wound healing. New alternatives for standard antibiotics have been tried to decrease the incidence of bacteria resistance and to increase the therapeutical response. Silver nanoparticles (AgNPs) are extensively studied for their ability to treat bacterial, fungal and viral infections along with their ability to promote wound healing. The advantage of using silver nanoparticles is related to low cost, high efficacy and low toxicity. In this study we synthesized ethylene glycol (EG) silver nanoparticles through a simple reduction reaction of silver nitrate in an alkaline solution of EG and sodium hydroxide. The sub-chronic toxicity of AgNPs was tested on forty 12-week CD-SD rats (20 males and 20 females). Animals were divided into 4 groups of 10 rats per group (5 females and 5 males) and exposed for 28 days intraperitoneally at 0 mg\/body weight; 1 mg \/kg body weight Ag-EG, 2 mg\/kg body weight Ag-EG, 4 mg\/kg of Ag-EG body. AgNPs functionalized with EG showed low toxicity at the maximum tested doses of 4 mg\/kg body weight administered intraperitoneally. The silver was accumulated especially in the liver and spleen and in low levels in the heart, lung, kidney and brain. No histopathological changes have been observed in the organs of accumulation. In conclusion, ethylene glycol silver nanoparticles are considered a safe option for the treatment of wound healing, even if they are absorbed in the systemic circulation.<\/p>\n Scurt CV<\/span><\/p>\n Anca Oana Docea este conferen\u021biar universitar cu abilitare \u00een Farmacie \u00een cadrul Facult\u0103\u021bii de Farmacie, Universitatea de Medicina si Farmacie din Craiova, unde pred\u0103 Toxicologie \u0219i reprezentanta Rom\u00e2niei \u00een Comitetul Pentru Evaluarea Riscurilor din cadrul Agentiei Europene pentru Produse Chimice (ECHA). Este farmacist specialist Farmacie Clinic\u0103, de\u021bine un masterat \u00een Farmacologie \u0219i Toxicologie, titlul de Toxicolog recunoscut la nivel European (ERT \u2013 European Registered Toxicologist) \u0219i titlul de doctor \u00een Medicin\u0103. S-a specializat \u00een test\u0103rile toxicologice pe animale, test\u0103rile neurocognitive in vivo \u0219i analize biochimice \u0219i imunohistochimice. A urmat specializ\u0103ri de toxicologie clinic\u0103 la Universitatea Aristotle din Thessaloniki, Grecia \u0219i Universitatea din Granada, Spania, specializare \u00een metode de analiz\u0103 a bazelor de date transcriptomice la King\u2019s College London \u0219i specializare \u00een noi modele in vivo \u0219i in vitro de evaluare a neurotoxicit\u0103\u021bii xenobioticelor la Albert Einstein College of Medicine, New York, USA. [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n Contacteaz\u0103 operatorul PDI 2021<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2021\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.9.4″ title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” 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button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2021<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,9252,9464″ fullwidth=”on” _builder_version=”4.9.6″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Conf. Univ. Dr. Anca Oana DoceaDepartamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia Nanoparticulele de argint stabilizate cu etilen glicol ca nou\u0103 op\u021biune pentru tratamentul infec\u021biilor antibacteriene \u00een vindecarea r\u0103nilor: o evaluare toxicologic\u0103 Autori: Anca Oana Docea1, Laurentiu Mogoanta2, Daniela Calina3 1Departamentul de toxicologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-9734","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9734","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=9734"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9734\/revisions"}],"predecessor-version":[{"id":9746,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9734\/revisions\/9746"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=9734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
2 Departamentul de histologie, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia
3Departamentul de Farmacie Clinic\u0103, Universitatea de Medicin\u0103 \u0219i Farmacie din Craiova, Craiova, Rom\u00e2nia
<\/span><\/p>\n
Autori: Anca Oana Docea1, Laurentiu Mogoanta2, Daniela Calina3<\/span><\/p>\n
2 Department of Histology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
3 Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
<\/span><\/p>\n
\u00cen prezent este editor asociat pentru Toxicology Reports Journal (ELSEVIER) \u0219i guest-editor pentru o serie de edi\u021bii speciale \u00een cadrul Toxicology Reports journal (ELSEVIER), Food and Chemical Toxicology (ELSEVIER), Frontiers in Pharmacology (Frontiers), Medicina (MDPI), Life (MDPI). A publicat peste 110 de articole \u0219tiin\u021bifice (dintre care 103 indexate ISI Clarivate), 2 c\u0103r\u021bi cu profil didactic \u0219i 5 capitole de carte de specialitate \u00een edituri interna\u021bionale, recunoa\u0219terea na\u021bional \u0219i interna\u021bional\u0103 fiind redat\u0103 printr-un H-index de 28 (Web of Science, Clarivate Analytics).
<\/span><\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n