<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nConf. Univ.Dr. Andra B\u0103l\u0103nescu
Universitatea de Medicin\u0103 \u0219i Farmacie \u201eCarol Davila\u201d Bucure\u0219ti
<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ locked=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.7″]<\/p>\n
EXIST\u0102 ARTRIT\u0102 PSORIAZIC\u0102 PRECOCE?<\/span>
Autor: Andra B\u0103l\u0103nescu<\/span><\/p>\nCuvinte cheie: artrita psoriazic\u0103, biomarkeri, diagnostic precoce, screening, recomand\u0103ri de management<\/p>\n
Artrita psoriazic\u0103 (APs) precoce reprezint\u0103 o provocare at\u00e2t pentru dermatologi, c\u00e2t \u0219i pentru reumatologi. Dificultatea diagnostic\u0103rii precoce a APs este determinat\u0103 de heterogenitatea manifest\u0103rilor clinice, lipsa unor biomarkeri specifici \u0219i uneori de o colaborare insuficient\u0103 \u00eentre cele dou\u0103 specialit\u0103\u021bi. Existe studii care arat\u0103 c\u0103 \u00eentre 15-29% dintre pacien\u021bii cu psoriazis au APs nediagnosticat\u0103, iar diagnosticul de APs se pune cu o \u00eent\u00e2rziere de 5 ani. Un diagnostic precoce este esen\u021bial pentru evolu\u021bia ulterioar\u0103 a bolii, \u00eent\u00e2rzierea acestuia put\u00e2nd avea consecin\u021be severe: 67% dintre pacien\u021bi au cel pu\u021bin o eroziune c\u00e2nd se prezent\u0103 la reumatolog, jum\u0103tate dintre pacien\u021bi au modific\u0103ri radiologice \u00een primii 2 ani, iar o \u00eent\u00e2rziere de 6 luni a diagnosticului are un impact func\u021bional semnificativ. Ultimii ani au adus progrese \u00een identificarea factorilor de risc \u0219i \u00een aprofundarea mecanismelor imune din APs, dar este \u00eenc\u0103 nevoie de g\u0103sirea unor biomarkeri specifici \u0219i de dezvoltarea tehnicilor imagistice care s\u0103 ajute la stabilirea unui diagnostic precoce. Exist\u0103 unele manifest\u0103ri clinice, semne imagistice \u0219i chestionare de \u201escreening\u201d care dac\u0103 sunt cunoscute \u0219i aplicate pacien\u021bilor cu psoriazis pot identifica pacien\u021bii \u201ela risc\u201d. Acest lucru este cu at\u00e2t mai important cu c\u00e2t instituirea c\u00e2t mai rapid\u0103 a tratamentului este un deziderat important \u00een prezent, c\u00e2nd paleta terapeutic\u0103 din aceast\u0103 boal\u0103 s-a l\u0103rgit semnificativ, cu noi medicamente cu multiple mecanisme de ac\u021biune. Ultimele recomand\u0103ri privind managementul APs ale EULAR (The European Alliance of Associations for Rheumatology) \u021bin cont de formele \u0219i domeniile clinice afectate, promoveaz\u0103 o abordare dinamic\u0103 \u0219i instituirea precoce a tratamentului remisiv. \u00cen viitor este nevoie de studii dedicate APs precoce, inclusiv de studii de strategie, dar mai ales de realizarea unei bune colabor\u0103ri \u00eentre dermatologi \u0219i reumatologi.<\/p>\n
IS THERE EARLY PSORIASIC ARTHRITIS?<\/span><\/p>\nEarly psoriatic arthritis (PsA) is a challenge for both dermatologists and rheumatologists. The difficulty of an early diagnosis of PsA is determined by the heterogeneity of clinical manifestations, the lack of specific biomarkers and sometimes insufficient collaboration between the two specialties. There are studies that show that between 15-29% of patients with psoriasis have undiagnosed PsA, and the diagnosis of PsA is made with a delay of 5 years. An early diagnosis is essential for the further evolution of the disease, its delay having severe consequences: 67% of patients have at least one erosion when presenting to the rheumatologist, half of the patients have radiological changes in the first 2 years, and a delay of 6 months of the diagnosis has a significant functional impact. Recent years have made progress in identifying risk factors and understanding of the immune mechanisms in PsA, but there is still a need to find specific biomarkers and develop imaging techniques to help establish an early diagnosis. There are some clinical manifestations, imaging signs and “screening” questionnaires that if known and applied to patients with psoriasis can identify patients “at risk”. This is important as the initiation of treatment as soon as possible is an important requirement today, when the therapeutic range of this disease has expanded significantly, with new drugs with multiple mechanisms of action. The latest EULAR (The European Alliance of Associations for Rheumatology) recommendations regarding the management of PsA consider the clinical types and domains, promote a dynamic approach and the early initiation of disease-modifying antirheumatic drugs. In the future, there is a need for studies dedicated to early PsA, including strategy studies, but especially for the achievement of a good collaboration between dermatologists and rheumatologists.<\/p>\n
SCURT CV<\/span><\/p>\n– Absolvent\u0103 a Universit\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d, Bucure\u015fti, promo\u0163ia 1988
– Medic primar medicin\u0103 intern\u0103 \u015fi reumatologie
– Conferen\u0163iar universitar la Catedra de Medicin\u0103 Intern\u0103 \u015fi Reumatologie, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d, Spitalul Clinic \u201cSf. Maria\u201d, Bucure\u0219ti
– Doctor \u00een \u015etiinte Medicale \u2013 2003; tema: \u201cAspecte biologice, anatomopatologice \u015fi imunohistochimice ale sinovialei reumatoide \u00een cursul tratamentului imunosupresor\u201d
– Director al urm\u0103toarelor proiecte:
\u00a0 o Programul 4\/Parteneriate in domenii prioritare \u2013 Contract CNMP 41044 \/ 2007
\u201cIdentificarea unui panel de biomarkeri predictiv pentru evolutia bolilor reumatice de tip inflamator in cursul tratamentului imunosupresor\u201d
\u00a0 o Programul 4\/Parteneriate in domenii prioritare \u2013 Contract CNMP 42152\/01.10.2008 \u201cDezvoltarea unor metode inovatoare de cercetare a mecanismelor de actiune si de evaluare precoce a toxicitatii terapiilor imunosupresoare in unele boli reumatice autoimune\u201d
– Investigator na\u0163ional \u00een 5 proiecte EULAR (Societatea European\u0103 de Reumatologie)
C\u0103r\u021bi publicate:
\u00a0 o Poliartrita reumatoid\u0103 \u2013 de la patogenie la clinic\u0103, Andra B\u0103l\u0103nescu, Ed. Medical\u0103 Amaltea, 2006, ISBN (10) 973-7780-77-9
\u00a0 o Mecanisme imune \u00een reumatologie, sub redac\u021bia Andra \u2013 Rodica B\u0103l\u0103nescu, Ed. Medical\u0103, Bucure\u0219ti, 2019, ISBN 978-973-39-0853-1
\u00a0 o Afec\u021biunile reumatologice \u00een practica medicului de familie, sub redac\u021bia Andra \u2013 Rodica B\u0103l\u0103nescu, Ed. Medical\u0103, Bucure\u0219ti, 2020, ISBN 978-973-39-0876-0
– Autor si coautor a unui num\u0103r de 24 de capitole \u00een c\u0103r\u021bi de specialitate \u0219 a 240 articole publicate \u00een reviste de specialitate na\u021bionale \u0219i interna\u021bionale<\/p>\n
\u00a0<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2021<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2021\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.9.4″ title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2021<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
![\"\"](\"https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ.Dr. Andra B\u0103l\u0103nescuUniversitatea de Medicin\u0103 \u0219i Farmacie \u201eCarol Davila\u201d Bucure\u0219tiEXIST\u0102 ARTRIT\u0102 PSORIAZIC\u0102 PRECOCE? Autor: Andra B\u0103l\u0103nescu Cuvinte cheie: artrita psoriazic\u0103, biomarkeri, diagnostic precoce, screening, recomand\u0103ri de management Artrita psoriazic\u0103 (APs) precoce reprezint\u0103 o provocare at\u00e2t pentru dermatologi, c\u00e2t \u0219i pentru reumatologi. Dificultatea diagnostic\u0103rii precoce a APs este determinat\u0103 de heterogenitatea manifest\u0103rilor clinice, lipsa unor […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-9893","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9893","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=9893"}],"version-history":[{"count":3,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9893\/revisions"}],"predecessor-version":[{"id":9943,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9893\/revisions\/9943"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=9893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Conf. Univ.Dr. Andra B\u0103l\u0103nescu
Universitatea de Medicin\u0103 \u0219i Farmacie \u201eCarol Davila\u201d Bucure\u0219ti
<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ locked=”off”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.7″]<\/p>\n
EXIST\u0102 ARTRIT\u0102 PSORIAZIC\u0102 PRECOCE?<\/span>
Autor: Andra B\u0103l\u0103nescu<\/span><\/p>\nCuvinte cheie: artrita psoriazic\u0103, biomarkeri, diagnostic precoce, screening, recomand\u0103ri de management<\/p>\n
Artrita psoriazic\u0103 (APs) precoce reprezint\u0103 o provocare at\u00e2t pentru dermatologi, c\u00e2t \u0219i pentru reumatologi. Dificultatea diagnostic\u0103rii precoce a APs este determinat\u0103 de heterogenitatea manifest\u0103rilor clinice, lipsa unor biomarkeri specifici \u0219i uneori de o colaborare insuficient\u0103 \u00eentre cele dou\u0103 specialit\u0103\u021bi. Existe studii care arat\u0103 c\u0103 \u00eentre 15-29% dintre pacien\u021bii cu psoriazis au APs nediagnosticat\u0103, iar diagnosticul de APs se pune cu o \u00eent\u00e2rziere de 5 ani. Un diagnostic precoce este esen\u021bial pentru evolu\u021bia ulterioar\u0103 a bolii, \u00eent\u00e2rzierea acestuia put\u00e2nd avea consecin\u021be severe: 67% dintre pacien\u021bi au cel pu\u021bin o eroziune c\u00e2nd se prezent\u0103 la reumatolog, jum\u0103tate dintre pacien\u021bi au modific\u0103ri radiologice \u00een primii 2 ani, iar o \u00eent\u00e2rziere de 6 luni a diagnosticului are un impact func\u021bional semnificativ. Ultimii ani au adus progrese \u00een identificarea factorilor de risc \u0219i \u00een aprofundarea mecanismelor imune din APs, dar este \u00eenc\u0103 nevoie de g\u0103sirea unor biomarkeri specifici \u0219i de dezvoltarea tehnicilor imagistice care s\u0103 ajute la stabilirea unui diagnostic precoce. Exist\u0103 unele manifest\u0103ri clinice, semne imagistice \u0219i chestionare de \u201escreening\u201d care dac\u0103 sunt cunoscute \u0219i aplicate pacien\u021bilor cu psoriazis pot identifica pacien\u021bii \u201ela risc\u201d. Acest lucru este cu at\u00e2t mai important cu c\u00e2t instituirea c\u00e2t mai rapid\u0103 a tratamentului este un deziderat important \u00een prezent, c\u00e2nd paleta terapeutic\u0103 din aceast\u0103 boal\u0103 s-a l\u0103rgit semnificativ, cu noi medicamente cu multiple mecanisme de ac\u021biune. Ultimele recomand\u0103ri privind managementul APs ale EULAR (The European Alliance of Associations for Rheumatology) \u021bin cont de formele \u0219i domeniile clinice afectate, promoveaz\u0103 o abordare dinamic\u0103 \u0219i instituirea precoce a tratamentului remisiv. \u00cen viitor este nevoie de studii dedicate APs precoce, inclusiv de studii de strategie, dar mai ales de realizarea unei bune colabor\u0103ri \u00eentre dermatologi \u0219i reumatologi.<\/p>\n
IS THERE EARLY PSORIASIC ARTHRITIS?<\/span><\/p>\nEarly psoriatic arthritis (PsA) is a challenge for both dermatologists and rheumatologists. The difficulty of an early diagnosis of PsA is determined by the heterogeneity of clinical manifestations, the lack of specific biomarkers and sometimes insufficient collaboration between the two specialties. There are studies that show that between 15-29% of patients with psoriasis have undiagnosed PsA, and the diagnosis of PsA is made with a delay of 5 years. An early diagnosis is essential for the further evolution of the disease, its delay having severe consequences: 67% of patients have at least one erosion when presenting to the rheumatologist, half of the patients have radiological changes in the first 2 years, and a delay of 6 months of the diagnosis has a significant functional impact. Recent years have made progress in identifying risk factors and understanding of the immune mechanisms in PsA, but there is still a need to find specific biomarkers and develop imaging techniques to help establish an early diagnosis. There are some clinical manifestations, imaging signs and “screening” questionnaires that if known and applied to patients with psoriasis can identify patients “at risk”. This is important as the initiation of treatment as soon as possible is an important requirement today, when the therapeutic range of this disease has expanded significantly, with new drugs with multiple mechanisms of action. The latest EULAR (The European Alliance of Associations for Rheumatology) recommendations regarding the management of PsA consider the clinical types and domains, promote a dynamic approach and the early initiation of disease-modifying antirheumatic drugs. In the future, there is a need for studies dedicated to early PsA, including strategy studies, but especially for the achievement of a good collaboration between dermatologists and rheumatologists.<\/p>\n
SCURT CV<\/span><\/p>\n– Absolvent\u0103 a Universit\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d, Bucure\u015fti, promo\u0163ia 1988
– Medic primar medicin\u0103 intern\u0103 \u015fi reumatologie
– Conferen\u0163iar universitar la Catedra de Medicin\u0103 Intern\u0103 \u015fi Reumatologie, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d, Spitalul Clinic \u201cSf. Maria\u201d, Bucure\u0219ti
– Doctor \u00een \u015etiinte Medicale \u2013 2003; tema: \u201cAspecte biologice, anatomopatologice \u015fi imunohistochimice ale sinovialei reumatoide \u00een cursul tratamentului imunosupresor\u201d
– Director al urm\u0103toarelor proiecte:
\u00a0 o Programul 4\/Parteneriate in domenii prioritare \u2013 Contract CNMP 41044 \/ 2007
\u201cIdentificarea unui panel de biomarkeri predictiv pentru evolutia bolilor reumatice de tip inflamator in cursul tratamentului imunosupresor\u201d
\u00a0 o Programul 4\/Parteneriate in domenii prioritare \u2013 Contract CNMP 42152\/01.10.2008 \u201cDezvoltarea unor metode inovatoare de cercetare a mecanismelor de actiune si de evaluare precoce a toxicitatii terapiilor imunosupresoare in unele boli reumatice autoimune\u201d
– Investigator na\u0163ional \u00een 5 proiecte EULAR (Societatea European\u0103 de Reumatologie)
C\u0103r\u021bi publicate:
\u00a0 o Poliartrita reumatoid\u0103 \u2013 de la patogenie la clinic\u0103, Andra B\u0103l\u0103nescu, Ed. Medical\u0103 Amaltea, 2006, ISBN (10) 973-7780-77-9
\u00a0 o Mecanisme imune \u00een reumatologie, sub redac\u021bia Andra \u2013 Rodica B\u0103l\u0103nescu, Ed. Medical\u0103, Bucure\u0219ti, 2019, ISBN 978-973-39-0853-1
\u00a0 o Afec\u021biunile reumatologice \u00een practica medicului de familie, sub redac\u021bia Andra \u2013 Rodica B\u0103l\u0103nescu, Ed. Medical\u0103, Bucure\u0219ti, 2020, ISBN 978-973-39-0876-0
– Autor si coautor a unui num\u0103r de 24 de capitole \u00een c\u0103r\u021bi de specialitate \u0219 a 240 articole publicate \u00een reviste de specialitate na\u021bionale \u0219i interna\u021bionale<\/p>\n
\u00a0<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2021<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2021\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.9.4″ title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Operatorul PDI 2021<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n
Parteneri Media<\/p>\n
[\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,9252,9464″ fullwidth=”on” _builder_version=”4.9.6″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Conf. Univ.Dr. Andra B\u0103l\u0103nescuUniversitatea de Medicin\u0103 \u0219i Farmacie \u201eCarol Davila\u201d Bucure\u0219tiEXIST\u0102 ARTRIT\u0102 PSORIAZIC\u0102 PRECOCE? Autor: Andra B\u0103l\u0103nescu Cuvinte cheie: artrita psoriazic\u0103, biomarkeri, diagnostic precoce, screening, recomand\u0103ri de management Artrita psoriazic\u0103 (APs) precoce reprezint\u0103 o provocare at\u00e2t pentru dermatologi, c\u00e2t \u0219i pentru reumatologi. Dificultatea diagnostic\u0103rii precoce a APs este determinat\u0103 de heterogenitatea manifest\u0103rilor clinice, lipsa unor […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-9893","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9893","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=9893"}],"version-history":[{"count":3,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9893\/revisions"}],"predecessor-version":[{"id":9943,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9893\/revisions\/9943"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=9893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Andra B\u0103l\u0103nescu<\/span><\/p>\n
Cuvinte cheie: artrita psoriazic\u0103, biomarkeri, diagnostic precoce, screening, recomand\u0103ri de management<\/p>\n
Artrita psoriazic\u0103 (APs) precoce reprezint\u0103 o provocare at\u00e2t pentru dermatologi, c\u00e2t \u0219i pentru reumatologi. Dificultatea diagnostic\u0103rii precoce a APs este determinat\u0103 de heterogenitatea manifest\u0103rilor clinice, lipsa unor biomarkeri specifici \u0219i uneori de o colaborare insuficient\u0103 \u00eentre cele dou\u0103 specialit\u0103\u021bi. Existe studii care arat\u0103 c\u0103 \u00eentre 15-29% dintre pacien\u021bii cu psoriazis au APs nediagnosticat\u0103, iar diagnosticul de APs se pune cu o \u00eent\u00e2rziere de 5 ani. Un diagnostic precoce este esen\u021bial pentru evolu\u021bia ulterioar\u0103 a bolii, \u00eent\u00e2rzierea acestuia put\u00e2nd avea consecin\u021be severe: 67% dintre pacien\u021bi au cel pu\u021bin o eroziune c\u00e2nd se prezent\u0103 la reumatolog, jum\u0103tate dintre pacien\u021bi au modific\u0103ri radiologice \u00een primii 2 ani, iar o \u00eent\u00e2rziere de 6 luni a diagnosticului are un impact func\u021bional semnificativ. Ultimii ani au adus progrese \u00een identificarea factorilor de risc \u0219i \u00een aprofundarea mecanismelor imune din APs, dar este \u00eenc\u0103 nevoie de g\u0103sirea unor biomarkeri specifici \u0219i de dezvoltarea tehnicilor imagistice care s\u0103 ajute la stabilirea unui diagnostic precoce. Exist\u0103 unele manifest\u0103ri clinice, semne imagistice \u0219i chestionare de \u201escreening\u201d care dac\u0103 sunt cunoscute \u0219i aplicate pacien\u021bilor cu psoriazis pot identifica pacien\u021bii \u201ela risc\u201d. Acest lucru este cu at\u00e2t mai important cu c\u00e2t instituirea c\u00e2t mai rapid\u0103 a tratamentului este un deziderat important \u00een prezent, c\u00e2nd paleta terapeutic\u0103 din aceast\u0103 boal\u0103 s-a l\u0103rgit semnificativ, cu noi medicamente cu multiple mecanisme de ac\u021biune. Ultimele recomand\u0103ri privind managementul APs ale EULAR (The European Alliance of Associations for Rheumatology) \u021bin cont de formele \u0219i domeniile clinice afectate, promoveaz\u0103 o abordare dinamic\u0103 \u0219i instituirea precoce a tratamentului remisiv. \u00cen viitor este nevoie de studii dedicate APs precoce, inclusiv de studii de strategie, dar mai ales de realizarea unei bune colabor\u0103ri \u00eentre dermatologi \u0219i reumatologi.<\/p>\n
IS THERE EARLY PSORIASIC ARTHRITIS?<\/span><\/p>\n Early psoriatic arthritis (PsA) is a challenge for both dermatologists and rheumatologists. The difficulty of an early diagnosis of PsA is determined by the heterogeneity of clinical manifestations, the lack of specific biomarkers and sometimes insufficient collaboration between the two specialties. There are studies that show that between 15-29% of patients with psoriasis have undiagnosed PsA, and the diagnosis of PsA is made with a delay of 5 years. An early diagnosis is essential for the further evolution of the disease, its delay having severe consequences: 67% of patients have at least one erosion when presenting to the rheumatologist, half of the patients have radiological changes in the first 2 years, and a delay of 6 months of the diagnosis has a significant functional impact. Recent years have made progress in identifying risk factors and understanding of the immune mechanisms in PsA, but there is still a need to find specific biomarkers and develop imaging techniques to help establish an early diagnosis. There are some clinical manifestations, imaging signs and “screening” questionnaires that if known and applied to patients with psoriasis can identify patients “at risk”. This is important as the initiation of treatment as soon as possible is an important requirement today, when the therapeutic range of this disease has expanded significantly, with new drugs with multiple mechanisms of action. The latest EULAR (The European Alliance of Associations for Rheumatology) recommendations regarding the management of PsA consider the clinical types and domains, promote a dynamic approach and the early initiation of disease-modifying antirheumatic drugs. In the future, there is a need for studies dedicated to early PsA, including strategy studies, but especially for the achievement of a good collaboration between dermatologists and rheumatologists.<\/p>\n SCURT CV<\/span><\/p>\n – Absolvent\u0103 a Universit\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d, Bucure\u015fti, promo\u0163ia 1988 \u00a0<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2021\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop”]<\/p>\n Contacteaz\u0103 operatorul PDI 2021<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2021\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.9.4″ title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”3.18.9″ 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field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”3.18.9″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n Operatorul PDI 2021<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.0.11″ text_font=”||||||||”]<\/p>\n <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.0.11″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,9252,9464″ fullwidth=”on” _builder_version=”4.9.6″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Conf. Univ.Dr. Andra B\u0103l\u0103nescuUniversitatea de Medicin\u0103 \u0219i Farmacie \u201eCarol Davila\u201d Bucure\u0219tiEXIST\u0102 ARTRIT\u0102 PSORIAZIC\u0102 PRECOCE? Autor: Andra B\u0103l\u0103nescu Cuvinte cheie: artrita psoriazic\u0103, biomarkeri, diagnostic precoce, screening, recomand\u0103ri de management Artrita psoriazic\u0103 (APs) precoce reprezint\u0103 o provocare at\u00e2t pentru dermatologi, c\u00e2t \u0219i pentru reumatologi. Dificultatea diagnostic\u0103rii precoce a APs este determinat\u0103 de heterogenitatea manifest\u0103rilor clinice, lipsa unor […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-9893","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9893","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/comments?post=9893"}],"version-history":[{"count":3,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9893\/revisions"}],"predecessor-version":[{"id":9943,"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/pages\/9893\/revisions\/9943"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2021\/wp-json\/wp\/v2\/media?parent=9893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
– Medic primar medicin\u0103 intern\u0103 \u015fi reumatologie
– Conferen\u0163iar universitar la Catedra de Medicin\u0103 Intern\u0103 \u015fi Reumatologie, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d, Spitalul Clinic \u201cSf. Maria\u201d, Bucure\u0219ti
– Doctor \u00een \u015etiinte Medicale \u2013 2003; tema: \u201cAspecte biologice, anatomopatologice \u015fi imunohistochimice ale sinovialei reumatoide \u00een cursul tratamentului imunosupresor\u201d
– Director al urm\u0103toarelor proiecte:
\u00a0 o Programul 4\/Parteneriate in domenii prioritare \u2013 Contract CNMP 41044 \/ 2007
\u201cIdentificarea unui panel de biomarkeri predictiv pentru evolutia bolilor reumatice de tip inflamator in cursul tratamentului imunosupresor\u201d
\u00a0 o Programul 4\/Parteneriate in domenii prioritare \u2013 Contract CNMP 42152\/01.10.2008 \u201cDezvoltarea unor metode inovatoare de cercetare a mecanismelor de actiune si de evaluare precoce a toxicitatii terapiilor imunosupresoare in unele boli reumatice autoimune\u201d
– Investigator na\u0163ional \u00een 5 proiecte EULAR (Societatea European\u0103 de Reumatologie)
C\u0103r\u021bi publicate:
\u00a0 o Poliartrita reumatoid\u0103 \u2013 de la patogenie la clinic\u0103, Andra B\u0103l\u0103nescu, Ed. Medical\u0103 Amaltea, 2006, ISBN (10) 973-7780-77-9
\u00a0 o Mecanisme imune \u00een reumatologie, sub redac\u021bia Andra \u2013 Rodica B\u0103l\u0103nescu, Ed. Medical\u0103, Bucure\u0219ti, 2019, ISBN 978-973-39-0853-1
\u00a0 o Afec\u021biunile reumatologice \u00een practica medicului de familie, sub redac\u021bia Andra \u2013 Rodica B\u0103l\u0103nescu, Ed. Medical\u0103, Bucure\u0219ti, 2020, ISBN 978-973-39-0876-0
– Autor si coautor a unui num\u0103r de 24 de capitole \u00een c\u0103r\u021bi de specialitate \u0219 a 240 articole publicate \u00een reviste de specialitate na\u021bionale \u0219i interna\u021bionale<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n