\u0218ef Lucr. Dr. Brihan Ilarie
Facultatea de Medicin\u0103, Universitatea din Oradea, Rom\u00e2nia
Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 Oradea<\/p>\n<\/strong><\/span><\/h4>\n
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C\u00e2nd \u0219i cum schimb\u0103m un agent biologic \u00een terapia psoriazisului?
Autor: Ilarie Brihan<\/span><\/p>\nUniversitatea din Oradea. Facultatea de Medicin\u0103 \u0219i Farmacie<\/p>\n
Psoriazisul este o afec\u021biune inflamatorie sistemic\u0103 cronic\u0103, mediat\u0103 imun, cu evolu\u021bie ondulant\u0103 \u0219i, uneori, invalidant\u0103. Psoriazisul a beneficiat, \u00een ultimul timp, de o serie de cercet\u0103ri \u0219i descoperiri privind mecanismele fizio-patologice ale bolii, ceea ce a generat posibilitatea unei noi abord\u0103ri terapeutice. Introducerea agen\u021bilor biologici a prezentat o contribu\u021bie major\u0103 \u00een arsenalul terapeutic al bolii. Totu\u0219i, nu to\u021bi pacien\u021bii prezint\u0103 un r\u0103spuns favorabil la terapia biologic\u0103. Prezen\u021ba mai multor clase de agen\u021bi biologici, cu mecanisme de ac\u021biune fisio-patologice diferite, permit ast\u0103zi o particularizare mai bun\u0103 a terapiei pentru fiecare pacient. Lipsa de r\u0103spuns terapeutic la un agent permite, ast\u0103zi, schimbarea lui cu un alt agent biologic, cu mecanism de ac\u021biune similar sau total diferit. Ast\u0103zi, schimbarea agentului biologic presupune evaluarea complex\u0103 a unor factori lega\u021bi de aspectele farmacologice ale medicamentelor, prezen\u021ba comorbidit\u0103\u021bilor, perioada de wash-out \u0219i unele aspecte privind avantajele \u0219i dezavantajele tratamentului din punct de vedere al pacientului.
Din acest punct de vedere \u00eencerc\u0103m s\u0103 prezent\u0103m care sunt oportunit\u0103\u021bile \u0219i recomand\u0103rile schimb\u0103rii agentului biologic \u00een tratamentul psoriazisului.<\/p>\n
When and How do we change a biological agent in the psoriasis therapy?
Author: Ilarie Brihan<\/span><\/p>\nOradea University. Faculty of Medicine and Pharmacy<\/p>\n
Psoriasis is a chronic, immune-mediated systemic inflammatory condition, with an undulating and, sometimes, disabling evolution. Psoriasis has recently benefited from a series of research and discoveries on the pathophysiological mechanisms of the disease, which has generated the possibility of a new therapeutic approach. The introduction of the biological agents has made a major contribution to the therapeutic arsenal of the disease. However, not all patients have a favorable response to the biologic therapy. The presence of several classes of biological agents, with different pathophysiological mechanisms of action, allow today a better customization of the therapy for each patient. The lack of a therapeutic response to an agent allows, nowadays, its exchange with another biological agent, with a similar or totally different mechanism of action. Nowadays, the change of the biological agent involves the complex assessment of the factors related to the pharmacological aspects of the drugs, the presence of comorbidities, the wash-out period and some aspects of the advantages and disadvantages of the treatment from the patient’s point of view.
Therefore, the aim of our paper is to present the opportunities and recommendations for changing the biological agent in the treatment of psoriasis.<\/p>\n
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\u0218ef Lucr. Dr. Brihan IlarieFacultatea de Medicin\u0103, Universitatea din Oradea, Rom\u00e2niaSpitalul Clinic Jude\u021bean de Urgen\u021b\u0103 Oradea C\u00e2nd \u0219i cum schimb\u0103m un agent biologic \u00een terapia psoriazisului?Autor: Ilarie Brihan Universitatea din Oradea. Facultatea de Medicin\u0103 \u0219i Farmacie Psoriazisul este o afec\u021biune inflamatorie sistemic\u0103 cronic\u0103, mediat\u0103 imun, cu evolu\u021bie ondulant\u0103 \u0219i, uneori, invalidant\u0103. Psoriazisul a beneficiat, \u00een […]<\/p>\n","protected":false},"author":2,"featured_media":11505,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-10384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/10384","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=10384"}],"version-history":[{"count":13,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/10384\/revisions"}],"predecessor-version":[{"id":11526,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/10384\/revisions\/11526"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11505"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=10384"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=10384"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=10384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Ilarie Brihan<\/span><\/p>\n
Universitatea din Oradea. Facultatea de Medicin\u0103 \u0219i Farmacie<\/p>\n
Psoriazisul este o afec\u021biune inflamatorie sistemic\u0103 cronic\u0103, mediat\u0103 imun, cu evolu\u021bie ondulant\u0103 \u0219i, uneori, invalidant\u0103. Psoriazisul a beneficiat, \u00een ultimul timp, de o serie de cercet\u0103ri \u0219i descoperiri privind mecanismele fizio-patologice ale bolii, ceea ce a generat posibilitatea unei noi abord\u0103ri terapeutice. Introducerea agen\u021bilor biologici a prezentat o contribu\u021bie major\u0103 \u00een arsenalul terapeutic al bolii. Totu\u0219i, nu to\u021bi pacien\u021bii prezint\u0103 un r\u0103spuns favorabil la terapia biologic\u0103. Prezen\u021ba mai multor clase de agen\u021bi biologici, cu mecanisme de ac\u021biune fisio-patologice diferite, permit ast\u0103zi o particularizare mai bun\u0103 a terapiei pentru fiecare pacient. Lipsa de r\u0103spuns terapeutic la un agent permite, ast\u0103zi, schimbarea lui cu un alt agent biologic, cu mecanism de ac\u021biune similar sau total diferit. Ast\u0103zi, schimbarea agentului biologic presupune evaluarea complex\u0103 a unor factori lega\u021bi de aspectele farmacologice ale medicamentelor, prezen\u021ba comorbidit\u0103\u021bilor, perioada de wash-out \u0219i unele aspecte privind avantajele \u0219i dezavantajele tratamentului din punct de vedere al pacientului.
Din acest punct de vedere \u00eencerc\u0103m s\u0103 prezent\u0103m care sunt oportunit\u0103\u021bile \u0219i recomand\u0103rile schimb\u0103rii agentului biologic \u00een tratamentul psoriazisului.<\/p>\n
When and How do we change a biological agent in the psoriasis therapy? Oradea University. Faculty of Medicine and Pharmacy<\/p>\n Psoriasis is a chronic, immune-mediated systemic inflammatory condition, with an undulating and, sometimes, disabling evolution. Psoriasis has recently benefited from a series of research and discoveries on the pathophysiological mechanisms of the disease, which has generated the possibility of a new therapeutic approach. The introduction of the biological agents has made a major contribution to the therapeutic arsenal of the disease. However, not all patients have a favorable response to the biologic therapy. The presence of several classes of biological agents, with different pathophysiological mechanisms of action, allow today a better customization of the therapy for each patient. The lack of a therapeutic response to an agent allows, nowadays, its exchange with another biological agent, with a similar or totally different mechanism of action. Nowadays, the change of the biological agent involves the complex assessment of the factors related to the pharmacological aspects of the drugs, the presence of comorbidities, the wash-out period and some aspects of the advantages and disadvantages of the treatment from the patient’s point of view. <\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” 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A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”9252,9464,10556″ fullwidth=”on” disabled_on=”off|off|off” _builder_version=”4.17.1″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off” global_colors_info=”{}”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" \u0218ef Lucr. Dr. Brihan IlarieFacultatea de Medicin\u0103, Universitatea din Oradea, Rom\u00e2niaSpitalul Clinic Jude\u021bean de Urgen\u021b\u0103 Oradea C\u00e2nd \u0219i cum schimb\u0103m un agent biologic \u00een terapia psoriazisului?Autor: Ilarie Brihan Universitatea din Oradea. Facultatea de Medicin\u0103 \u0219i Farmacie Psoriazisul este o afec\u021biune inflamatorie sistemic\u0103 cronic\u0103, mediat\u0103 imun, cu evolu\u021bie ondulant\u0103 \u0219i, uneori, invalidant\u0103. Psoriazisul a beneficiat, \u00een […]<\/p>\n","protected":false},"author":2,"featured_media":11505,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-10384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/10384","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=10384"}],"version-history":[{"count":13,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/10384\/revisions"}],"predecessor-version":[{"id":11526,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/10384\/revisions\/11526"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11505"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=10384"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=10384"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=10384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Author: Ilarie Brihan<\/span><\/p>\n
Therefore, the aim of our paper is to present the opportunities and recommendations for changing the biological agent in the treatment of psoriasis.<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n