{"id":7441,"date":"2021-06-25T20:20:39","date_gmt":"2021-06-25T18:20:39","guid":{"rendered":"https:\/\/primaderma.ro\/?page_id=7441"},"modified":"2022-04-08T16:23:26","modified_gmt":"2022-04-08T14:23:26","slug":"prof-dr-alecu-mihail","status":"publish","type":"post","link":"https:\/\/pdi.ro\/2022\/prof-dr-alecu-mihail\/","title":{"rendered":"Prof. Dr. Alecu Mihail"},"content":{"rendered":"

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Prof. Univ. Dr. Alecu Mihail<\/strong><\/span>
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Dr. Victor Babe\u015f\u201d Bucure\u015fti<\/strong><\/span>
Universitatea “Titu Maiorescu” Facultatea de Medicin\u0103, Bucure\u015fti<\/strong><\/span><\/h4>\n

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MicroARN in patogenia dermitei atopice si a psoriazisului<\/span>
Autori: M. Alecu1, Gabriela Coman2<\/span>
1Universitatea “Titu Maiorescu”, Facultatea de Medicin\u0103, Bucure\u0219ti, Rom\u00e2nia
2Spitalul Clinic de Boli Infec\u021bioase \u0219i Tropicale “Dr. Victor Babe\u0219”, Bucure\u0219ti, Rom\u00e2nia<\/p>\n

MicroARN reprezint\u0103 un mic fragment de ARN de circa 10-25 nucleotide, care nu con\u021bine informa\u021bie genetic\u0103 dar care are capacitatea de a se cupla cu ARN mesager \u00eempiedic\u00e2nd transmiterea informa\u021biei genetice la ribozomi. \u00cen acest mod are loc un control posttranscrip\u021bional al mai multor tipuri de gene implicate \u00een procese fiziologice \u0219i patologice.
S-au identificat peste 2500 de tipuri de microARN at\u00e2t \u00een celule c\u00e2t \u0219i \u00een plasm\u0103, urin\u0103, saliv\u0103. Alterarea expresiei microARN a fost eviden\u021biat\u0103 \u00een numeroase afec\u021biuni, inclusiv \u00een afec\u021biuni ale pielii
\u00cen dermatita atopic\u0103 s-au identificat mai multe zeci de microARN care au avut valori sc\u0103zute sau crescute \u00een keratinocitele lezionale comparativ cu pielea normal\u0103 la acela\u0219i pacient. Dintre acestea cele mai semnificative modific\u0103ri s-au \u00eent\u00e2lnit \u00een microARN155 \u0219i microARN146a. Aceste tipuri de ARN nu sunt specifice dermatitei atopice ci sunt asociate cu o serie de fenomene ca: dezvoltarea epidermului (microARN203), reglarea r\u0103spunsului imun \u00eenn\u0103scut \u0219i adaptativ (microARN155), reglarea c\u0103ii de semnalizare \u00een care este implicat TNF (microARN146).
\u00cen psoriazis, s-au eviden\u021biat \u00een leziune, niveluri crescute de microARN31, microARN21, microARN200, microARN210, \u00een timp ce microARN 125, care are capacitatea de a supresa proliferarea keratinocitelor, este sc\u0103zut. MicroARN 125 este foarte bine corelat cu evolu\u021bia psoriazisului \u00een cursul terapiai biologice.
P\u00e2n\u0103 \u00een prezent s-a putut stabili c\u0103 exist\u0103 o anumit\u0103 specificitate a unui grup de microARN pentru anumite procese patologice: inflama\u021bie, carcinogenez\u0103, r\u0103spuns imun alterat, f\u0103r\u0103 \u00eens\u0103 a se putea stabili un profil microARN pentru dermatita atopic\u0103 sau psoriazis. Cu toate acestea, ac\u021biunea asupra microARN deschide perspective terapeutice importante.<\/p>\n

MicroARN in the pathogeny of atopic dermatitis and psoriasis<\/span>
Authors: Mihail Alecu1, Gabriela Coman2<\/span>
1. Titu Maiorescu University, Bucharest
2. Dr. V. Babe\u0219 Infectious and Tropical Diseases Clinical Hospital, Bucharest<\/p>\n

MicroRNA is a small RNA fragment of about 10-25 nucleotides, which does not contain genetic information but has the ability to bind to messenger RNA preventing the transmission of genetic information to ribosomes. In this way, a post-transcriptional control of several types of genes involved in physiological and pathological processes takes place.
More than 2,500 types of microRNAs have been identified in both cells and plasma, urine, saliva. Impaired microRNA expression has been shown in many conditions, including skin diseases.
In atopic dermatitis, several dozen microRNAs have been identified that had low or high levels in lesional keratinocytes compared to normal skin, in the same patient. Of these, the most significant changes were found in microRNA155 and microRNA146a. These types of RNA are not specific to atopic dermatitis but are associated with a number of phenomena such as: epidermal development (microRNA203), regulation of the innate and adaptive immune response (microRNA155), regulation of the signaling pathway in which TNF is involved (microRNA146).
In psoriasis, high levels of microRNA31, microRNA21, microRNA200, microRNA210 were detected, while microRNA 125, which has the ability to suppress keratinocyte proliferation, are low in the lesion. MicroRNA 125 is very well correlated with the evolution of psoriasis during biological therapy.
So far, it has been established that there is a certain specificity of a group of microRNAs for certain pathological processes: inflammation, carcinogenesis, altered immune response, but without being able to establish a microRNA profile for atopic dermatitis or psoriasis. However, the action on microRNA opens up important therapeutic perspectives.<\/p>\n

Scurt CV<\/span><\/p>\n

Studii:<\/strong> Facultatea de Medicin\u0103 Bucure\u0219ti
Specialitatea<\/strong>: Medicin\u0103 general\u0103
Titluri didactice, \u0219tiin\u021bifice \u0219i academice<\/strong>
Cercetator \u0219tiin\u021bific principal gradul I
Doctor \u00een medicin\u0103 cu teza \u201dCitochinele \u00een tratamentul local al unor tumori maligne cutanate\u201d (1994), UMF Bucure\u0219ti
Profesor titular de curs Dermato-venerologie, Univ. Titu Maiorescu, Bucure\u0219ti
Specialitate:<\/strong> – medic primar dermato-venerologie
medic primar alergologie \u0219i imunologie clinic\u0103
Membru \u00een asocia\u021bii profesionale, academii:<\/strong>
Societatea Rom\u00e2na de Dermatologie
Societatea Rom\u00e2na de Alergologie \u0219i Imunologie Clinica
ISIR (Asocia\u021bia Interna\u021bionala de Studiu a Interferonului \u0219i a citokinelor)
EADV (Asocia\u021bia Europeana de Dermato-Venerologie) Distinc\u021bii :
Premiul Academiei Rom\u00e2ne \u201d Daniel Danielopolu\u201d – 1990
Premiul Conferin\u021bei Interbalcanice de alergologie -Bucuresti \u2014 1995 e Premiul Academiei Rom\u00e2ne \u201dGheorghe Marinescu\u201d \u2013 2001
\u00cencadrarea prezenta \u0219i cea anterioara:<\/strong>
Bucure\u0219ti, Spitalul Clinic de Boli Infec\u021bioase \u0219i Tropicale Dr. Victor Babe\u0219 Laboratorul de
Imunologie, din 1981 p\u00e2na in prezent \u2014 Conducator Laborator Imunologie
Lucrari \u0219tiin\u021bifice publicate:<\/strong>
-un numar de 100 de comunic\u0103ri \u0219i articole dintre care 25 articole publicate \u00een reviste de specialitate de circula\u021bie interna\u021bional\u0103, indexate
monografii: \u201dSarcomul Kaposi\u201d Editura Tehnic\u0103, 1998, 230 pagini, unic autor \u201dApoptoza-Moartea celular\u0103 programat\u0103\u201d Ed. Academiei, 1999, 410 pagini, coautor Reac\u021bii alergice la medicamente\u201d Ed. Medical\u0103, 2002, 400 pagini, prim autor \u201dPatologia molecular\u0103 a pielii\u201d Ed. Medical\u0103, 2006, 495 pagini, unic autor \u201dDermato-Venerologie\u201d Ed. Didactic\u0103 \u0219i Pedagogic\u0103 2010, 300 pagini<\/p>\n

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Contacteaz\u0103 operatorul PDI 2022<\/p>\n

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Operatorul PDI 2022<\/p>\n

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Adresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
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Prof. Univ. Dr. Alecu Mihail Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Dr. Victor Babe\u015f\u201d Bucure\u015fti Universitatea “Titu Maiorescu” Facultatea de Medicin\u0103, Bucure\u015ftiMicroARN in patogenia dermitei atopice si a psoriazisuluiAutori: M. Alecu1, Gabriela Coman21Universitatea “Titu Maiorescu”, Facultatea de Medicin\u0103, Bucure\u0219ti, Rom\u00e2nia2Spitalul Clinic de Boli Infec\u021bioase \u0219i Tropicale “Dr. Victor Babe\u0219”, Bucure\u0219ti, Rom\u00e2nia MicroARN reprezint\u0103 un […]<\/p>\n","protected":false},"author":2,"featured_media":11336,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7441","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=7441"}],"version-history":[{"count":14,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7441\/revisions"}],"predecessor-version":[{"id":11337,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7441\/revisions\/11337"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11336"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=7441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=7441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=7441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}