<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nProf. Dr. Ciocoiu Manuela<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.1″ global_colors_info=”{}”]<\/p>\n
Mecanisme fiziopatologice implicate \u00een interrela\u0163ia psoriazis \u2013 inflama\u0163ie \u2013 disfunc\u0163ia sistemului imun<\/span>
Autori: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2<\/span><\/p>\n1 \u2013 Disciplina de Fiziopatologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi
2\u2013Departamentul Specialit\u0103\u0163ilor Medicale I, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi<\/p>\n
Cuvinte cheie: psoriazis, inflama\u0163ie, clusterina \u0219i elafina<\/p>\n
Psoriazisul este o boal\u0103 sistemic\u0103 cronic\u0103 mediat\u0103 imun cu o baz\u0103 imunogenetic\u0103, care poate fi declan\u0219at intrinsec (factori genetici) \u0219i extrinsec de diver\u0219i factori (de exemplu, stres, traume mecanice, infec\u021bie, medicamente, nutri\u021bie, fumat sau obezitate). Locusul de susceptibilitate la psoriazis de pe cromozomul 6p21 (loca\u021bia genelor HLA) este considerat a fi un determinant genetic major al psoriazisului. Psoriazisul prezint\u0103 tr\u0103s\u0103turi ale unei boli autoimune pe un fundal (auto)inflamator, cu ambele mecanisme suprapun\u00e2ndu-se \u0219i chiar poten\u021b\u00e2ndu-se unul pe cel\u0103lalt. Patogenia psoriazic\u0103 poate fi conceptualizat\u0103 \u00een 2 faze: o faz\u0103 ini\u021bial\u0103 declan\u0219at\u0103, probabil, de o traum\u0103, infec\u021bie sau medicamente \u0219i o faz\u0103 de \u00eentre\u021binere caracterizat\u0103 printr-o progresie clinic\u0103 cronic\u0103. \u00cen timp ce axa TNF-IL23-Th17 joac\u0103 un rol central \u00een psoriazisul \u00een pl\u0103ci mediat de celulele T, sistemul imunitar \u00eenn\u0103scut pare s\u0103 joace un rol mai proeminent \u00een variantele pustuloase ale psoriazisului. \u00cen psoriazisul gutat, se crede c\u0103 superantigenele streptococice stimuleaz\u0103 expansiunea celulelor T \u00een piele, \u00eentruc\u00e2t s-a demonstrat c\u0103 exist\u0103 o omologie considerabil\u0103 de secven\u021b\u0103 \u00eentre proteinele M streptococice \u0219i proteinele 17 ale keratinei umane. Psoriazisul pustular este caracterizat printr-o exprimare crescut\u0103 a transcrierilor IL-1\u03b2, IL-36\u03b1 \u0219i IL-36\u03b3 comparativ cu psoriazisul vulgar. \u00cen fiziopatologia psoriazisului sunt implicate o gam\u0103 larg\u0103 de molecule, fie ca factori care influen\u0163eaz\u0103 patogenia, fie ca factori de protec\u021bie. Nivelurile de clusterina \u0219i elafina, care sunt str\u00e2ns legate de inflama\u021bie, au fost semnificativ crescute la pacien\u021bii cu psoriazis, comparativ cu martorii s\u0103n\u0103to\u015fi, Cercet\u0103rile viitoare vor contribui la elucidarea fiziopatologiei interrela\u0163iilor dintre psoriazis, comorbidit\u0103\u0163ile pro-inflamatorii \u015fi disfunc\u0163ia sistemului imun.<\/p>\n
Pathophysiological mechanisms involved in the interrelationship of psoriasis – inflammation – immune system dysfunction<\/span>
Authors: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2<\/span><\/p>\n1 – Department of Pathophysiology, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi
2 – Department of Internal Medicine I, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi<\/p>\n
Keywords: psoriasis, inflammation, clusterin and elafin<\/p>\n
Psoriasis is an immune-mediated chronic systemic disease with an immunogenetic basis, which can be triggered intrinsically (genetic factors) and extrinsically by various factors (e.g., stress, mechanical trauma, infection, medication, nutrition, smoking, or obesity). The psoriasis\u2011susceptibility locus on chromosome 6p21 (location of the HLA genes) is thought to be a major genetic determinant of psoriasis. Psoriasis has features of an autoimmune disease on a (self) inflammatory background, with both mechanisms overlapping and even potentiating each other. Psoriatic pathogenesis can be conceptualized in 2 phases: an initial phase, probably triggered by trauma, infection or medication, and a maintenance phase characterized by a chronic clinical progression. While the TNF-IL23-Th17 axis plays a central role in T-cell-mediated plaque psoriasis, the innate immune system appears to play a more prominent role in the pustular variants of psoriasis. In guttate psoriasis, streptococcal superantigens are thought to stimulate the expansion of T cells in the skin, as there has been shown to be considerable sequence homology between streptococcal M proteins and human keratin 17 proteins. Pustular psoriasis is characterized by an increased expression of IL-1\u03b2, IL-36\u03b1 and IL-36\u03b3 transcripts compared to vulgar psoriasis. A wide range of molecules are involved in the pathophysiology of psoriasis, either as factors influencing the pathogenesis or as protective factors. Clusterin and elafin levels, which are closely linked to inflammation, have been significantly increased in patients with psoriasis compared to healthy controls. Future research will help elucidate the pathophysiology of the interrelationships between psoriasis, pro-inflammatory comorbidities, and immune system dysfunction.<\/p>\n
\u00a0Scurt CV<\/span><\/p>\nCoordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n
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Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiMecanisme fiziopatologice implicate \u00een interrela\u0163ia psoriazis \u2013 inflama\u0163ie \u2013 disfunc\u0163ia sistemului imunAutori: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2 1 \u2013 Disciplina de Fiziopatologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi2\u2013Departamentul Specialit\u0103\u0163ilor Medicale I, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi Cuvinte cheie: psoriazis, inflama\u0163ie, clusterina […]<\/p>\n","protected":false},"author":2,"featured_media":11332,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7501","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=7501"}],"version-history":[{"count":11,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501\/revisions"}],"predecessor-version":[{"id":11333,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501\/revisions\/11333"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11332"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=7501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=7501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=7501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nProf. Dr. Ciocoiu Manuela<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.1″ global_colors_info=”{}”]<\/p>\n
Mecanisme fiziopatologice implicate \u00een interrela\u0163ia psoriazis \u2013 inflama\u0163ie \u2013 disfunc\u0163ia sistemului imun<\/span>
Autori: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2<\/span><\/p>\n1 \u2013 Disciplina de Fiziopatologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi
2\u2013Departamentul Specialit\u0103\u0163ilor Medicale I, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi<\/p>\n
Cuvinte cheie: psoriazis, inflama\u0163ie, clusterina \u0219i elafina<\/p>\n
Psoriazisul este o boal\u0103 sistemic\u0103 cronic\u0103 mediat\u0103 imun cu o baz\u0103 imunogenetic\u0103, care poate fi declan\u0219at intrinsec (factori genetici) \u0219i extrinsec de diver\u0219i factori (de exemplu, stres, traume mecanice, infec\u021bie, medicamente, nutri\u021bie, fumat sau obezitate). Locusul de susceptibilitate la psoriazis de pe cromozomul 6p21 (loca\u021bia genelor HLA) este considerat a fi un determinant genetic major al psoriazisului. Psoriazisul prezint\u0103 tr\u0103s\u0103turi ale unei boli autoimune pe un fundal (auto)inflamator, cu ambele mecanisme suprapun\u00e2ndu-se \u0219i chiar poten\u021b\u00e2ndu-se unul pe cel\u0103lalt. Patogenia psoriazic\u0103 poate fi conceptualizat\u0103 \u00een 2 faze: o faz\u0103 ini\u021bial\u0103 declan\u0219at\u0103, probabil, de o traum\u0103, infec\u021bie sau medicamente \u0219i o faz\u0103 de \u00eentre\u021binere caracterizat\u0103 printr-o progresie clinic\u0103 cronic\u0103. \u00cen timp ce axa TNF-IL23-Th17 joac\u0103 un rol central \u00een psoriazisul \u00een pl\u0103ci mediat de celulele T, sistemul imunitar \u00eenn\u0103scut pare s\u0103 joace un rol mai proeminent \u00een variantele pustuloase ale psoriazisului. \u00cen psoriazisul gutat, se crede c\u0103 superantigenele streptococice stimuleaz\u0103 expansiunea celulelor T \u00een piele, \u00eentruc\u00e2t s-a demonstrat c\u0103 exist\u0103 o omologie considerabil\u0103 de secven\u021b\u0103 \u00eentre proteinele M streptococice \u0219i proteinele 17 ale keratinei umane. Psoriazisul pustular este caracterizat printr-o exprimare crescut\u0103 a transcrierilor IL-1\u03b2, IL-36\u03b1 \u0219i IL-36\u03b3 comparativ cu psoriazisul vulgar. \u00cen fiziopatologia psoriazisului sunt implicate o gam\u0103 larg\u0103 de molecule, fie ca factori care influen\u0163eaz\u0103 patogenia, fie ca factori de protec\u021bie. Nivelurile de clusterina \u0219i elafina, care sunt str\u00e2ns legate de inflama\u021bie, au fost semnificativ crescute la pacien\u021bii cu psoriazis, comparativ cu martorii s\u0103n\u0103to\u015fi, Cercet\u0103rile viitoare vor contribui la elucidarea fiziopatologiei interrela\u0163iilor dintre psoriazis, comorbidit\u0103\u0163ile pro-inflamatorii \u015fi disfunc\u0163ia sistemului imun.<\/p>\n
Pathophysiological mechanisms involved in the interrelationship of psoriasis – inflammation – immune system dysfunction<\/span>
Authors: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2<\/span><\/p>\n1 – Department of Pathophysiology, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi
2 – Department of Internal Medicine I, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi<\/p>\n
Keywords: psoriasis, inflammation, clusterin and elafin<\/p>\n
Psoriasis is an immune-mediated chronic systemic disease with an immunogenetic basis, which can be triggered intrinsically (genetic factors) and extrinsically by various factors (e.g., stress, mechanical trauma, infection, medication, nutrition, smoking, or obesity). The psoriasis\u2011susceptibility locus on chromosome 6p21 (location of the HLA genes) is thought to be a major genetic determinant of psoriasis. Psoriasis has features of an autoimmune disease on a (self) inflammatory background, with both mechanisms overlapping and even potentiating each other. Psoriatic pathogenesis can be conceptualized in 2 phases: an initial phase, probably triggered by trauma, infection or medication, and a maintenance phase characterized by a chronic clinical progression. While the TNF-IL23-Th17 axis plays a central role in T-cell-mediated plaque psoriasis, the innate immune system appears to play a more prominent role in the pustular variants of psoriasis. In guttate psoriasis, streptococcal superantigens are thought to stimulate the expansion of T cells in the skin, as there has been shown to be considerable sequence homology between streptococcal M proteins and human keratin 17 proteins. Pustular psoriasis is characterized by an increased expression of IL-1\u03b2, IL-36\u03b1 and IL-36\u03b3 transcripts compared to vulgar psoriasis. A wide range of molecules are involved in the pathophysiology of psoriasis, either as factors influencing the pathogenesis or as protective factors. Clusterin and elafin levels, which are closely linked to inflammation, have been significantly increased in patients with psoriasis compared to healthy controls. Future research will help elucidate the pathophysiology of the interrelationships between psoriasis, pro-inflammatory comorbidities, and immune system dysfunction.<\/p>\n
\u00a0Scurt CV<\/span><\/p>\nCoordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n
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Contacteaz\u0103 operatorul PDI 2020<\/p>\n
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Operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” global_colors_info=”{}”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiMecanisme fiziopatologice implicate \u00een interrela\u0163ia psoriazis \u2013 inflama\u0163ie \u2013 disfunc\u0163ia sistemului imunAutori: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2 1 \u2013 Disciplina de Fiziopatologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi2\u2013Departamentul Specialit\u0103\u0163ilor Medicale I, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi Cuvinte cheie: psoriazis, inflama\u0163ie, clusterina […]<\/p>\n","protected":false},"author":2,"featured_media":11332,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7501","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=7501"}],"version-history":[{"count":11,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501\/revisions"}],"predecessor-version":[{"id":11333,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501\/revisions\/11333"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11332"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=7501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=7501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=7501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Prof. Dr. Ciocoiu Manuela<\/strong><\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.1″ global_colors_info=”{}”]<\/p>\n
Mecanisme fiziopatologice implicate \u00een interrela\u0163ia psoriazis \u2013 inflama\u0163ie \u2013 disfunc\u0163ia sistemului imun<\/span>
Autori: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2<\/span><\/p>\n1 \u2013 Disciplina de Fiziopatologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi
2\u2013Departamentul Specialit\u0103\u0163ilor Medicale I, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi<\/p>\n
Cuvinte cheie: psoriazis, inflama\u0163ie, clusterina \u0219i elafina<\/p>\n
Psoriazisul este o boal\u0103 sistemic\u0103 cronic\u0103 mediat\u0103 imun cu o baz\u0103 imunogenetic\u0103, care poate fi declan\u0219at intrinsec (factori genetici) \u0219i extrinsec de diver\u0219i factori (de exemplu, stres, traume mecanice, infec\u021bie, medicamente, nutri\u021bie, fumat sau obezitate). Locusul de susceptibilitate la psoriazis de pe cromozomul 6p21 (loca\u021bia genelor HLA) este considerat a fi un determinant genetic major al psoriazisului. Psoriazisul prezint\u0103 tr\u0103s\u0103turi ale unei boli autoimune pe un fundal (auto)inflamator, cu ambele mecanisme suprapun\u00e2ndu-se \u0219i chiar poten\u021b\u00e2ndu-se unul pe cel\u0103lalt. Patogenia psoriazic\u0103 poate fi conceptualizat\u0103 \u00een 2 faze: o faz\u0103 ini\u021bial\u0103 declan\u0219at\u0103, probabil, de o traum\u0103, infec\u021bie sau medicamente \u0219i o faz\u0103 de \u00eentre\u021binere caracterizat\u0103 printr-o progresie clinic\u0103 cronic\u0103. \u00cen timp ce axa TNF-IL23-Th17 joac\u0103 un rol central \u00een psoriazisul \u00een pl\u0103ci mediat de celulele T, sistemul imunitar \u00eenn\u0103scut pare s\u0103 joace un rol mai proeminent \u00een variantele pustuloase ale psoriazisului. \u00cen psoriazisul gutat, se crede c\u0103 superantigenele streptococice stimuleaz\u0103 expansiunea celulelor T \u00een piele, \u00eentruc\u00e2t s-a demonstrat c\u0103 exist\u0103 o omologie considerabil\u0103 de secven\u021b\u0103 \u00eentre proteinele M streptococice \u0219i proteinele 17 ale keratinei umane. Psoriazisul pustular este caracterizat printr-o exprimare crescut\u0103 a transcrierilor IL-1\u03b2, IL-36\u03b1 \u0219i IL-36\u03b3 comparativ cu psoriazisul vulgar. \u00cen fiziopatologia psoriazisului sunt implicate o gam\u0103 larg\u0103 de molecule, fie ca factori care influen\u0163eaz\u0103 patogenia, fie ca factori de protec\u021bie. Nivelurile de clusterina \u0219i elafina, care sunt str\u00e2ns legate de inflama\u021bie, au fost semnificativ crescute la pacien\u021bii cu psoriazis, comparativ cu martorii s\u0103n\u0103to\u015fi, Cercet\u0103rile viitoare vor contribui la elucidarea fiziopatologiei interrela\u0163iilor dintre psoriazis, comorbidit\u0103\u0163ile pro-inflamatorii \u015fi disfunc\u0163ia sistemului imun.<\/p>\n
Pathophysiological mechanisms involved in the interrelationship of psoriasis – inflammation – immune system dysfunction<\/span>
Authors: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2<\/span><\/p>\n1 – Department of Pathophysiology, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi
2 – Department of Internal Medicine I, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi<\/p>\n
Keywords: psoriasis, inflammation, clusterin and elafin<\/p>\n
Psoriasis is an immune-mediated chronic systemic disease with an immunogenetic basis, which can be triggered intrinsically (genetic factors) and extrinsically by various factors (e.g., stress, mechanical trauma, infection, medication, nutrition, smoking, or obesity). The psoriasis\u2011susceptibility locus on chromosome 6p21 (location of the HLA genes) is thought to be a major genetic determinant of psoriasis. Psoriasis has features of an autoimmune disease on a (self) inflammatory background, with both mechanisms overlapping and even potentiating each other. Psoriatic pathogenesis can be conceptualized in 2 phases: an initial phase, probably triggered by trauma, infection or medication, and a maintenance phase characterized by a chronic clinical progression. While the TNF-IL23-Th17 axis plays a central role in T-cell-mediated plaque psoriasis, the innate immune system appears to play a more prominent role in the pustular variants of psoriasis. In guttate psoriasis, streptococcal superantigens are thought to stimulate the expansion of T cells in the skin, as there has been shown to be considerable sequence homology between streptococcal M proteins and human keratin 17 proteins. Pustular psoriasis is characterized by an increased expression of IL-1\u03b2, IL-36\u03b1 and IL-36\u03b3 transcripts compared to vulgar psoriasis. A wide range of molecules are involved in the pathophysiology of psoriasis, either as factors influencing the pathogenesis or as protective factors. Clusterin and elafin levels, which are closely linked to inflammation, have been significantly increased in patients with psoriasis compared to healthy controls. Future research will help elucidate the pathophysiology of the interrelationships between psoriasis, pro-inflammatory comorbidities, and immune system dysfunction.<\/p>\n
\u00a0Scurt CV<\/span><\/p>\nCoordonator al activit\u0103\u0163ii didactice la Disciplina de Fiziopatologie
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n
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Contacteaz\u0103 operatorul PDI 2020<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.16″ _unique_id=”2a31f717-de71-49cb-a70f-4300a10c8f97″ title_font=”||||||||” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n
Operatorul PDI 2020<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Prof. Dr. Ciocoiu Manuela Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiMecanisme fiziopatologice implicate \u00een interrela\u0163ia psoriazis \u2013 inflama\u0163ie \u2013 disfunc\u0163ia sistemului imunAutori: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2 1 \u2013 Disciplina de Fiziopatologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi2\u2013Departamentul Specialit\u0103\u0163ilor Medicale I, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi Cuvinte cheie: psoriazis, inflama\u0163ie, clusterina […]<\/p>\n","protected":false},"author":2,"featured_media":11332,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7501","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=7501"}],"version-history":[{"count":11,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501\/revisions"}],"predecessor-version":[{"id":11333,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501\/revisions\/11333"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11332"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=7501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=7501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=7501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2<\/span><\/p>\n
1 \u2013 Disciplina de Fiziopatologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi
2\u2013Departamentul Specialit\u0103\u0163ilor Medicale I, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi<\/p>\n
Cuvinte cheie: psoriazis, inflama\u0163ie, clusterina \u0219i elafina<\/p>\n
Psoriazisul este o boal\u0103 sistemic\u0103 cronic\u0103 mediat\u0103 imun cu o baz\u0103 imunogenetic\u0103, care poate fi declan\u0219at intrinsec (factori genetici) \u0219i extrinsec de diver\u0219i factori (de exemplu, stres, traume mecanice, infec\u021bie, medicamente, nutri\u021bie, fumat sau obezitate). Locusul de susceptibilitate la psoriazis de pe cromozomul 6p21 (loca\u021bia genelor HLA) este considerat a fi un determinant genetic major al psoriazisului. Psoriazisul prezint\u0103 tr\u0103s\u0103turi ale unei boli autoimune pe un fundal (auto)inflamator, cu ambele mecanisme suprapun\u00e2ndu-se \u0219i chiar poten\u021b\u00e2ndu-se unul pe cel\u0103lalt. Patogenia psoriazic\u0103 poate fi conceptualizat\u0103 \u00een 2 faze: o faz\u0103 ini\u021bial\u0103 declan\u0219at\u0103, probabil, de o traum\u0103, infec\u021bie sau medicamente \u0219i o faz\u0103 de \u00eentre\u021binere caracterizat\u0103 printr-o progresie clinic\u0103 cronic\u0103. \u00cen timp ce axa TNF-IL23-Th17 joac\u0103 un rol central \u00een psoriazisul \u00een pl\u0103ci mediat de celulele T, sistemul imunitar \u00eenn\u0103scut pare s\u0103 joace un rol mai proeminent \u00een variantele pustuloase ale psoriazisului. \u00cen psoriazisul gutat, se crede c\u0103 superantigenele streptococice stimuleaz\u0103 expansiunea celulelor T \u00een piele, \u00eentruc\u00e2t s-a demonstrat c\u0103 exist\u0103 o omologie considerabil\u0103 de secven\u021b\u0103 \u00eentre proteinele M streptococice \u0219i proteinele 17 ale keratinei umane. Psoriazisul pustular este caracterizat printr-o exprimare crescut\u0103 a transcrierilor IL-1\u03b2, IL-36\u03b1 \u0219i IL-36\u03b3 comparativ cu psoriazisul vulgar. \u00cen fiziopatologia psoriazisului sunt implicate o gam\u0103 larg\u0103 de molecule, fie ca factori care influen\u0163eaz\u0103 patogenia, fie ca factori de protec\u021bie. Nivelurile de clusterina \u0219i elafina, care sunt str\u00e2ns legate de inflama\u021bie, au fost semnificativ crescute la pacien\u021bii cu psoriazis, comparativ cu martorii s\u0103n\u0103to\u015fi, Cercet\u0103rile viitoare vor contribui la elucidarea fiziopatologiei interrela\u0163iilor dintre psoriazis, comorbidit\u0103\u0163ile pro-inflamatorii \u015fi disfunc\u0163ia sistemului imun.<\/p>\n
Pathophysiological mechanisms involved in the interrelationship of psoriasis – inflammation – immune system dysfunction<\/span> 1 – Department of Pathophysiology, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi Keywords: psoriasis, inflammation, clusterin and elafin<\/p>\n Psoriasis is an immune-mediated chronic systemic disease with an immunogenetic basis, which can be triggered intrinsically (genetic factors) and extrinsically by various factors (e.g., stress, mechanical trauma, infection, medication, nutrition, smoking, or obesity). The psoriasis\u2011susceptibility locus on chromosome 6p21 (location of the HLA genes) is thought to be a major genetic determinant of psoriasis. Psoriasis has features of an autoimmune disease on a (self) inflammatory background, with both mechanisms overlapping and even potentiating each other. Psoriatic pathogenesis can be conceptualized in 2 phases: an initial phase, probably triggered by trauma, infection or medication, and a maintenance phase characterized by a chronic clinical progression. While the TNF-IL23-Th17 axis plays a central role in T-cell-mediated plaque psoriasis, the innate immune system appears to play a more prominent role in the pustular variants of psoriasis. In guttate psoriasis, streptococcal superantigens are thought to stimulate the expansion of T cells in the skin, as there has been shown to be considerable sequence homology between streptococcal M proteins and human keratin 17 proteins. Pustular psoriasis is characterized by an increased expression of IL-1\u03b2, IL-36\u03b1 and IL-36\u03b3 transcripts compared to vulgar psoriasis. A wide range of molecules are involved in the pathophysiology of psoriasis, either as factors influencing the pathogenesis or as protective factors. Clusterin and elafin levels, which are closely linked to inflammation, have been significantly increased in patients with psoriasis compared to healthy controls. 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Popa\u201d Ia\u015fiMecanisme fiziopatologice implicate \u00een interrela\u0163ia psoriazis \u2013 inflama\u0163ie \u2013 disfunc\u0163ia sistemului imunAutori: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2 1 \u2013 Disciplina de Fiziopatologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi2\u2013Departamentul Specialit\u0103\u0163ilor Medicale I, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi Cuvinte cheie: psoriazis, inflama\u0163ie, clusterina […]<\/p>\n","protected":false},"author":2,"featured_media":11332,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7501","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=7501"}],"version-history":[{"count":11,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501\/revisions"}],"predecessor-version":[{"id":11333,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7501\/revisions\/11333"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11332"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=7501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=7501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=7501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Authors: Manuela Ciocoiu1, T. Ionescu1, Codru\u0163a B\u0103descu2<\/span><\/p>\n
2 – Department of Internal Medicine I, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi<\/p>\n
Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGr. T. Popa\u201d Ia\u015fi
Medic primar Medicin\u0103 Intern\u0103
Vicepre\u015fedintele Societ\u0103\u0163ii Rom\u00e2ne de Fiziopatologie<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n