<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nC.\u0218.I. Dr. Neagu Monica<\/strong><\/span>
Institutul Na\u0163ional \u201cVictor Babe\u015f\u201d, Bucure\u015fti<\/strong><\/span>
Spitalul Clinic \u201dColentina\u201d, Bucure\u015fti<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.0″ global_colors_info=”{}”]<\/p>\n
Dinamica anticorpilor specifici IgG si IgA IN vaccinarea anti-SARS-COV2\u00a0<\/span>
Autori: Monica Neagu 1,2, Carolina Constantin 1,2 , Sabina Zurac 2,3<\/span><\/p>\n1. Departamentul de Imunologie, Institutul Na\u021bional de Patologie Victor Babe\u0219, Bucure\u0219ti, Rom\u00e2nia;
2. Sec\u021bia Patologie, Spitalul Clinic Colentina; Bucure\u0219ti, Rom\u00e2nia;
3. Departamentul de Patologie, Facultatea de Medicin\u0103 Dentar\u0103, Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila”, Bucure\u0219ti, Rom\u00e2nia<\/p>\n
Cuvinte cheie: vaccinare, COVID-19, IgG specific, IgA specific<\/p>\n
Introducere. Studii recente se concentreaz\u0103 pe stabilirea nivelurilor de anticorpi care scad \u00een timp at\u00e2t post-vaccinare c\u00e2t \u0219i post-infec\u021bie cu virusul SARS-CoV-2, dar \u0219i asupra relevan\u021bei vaccin\u0103rii de rapel. Scopul studiului nostru a fost de a stabili memoria imunit\u0103\u021bii umorale \u00een cadrul protocoalelor de vaccinare \u00een COVID-19. Metode. 70 de subiec\u021bi, cadre medicale \u00een contact cu pacien\u021bi \u0219i probe infecta\u021be cu SARS-Cov-2, au fost urm\u0103ri\u021bi \u00een perioada mai 2020 – octombrie 2021. A fost utilizat testul ELISA pentru detectarea IgG \u0219i IgA anti-SARS-CoV-2 (EUROIMMUN). Rezultate. Dup\u0103 8 luni de la prima vaccinare (ianuarie 2021), grupul a prezentat valori statistic sc\u0103zute privind nivelurile ambilor anticorpi testa\u021bi, indiferent dac\u0103 subiec\u021bii au fost infecta\u021bi sau nu in perioada investigat\u0103. Mai exact, concentra\u021bia medie a IgG a sc\u0103zut \u00een 8 luni de 2,4 ori, \u00een timp ce IgA a sc\u0103zut de 2,7 ori. Dup\u0103 vaccinarea de rapel (octombrie 2021), nivelul IgG cre\u0219te imediat dup\u0103 rapel de 2,7 ori, \u00een timp ce IgA a crescut dup\u0103 rapel de 2,5 ori. Rezultatele ob\u021binute post-rapel arat\u0103 r\u0103spunsul IgG statistic mai mare comparativ cu cel ob\u021binut dup\u0103 prima vaccinare. Spre deosebire de IgG, r\u0103spunsul IgA este aproape identic cu cel ob\u021binut la prima vaccinare. \u00cen studii de caz investigate unde s-a constatat c\u0103 dup\u0103 8 luni de la prima vaccinare nu au fost detecta\u021bi anticorpi circulan\u021bi detectabili, rapelul a indus rapid, dup\u0103 prima s\u0103pt\u0103m\u00e2n\u0103, o valoare ridicat\u0103 at\u00e2t pentru IgG, c\u00e2t \u0219i pentru IgA, iar nivelurile au continuat s\u0103 creasc\u0103 dup\u0103 dou\u0103 \u0219i trei s\u0103pt\u0103m\u00e2ni de la rapel. Concluzie. Vaccinarea de rapel induce niveluri mai ridicate de IgG \u00een \u00eentregul grup comparativ cu prima rund\u0103 de vaccinare, \u00een timp ce nivelurile IgA au fost similar cu cele ob\u021binute dup\u0103 prima vaccinare, date care sus\u021bin existen\u021ba unei memorii imunologice robuste.<\/p>\n
Dynamics of specific immunoglobulins IgG and IgA upon BNT162B2 booster vaccination\u00a0<\/span>
Authors: Monica Neagu 1,2, Carolina Constantin 1,2, Sabina Zurac 2,3<\/span><\/p>\n1. Department of Immunology, Victor Babes National Institute of Pathology, Bucharest, Romania;
2. Department of Pathology, Colentina Clinical Hospital; Bucharest, Romania;
3. Department of Pathology, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania<\/p>\n
Key words: vaccination, COVID-19, specific IgG, specific IgA<\/p>\n
Introduction. Extended studies focus on the antibody levels that are decreasing in time whether upon vaccination against or infection with SARS-CoV-2 virus, but still, we have to focus on the relevance of the booster vaccination. The aim of our study was to establish the humoral immunity memory in COVID-19 vaccination protocols. Methods. 70 subjects, healthcare workers in contact with SARS-Cov-2-infected patients and samples, were followed-up May, 2020 – October, 2021. ELISA for detection of anti-SARS-CoV-2 IgG and IgA (EUROIMMUN) was used. Results. After 8 months post first vaccination (January 2021), the group presented statistically decreased values for both antibodies, regardless of the infection status during these 8 months. More specifically, IgG\u2019s mean concentration decreased in 8 month 2.4 times, while IgA decreased 2.7 times. After booster vaccination (October 2021) IgG level increases immediately 2.7 times, while IgA increased 2.5 times. Our results show that the IgG response after booster is statistically higher compared to the first vaccination and, in contrast, the IgA response is almost identical with the level obtained after first vaccination. In study cases it was found that after 8 months post- first vaccination where no detectable circulating antibodies were detected, the booster induced after the first week a high value for both IgG and IgA, and the levels continued to raise after two and three weeks after booster. Conclusion. Booster vaccination induces higher levels of IgG in the entire group compared to the first round of vaccination, while the IgA levels were similar, data is proving a proper immunological memory. <\/p>\n
Scurt CV<\/span><\/p>\nProfessor Monica Neagu \u2013 Head of Immunology laboratory, Habilitation in Immunology, Doctoral School of the Faculty of Biology, University of Bucharest, Senior Researcher at Pathology Department, Colentina Clinical Hospital; President of the Romanian Society of Immunology, member of the World Academy of Sciences.<\/p>\n
She was Project Director for several international projects (Bilateral Cooperation Romania-China 511\/2011 Biomarker discovery in digestive tract cancer and skin melanoma using proteomic approaches (Beijing Institute of Genomics), Bilateral Cooperation Romania-Greece project no. 7285\/02 Immunomodulating potential of prothymosin alpha [….] (University of Athens), NATO SfP 982838\/2007 Development of a novel immunoassay for the very early detection of Biothreatening Bacterial Infections) and member of the research team in several international projects FP7, ERA-NET. Currently she is member of the management committee for Horizon2020 COST project CA16120 – European Epitranscriptomics Network (EPITRAN) and CA18125 – Advanced Engineering and Research of Aerogels for Environment and Life Sciences (AEROGELS). She has autoimmunity specialization at Sandoz Pharma Ltd., Basel. In 2010-2013 she was full member of Commission for Advanced Therapies \u2013 EMEA.<\/p>\n
In the last 5 years she has led or been involved in more than 10 national funded projects.
Fields of interest: immuno-oncology, melanoma biomarkers, proteomic array approaches, animal models for skin carcinogenesis, melanoma, wound healing, regeneration. She is co-inventor in several patents in dermato-oncology, biomarkers panel and tumor cell clones.
She is member in Editorial Boards for 4 international journals, Editor for an international book, invited Editor for 4 international journals, and has published over 200 scientific papers and book chapters. Hirsch Index =27 (ISI web of Science\/Clarivate).<\/p>\n
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Operatorul PDI 2021<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
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C.\u0218.I. Dr. Neagu Monica Institutul Na\u0163ional \u201cVictor Babe\u015f\u201d, Bucure\u015fti Spitalul Clinic \u201dColentina\u201d, Bucure\u015ftiDinamica anticorpilor specifici IgG si IgA IN vaccinarea anti-SARS-COV2\u00a0Autori: Monica Neagu 1,2, Carolina Constantin 1,2 , Sabina Zurac 2,3 1. Departamentul de Imunologie, Institutul Na\u021bional de Patologie Victor Babe\u0219, Bucure\u0219ti, Rom\u00e2nia; 2. Sec\u021bia Patologie, Spitalul Clinic Colentina; Bucure\u0219ti, Rom\u00e2nia; 3. Departamentul de Patologie, […]<\/p>\n","protected":false},"author":2,"featured_media":11428,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7583","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=7583"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7583\/revisions"}],"predecessor-version":[{"id":11429,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7583\/revisions\/11429"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11428"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=7583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=7583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=7583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
C.\u0218.I. Dr. Neagu Monica<\/strong><\/span>
Institutul Na\u0163ional \u201cVictor Babe\u015f\u201d, Bucure\u015fti<\/strong><\/span>
Spitalul Clinic \u201dColentina\u201d, Bucure\u015fti<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.0″ global_colors_info=”{}”]<\/p>\n
Dinamica anticorpilor specifici IgG si IgA IN vaccinarea anti-SARS-COV2\u00a0<\/span>
Autori: Monica Neagu 1,2, Carolina Constantin 1,2 , Sabina Zurac 2,3<\/span><\/p>\n1. Departamentul de Imunologie, Institutul Na\u021bional de Patologie Victor Babe\u0219, Bucure\u0219ti, Rom\u00e2nia;
2. Sec\u021bia Patologie, Spitalul Clinic Colentina; Bucure\u0219ti, Rom\u00e2nia;
3. Departamentul de Patologie, Facultatea de Medicin\u0103 Dentar\u0103, Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila”, Bucure\u0219ti, Rom\u00e2nia<\/p>\n
Cuvinte cheie: vaccinare, COVID-19, IgG specific, IgA specific<\/p>\n
Introducere. Studii recente se concentreaz\u0103 pe stabilirea nivelurilor de anticorpi care scad \u00een timp at\u00e2t post-vaccinare c\u00e2t \u0219i post-infec\u021bie cu virusul SARS-CoV-2, dar \u0219i asupra relevan\u021bei vaccin\u0103rii de rapel. Scopul studiului nostru a fost de a stabili memoria imunit\u0103\u021bii umorale \u00een cadrul protocoalelor de vaccinare \u00een COVID-19. Metode. 70 de subiec\u021bi, cadre medicale \u00een contact cu pacien\u021bi \u0219i probe infecta\u021be cu SARS-Cov-2, au fost urm\u0103ri\u021bi \u00een perioada mai 2020 – octombrie 2021. A fost utilizat testul ELISA pentru detectarea IgG \u0219i IgA anti-SARS-CoV-2 (EUROIMMUN). Rezultate. Dup\u0103 8 luni de la prima vaccinare (ianuarie 2021), grupul a prezentat valori statistic sc\u0103zute privind nivelurile ambilor anticorpi testa\u021bi, indiferent dac\u0103 subiec\u021bii au fost infecta\u021bi sau nu in perioada investigat\u0103. Mai exact, concentra\u021bia medie a IgG a sc\u0103zut \u00een 8 luni de 2,4 ori, \u00een timp ce IgA a sc\u0103zut de 2,7 ori. Dup\u0103 vaccinarea de rapel (octombrie 2021), nivelul IgG cre\u0219te imediat dup\u0103 rapel de 2,7 ori, \u00een timp ce IgA a crescut dup\u0103 rapel de 2,5 ori. Rezultatele ob\u021binute post-rapel arat\u0103 r\u0103spunsul IgG statistic mai mare comparativ cu cel ob\u021binut dup\u0103 prima vaccinare. Spre deosebire de IgG, r\u0103spunsul IgA este aproape identic cu cel ob\u021binut la prima vaccinare. \u00cen studii de caz investigate unde s-a constatat c\u0103 dup\u0103 8 luni de la prima vaccinare nu au fost detecta\u021bi anticorpi circulan\u021bi detectabili, rapelul a indus rapid, dup\u0103 prima s\u0103pt\u0103m\u00e2n\u0103, o valoare ridicat\u0103 at\u00e2t pentru IgG, c\u00e2t \u0219i pentru IgA, iar nivelurile au continuat s\u0103 creasc\u0103 dup\u0103 dou\u0103 \u0219i trei s\u0103pt\u0103m\u00e2ni de la rapel. Concluzie. Vaccinarea de rapel induce niveluri mai ridicate de IgG \u00een \u00eentregul grup comparativ cu prima rund\u0103 de vaccinare, \u00een timp ce nivelurile IgA au fost similar cu cele ob\u021binute dup\u0103 prima vaccinare, date care sus\u021bin existen\u021ba unei memorii imunologice robuste.<\/p>\n
Dynamics of specific immunoglobulins IgG and IgA upon BNT162B2 booster vaccination\u00a0<\/span>
Authors: Monica Neagu 1,2, Carolina Constantin 1,2, Sabina Zurac 2,3<\/span><\/p>\n1. Department of Immunology, Victor Babes National Institute of Pathology, Bucharest, Romania;
2. Department of Pathology, Colentina Clinical Hospital; Bucharest, Romania;
3. Department of Pathology, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania<\/p>\n
Key words: vaccination, COVID-19, specific IgG, specific IgA<\/p>\n
Introduction. Extended studies focus on the antibody levels that are decreasing in time whether upon vaccination against or infection with SARS-CoV-2 virus, but still, we have to focus on the relevance of the booster vaccination. The aim of our study was to establish the humoral immunity memory in COVID-19 vaccination protocols. Methods. 70 subjects, healthcare workers in contact with SARS-Cov-2-infected patients and samples, were followed-up May, 2020 – October, 2021. ELISA for detection of anti-SARS-CoV-2 IgG and IgA (EUROIMMUN) was used. Results. After 8 months post first vaccination (January 2021), the group presented statistically decreased values for both antibodies, regardless of the infection status during these 8 months. More specifically, IgG\u2019s mean concentration decreased in 8 month 2.4 times, while IgA decreased 2.7 times. After booster vaccination (October 2021) IgG level increases immediately 2.7 times, while IgA increased 2.5 times. Our results show that the IgG response after booster is statistically higher compared to the first vaccination and, in contrast, the IgA response is almost identical with the level obtained after first vaccination. In study cases it was found that after 8 months post- first vaccination where no detectable circulating antibodies were detected, the booster induced after the first week a high value for both IgG and IgA, and the levels continued to raise after two and three weeks after booster. Conclusion. Booster vaccination induces higher levels of IgG in the entire group compared to the first round of vaccination, while the IgA levels were similar, data is proving a proper immunological memory. <\/p>\n
Scurt CV<\/span><\/p>\nProfessor Monica Neagu \u2013 Head of Immunology laboratory, Habilitation in Immunology, Doctoral School of the Faculty of Biology, University of Bucharest, Senior Researcher at Pathology Department, Colentina Clinical Hospital; President of the Romanian Society of Immunology, member of the World Academy of Sciences.<\/p>\n
She was Project Director for several international projects (Bilateral Cooperation Romania-China 511\/2011 Biomarker discovery in digestive tract cancer and skin melanoma using proteomic approaches (Beijing Institute of Genomics), Bilateral Cooperation Romania-Greece project no. 7285\/02 Immunomodulating potential of prothymosin alpha [….] (University of Athens), NATO SfP 982838\/2007 Development of a novel immunoassay for the very early detection of Biothreatening Bacterial Infections) and member of the research team in several international projects FP7, ERA-NET. Currently she is member of the management committee for Horizon2020 COST project CA16120 – European Epitranscriptomics Network (EPITRAN) and CA18125 – Advanced Engineering and Research of Aerogels for Environment and Life Sciences (AEROGELS). She has autoimmunity specialization at Sandoz Pharma Ltd., Basel. In 2010-2013 she was full member of Commission for Advanced Therapies \u2013 EMEA.<\/p>\n
In the last 5 years she has led or been involved in more than 10 national funded projects.
Fields of interest: immuno-oncology, melanoma biomarkers, proteomic array approaches, animal models for skin carcinogenesis, melanoma, wound healing, regeneration. She is co-inventor in several patents in dermato-oncology, biomarkers panel and tumor cell clones.
She is member in Editorial Boards for 4 international journals, Editor for an international book, invited Editor for 4 international journals, and has published over 200 scientific papers and book chapters. Hirsch Index =27 (ISI web of Science\/Clarivate).<\/p>\n
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C.\u0218.I. Dr. Neagu Monica Institutul Na\u0163ional \u201cVictor Babe\u015f\u201d, Bucure\u015fti Spitalul Clinic \u201dColentina\u201d, Bucure\u015ftiDinamica anticorpilor specifici IgG si IgA IN vaccinarea anti-SARS-COV2\u00a0Autori: Monica Neagu 1,2, Carolina Constantin 1,2 , Sabina Zurac 2,3 1. Departamentul de Imunologie, Institutul Na\u021bional de Patologie Victor Babe\u0219, Bucure\u0219ti, Rom\u00e2nia; 2. Sec\u021bia Patologie, Spitalul Clinic Colentina; Bucure\u0219ti, Rom\u00e2nia; 3. Departamentul de Patologie, […]<\/p>\n","protected":false},"author":2,"featured_media":11428,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7583","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=7583"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7583\/revisions"}],"predecessor-version":[{"id":11429,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7583\/revisions\/11429"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11428"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=7583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=7583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=7583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Monica Neagu 1,2, Carolina Constantin 1,2 , Sabina Zurac 2,3<\/span><\/p>\n
1. Departamentul de Imunologie, Institutul Na\u021bional de Patologie Victor Babe\u0219, Bucure\u0219ti, Rom\u00e2nia;
2. Sec\u021bia Patologie, Spitalul Clinic Colentina; Bucure\u0219ti, Rom\u00e2nia;
3. Departamentul de Patologie, Facultatea de Medicin\u0103 Dentar\u0103, Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila”, Bucure\u0219ti, Rom\u00e2nia<\/p>\n
Cuvinte cheie: vaccinare, COVID-19, IgG specific, IgA specific<\/p>\n
Introducere. Studii recente se concentreaz\u0103 pe stabilirea nivelurilor de anticorpi care scad \u00een timp at\u00e2t post-vaccinare c\u00e2t \u0219i post-infec\u021bie cu virusul SARS-CoV-2, dar \u0219i asupra relevan\u021bei vaccin\u0103rii de rapel. Scopul studiului nostru a fost de a stabili memoria imunit\u0103\u021bii umorale \u00een cadrul protocoalelor de vaccinare \u00een COVID-19. Metode. 70 de subiec\u021bi, cadre medicale \u00een contact cu pacien\u021bi \u0219i probe infecta\u021be cu SARS-Cov-2, au fost urm\u0103ri\u021bi \u00een perioada mai 2020 – octombrie 2021. A fost utilizat testul ELISA pentru detectarea IgG \u0219i IgA anti-SARS-CoV-2 (EUROIMMUN). Rezultate. Dup\u0103 8 luni de la prima vaccinare (ianuarie 2021), grupul a prezentat valori statistic sc\u0103zute privind nivelurile ambilor anticorpi testa\u021bi, indiferent dac\u0103 subiec\u021bii au fost infecta\u021bi sau nu in perioada investigat\u0103. Mai exact, concentra\u021bia medie a IgG a sc\u0103zut \u00een 8 luni de 2,4 ori, \u00een timp ce IgA a sc\u0103zut de 2,7 ori. Dup\u0103 vaccinarea de rapel (octombrie 2021), nivelul IgG cre\u0219te imediat dup\u0103 rapel de 2,7 ori, \u00een timp ce IgA a crescut dup\u0103 rapel de 2,5 ori. Rezultatele ob\u021binute post-rapel arat\u0103 r\u0103spunsul IgG statistic mai mare comparativ cu cel ob\u021binut dup\u0103 prima vaccinare. Spre deosebire de IgG, r\u0103spunsul IgA este aproape identic cu cel ob\u021binut la prima vaccinare. \u00cen studii de caz investigate unde s-a constatat c\u0103 dup\u0103 8 luni de la prima vaccinare nu au fost detecta\u021bi anticorpi circulan\u021bi detectabili, rapelul a indus rapid, dup\u0103 prima s\u0103pt\u0103m\u00e2n\u0103, o valoare ridicat\u0103 at\u00e2t pentru IgG, c\u00e2t \u0219i pentru IgA, iar nivelurile au continuat s\u0103 creasc\u0103 dup\u0103 dou\u0103 \u0219i trei s\u0103pt\u0103m\u00e2ni de la rapel. Concluzie. Vaccinarea de rapel induce niveluri mai ridicate de IgG \u00een \u00eentregul grup comparativ cu prima rund\u0103 de vaccinare, \u00een timp ce nivelurile IgA au fost similar cu cele ob\u021binute dup\u0103 prima vaccinare, date care sus\u021bin existen\u021ba unei memorii imunologice robuste.<\/p>\n
Dynamics of specific immunoglobulins IgG and IgA upon BNT162B2 booster vaccination\u00a0<\/span> 1. Department of Immunology, Victor Babes National Institute of Pathology, Bucharest, Romania; Key words: vaccination, COVID-19, specific IgG, specific IgA<\/p>\n Introduction. Extended studies focus on the antibody levels that are decreasing in time whether upon vaccination against or infection with SARS-CoV-2 virus, but still, we have to focus on the relevance of the booster vaccination. The aim of our study was to establish the humoral immunity memory in COVID-19 vaccination protocols. Methods. 70 subjects, healthcare workers in contact with SARS-Cov-2-infected patients and samples, were followed-up May, 2020 – October, 2021. ELISA for detection of anti-SARS-CoV-2 IgG and IgA (EUROIMMUN) was used. Results. After 8 months post first vaccination (January 2021), the group presented statistically decreased values for both antibodies, regardless of the infection status during these 8 months. More specifically, IgG\u2019s mean concentration decreased in 8 month 2.4 times, while IgA decreased 2.7 times. After booster vaccination (October 2021) IgG level increases immediately 2.7 times, while IgA increased 2.5 times. Our results show that the IgG response after booster is statistically higher compared to the first vaccination and, in contrast, the IgA response is almost identical with the level obtained after first vaccination. In study cases it was found that after 8 months post- first vaccination where no detectable circulating antibodies were detected, the booster induced after the first week a high value for both IgG and IgA, and the levels continued to raise after two and three weeks after booster. Conclusion. Booster vaccination induces higher levels of IgG in the entire group compared to the first round of vaccination, while the IgA levels were similar, data is proving a proper immunological memory. <\/p>\n Scurt CV<\/span><\/p>\n Professor Monica Neagu \u2013 Head of Immunology laboratory, Habilitation in Immunology, Doctoral School of the Faculty of Biology, University of Bucharest, Senior Researcher at Pathology Department, Colentina Clinical Hospital; President of the Romanian Society of Immunology, member of the World Academy of Sciences.<\/p>\n She was Project Director for several international projects (Bilateral Cooperation Romania-China 511\/2011 Biomarker discovery in digestive tract cancer and skin melanoma using proteomic approaches (Beijing Institute of Genomics), Bilateral Cooperation Romania-Greece project no. 7285\/02 Immunomodulating potential of prothymosin alpha [….] (University of Athens), NATO SfP 982838\/2007 Development of a novel immunoassay for the very early detection of Biothreatening Bacterial Infections) and member of the research team in several international projects FP7, ERA-NET. Currently she is member of the management committee for Horizon2020 COST project CA16120 – European Epitranscriptomics Network (EPITRAN) and CA18125 – Advanced Engineering and Research of Aerogels for Environment and Life Sciences (AEROGELS). She has autoimmunity specialization at Sandoz Pharma Ltd., Basel. In 2010-2013 she was full member of Commission for Advanced Therapies \u2013 EMEA.<\/p>\n In the last 5 years she has led or been involved in more than 10 national funded projects. 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A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.16″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off” global_colors_info=”{}”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" C.\u0218.I. Dr. Neagu Monica Institutul Na\u0163ional \u201cVictor Babe\u015f\u201d, Bucure\u015fti Spitalul Clinic \u201dColentina\u201d, Bucure\u015ftiDinamica anticorpilor specifici IgG si IgA IN vaccinarea anti-SARS-COV2\u00a0Autori: Monica Neagu 1,2, Carolina Constantin 1,2 , Sabina Zurac 2,3 1. Departamentul de Imunologie, Institutul Na\u021bional de Patologie Victor Babe\u0219, Bucure\u0219ti, Rom\u00e2nia; 2. Sec\u021bia Patologie, Spitalul Clinic Colentina; Bucure\u0219ti, Rom\u00e2nia; 3. Departamentul de Patologie, […]<\/p>\n","protected":false},"author":2,"featured_media":11428,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7583","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=7583"}],"version-history":[{"count":10,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7583\/revisions"}],"predecessor-version":[{"id":11429,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7583\/revisions\/11429"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11428"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=7583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=7583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=7583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Authors: Monica Neagu 1,2, Carolina Constantin 1,2, Sabina Zurac 2,3<\/span><\/p>\n
2. Department of Pathology, Colentina Clinical Hospital; Bucharest, Romania;
3. Department of Pathology, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania<\/p>\n
Fields of interest: immuno-oncology, melanoma biomarkers, proteomic array approaches, animal models for skin carcinogenesis, melanoma, wound healing, regeneration. She is co-inventor in several patents in dermato-oncology, biomarkers panel and tumor cell clones.
She is member in Editorial Boards for 4 international journals, Editor for an international book, invited Editor for 4 international journals, and has published over 200 scientific papers and book chapters. Hirsch Index =27 (ISI web of Science\/Clarivate).<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n