<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nDr. Ungureanu Gabriela<\/span><\/strong>
\n Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.0″ global_colors_info=”{}”]<\/p>\n
Urticaria cronic\u0103 spontan\u0103 – Prezentare de caz<\/span>
Autor: Gabriela Ungureanu <\/span><\/p>\nSef sectie dermatogie-alergologie – Spitalul judetean de urgenta Bacau<\/p>\n
Angioedemul ereditar este o boala genetica rara, cu transmitere autosomal dominanta, cauzata de un deficit de C1 inhibitor esteraza, prin mutatia genei SERPING1 ,caracterizata clinic prin episoade recurente de angioedem subcutanat sau submucos ce implica extremitatile, fata, caile aeriene respiratorii superioare si tractul gastro-intestinal.
Fiziopatologic deficitul de C1 inhibitor esteraza serologic sau functional duce la cresterea productiei de bradikinina ceea ce duce la cresterea permeabilitati vasculare cu aparitia angioedemului.
Cel mai grav este angioedemul laringeal cu potential fatal prin asfixie si care necesita terapie imediata.
Diagnosticul corect si promt este esential la pacientul cu angioedem ereditar care nu raspunde la medicatia antihistaminica si corticoterapia sistemica tipic utilizata in angioedemul mediat histaminergic. Intarzierea diagnosticului poate fi amenintatoare de viata la pacientul cu angioedem laringeal.
Accesul facil la medicul specialist si terapiile eficente din ultimi 10 ani au imbunatatit calitatea vietii pacientului cu angioedem ereditar si au redus rata mortalitati acestor pacienti.
Scopul terapiei in atacurile acute, ca si profilaxia pe termen lung, este de a reduce frecventa si severitatea atacurilor prin monitorizare, terapie si administre de catre pacienti la domiciliu a concentratelor de C1 inhibitori.<\/p>\n
Hereditary angioedema update and case report\u00a0<\/span>
Author: Gabriela Ungureanu <\/span><\/p>\nSenior Physician in Allergology and clinical Immunology
Head of the Department of Dermatology and Allergology, Emergency Hospital Bacau<\/p>\n
Hereditary angioedema is a rare genetic disorder \u2013 autosomal dominant caused by C1 esterase inhibitor \u2013 C1INH deficiency and it\u2019s characterized by recurrent episodes of severe swelling which involves the face, limbs, airways or gastro-intestinal tract.
Deficiencies in C1INH plasma level or function lead to increased production of bradykinin, which mediates vascular permeability, thus causing angioedema.
Laryngeal oedema is potentially life-threatening as a result of asphyxiation and requires immediate treatment.
Prompt and accurate diagnosis is essential as patients with hereditary angioedema do not respond to drugs typically prescribed for histaminergic mediated angeoedema. Delays in diagnosis can be fatal, particularly in the case of laryngeal oedema.
Hereditary angioedema therapy aims to avoid fatalities and to reduce the frequency and severity of angioedema attacks by means of on demand and short \u2013 and long \u2013 term prophilactic treatment. Acute treatment option includes C1INH concentrate (icatibant or ecallantide) administratied on site or self administratied at home when swelling appears.
Acces to specialist care and effective treatment in the past 10 years has improved the quality of life and has reduced the mortality rate in patients with hereditary angioedema.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u021ba:<\/strong>
2014 – Prezent – Manager clinica \u201dNew Medical\u201d Bac\u0103u \u2013 Clinica alergologie\u2013imunologie clinic\u0103
2004 – Prezent \u2013 Coordonator compartiment alergologie\u2013imunologie clinic\u0103, Sec\u021bia dermato\u2013venerice , Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u
2019 – Specialist dermato\u2013venerice
2009 – Medic primar alergologie imunologie clinic\u0103
2004 – Medic specialist alergologie imunologie clinic\u0103
1999 – 2004 – Rezident alergologie imunologie clinic\u0103 Spital Clinic \u201cNicolae Malaxa\u201d Bucure\u0219ti, U.M.F. \u201cCarol Davila\u201d
1996 – 1999 \u2013 Serviciu de Ambulan\u021b\u0103 Jude\u021bean Bac\u0103u
1990 – 1996 \u2013 U.M.F. \u201cGrigore T. Popa\u201c Ia\u0219i \u2013 Medic Generalist<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
Membru Societatea Rom\u00e2n\u0103 Dermatologie
Membru Societatea Rom\u00e2n\u0103 de Alergologie Imunologie Clinic\u0103
Membru Academia European\u0103 de Alergologie Imunologie Clinic\u0103
Membru Asocia\u021bia Dermatologilor din Moldova<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ custom_padding=”61px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2022<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.16″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n
Operatorul PDI 2022<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” global_colors_info=”{}”]<\/p>\n
![\"\"](\"https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
[\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,9252,9464,10156,10157,10556″ fullwidth=”on” disabled_on=”on|on|on” _builder_version=”4.16″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” disabled=”on” locked=”off” global_colors_info=”{}”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Dr. Ungureanu Gabriela Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103uUrticaria cronic\u0103 spontan\u0103 – Prezentare de cazAutor: Gabriela Ungureanu Sef sectie dermatogie-alergologie – Spitalul judetean de urgenta Bacau Angioedemul ereditar este o boala genetica rara, cu transmitere autosomal dominanta, cauzata de un deficit de C1 inhibitor esteraza, prin mutatia genei SERPING1 ,caracterizata clinic prin episoade recurente de angioedem […]<\/p>\n","protected":false},"author":2,"featured_media":11466,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7995","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=7995"}],"version-history":[{"count":14,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7995\/revisions"}],"predecessor-version":[{"id":11467,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7995\/revisions\/11467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11466"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=7995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=7995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=7995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Dr. Ungureanu Gabriela<\/span><\/strong>
\n Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.0″ global_colors_info=”{}”]<\/p>\n
Urticaria cronic\u0103 spontan\u0103 – Prezentare de caz<\/span>
Autor: Gabriela Ungureanu <\/span><\/p>\nSef sectie dermatogie-alergologie – Spitalul judetean de urgenta Bacau<\/p>\n
Angioedemul ereditar este o boala genetica rara, cu transmitere autosomal dominanta, cauzata de un deficit de C1 inhibitor esteraza, prin mutatia genei SERPING1 ,caracterizata clinic prin episoade recurente de angioedem subcutanat sau submucos ce implica extremitatile, fata, caile aeriene respiratorii superioare si tractul gastro-intestinal.
Fiziopatologic deficitul de C1 inhibitor esteraza serologic sau functional duce la cresterea productiei de bradikinina ceea ce duce la cresterea permeabilitati vasculare cu aparitia angioedemului.
Cel mai grav este angioedemul laringeal cu potential fatal prin asfixie si care necesita terapie imediata.
Diagnosticul corect si promt este esential la pacientul cu angioedem ereditar care nu raspunde la medicatia antihistaminica si corticoterapia sistemica tipic utilizata in angioedemul mediat histaminergic. Intarzierea diagnosticului poate fi amenintatoare de viata la pacientul cu angioedem laringeal.
Accesul facil la medicul specialist si terapiile eficente din ultimi 10 ani au imbunatatit calitatea vietii pacientului cu angioedem ereditar si au redus rata mortalitati acestor pacienti.
Scopul terapiei in atacurile acute, ca si profilaxia pe termen lung, este de a reduce frecventa si severitatea atacurilor prin monitorizare, terapie si administre de catre pacienti la domiciliu a concentratelor de C1 inhibitori.<\/p>\n
Hereditary angioedema update and case report\u00a0<\/span>
Author: Gabriela Ungureanu <\/span><\/p>\nSenior Physician in Allergology and clinical Immunology
Head of the Department of Dermatology and Allergology, Emergency Hospital Bacau<\/p>\n
Hereditary angioedema is a rare genetic disorder \u2013 autosomal dominant caused by C1 esterase inhibitor \u2013 C1INH deficiency and it\u2019s characterized by recurrent episodes of severe swelling which involves the face, limbs, airways or gastro-intestinal tract.
Deficiencies in C1INH plasma level or function lead to increased production of bradykinin, which mediates vascular permeability, thus causing angioedema.
Laryngeal oedema is potentially life-threatening as a result of asphyxiation and requires immediate treatment.
Prompt and accurate diagnosis is essential as patients with hereditary angioedema do not respond to drugs typically prescribed for histaminergic mediated angeoedema. Delays in diagnosis can be fatal, particularly in the case of laryngeal oedema.
Hereditary angioedema therapy aims to avoid fatalities and to reduce the frequency and severity of angioedema attacks by means of on demand and short \u2013 and long \u2013 term prophilactic treatment. Acute treatment option includes C1INH concentrate (icatibant or ecallantide) administratied on site or self administratied at home when swelling appears.
Acces to specialist care and effective treatment in the past 10 years has improved the quality of life and has reduced the mortality rate in patients with hereditary angioedema.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u021ba:<\/strong>
2014 – Prezent – Manager clinica \u201dNew Medical\u201d Bac\u0103u \u2013 Clinica alergologie\u2013imunologie clinic\u0103
2004 – Prezent \u2013 Coordonator compartiment alergologie\u2013imunologie clinic\u0103, Sec\u021bia dermato\u2013venerice , Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u
2019 – Specialist dermato\u2013venerice
2009 – Medic primar alergologie imunologie clinic\u0103
2004 – Medic specialist alergologie imunologie clinic\u0103
1999 – 2004 – Rezident alergologie imunologie clinic\u0103 Spital Clinic \u201cNicolae Malaxa\u201d Bucure\u0219ti, U.M.F. \u201cCarol Davila\u201d
1996 – 1999 \u2013 Serviciu de Ambulan\u021b\u0103 Jude\u021bean Bac\u0103u
1990 – 1996 \u2013 U.M.F. \u201cGrigore T. Popa\u201c Ia\u0219i \u2013 Medic Generalist<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
Membru Societatea Rom\u00e2n\u0103 Dermatologie
Membru Societatea Rom\u00e2n\u0103 de Alergologie Imunologie Clinic\u0103
Membru Academia European\u0103 de Alergologie Imunologie Clinic\u0103
Membru Asocia\u021bia Dermatologilor din Moldova<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ custom_padding=”61px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2022<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.16″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n
Operatorul PDI 2022<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” global_colors_info=”{}”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
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Dr. Ungureanu Gabriela Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103uUrticaria cronic\u0103 spontan\u0103 – Prezentare de cazAutor: Gabriela Ungureanu Sef sectie dermatogie-alergologie – Spitalul judetean de urgenta Bacau Angioedemul ereditar este o boala genetica rara, cu transmitere autosomal dominanta, cauzata de un deficit de C1 inhibitor esteraza, prin mutatia genei SERPING1 ,caracterizata clinic prin episoade recurente de angioedem […]<\/p>\n","protected":false},"author":2,"featured_media":11466,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7995","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=7995"}],"version-history":[{"count":14,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7995\/revisions"}],"predecessor-version":[{"id":11467,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/7995\/revisions\/11467"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11466"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=7995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=7995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=7995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Gabriela Ungureanu <\/span><\/p>\n
Sef sectie dermatogie-alergologie – Spitalul judetean de urgenta Bacau<\/p>\n
Angioedemul ereditar este o boala genetica rara, cu transmitere autosomal dominanta, cauzata de un deficit de C1 inhibitor esteraza, prin mutatia genei SERPING1 ,caracterizata clinic prin episoade recurente de angioedem subcutanat sau submucos ce implica extremitatile, fata, caile aeriene respiratorii superioare si tractul gastro-intestinal.
Fiziopatologic deficitul de C1 inhibitor esteraza serologic sau functional duce la cresterea productiei de bradikinina ceea ce duce la cresterea permeabilitati vasculare cu aparitia angioedemului.
Cel mai grav este angioedemul laringeal cu potential fatal prin asfixie si care necesita terapie imediata.
Diagnosticul corect si promt este esential la pacientul cu angioedem ereditar care nu raspunde la medicatia antihistaminica si corticoterapia sistemica tipic utilizata in angioedemul mediat histaminergic. Intarzierea diagnosticului poate fi amenintatoare de viata la pacientul cu angioedem laringeal.
Accesul facil la medicul specialist si terapiile eficente din ultimi 10 ani au imbunatatit calitatea vietii pacientului cu angioedem ereditar si au redus rata mortalitati acestor pacienti.
Scopul terapiei in atacurile acute, ca si profilaxia pe termen lung, este de a reduce frecventa si severitatea atacurilor prin monitorizare, terapie si administre de catre pacienti la domiciliu a concentratelor de C1 inhibitori.<\/p>\n
Hereditary angioedema update and case report\u00a0<\/span> Senior Physician in Allergology and clinical Immunology Hereditary angioedema is a rare genetic disorder \u2013 autosomal dominant caused by C1 esterase inhibitor \u2013 C1INH deficiency and it\u2019s characterized by recurrent episodes of severe swelling which involves the face, limbs, airways or gastro-intestinal tract. 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Author: Gabriela Ungureanu <\/span><\/p>\n
Head of the Department of Dermatology and Allergology, Emergency Hospital Bacau<\/p>\n
Deficiencies in C1INH plasma level or function lead to increased production of bradykinin, which mediates vascular permeability, thus causing angioedema.
Laryngeal oedema is potentially life-threatening as a result of asphyxiation and requires immediate treatment.
Prompt and accurate diagnosis is essential as patients with hereditary angioedema do not respond to drugs typically prescribed for histaminergic mediated angeoedema. Delays in diagnosis can be fatal, particularly in the case of laryngeal oedema.
Hereditary angioedema therapy aims to avoid fatalities and to reduce the frequency and severity of angioedema attacks by means of on demand and short \u2013 and long \u2013 term prophilactic treatment. Acute treatment option includes C1INH concentrate (icatibant or ecallantide) administratied on site or self administratied at home when swelling appears.
Acces to specialist care and effective treatment in the past 10 years has improved the quality of life and has reduced the mortality rate in patients with hereditary angioedema.<\/p>\n
2014 – Prezent – Manager clinica \u201dNew Medical\u201d Bac\u0103u \u2013 Clinica alergologie\u2013imunologie clinic\u0103
2004 – Prezent \u2013 Coordonator compartiment alergologie\u2013imunologie clinic\u0103, Sec\u021bia dermato\u2013venerice , Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u
2019 – Specialist dermato\u2013venerice
2009 – Medic primar alergologie imunologie clinic\u0103
2004 – Medic specialist alergologie imunologie clinic\u0103
1999 – 2004 – Rezident alergologie imunologie clinic\u0103 Spital Clinic \u201cNicolae Malaxa\u201d Bucure\u0219ti, U.M.F. \u201cCarol Davila\u201d
1996 – 1999 \u2013 Serviciu de Ambulan\u021b\u0103 Jude\u021bean Bac\u0103u
1990 – 1996 \u2013 U.M.F. \u201cGrigore T. Popa\u201c Ia\u0219i \u2013 Medic Generalist<\/p>\n
Membru Societatea Rom\u00e2n\u0103 Dermatologie
Membru Societatea Rom\u00e2n\u0103 de Alergologie Imunologie Clinic\u0103
Membru Academia European\u0103 de Alergologie Imunologie Clinic\u0103
Membru Asocia\u021bia Dermatologilor din Moldova<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n