<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nConf. Univ. Dr. Gabriela Stoleriu<\/span><\/strong>
\nFacultatea de Medicin\u0103 \u015fi Farmacie, Universitatea \u201dDun\u0103rea de Jos\u201d, Gala\u0163i<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.1″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Rolul canabinoizilor \u00een dermatologie<\/span>
Autori: Gabriela Stoleriu1, Smaranda \u0162\u0103rean2, Florina Filip-Ciubotaru3, Nicu\u021ba Manolache4, Daciana Elena Br\u0103ni\u0219teanu5, M\u0103d\u0103lina Nicoleta Matei6<\/span><\/p>\n1 Disciplina Medicin\u0103 de Familie Adul\u021bi, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
2 Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
3 Departamentul \u015etiin\u0163e Farmaceutice, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
4 Disciplina Boli infec\u0163ioase, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
5 Disciplina Dermatologie, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
6 Departamentul de Medicin\u0103 Dentar\u0103, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia<\/p>\n
Cuvinte cheie: fitocanabinoizi, endocanabinoizi, dermatit\u0103, prurit, cancer cutanat, sclerodermie<\/p>\n
P\u00e2n\u0103 \u00een prezent, canabinoizii (fitocanabinoizi, endocanabinoizi \u0219i canabinoizi sintetici chimic) \u0219i-au demonstrat eficacitatea \u00een tratamentul cancerului, obezit\u0103\u021bii, bolilor neurologice \u0219i afec\u021biuni dermatologice. Sistemul endocanabinoid (SEC) cutanat este o re\u021bea complex\u0103 \u0219i aproape omniprezent\u0103 de liganzi, enzime \u0219i receptori endogeni (CB1R\/CB2R, THC, HU210, TVRP, PPAR \u0219i GPR55) care pot fi stimula\u021bi \u0219i de compu\u0219i canabinoizi endogeni \u0219i exogeni, cum ar fi cei deriva\u021bi din Cannabis sativa, contribuind la homeostazia, modularea imunit\u0103\u021bii, inflama\u021bia \u0219i patologia pielii prin eliberarea mediatorilor inflamatori \u0219i prin reglarea multor aspecte ale prolifer\u0103rii \u0219i diferen\u021bierii celulare. SEC a fost studiat pentru capacitatea sa de a regla unele neoplazii cutanate, pruritul, boli inflamatorii precum: acneea vulgar\u0103, psoriazisul, dermatita de contact alergic\u0103, dermatita atopic\u0103 \u0219i sclerodermia sistemic\u0103. Explorarea \u00een continuare a SEC ar putea dezv\u0103lui noi \u021binte terapeutice pentru o varietate de boli inflamatorii \u0219i neoplazice ale pielii. Majoritatea datelor din literatura medical\u0103 eviden\u021biaz\u0103 propriet\u0103\u021bile antiinflamatoare, imunosupresoare, anti-neoplazice ale SEC, dar unele rapoarte sugereaz\u0103 activitate pro-inflamatorie \u0219i pro-neoplazic\u0103. Sunt necesare investiga\u021bii suplimentare pentru a \u00een\u021belege complexitatea \u0219i influen\u021be specifice ale fiec\u0103rui tip de canabinoid cutanat, receptorului, metodei de administrare \u0219i concentra\u021biei utile, pentru a oferi oportunitatea de a extinde poten\u021bialul terapeutic \u00een dermatologia clinic\u0103.<\/p>\n
Simpozion Genesis Pharma<\/span><\/p>\n\u201cAPREMILAST \u2013 PDE 4 , MOLECULA INOVATOARE UNICA, DISPONIBILA PE CALE ORALA IN PSORIASIS\u201d<\/span><\/p>\nAPREMILAST – O noua abordare in psoriazis \u201d<\/span><\/p>\nGabriela Stoleriu<\/span><\/p>\nConf. Dr. Universitatea \u201dDun\u0103rea de Jos\u201d din Gala\u021bi, Facultatea de Medicin\u0103 \u0219i Farmacie, Departamentul \u0218tiin\u021be Farmaceutice<\/span><\/p>\nPsoriazisul este o afec\u021biune cronic\u0103, inflamatorie, care se manifest\u0103 pe piele, dar care are de multe ori cauze \u0219i manifest\u0103ri sistemice. Psoriazisul este caracterizat de apari\u021bia pe piele a unor pete ro\u0219iatice, proeminente, bine definite, acoperite de scuame (coji) alb sidefii.
Exist\u0103 numeroase tipuri de psoriazis \u0219i acestea se disting adesea, dup\u0103 localizarea sau aspectul leziunilor. Persoanele cu aceast\u0103 afec\u021biune prezint\u0103 sau pot dezvolta comorbidit\u0103\u021bi (afec\u021biuni cardiovasculare, afec\u021biuni oculare, afec\u021biuni articulare, diabet, obezitate, boala Crohn) care o transform\u0103 \u00eentr-o boal\u0103 cu r\u0103sunet sistemic.
Apremilast este un inhibitor inovator de fosfodiesteraz\u0103 4 (PDE4), disponibil pe cale oral\u0103, cu o molecul\u0103 mica, care moduleaz\u0103 o re\u021bea de proinflamatori (de exemplu TNF-\u03b1, IL-23, IL-17) \u0219i antiinflamatori (de exemplu IL-10) implica\u021bi \u00een psoriazis, artrit\u0103 psoriazic\u0103, boal\u0103 Beh\u00e7et- stabilind un nou echilibru \u00eentre ele.
Mai mult, inhib\u0103 selectiv PDE4, f\u0103r\u0103 efecte semnificative asupra altor PDE, kinaze, enzime sau receptori.
Prin modul s\u0103u unic de ac\u021biune \u0219i, av\u00e2nd \u00een vedere c\u0103 citokinele diferite sunt asociate cu simptome specifice ale bolii, Apremilast exercit\u0103 un efect larg, pozitiv asupra multiplelor manifest\u0103ri care constituie boala psoriazic\u0103.<\/span><\/p>\n“PREMILAST \u2013 PDE 4 , The Unique Innovative Molecule, Available Orally In Psoriasis”<\/span><\/p>\n“APREMILAST \u2013 A new approach in psoriasis”<\/span><\/p>\nStoleriu Gabriela<\/span><\/p>\nAssoc. Prof. Dr. “Dun\u0103rea de Jos” University of Gala\u021bi, Faculty of Medicine and Pharmacy, Department of Pharmaceutical Sciences<\/span><\/p>\n
Psoriasis is a chronic, inflammatory condition that manifests itself on the skin, but that often has systemic causes and manifestations. Psoriasis is characterized by the appearance on the skin of reddish, protruding, well-defined spots on the skin, covered by white pearly scabs (shells).
There are many types of psoriasis, and they are often distinguished, by the location or appearance of the lesions. People with this condition have or may develop comorbidities (cardiovascular diseases, eye diseases, joint diseases, diabetes, obesity, Crohn’s disease) that turn it into a disease with systemic resonance.
Apremilast is an innovative inhibitor of phosphodiesterase 4 (PDE4), available orally, with a small molecule, which modulates a network of pro-inflammatories (e.g. TNF-\u03b1, IL-23, IL-17) and anti-inflammatory (e.g. IL-10) involved in psoriasis, psoriatic arthritis, Beh\u00e7et’s disease- establishing a new balance between them.
Furthermore, it selectively inhibits PDE4, with no significant effects on other PDE, kinases, enzymes or receptors.
By its unique mode of action, and given that different cytokines are associated with specific symptoms of the disease, Apremilast exerts a wide, positive effect on the multiple manifestations that constitute the psoriatic disease.<\/span><\/p>\nSIMPOZION LA ROCHE-POSAY<\/span><\/p>\nRolul lipikar \u00een echilibrarea microbiomului \u2013 ecosistemul invizibil al pielii s\u0103n\u0103toase<\/span><\/p>\nStoleriu Gabriela<\/span><\/p>\nMedic Primar Dermato-Venerologie
Doctor \u00een \u0219tiin\u021be medicale
Conferen\u021biar universitar<\/p>\n
Restabilirea echilibrului microbiomului cutanat constituie o componenta important\u0103 \u00een tratamentul pielii uscate cu tendin\u021b\u0103 atopic\u0103. Dovezi \u0219tiin\u021bifice recente au ar\u0103tat c\u0103 limitarea form\u0103rii biopeliculei stafilococcice reprezint\u0103 un pas important \u00een restabilirea acestui echilibru.
Atunci c\u00e2nd vorbim despre pielea s\u0103n\u0103toas\u0103, prezen\u021ba keratinocitelor care secret\u0103 peptide antimicrobiene (AMP) (cum ar fi catelicidin LL-37, \u03b2-defensine \u0219i dermicidin) asigur\u0103 protejarea \u00eempotriva bacteriilor patogene (inclusiv S. aureus).
Pe de alt\u0103 parte, \u00een timpul fazei acute \u0219i cronice ale dermatitei atopice, citokinele inflamatorii supraexprimate pot stimula cre\u0219terea S. aureus determin\u00e2nd formarea de biofilm. O astfel de activitate de proliferare pare s\u0103 sus\u021bin\u0103 selectiv S. aureus \u00een detrimentul altor bacterii comensale de la nivel cutanat, suger\u00e2nd c\u0103 acesta ar putea induce un r\u0103spuns adaptativ la semnalele celulelor pielii.
\u00cen rolul s\u0103u de pionier \u00een studiul microbiomului uman, cercetarile LA ROCHE-POSAY au demonstrat deja c\u0103 gestionarea acestuia este o modalitate eficient\u0103 de a aborda diverse patologii\u00a0cutanate, precum dermatita atopic\u0103, acneea, pielea sensibil\u0103 sau psoriazis.
Managementul acestor afec\u021biuni devine astfel un punct important \u00een cre\u0219terea calit\u0103\u021bii vie\u021bii pacien\u021bilor, rutina LIPIKAR fiind parte integrant\u0103 din solu\u021bia terapeutic\u0103.<\/p>\n
Restoring the balance of the skin microbiome is an important component in the treatment of atopic dry skin. Recent scientific evidence has shown that limiting the formation of staphylococcal biofilm is an important step in restoring this balance.
In healthy skin, keratinocytes secrete antimicrobial peptides (AMP) (such as cathelicidine LL-37, \u03b2-defensins and dermicidine) to fight against pathogenic bacteria (including S. aureus).
Inflammatory cytokines overexpressed in AD can stimulate the growth of biofilm-producing S. aureus during both the acute and chronic phases of the disease. Such a growth-promoting activity appears to selectively support S. aureus at the expense of other bacterial skin commensals, suggesting that S. aureus might take advantage of an adaptive response to skin cell signals.
In its pioneering role in the study of the human microbiome, LA ROCHE-POSAY research have already shown that its management is an effective way to address various skin conditions, such as atopic dermatitis, acne, sensitive skin, or psoriasis.
The management of these diseases becomes an important point in increasing patient\u2019s quality of life, LIPIKAR routine being an integral part of the therapeutic solution.<\/p>\n
Scurt CV<\/span><\/p>\n\n- Medic primar dermatovenerologie<\/li>\n
- Doctor \u00een medicin\u0103<\/li>\n
- Atestat \u00een dermato-cosmetologie<\/li>\n
- Formator \u00een dermato-cosmetologie (Lector)<\/li>\n<\/ul>\n
Colabor\u0103ri:<\/em>
Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 \u201dSf. Spiridon\u201d, Ia\u0219i
Derma Clinique, Ia\u0219i<\/p>\nAfiliere profesional\u0103:<\/em><\/p>\n\n- Societatea Rom\u00e2n\u0103 de Dermatologie (SRD)<\/li>\n
- \u00a0Societatea de Medici \u0219i Naturali\u0219ti \u2013 Ia\u015fi (SMN)<\/li>\n
- Asocia\u0163ia Dermatologilor din Moldova (ADEM)<\/li>\n
- Societatea Rom\u00e2n\u0103 de Dermato-Oncologie (SRDO)<\/li>\n
- Asocia\u021bia Rom\u00e2n\u0103 de Imuno-Dermatologie (ARID)<\/li>\n
- European Academy of Dermato-Venerology (EADV)<\/li>\n
- International Dermoscopy Society (IDS)<\/li>\n
- World Academy of Medical Sciences (WAMS)<\/li>\n
- American Academy of Dermatology (AAD)<\/li>\n<\/ul>\n
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Contacteaz\u0103 operatorul PDI 2022<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.16″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n
Operatorul PDI 2022<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ. Dr. Gabriela Stoleriu Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea \u201dDun\u0103rea de Jos\u201d, Gala\u0163iRolul canabinoizilor \u00een dermatologieAutori: Gabriela Stoleriu1, Smaranda \u0162\u0103rean2, Florina Filip-Ciubotaru3, Nicu\u021ba Manolache4, Daciana Elena Br\u0103ni\u0219teanu5, M\u0103d\u0103lina Nicoleta Matei6 1 Disciplina Medicin\u0103 de Familie Adul\u021bi, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia2 Departamentul Clinic Medical, Facultatea […]<\/p>\n","protected":false},"author":2,"featured_media":11317,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8124","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=8124"}],"version-history":[{"count":14,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8124\/revisions"}],"predecessor-version":[{"id":11598,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8124\/revisions\/11598"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11317"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=8124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=8124"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=8124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Conf. Univ. Dr. Gabriela Stoleriu<\/span><\/strong>
\nFacultatea de Medicin\u0103 \u015fi Farmacie, Universitatea \u201dDun\u0103rea de Jos\u201d, Gala\u0163i<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.1″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Rolul canabinoizilor \u00een dermatologie<\/span>
Autori: Gabriela Stoleriu1, Smaranda \u0162\u0103rean2, Florina Filip-Ciubotaru3, Nicu\u021ba Manolache4, Daciana Elena Br\u0103ni\u0219teanu5, M\u0103d\u0103lina Nicoleta Matei6<\/span><\/p>\n1 Disciplina Medicin\u0103 de Familie Adul\u021bi, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
2 Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
3 Departamentul \u015etiin\u0163e Farmaceutice, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
4 Disciplina Boli infec\u0163ioase, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
5 Disciplina Dermatologie, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
6 Departamentul de Medicin\u0103 Dentar\u0103, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia<\/p>\n
Cuvinte cheie: fitocanabinoizi, endocanabinoizi, dermatit\u0103, prurit, cancer cutanat, sclerodermie<\/p>\n
P\u00e2n\u0103 \u00een prezent, canabinoizii (fitocanabinoizi, endocanabinoizi \u0219i canabinoizi sintetici chimic) \u0219i-au demonstrat eficacitatea \u00een tratamentul cancerului, obezit\u0103\u021bii, bolilor neurologice \u0219i afec\u021biuni dermatologice. Sistemul endocanabinoid (SEC) cutanat este o re\u021bea complex\u0103 \u0219i aproape omniprezent\u0103 de liganzi, enzime \u0219i receptori endogeni (CB1R\/CB2R, THC, HU210, TVRP, PPAR \u0219i GPR55) care pot fi stimula\u021bi \u0219i de compu\u0219i canabinoizi endogeni \u0219i exogeni, cum ar fi cei deriva\u021bi din Cannabis sativa, contribuind la homeostazia, modularea imunit\u0103\u021bii, inflama\u021bia \u0219i patologia pielii prin eliberarea mediatorilor inflamatori \u0219i prin reglarea multor aspecte ale prolifer\u0103rii \u0219i diferen\u021bierii celulare. SEC a fost studiat pentru capacitatea sa de a regla unele neoplazii cutanate, pruritul, boli inflamatorii precum: acneea vulgar\u0103, psoriazisul, dermatita de contact alergic\u0103, dermatita atopic\u0103 \u0219i sclerodermia sistemic\u0103. Explorarea \u00een continuare a SEC ar putea dezv\u0103lui noi \u021binte terapeutice pentru o varietate de boli inflamatorii \u0219i neoplazice ale pielii. Majoritatea datelor din literatura medical\u0103 eviden\u021biaz\u0103 propriet\u0103\u021bile antiinflamatoare, imunosupresoare, anti-neoplazice ale SEC, dar unele rapoarte sugereaz\u0103 activitate pro-inflamatorie \u0219i pro-neoplazic\u0103. Sunt necesare investiga\u021bii suplimentare pentru a \u00een\u021belege complexitatea \u0219i influen\u021be specifice ale fiec\u0103rui tip de canabinoid cutanat, receptorului, metodei de administrare \u0219i concentra\u021biei utile, pentru a oferi oportunitatea de a extinde poten\u021bialul terapeutic \u00een dermatologia clinic\u0103.<\/p>\n
Simpozion Genesis Pharma<\/span><\/p>\n\u201cAPREMILAST \u2013 PDE 4 , MOLECULA INOVATOARE UNICA, DISPONIBILA PE CALE ORALA IN PSORIASIS\u201d<\/span><\/p>\nAPREMILAST – O noua abordare in psoriazis \u201d<\/span><\/p>\nGabriela Stoleriu<\/span><\/p>\nConf. Dr. Universitatea \u201dDun\u0103rea de Jos\u201d din Gala\u021bi, Facultatea de Medicin\u0103 \u0219i Farmacie, Departamentul \u0218tiin\u021be Farmaceutice<\/span><\/p>\nPsoriazisul este o afec\u021biune cronic\u0103, inflamatorie, care se manifest\u0103 pe piele, dar care are de multe ori cauze \u0219i manifest\u0103ri sistemice. Psoriazisul este caracterizat de apari\u021bia pe piele a unor pete ro\u0219iatice, proeminente, bine definite, acoperite de scuame (coji) alb sidefii.
Exist\u0103 numeroase tipuri de psoriazis \u0219i acestea se disting adesea, dup\u0103 localizarea sau aspectul leziunilor. Persoanele cu aceast\u0103 afec\u021biune prezint\u0103 sau pot dezvolta comorbidit\u0103\u021bi (afec\u021biuni cardiovasculare, afec\u021biuni oculare, afec\u021biuni articulare, diabet, obezitate, boala Crohn) care o transform\u0103 \u00eentr-o boal\u0103 cu r\u0103sunet sistemic.
Apremilast este un inhibitor inovator de fosfodiesteraz\u0103 4 (PDE4), disponibil pe cale oral\u0103, cu o molecul\u0103 mica, care moduleaz\u0103 o re\u021bea de proinflamatori (de exemplu TNF-\u03b1, IL-23, IL-17) \u0219i antiinflamatori (de exemplu IL-10) implica\u021bi \u00een psoriazis, artrit\u0103 psoriazic\u0103, boal\u0103 Beh\u00e7et- stabilind un nou echilibru \u00eentre ele.
Mai mult, inhib\u0103 selectiv PDE4, f\u0103r\u0103 efecte semnificative asupra altor PDE, kinaze, enzime sau receptori.
Prin modul s\u0103u unic de ac\u021biune \u0219i, av\u00e2nd \u00een vedere c\u0103 citokinele diferite sunt asociate cu simptome specifice ale bolii, Apremilast exercit\u0103 un efect larg, pozitiv asupra multiplelor manifest\u0103ri care constituie boala psoriazic\u0103.<\/span><\/p>\n“PREMILAST \u2013 PDE 4 , The Unique Innovative Molecule, Available Orally In Psoriasis”<\/span><\/p>\n“APREMILAST \u2013 A new approach in psoriasis”<\/span><\/p>\nStoleriu Gabriela<\/span><\/p>\nAssoc. Prof. Dr. “Dun\u0103rea de Jos” University of Gala\u021bi, Faculty of Medicine and Pharmacy, Department of Pharmaceutical Sciences<\/span><\/p>\n
Psoriasis is a chronic, inflammatory condition that manifests itself on the skin, but that often has systemic causes and manifestations. Psoriasis is characterized by the appearance on the skin of reddish, protruding, well-defined spots on the skin, covered by white pearly scabs (shells).
There are many types of psoriasis, and they are often distinguished, by the location or appearance of the lesions. People with this condition have or may develop comorbidities (cardiovascular diseases, eye diseases, joint diseases, diabetes, obesity, Crohn’s disease) that turn it into a disease with systemic resonance.
Apremilast is an innovative inhibitor of phosphodiesterase 4 (PDE4), available orally, with a small molecule, which modulates a network of pro-inflammatories (e.g. TNF-\u03b1, IL-23, IL-17) and anti-inflammatory (e.g. IL-10) involved in psoriasis, psoriatic arthritis, Beh\u00e7et’s disease- establishing a new balance between them.
Furthermore, it selectively inhibits PDE4, with no significant effects on other PDE, kinases, enzymes or receptors.
By its unique mode of action, and given that different cytokines are associated with specific symptoms of the disease, Apremilast exerts a wide, positive effect on the multiple manifestations that constitute the psoriatic disease.<\/span><\/p>\nSIMPOZION LA ROCHE-POSAY<\/span><\/p>\nRolul lipikar \u00een echilibrarea microbiomului \u2013 ecosistemul invizibil al pielii s\u0103n\u0103toase<\/span><\/p>\nStoleriu Gabriela<\/span><\/p>\nMedic Primar Dermato-Venerologie
Doctor \u00een \u0219tiin\u021be medicale
Conferen\u021biar universitar<\/p>\n
Restabilirea echilibrului microbiomului cutanat constituie o componenta important\u0103 \u00een tratamentul pielii uscate cu tendin\u021b\u0103 atopic\u0103. Dovezi \u0219tiin\u021bifice recente au ar\u0103tat c\u0103 limitarea form\u0103rii biopeliculei stafilococcice reprezint\u0103 un pas important \u00een restabilirea acestui echilibru.
Atunci c\u00e2nd vorbim despre pielea s\u0103n\u0103toas\u0103, prezen\u021ba keratinocitelor care secret\u0103 peptide antimicrobiene (AMP) (cum ar fi catelicidin LL-37, \u03b2-defensine \u0219i dermicidin) asigur\u0103 protejarea \u00eempotriva bacteriilor patogene (inclusiv S. aureus).
Pe de alt\u0103 parte, \u00een timpul fazei acute \u0219i cronice ale dermatitei atopice, citokinele inflamatorii supraexprimate pot stimula cre\u0219terea S. aureus determin\u00e2nd formarea de biofilm. O astfel de activitate de proliferare pare s\u0103 sus\u021bin\u0103 selectiv S. aureus \u00een detrimentul altor bacterii comensale de la nivel cutanat, suger\u00e2nd c\u0103 acesta ar putea induce un r\u0103spuns adaptativ la semnalele celulelor pielii.
\u00cen rolul s\u0103u de pionier \u00een studiul microbiomului uman, cercetarile LA ROCHE-POSAY au demonstrat deja c\u0103 gestionarea acestuia este o modalitate eficient\u0103 de a aborda diverse patologii\u00a0cutanate, precum dermatita atopic\u0103, acneea, pielea sensibil\u0103 sau psoriazis.
Managementul acestor afec\u021biuni devine astfel un punct important \u00een cre\u0219terea calit\u0103\u021bii vie\u021bii pacien\u021bilor, rutina LIPIKAR fiind parte integrant\u0103 din solu\u021bia terapeutic\u0103.<\/p>\n
Restoring the balance of the skin microbiome is an important component in the treatment of atopic dry skin. Recent scientific evidence has shown that limiting the formation of staphylococcal biofilm is an important step in restoring this balance.
In healthy skin, keratinocytes secrete antimicrobial peptides (AMP) (such as cathelicidine LL-37, \u03b2-defensins and dermicidine) to fight against pathogenic bacteria (including S. aureus).
Inflammatory cytokines overexpressed in AD can stimulate the growth of biofilm-producing S. aureus during both the acute and chronic phases of the disease. Such a growth-promoting activity appears to selectively support S. aureus at the expense of other bacterial skin commensals, suggesting that S. aureus might take advantage of an adaptive response to skin cell signals.
In its pioneering role in the study of the human microbiome, LA ROCHE-POSAY research have already shown that its management is an effective way to address various skin conditions, such as atopic dermatitis, acne, sensitive skin, or psoriasis.
The management of these diseases becomes an important point in increasing patient\u2019s quality of life, LIPIKAR routine being an integral part of the therapeutic solution.<\/p>\n
Scurt CV<\/span><\/p>\n\n- Medic primar dermatovenerologie<\/li>\n
- Doctor \u00een medicin\u0103<\/li>\n
- Atestat \u00een dermato-cosmetologie<\/li>\n
- Formator \u00een dermato-cosmetologie (Lector)<\/li>\n<\/ul>\n
Colabor\u0103ri:<\/em>
Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 \u201dSf. Spiridon\u201d, Ia\u0219i
Derma Clinique, Ia\u0219i<\/p>\nAfiliere profesional\u0103:<\/em><\/p>\n\n- Societatea Rom\u00e2n\u0103 de Dermatologie (SRD)<\/li>\n
- \u00a0Societatea de Medici \u0219i Naturali\u0219ti \u2013 Ia\u015fi (SMN)<\/li>\n
- Asocia\u0163ia Dermatologilor din Moldova (ADEM)<\/li>\n
- Societatea Rom\u00e2n\u0103 de Dermato-Oncologie (SRDO)<\/li>\n
- Asocia\u021bia Rom\u00e2n\u0103 de Imuno-Dermatologie (ARID)<\/li>\n
- European Academy of Dermato-Venerology (EADV)<\/li>\n
- International Dermoscopy Society (IDS)<\/li>\n
- World Academy of Medical Sciences (WAMS)<\/li>\n
- American Academy of Dermatology (AAD)<\/li>\n<\/ul>\n
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Contacteaz\u0103 operatorul PDI 2022<\/p>\n
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Operatorul PDI 2022<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ. Dr. Gabriela Stoleriu Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea \u201dDun\u0103rea de Jos\u201d, Gala\u0163iRolul canabinoizilor \u00een dermatologieAutori: Gabriela Stoleriu1, Smaranda \u0162\u0103rean2, Florina Filip-Ciubotaru3, Nicu\u021ba Manolache4, Daciana Elena Br\u0103ni\u0219teanu5, M\u0103d\u0103lina Nicoleta Matei6 1 Disciplina Medicin\u0103 de Familie Adul\u021bi, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia2 Departamentul Clinic Medical, Facultatea […]<\/p>\n","protected":false},"author":2,"featured_media":11317,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8124","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=8124"}],"version-history":[{"count":14,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8124\/revisions"}],"predecessor-version":[{"id":11598,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8124\/revisions\/11598"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11317"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=8124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=8124"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=8124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Gabriela Stoleriu1, Smaranda \u0162\u0103rean2, Florina Filip-Ciubotaru3, Nicu\u021ba Manolache4, Daciana Elena Br\u0103ni\u0219teanu5, M\u0103d\u0103lina Nicoleta Matei6<\/span><\/p>\n
1 Disciplina Medicin\u0103 de Familie Adul\u021bi, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
2 Departamentul Clinic Medical, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
3 Departamentul \u015etiin\u0163e Farmaceutice, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia
4 Disciplina Boli infec\u0163ioase, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
5 Disciplina Dermatologie, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia
6 Departamentul de Medicin\u0103 Dentar\u0103, Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea Dun\u0103rea de Jos din Gala\u0163i, Rom\u00e2nia<\/p>\n
Cuvinte cheie: fitocanabinoizi, endocanabinoizi, dermatit\u0103, prurit, cancer cutanat, sclerodermie<\/p>\n
P\u00e2n\u0103 \u00een prezent, canabinoizii (fitocanabinoizi, endocanabinoizi \u0219i canabinoizi sintetici chimic) \u0219i-au demonstrat eficacitatea \u00een tratamentul cancerului, obezit\u0103\u021bii, bolilor neurologice \u0219i afec\u021biuni dermatologice. Sistemul endocanabinoid (SEC) cutanat este o re\u021bea complex\u0103 \u0219i aproape omniprezent\u0103 de liganzi, enzime \u0219i receptori endogeni (CB1R\/CB2R, THC, HU210, TVRP, PPAR \u0219i GPR55) care pot fi stimula\u021bi \u0219i de compu\u0219i canabinoizi endogeni \u0219i exogeni, cum ar fi cei deriva\u021bi din Cannabis sativa, contribuind la homeostazia, modularea imunit\u0103\u021bii, inflama\u021bia \u0219i patologia pielii prin eliberarea mediatorilor inflamatori \u0219i prin reglarea multor aspecte ale prolifer\u0103rii \u0219i diferen\u021bierii celulare. SEC a fost studiat pentru capacitatea sa de a regla unele neoplazii cutanate, pruritul, boli inflamatorii precum: acneea vulgar\u0103, psoriazisul, dermatita de contact alergic\u0103, dermatita atopic\u0103 \u0219i sclerodermia sistemic\u0103. Explorarea \u00een continuare a SEC ar putea dezv\u0103lui noi \u021binte terapeutice pentru o varietate de boli inflamatorii \u0219i neoplazice ale pielii. Majoritatea datelor din literatura medical\u0103 eviden\u021biaz\u0103 propriet\u0103\u021bile antiinflamatoare, imunosupresoare, anti-neoplazice ale SEC, dar unele rapoarte sugereaz\u0103 activitate pro-inflamatorie \u0219i pro-neoplazic\u0103. Sunt necesare investiga\u021bii suplimentare pentru a \u00een\u021belege complexitatea \u0219i influen\u021be specifice ale fiec\u0103rui tip de canabinoid cutanat, receptorului, metodei de administrare \u0219i concentra\u021biei utile, pentru a oferi oportunitatea de a extinde poten\u021bialul terapeutic \u00een dermatologia clinic\u0103.<\/p>\n
Simpozion Genesis Pharma<\/span><\/p>\n \u201cAPREMILAST \u2013 PDE 4 , MOLECULA INOVATOARE UNICA, DISPONIBILA PE CALE ORALA IN PSORIASIS\u201d<\/span><\/p>\n APREMILAST – O noua abordare in psoriazis \u201d<\/span><\/p>\n Gabriela Stoleriu<\/span><\/p>\n Conf. Dr. Universitatea \u201dDun\u0103rea de Jos\u201d din Gala\u021bi, Facultatea de Medicin\u0103 \u0219i Farmacie, Departamentul \u0218tiin\u021be Farmaceutice<\/span><\/p>\n Psoriazisul este o afec\u021biune cronic\u0103, inflamatorie, care se manifest\u0103 pe piele, dar care are de multe ori cauze \u0219i manifest\u0103ri sistemice. Psoriazisul este caracterizat de apari\u021bia pe piele a unor pete ro\u0219iatice, proeminente, bine definite, acoperite de scuame (coji) alb sidefii. “PREMILAST \u2013 PDE 4 , The Unique Innovative Molecule, Available Orally In Psoriasis”<\/span><\/p>\n “APREMILAST \u2013 A new approach in psoriasis”<\/span><\/p>\n Stoleriu Gabriela<\/span><\/p>\n Assoc. Prof. Dr. “Dun\u0103rea de Jos” University of Gala\u021bi, Faculty of Medicine and Pharmacy, Department of Pharmaceutical Sciences<\/span><\/p>\n SIMPOZION LA ROCHE-POSAY<\/span><\/p>\n Rolul lipikar \u00een echilibrarea microbiomului \u2013 ecosistemul invizibil al pielii s\u0103n\u0103toase<\/span><\/p>\n Stoleriu Gabriela<\/span><\/p>\n Medic Primar Dermato-Venerologie Restabilirea echilibrului microbiomului cutanat constituie o componenta important\u0103 \u00een tratamentul pielii uscate cu tendin\u021b\u0103 atopic\u0103. Dovezi \u0219tiin\u021bifice recente au ar\u0103tat c\u0103 limitarea form\u0103rii biopeliculei stafilococcice reprezint\u0103 un pas important \u00een restabilirea acestui echilibru. Restoring the balance of the skin microbiome is an important component in the treatment of atopic dry skin. Recent scientific evidence has shown that limiting the formation of staphylococcal biofilm is an important step in restoring this balance. Scurt CV<\/span><\/p>\n Colabor\u0103ri:<\/em> Afiliere profesional\u0103:<\/em><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ custom_padding=”61px|0px|69px|0px|false|false” 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A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”9252,9464,10556″ fullwidth=”on” disabled_on=”off|off|off” _builder_version=”4.17.1″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off” global_colors_info=”{}”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Conf. Univ. Dr. Gabriela Stoleriu Facultatea de Medicin\u0103 \u015fi Farmacie, Universitatea \u201dDun\u0103rea de Jos\u201d, Gala\u0163iRolul canabinoizilor \u00een dermatologieAutori: Gabriela Stoleriu1, Smaranda \u0162\u0103rean2, Florina Filip-Ciubotaru3, Nicu\u021ba Manolache4, Daciana Elena Br\u0103ni\u0219teanu5, M\u0103d\u0103lina Nicoleta Matei6 1 Disciplina Medicin\u0103 de Familie Adul\u021bi, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGrigore T. Popa\u201d, Ia\u0219i, Rom\u00e2nia2 Departamentul Clinic Medical, Facultatea […]<\/p>\n","protected":false},"author":2,"featured_media":11317,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8124","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=8124"}],"version-history":[{"count":14,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8124\/revisions"}],"predecessor-version":[{"id":11598,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8124\/revisions\/11598"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11317"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=8124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=8124"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=8124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Exist\u0103 numeroase tipuri de psoriazis \u0219i acestea se disting adesea, dup\u0103 localizarea sau aspectul leziunilor. Persoanele cu aceast\u0103 afec\u021biune prezint\u0103 sau pot dezvolta comorbidit\u0103\u021bi (afec\u021biuni cardiovasculare, afec\u021biuni oculare, afec\u021biuni articulare, diabet, obezitate, boala Crohn) care o transform\u0103 \u00eentr-o boal\u0103 cu r\u0103sunet sistemic.
Apremilast este un inhibitor inovator de fosfodiesteraz\u0103 4 (PDE4), disponibil pe cale oral\u0103, cu o molecul\u0103 mica, care moduleaz\u0103 o re\u021bea de proinflamatori (de exemplu TNF-\u03b1, IL-23, IL-17) \u0219i antiinflamatori (de exemplu IL-10) implica\u021bi \u00een psoriazis, artrit\u0103 psoriazic\u0103, boal\u0103 Beh\u00e7et- stabilind un nou echilibru \u00eentre ele.
Mai mult, inhib\u0103 selectiv PDE4, f\u0103r\u0103 efecte semnificative asupra altor PDE, kinaze, enzime sau receptori.
Prin modul s\u0103u unic de ac\u021biune \u0219i, av\u00e2nd \u00een vedere c\u0103 citokinele diferite sunt asociate cu simptome specifice ale bolii, Apremilast exercit\u0103 un efect larg, pozitiv asupra multiplelor manifest\u0103ri care constituie boala psoriazic\u0103.<\/span><\/p>\n
Psoriasis is a chronic, inflammatory condition that manifests itself on the skin, but that often has systemic causes and manifestations. Psoriasis is characterized by the appearance on the skin of reddish, protruding, well-defined spots on the skin, covered by white pearly scabs (shells).
There are many types of psoriasis, and they are often distinguished, by the location or appearance of the lesions. People with this condition have or may develop comorbidities (cardiovascular diseases, eye diseases, joint diseases, diabetes, obesity, Crohn’s disease) that turn it into a disease with systemic resonance.
Apremilast is an innovative inhibitor of phosphodiesterase 4 (PDE4), available orally, with a small molecule, which modulates a network of pro-inflammatories (e.g. TNF-\u03b1, IL-23, IL-17) and anti-inflammatory (e.g. IL-10) involved in psoriasis, psoriatic arthritis, Beh\u00e7et’s disease- establishing a new balance between them.
Furthermore, it selectively inhibits PDE4, with no significant effects on other PDE, kinases, enzymes or receptors.
By its unique mode of action, and given that different cytokines are associated with specific symptoms of the disease, Apremilast exerts a wide, positive effect on the multiple manifestations that constitute the psoriatic disease.<\/span><\/p>\n
Doctor \u00een \u0219tiin\u021be medicale
Conferen\u021biar universitar<\/p>\n
Atunci c\u00e2nd vorbim despre pielea s\u0103n\u0103toas\u0103, prezen\u021ba keratinocitelor care secret\u0103 peptide antimicrobiene (AMP) (cum ar fi catelicidin LL-37, \u03b2-defensine \u0219i dermicidin) asigur\u0103 protejarea \u00eempotriva bacteriilor patogene (inclusiv S. aureus).
Pe de alt\u0103 parte, \u00een timpul fazei acute \u0219i cronice ale dermatitei atopice, citokinele inflamatorii supraexprimate pot stimula cre\u0219terea S. aureus determin\u00e2nd formarea de biofilm. O astfel de activitate de proliferare pare s\u0103 sus\u021bin\u0103 selectiv S. aureus \u00een detrimentul altor bacterii comensale de la nivel cutanat, suger\u00e2nd c\u0103 acesta ar putea induce un r\u0103spuns adaptativ la semnalele celulelor pielii.
\u00cen rolul s\u0103u de pionier \u00een studiul microbiomului uman, cercetarile LA ROCHE-POSAY au demonstrat deja c\u0103 gestionarea acestuia este o modalitate eficient\u0103 de a aborda diverse patologii\u00a0cutanate, precum dermatita atopic\u0103, acneea, pielea sensibil\u0103 sau psoriazis.
Managementul acestor afec\u021biuni devine astfel un punct important \u00een cre\u0219terea calit\u0103\u021bii vie\u021bii pacien\u021bilor, rutina LIPIKAR fiind parte integrant\u0103 din solu\u021bia terapeutic\u0103.<\/p>\n
In healthy skin, keratinocytes secrete antimicrobial peptides (AMP) (such as cathelicidine LL-37, \u03b2-defensins and dermicidine) to fight against pathogenic bacteria (including S. aureus).
Inflammatory cytokines overexpressed in AD can stimulate the growth of biofilm-producing S. aureus during both the acute and chronic phases of the disease. Such a growth-promoting activity appears to selectively support S. aureus at the expense of other bacterial skin commensals, suggesting that S. aureus might take advantage of an adaptive response to skin cell signals.
In its pioneering role in the study of the human microbiome, LA ROCHE-POSAY research have already shown that its management is an effective way to address various skin conditions, such as atopic dermatitis, acne, sensitive skin, or psoriasis.
The management of these diseases becomes an important point in increasing patient\u2019s quality of life, LIPIKAR routine being an integral part of the therapeutic solution.<\/p>\n\n
Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 \u201dSf. Spiridon\u201d, Ia\u0219i
Derma Clinique, Ia\u0219i<\/p>\n\n
<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n