<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nC.\u0218. gr. I Dr. Benea Vasile<\/span><\/strong>
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.1″ global_colors_info=”{}”]<\/p>\n
Anafilaxia<\/span>
Autori: Vasile Benea1, Simona-Roxana Georgescu1,2<\/span>
1. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti.
2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti<\/p>\nCuvinte cheie: anafilaxie, reac\u021bii alergice, autoinjector cu adrenalin\u0103.<\/p>\n
Anafilaxia, cea mai sever\u0103 form\u0103 de prezentare a reac\u021biilor alergice acute, poate fi definit\u0103 drept o reac\u021bie sistemic\u0103 acut\u0103, ce afectez\u0103 mai multe organe, cu evolu\u021bie rapid\u0103, poten\u021bial letal\u0103, determinat\u0103 de eliberarea mediatorilor chimici din mastocitele \u0219i bazofilele activate ca urmare a expunerii la un alergen cunoscut sau probabil \u0219i care necesit\u0103 interven\u021bia medical\u0103 de urgen\u021b\u0103. Inciden\u021ba anafilaxiei, care variaz\u0103 \u00eentre 8 \u0219i 50 de cazuri la 100.000 locuitori, este \u00een continu\u0103 cre\u0219tere, cel pu\u021bin \u00een statele industrializate. \u00cen ciuda progreselor ob\u021binute \u00een \u00een\u021belegerea mecanismelor fiziopatologice ale reac\u021biilor alergice, de multe ori manifest\u0103rile clinice ale anafilaxiei nu sunt recunoscute, diagnosticul este adeseori omis, m\u0103surile terapeutice, inclusiv administrarea adrenalinei, sunt \u00eent\u00e2rziate, iar pacien\u021bii sunt subinvestiga\u021bi.
Din punct de vedere fiziopatologic reac\u021biile implicate \u00een anafilaxie pot fi alergice (mediate prin mecanisme imunologice \u2013 IgE, IgG sau complexe imune) sau non-alergice (prin intermediul complementului sau bradikininei care activeaz\u0103 nespecific mastocitele \u0219i bazofilele). Cei mai frecven\u021bi factori trigger ai anafilaxiei sunt alergenele alimentare, medicamente \u0219i veninul de Hymenoptera; prevalen\u021ba acestora variaz\u0103 \u00een func\u021bie de regiunea geografic\u0103 \u0219i de v\u00e2rsta pacien\u021bilor.
Diagnosticul anafilaxiei se bazeaz\u0103 \u00een principal pe criterii clinice. Manifest\u0103rile cutanate \u0219i\/sau mucoase (urticarie, angioedem) sunt prezente \u00een cele mai multe cazuri, fiind considerate \u00een mod tradi\u021bional drept o condi\u021bie sine qua non pentru stabilirea diagnosticului. Alte afect\u0103ri de organ ce sugereaz\u0103 diagnosticul de anafilaxie, mai ales dac\u0103 apar dup\u0103 expunerea la un posibil alergen, sunt manifest\u0103rile respiratorii (edem laringian, bronhospasm), cardiovasculare (hipotensiune) sau gastrointestinale (crampe abdominale, v\u0103rs\u0103turi). Triptaza, care reflect\u0103 degranularea mastocitelor \u0219i a bazofilelor, reprezint\u0103 standardul de aur al investiga\u021biilor de laborator, cre\u0219terea sa \u00een faza acut\u0103 fiind diagnostic\u0103.
Anafilaxia reprezint\u0103 o urgen\u021b\u0103 medical\u0103 major\u0103 care necesit\u0103 recunoa\u0219terea \u0219i ini\u021bierea rapid\u0103 a tratamentului, cu internarea \u00eentr-un serviciu de urgen\u021b\u0103. Managementul pacientului depinde de severitatea reac\u021biei ini\u021biale \u0219i de r\u0103spunsul la tratament. Sunt necesare administrarea c\u00e2t mai precoce a adrenalinei \u0219i m\u0103suri de sus\u021binere a func\u021biilor vitale. Adrenalina reprezint\u0103 singura medica\u021bie care poate salva via\u021ba pacien\u021bilor \u0219i care este eficient\u0103 pentru toate manifest\u0103rile anafilaxiei. Dup\u0103 remiterea episodului acut sunt necesare investiga\u021bii pentru eviden\u021bierea posibilului factor trigger \u0219i m\u0103suri de educare a pacien\u021bilor, inclusiv pentru utilizarea adrenalinei auto-injectabile.<\/p>\n
Anaphylaxis<\/span><\/p>\nVasile Benea1, Simona-Roxana Georgescu1,2<\/span>
1. Dermato-venereology Clinic, “Victor Babe\u0219” Clinical Hospital for Infectious and Tropical Diseases Bucharest.
2. University of Medicine and Pharmacy “Carol Davila” Bucharest<\/p>\nKey words: anaphylaxis, allergic reactions, adrenaline autoinjector.<\/p>\n
Anaphylaxis, the most severe clinical presentation of acute allergic reactions, can be defined as an acute multiorgan systemic reaction, with rapidly, potentially fatal evolution, caused by the release of chemical mediators from mast cells and basophils activated as a result of exposure to a known or probable allergen and requiring emergency medical intervention. The incidence of anaphylaxis, which ranges from 8 to 50 cases per 100,000 inhabitants, is constantly increasing, especially in industrialized states. Despite the advances in understanding the pathophysiological mechanisms of allergy, frequently the clinical manifestations of anaphylaxis are under-recognized, the diagnosis is often missed, therapeutic measures, including the epinephrine use, are delayed, and patients are under-investigated.<\/p>\n
From a pathophysiological point of view, the reactions involved in anaphylaxis can be allergic (mediated by immunological mechanisms \u2013 IgE, IgG or immune complexes) or non-allergic (eg, direct activation of mast cells and basophils by bradykinin or complement). Food, drug, and Hymenoptera venom are the most common elicitors of anaphylactic reactions; their prevalence varies depending on the geographical region and the patients\u2019 age.
Anaphylaxis is primarily a clinical diagnosis. Cutaneous and\/or mucosal involvement (urticaria, angioedema) is present in most cases, traditionally being considered as a sine qua non condition for diagnosis. Other organ involvements that suggest the diagnosis of anaphylaxis, especially if they occur after exposure to a possible allergen, are respiratory (laryngeal edema, bronchospasm), cardiovascular (hypotension) or gastrointestinal (abdominal cramps, vomiting) manifestations. Triptase, which reflects the degranulation of mast cells and basophils, is the gold standard laboratory test of IgE-mediated anaphylaxis, its increase in the acute phase being diagnostic.
Anaphylaxis is a major medical emergency that requires immediate recognition and rapid initiation of treatment, with admission to an emergency department. Patient management depends on the severity of the initial reaction and the response to treatment. It is necessary to administer adrenaline as early as possible and measures to support vital functions. Adrenaline is the only life-saving medication and is effective for all manifestations of anaphylaxis. After remission of the acute episode, investigations are needed to highlight the possible trigger factor and measures to educate patients, including the use of auto-injectable epinephrine.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103:<\/strong>
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, \u015eoseaua Mihai Bravu 281, sector 3, 030303 Bucure\u015fti
Educa\u0163ie \u015fi formare:<\/strong>
Perioada:
Calificarea \/ diploma ob\u0163inut\u0103:
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ custom_padding=”61px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2021<\/p>\n
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Operatorul PDI 2021<\/p>\n
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![\"\"](\"https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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C.\u0218. gr. I Dr. Benea VasileSpitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015ftiAnafilaxiaAutori: Vasile Benea1, Simona-Roxana Georgescu1,21. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti.2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti Cuvinte cheie: anafilaxie, reac\u021bii alergice, autoinjector cu adrenalin\u0103. Anafilaxia, cea mai sever\u0103 form\u0103 de prezentare […]<\/p>\n","protected":false},"author":2,"featured_media":11281,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8447","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=8447"}],"version-history":[{"count":16,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8447\/revisions"}],"predecessor-version":[{"id":11218,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8447\/revisions\/11218"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11281"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=8447"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=8447"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=8447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
C.\u0218. gr. I Dr. Benea Vasile<\/span><\/strong>
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.1″ global_colors_info=”{}”]<\/p>\n
Anafilaxia<\/span>
Autori: Vasile Benea1, Simona-Roxana Georgescu1,2<\/span>
1. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti.
2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti<\/p>\nCuvinte cheie: anafilaxie, reac\u021bii alergice, autoinjector cu adrenalin\u0103.<\/p>\n
Anafilaxia, cea mai sever\u0103 form\u0103 de prezentare a reac\u021biilor alergice acute, poate fi definit\u0103 drept o reac\u021bie sistemic\u0103 acut\u0103, ce afectez\u0103 mai multe organe, cu evolu\u021bie rapid\u0103, poten\u021bial letal\u0103, determinat\u0103 de eliberarea mediatorilor chimici din mastocitele \u0219i bazofilele activate ca urmare a expunerii la un alergen cunoscut sau probabil \u0219i care necesit\u0103 interven\u021bia medical\u0103 de urgen\u021b\u0103. Inciden\u021ba anafilaxiei, care variaz\u0103 \u00eentre 8 \u0219i 50 de cazuri la 100.000 locuitori, este \u00een continu\u0103 cre\u0219tere, cel pu\u021bin \u00een statele industrializate. \u00cen ciuda progreselor ob\u021binute \u00een \u00een\u021belegerea mecanismelor fiziopatologice ale reac\u021biilor alergice, de multe ori manifest\u0103rile clinice ale anafilaxiei nu sunt recunoscute, diagnosticul este adeseori omis, m\u0103surile terapeutice, inclusiv administrarea adrenalinei, sunt \u00eent\u00e2rziate, iar pacien\u021bii sunt subinvestiga\u021bi.
Din punct de vedere fiziopatologic reac\u021biile implicate \u00een anafilaxie pot fi alergice (mediate prin mecanisme imunologice \u2013 IgE, IgG sau complexe imune) sau non-alergice (prin intermediul complementului sau bradikininei care activeaz\u0103 nespecific mastocitele \u0219i bazofilele). Cei mai frecven\u021bi factori trigger ai anafilaxiei sunt alergenele alimentare, medicamente \u0219i veninul de Hymenoptera; prevalen\u021ba acestora variaz\u0103 \u00een func\u021bie de regiunea geografic\u0103 \u0219i de v\u00e2rsta pacien\u021bilor.
Diagnosticul anafilaxiei se bazeaz\u0103 \u00een principal pe criterii clinice. Manifest\u0103rile cutanate \u0219i\/sau mucoase (urticarie, angioedem) sunt prezente \u00een cele mai multe cazuri, fiind considerate \u00een mod tradi\u021bional drept o condi\u021bie sine qua non pentru stabilirea diagnosticului. Alte afect\u0103ri de organ ce sugereaz\u0103 diagnosticul de anafilaxie, mai ales dac\u0103 apar dup\u0103 expunerea la un posibil alergen, sunt manifest\u0103rile respiratorii (edem laringian, bronhospasm), cardiovasculare (hipotensiune) sau gastrointestinale (crampe abdominale, v\u0103rs\u0103turi). Triptaza, care reflect\u0103 degranularea mastocitelor \u0219i a bazofilelor, reprezint\u0103 standardul de aur al investiga\u021biilor de laborator, cre\u0219terea sa \u00een faza acut\u0103 fiind diagnostic\u0103.
Anafilaxia reprezint\u0103 o urgen\u021b\u0103 medical\u0103 major\u0103 care necesit\u0103 recunoa\u0219terea \u0219i ini\u021bierea rapid\u0103 a tratamentului, cu internarea \u00eentr-un serviciu de urgen\u021b\u0103. Managementul pacientului depinde de severitatea reac\u021biei ini\u021biale \u0219i de r\u0103spunsul la tratament. Sunt necesare administrarea c\u00e2t mai precoce a adrenalinei \u0219i m\u0103suri de sus\u021binere a func\u021biilor vitale. Adrenalina reprezint\u0103 singura medica\u021bie care poate salva via\u021ba pacien\u021bilor \u0219i care este eficient\u0103 pentru toate manifest\u0103rile anafilaxiei. Dup\u0103 remiterea episodului acut sunt necesare investiga\u021bii pentru eviden\u021bierea posibilului factor trigger \u0219i m\u0103suri de educare a pacien\u021bilor, inclusiv pentru utilizarea adrenalinei auto-injectabile.<\/p>\n
Anaphylaxis<\/span><\/p>\nVasile Benea1, Simona-Roxana Georgescu1,2<\/span>
1. Dermato-venereology Clinic, “Victor Babe\u0219” Clinical Hospital for Infectious and Tropical Diseases Bucharest.
2. University of Medicine and Pharmacy “Carol Davila” Bucharest<\/p>\nKey words: anaphylaxis, allergic reactions, adrenaline autoinjector.<\/p>\n
Anaphylaxis, the most severe clinical presentation of acute allergic reactions, can be defined as an acute multiorgan systemic reaction, with rapidly, potentially fatal evolution, caused by the release of chemical mediators from mast cells and basophils activated as a result of exposure to a known or probable allergen and requiring emergency medical intervention. The incidence of anaphylaxis, which ranges from 8 to 50 cases per 100,000 inhabitants, is constantly increasing, especially in industrialized states. Despite the advances in understanding the pathophysiological mechanisms of allergy, frequently the clinical manifestations of anaphylaxis are under-recognized, the diagnosis is often missed, therapeutic measures, including the epinephrine use, are delayed, and patients are under-investigated.<\/p>\n
From a pathophysiological point of view, the reactions involved in anaphylaxis can be allergic (mediated by immunological mechanisms \u2013 IgE, IgG or immune complexes) or non-allergic (eg, direct activation of mast cells and basophils by bradykinin or complement). Food, drug, and Hymenoptera venom are the most common elicitors of anaphylactic reactions; their prevalence varies depending on the geographical region and the patients\u2019 age.
Anaphylaxis is primarily a clinical diagnosis. Cutaneous and\/or mucosal involvement (urticaria, angioedema) is present in most cases, traditionally being considered as a sine qua non condition for diagnosis. Other organ involvements that suggest the diagnosis of anaphylaxis, especially if they occur after exposure to a possible allergen, are respiratory (laryngeal edema, bronchospasm), cardiovascular (hypotension) or gastrointestinal (abdominal cramps, vomiting) manifestations. Triptase, which reflects the degranulation of mast cells and basophils, is the gold standard laboratory test of IgE-mediated anaphylaxis, its increase in the acute phase being diagnostic.
Anaphylaxis is a major medical emergency that requires immediate recognition and rapid initiation of treatment, with admission to an emergency department. Patient management depends on the severity of the initial reaction and the response to treatment. It is necessary to administer adrenaline as early as possible and measures to support vital functions. Adrenaline is the only life-saving medication and is effective for all manifestations of anaphylaxis. After remission of the acute episode, investigations are needed to highlight the possible trigger factor and measures to educate patients, including the use of auto-injectable epinephrine.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103:<\/strong>
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, \u015eoseaua Mihai Bravu 281, sector 3, 030303 Bucure\u015fti
Educa\u0163ie \u015fi formare:<\/strong>
Perioada:
Calificarea \/ diploma ob\u0163inut\u0103:
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ custom_padding=”61px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2021<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.16″ _unique_id=”d6edf90b-6884-4eb2-9044-205ea5d1fec8″ title_font=”||||||||” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n
Operatorul PDI 2021<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” global_colors_info=”{}”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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C.\u0218. gr. I Dr. Benea VasileSpitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015ftiAnafilaxiaAutori: Vasile Benea1, Simona-Roxana Georgescu1,21. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti.2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti Cuvinte cheie: anafilaxie, reac\u021bii alergice, autoinjector cu adrenalin\u0103. Anafilaxia, cea mai sever\u0103 form\u0103 de prezentare […]<\/p>\n","protected":false},"author":2,"featured_media":11281,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8447","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=8447"}],"version-history":[{"count":16,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8447\/revisions"}],"predecessor-version":[{"id":11218,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8447\/revisions\/11218"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11281"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=8447"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=8447"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=8447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Vasile Benea1, Simona-Roxana Georgescu1,2<\/span>
1. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti.
2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti<\/p>\n
Cuvinte cheie: anafilaxie, reac\u021bii alergice, autoinjector cu adrenalin\u0103.<\/p>\n
Anafilaxia, cea mai sever\u0103 form\u0103 de prezentare a reac\u021biilor alergice acute, poate fi definit\u0103 drept o reac\u021bie sistemic\u0103 acut\u0103, ce afectez\u0103 mai multe organe, cu evolu\u021bie rapid\u0103, poten\u021bial letal\u0103, determinat\u0103 de eliberarea mediatorilor chimici din mastocitele \u0219i bazofilele activate ca urmare a expunerii la un alergen cunoscut sau probabil \u0219i care necesit\u0103 interven\u021bia medical\u0103 de urgen\u021b\u0103. Inciden\u021ba anafilaxiei, care variaz\u0103 \u00eentre 8 \u0219i 50 de cazuri la 100.000 locuitori, este \u00een continu\u0103 cre\u0219tere, cel pu\u021bin \u00een statele industrializate. \u00cen ciuda progreselor ob\u021binute \u00een \u00een\u021belegerea mecanismelor fiziopatologice ale reac\u021biilor alergice, de multe ori manifest\u0103rile clinice ale anafilaxiei nu sunt recunoscute, diagnosticul este adeseori omis, m\u0103surile terapeutice, inclusiv administrarea adrenalinei, sunt \u00eent\u00e2rziate, iar pacien\u021bii sunt subinvestiga\u021bi.
Din punct de vedere fiziopatologic reac\u021biile implicate \u00een anafilaxie pot fi alergice (mediate prin mecanisme imunologice \u2013 IgE, IgG sau complexe imune) sau non-alergice (prin intermediul complementului sau bradikininei care activeaz\u0103 nespecific mastocitele \u0219i bazofilele). Cei mai frecven\u021bi factori trigger ai anafilaxiei sunt alergenele alimentare, medicamente \u0219i veninul de Hymenoptera; prevalen\u021ba acestora variaz\u0103 \u00een func\u021bie de regiunea geografic\u0103 \u0219i de v\u00e2rsta pacien\u021bilor.
Diagnosticul anafilaxiei se bazeaz\u0103 \u00een principal pe criterii clinice. Manifest\u0103rile cutanate \u0219i\/sau mucoase (urticarie, angioedem) sunt prezente \u00een cele mai multe cazuri, fiind considerate \u00een mod tradi\u021bional drept o condi\u021bie sine qua non pentru stabilirea diagnosticului. Alte afect\u0103ri de organ ce sugereaz\u0103 diagnosticul de anafilaxie, mai ales dac\u0103 apar dup\u0103 expunerea la un posibil alergen, sunt manifest\u0103rile respiratorii (edem laringian, bronhospasm), cardiovasculare (hipotensiune) sau gastrointestinale (crampe abdominale, v\u0103rs\u0103turi). Triptaza, care reflect\u0103 degranularea mastocitelor \u0219i a bazofilelor, reprezint\u0103 standardul de aur al investiga\u021biilor de laborator, cre\u0219terea sa \u00een faza acut\u0103 fiind diagnostic\u0103.
Anafilaxia reprezint\u0103 o urgen\u021b\u0103 medical\u0103 major\u0103 care necesit\u0103 recunoa\u0219terea \u0219i ini\u021bierea rapid\u0103 a tratamentului, cu internarea \u00eentr-un serviciu de urgen\u021b\u0103. Managementul pacientului depinde de severitatea reac\u021biei ini\u021biale \u0219i de r\u0103spunsul la tratament. Sunt necesare administrarea c\u00e2t mai precoce a adrenalinei \u0219i m\u0103suri de sus\u021binere a func\u021biilor vitale. Adrenalina reprezint\u0103 singura medica\u021bie care poate salva via\u021ba pacien\u021bilor \u0219i care este eficient\u0103 pentru toate manifest\u0103rile anafilaxiei. Dup\u0103 remiterea episodului acut sunt necesare investiga\u021bii pentru eviden\u021bierea posibilului factor trigger \u0219i m\u0103suri de educare a pacien\u021bilor, inclusiv pentru utilizarea adrenalinei auto-injectabile.<\/p>\n
Anaphylaxis<\/span><\/p>\n Vasile Benea1, Simona-Roxana Georgescu1,2<\/span> Key words: anaphylaxis, allergic reactions, adrenaline autoinjector.<\/p>\n Anaphylaxis, the most severe clinical presentation of acute allergic reactions, can be defined as an acute multiorgan systemic reaction, with rapidly, potentially fatal evolution, caused by the release of chemical mediators from mast cells and basophils activated as a result of exposure to a known or probable allergen and requiring emergency medical intervention. The incidence of anaphylaxis, which ranges from 8 to 50 cases per 100,000 inhabitants, is constantly increasing, especially in industrialized states. Despite the advances in understanding the pathophysiological mechanisms of allergy, frequently the clinical manifestations of anaphylaxis are under-recognized, the diagnosis is often missed, therapeutic measures, including the epinephrine use, are delayed, and patients are under-investigated.<\/p>\n From a pathophysiological point of view, the reactions involved in anaphylaxis can be allergic (mediated by immunological mechanisms \u2013 IgE, IgG or immune complexes) or non-allergic (eg, direct activation of mast cells and basophils by bradykinin or complement). Food, drug, and Hymenoptera venom are the most common elicitors of anaphylactic reactions; their prevalence varies depending on the geographical region and the patients\u2019 age. Scurt CV<\/span><\/p>\n Experien\u0163a profesional\u0103:<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2020\/02\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ custom_padding=”61px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ 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A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,7232,7231″ fullwidth=”on” _builder_version=”4.16″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” locked=”off” global_colors_info=”{}”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" C.\u0218. gr. I Dr. Benea VasileSpitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015ftiAnafilaxiaAutori: Vasile Benea1, Simona-Roxana Georgescu1,21. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti.2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti Cuvinte cheie: anafilaxie, reac\u021bii alergice, autoinjector cu adrenalin\u0103. Anafilaxia, cea mai sever\u0103 form\u0103 de prezentare […]<\/p>\n","protected":false},"author":2,"featured_media":11281,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8447","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=8447"}],"version-history":[{"count":16,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8447\/revisions"}],"predecessor-version":[{"id":11218,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/8447\/revisions\/11218"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11281"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=8447"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=8447"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=8447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
1. Dermato-venereology Clinic, “Victor Babe\u0219” Clinical Hospital for Infectious and Tropical Diseases Bucharest.
2. University of Medicine and Pharmacy “Carol Davila” Bucharest<\/p>\n
Anaphylaxis is primarily a clinical diagnosis. Cutaneous and\/or mucosal involvement (urticaria, angioedema) is present in most cases, traditionally being considered as a sine qua non condition for diagnosis. Other organ involvements that suggest the diagnosis of anaphylaxis, especially if they occur after exposure to a possible allergen, are respiratory (laryngeal edema, bronchospasm), cardiovascular (hypotension) or gastrointestinal (abdominal cramps, vomiting) manifestations. Triptase, which reflects the degranulation of mast cells and basophils, is the gold standard laboratory test of IgE-mediated anaphylaxis, its increase in the acute phase being diagnostic.
Anaphylaxis is a major medical emergency that requires immediate recognition and rapid initiation of treatment, with admission to an emergency department. Patient management depends on the severity of the initial reaction and the response to treatment. It is necessary to administer adrenaline as early as possible and measures to support vital functions. Adrenaline is the only life-saving medication and is effective for all manifestations of anaphylaxis. After remission of the acute episode, investigations are needed to highlight the possible trigger factor and measures to educate patients, including the use of auto-injectable epinephrine.<\/p>\n
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, \u015eoseaua Mihai Bravu 281, sector 3, 030303 Bucure\u015fti
Educa\u0163ie \u015fi formare:<\/strong>
Perioada:
Calificarea \/ diploma ob\u0163inut\u0103:
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n