<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nProf. Univ. Dr. Doina Dr\u0103g\u0103nescu<\/strong><\/span>
Facultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia<\/strong><\/span><\/h4>\n <\/p>\n
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Aderen\u021ba la tratamentul dermatologic \u2013 o problem\u0103 rezolvabil\u0103?<\/span>
Autor: Doina Dr\u0103g\u0103nescu<\/span><\/p>\nFacultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia
<\/span><\/p>\nCuvinte cheie: formulare farmaceutic\u0103, medicamente de uz topic<\/p>\n
Formularea unui medicament necesit\u0103 cunoa\u0219terea \u00een detaliu a factorilor fizico-chimici, tehnologici \u0219i fiziologici care influen\u021beaz\u0103 decisiv propriet\u0103\u021bile finale ale acestuia. Ace\u0219ti factori se reg\u0103sesc \u00een criteriile de calitate : puritatea, staabilitatea, inocuitatea \u0219i eficien\u021ba care sunt standardizate.
Pentru fiecare form\u0103 farmaceutic\u0103 \u00een parte exist\u0103 obiective specifice care sunt urm\u0103rite atunci c\u00e2nd se are \u00een vedere ob\u021binerea unei noi formule.
Calea cutanat\u0103 de administrare a medicamentelor are \u00een vedere \u00een principal ac\u021biunea local\u0103 a substan\u021belor active, iar dac\u0103 exist\u0103 interes pentru o activitate sistemic\u0103, acesta este bazat pe posibilitatea de a evita efectul primului pasaj hepatic sau pe efectul de rezervor de acumulare a substan\u021bei active.
Ceea ce au de \u00eent\u00e2mpinat formulatorii sunt problemele care \u021bin de specificitatea permeabilit\u0103\u021bii pielii, ceea ce face ca unele medicamente s\u0103 o poat\u0103 traversa \u0219i s\u0103 aib\u0103 efectele terapeutice urm\u0103rite, altele s\u0103 genereze reac\u021bii secundare sau chiar toxice. Un drum deloc u\u0219or, urmat de fiecare dat\u0103, obligatoriu pentru fiecare produs farmaceutic \u00een parte.<\/p>\n
Formulation of topical pharmaceutical products – the essential principles to be as close as possible to get the “Healing product”<\/span>
Author: Doina Dr\u0103g\u0103nescu<\/span><\/p>\nFaculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania<\/p>\n
Keywords: pharmaceutical formulation, topical pharmaceutical products<\/p>\n
The formulation of a drug requires detailed knowledge of the physico-chemical, technological and physiological factors that decisively influence its final properties. These factors are found in the quality criteria: purity, stability, safety and efficiency which are standardized.
For each pharmaceutical form there are specific objectives that are pursued when considering the obtaining of a new formula.
The cutaneous route of administration of the drug is mainly concerned with the local action of the active substances, and if there is interest in systemic activity, it is based on the possibility of avoiding the effect of the first hepatic passage or the reservoir effect of the active substance.
What the formulators have to deal with are the problems related to the specificity of the skin’s permeability, which makes some drugs able to cross it and have the intended therapeutic effects, others to generate side effects or even toxic. Not an easy road, followed every time, mandatory for each pharmaceutical product.<\/p>\n
Scurt CV<\/span><\/p>\nDoina Dr\u0103ganescu a absolvit \u00een 1988 Universitatea de Medicin\u0103 \u0219i Farmacie Carol Davila, Facultatea de Farmacie \u0219i a lucrat ca farmacist stagiar \u00een urm\u0103torii 2 ani, iar din 1990 c\u00e2nd a promovat concursul de asistent universitar lucreaz\u0103 la Disciplina de Fizic\u0103 farmaceutic\u0103 \u0219i Informatic\u0103 din facultatea de Farmacie. \u00cen prezent, Doina Dr\u0103ganescu este profesor la acela\u0219i departament, iar de la absolvire a sus\u021binut at\u00e2t activit\u0103\u021bi profesionale, c\u00e2t \u0219i administrative. Din 2016 este decanul Facult\u0103\u021bii de Farmacie, membru al Consiliului de Administra\u021bie al Universit\u0103\u021bii \u0219i al Senatului Universit\u0103\u021bii.
Este membr\u0103 a Colegiului Farmaci\u0219tilor din Rom\u00e2nia \u0219i a Societ\u0103\u021bii Farmaceutice din Rom\u00e2nia din 1990, a Societ\u0103\u021bii Na\u021bionale de Chimie, a Societ\u0103\u021bii Na\u021bionale de Istorie a Farmaciei \u0219i a altor societ\u0103\u021bi profesionale din Rom\u00e2nia sau din str\u0103in\u0103tate. \u00cencep\u00e2nd cu 2012, este pre\u0219edintele filialei din Bucure\u0219ti a Societ\u0103\u021bii de \u0218tiin\u021be Farmaceutice din Rom\u00e2nia \u0219i reprezint\u0103 Rom\u00e2nia \u00een Comitetul Executiv al Societ\u0103\u021bii Europene de \u0218tiin\u021be Farmaceutice. \u00cen prezent este numit\u0103 responsabil\u0103 pentru activitatea de audit a EUFEPS.
Urm\u0103toarele domenii pot fi men\u021bionate ca domenii de interes profesional: tehnologii medicale \u0219i farmaceutice, medicamente homeopate, medicamente radiofarmaceutice, fiind \u00een prezent implicat\u0103 \u0219i \u00een activit\u0103\u021bi profesionale la Institutul de Fizic\u0103 \u0219i Inginerie Nuclear\u0103 Horia Hulubei (M\u0103gurele) la Centrul de cercetare radiofarmaceutice. Din 2017 este persoan\u0103 calificat\u0103 \u00een domeniul produc\u021biei de medicamente pentru radiofarmaceutice \u0219i membru al echipei de cercetare \u00een mai multe proiecte realizate \u00een Universitatea de Medicin\u0103 \u0219i Farmacie Carol Davila, Bucure\u0219ti.
A fost manager al mai multor proiecte dedicate dezvolt\u0103rii resurselor umane (POSDRU) \u00een domeniul farmaceutic \u0219i este implicat\u0103 \u00een proiecte de dezvoltare institu\u021bional\u0103 privind etica \u0219i integritatea academic\u0103 \u00een activitatea didactic\u0103 \u00een universitate.
Este redactor \u0219ef adjunct al revistei Farmacist.ro, revist\u0103 care a fost lansat\u0103 \u00een 2004, indexat\u0103 \u00een EBSCO Academic Search & One Belt,
fiind \u00een acest moment cea mai cunoscut\u0103 publica\u0163ie independent\u0103 dedicat\u0103 farmaci\u015ftilor \u015fi asisten\u0163ilor de farmacie din Rom\u00e2nia, cu un concept editorial adaptat, at\u00e2t nevoilor speciali\u015ftilor \u00een domeniu, c\u00e2t \u015fi tendin\u0163elor pie\u0163ei farmaceutice.
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Contacteaz\u0103 operatorul PDI 2022<\/p>\n
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Operatorul PDI 2022<\/p>\n
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![\"\"](\"https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2020\/02\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Prof. Univ. Dr. Doina Dr\u0103g\u0103nescuFacultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia Aderen\u021ba la tratamentul dermatologic \u2013 o problem\u0103 rezolvabil\u0103? Autor: Doina Dr\u0103g\u0103nescu Facultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia Cuvinte cheie: formulare farmaceutic\u0103, medicamente de uz topic Formularea unui medicament necesit\u0103 cunoa\u0219terea \u00een […]<\/p>\n","protected":false},"author":2,"featured_media":11271,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-9747","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9747","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=9747"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9747\/revisions"}],"predecessor-version":[{"id":11255,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9747\/revisions\/11255"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11271"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=9747"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=9747"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=9747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Prof. Univ. Dr. Doina Dr\u0103g\u0103nescu<\/strong><\/span>
Facultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia<\/strong><\/span><\/h4>\n <\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16.1″ global_colors_info=”{}”]<\/p>\n
Aderen\u021ba la tratamentul dermatologic \u2013 o problem\u0103 rezolvabil\u0103?<\/span>
Autor: Doina Dr\u0103g\u0103nescu<\/span><\/p>\nFacultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia
<\/span><\/p>\nCuvinte cheie: formulare farmaceutic\u0103, medicamente de uz topic<\/p>\n
Formularea unui medicament necesit\u0103 cunoa\u0219terea \u00een detaliu a factorilor fizico-chimici, tehnologici \u0219i fiziologici care influen\u021beaz\u0103 decisiv propriet\u0103\u021bile finale ale acestuia. Ace\u0219ti factori se reg\u0103sesc \u00een criteriile de calitate : puritatea, staabilitatea, inocuitatea \u0219i eficien\u021ba care sunt standardizate.
Pentru fiecare form\u0103 farmaceutic\u0103 \u00een parte exist\u0103 obiective specifice care sunt urm\u0103rite atunci c\u00e2nd se are \u00een vedere ob\u021binerea unei noi formule.
Calea cutanat\u0103 de administrare a medicamentelor are \u00een vedere \u00een principal ac\u021biunea local\u0103 a substan\u021belor active, iar dac\u0103 exist\u0103 interes pentru o activitate sistemic\u0103, acesta este bazat pe posibilitatea de a evita efectul primului pasaj hepatic sau pe efectul de rezervor de acumulare a substan\u021bei active.
Ceea ce au de \u00eent\u00e2mpinat formulatorii sunt problemele care \u021bin de specificitatea permeabilit\u0103\u021bii pielii, ceea ce face ca unele medicamente s\u0103 o poat\u0103 traversa \u0219i s\u0103 aib\u0103 efectele terapeutice urm\u0103rite, altele s\u0103 genereze reac\u021bii secundare sau chiar toxice. Un drum deloc u\u0219or, urmat de fiecare dat\u0103, obligatoriu pentru fiecare produs farmaceutic \u00een parte.<\/p>\n
Formulation of topical pharmaceutical products – the essential principles to be as close as possible to get the “Healing product”<\/span>
Author: Doina Dr\u0103g\u0103nescu<\/span><\/p>\nFaculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania<\/p>\n
Keywords: pharmaceutical formulation, topical pharmaceutical products<\/p>\n
The formulation of a drug requires detailed knowledge of the physico-chemical, technological and physiological factors that decisively influence its final properties. These factors are found in the quality criteria: purity, stability, safety and efficiency which are standardized.
For each pharmaceutical form there are specific objectives that are pursued when considering the obtaining of a new formula.
The cutaneous route of administration of the drug is mainly concerned with the local action of the active substances, and if there is interest in systemic activity, it is based on the possibility of avoiding the effect of the first hepatic passage or the reservoir effect of the active substance.
What the formulators have to deal with are the problems related to the specificity of the skin’s permeability, which makes some drugs able to cross it and have the intended therapeutic effects, others to generate side effects or even toxic. Not an easy road, followed every time, mandatory for each pharmaceutical product.<\/p>\n
Scurt CV<\/span><\/p>\nDoina Dr\u0103ganescu a absolvit \u00een 1988 Universitatea de Medicin\u0103 \u0219i Farmacie Carol Davila, Facultatea de Farmacie \u0219i a lucrat ca farmacist stagiar \u00een urm\u0103torii 2 ani, iar din 1990 c\u00e2nd a promovat concursul de asistent universitar lucreaz\u0103 la Disciplina de Fizic\u0103 farmaceutic\u0103 \u0219i Informatic\u0103 din facultatea de Farmacie. \u00cen prezent, Doina Dr\u0103ganescu este profesor la acela\u0219i departament, iar de la absolvire a sus\u021binut at\u00e2t activit\u0103\u021bi profesionale, c\u00e2t \u0219i administrative. Din 2016 este decanul Facult\u0103\u021bii de Farmacie, membru al Consiliului de Administra\u021bie al Universit\u0103\u021bii \u0219i al Senatului Universit\u0103\u021bii.
Este membr\u0103 a Colegiului Farmaci\u0219tilor din Rom\u00e2nia \u0219i a Societ\u0103\u021bii Farmaceutice din Rom\u00e2nia din 1990, a Societ\u0103\u021bii Na\u021bionale de Chimie, a Societ\u0103\u021bii Na\u021bionale de Istorie a Farmaciei \u0219i a altor societ\u0103\u021bi profesionale din Rom\u00e2nia sau din str\u0103in\u0103tate. \u00cencep\u00e2nd cu 2012, este pre\u0219edintele filialei din Bucure\u0219ti a Societ\u0103\u021bii de \u0218tiin\u021be Farmaceutice din Rom\u00e2nia \u0219i reprezint\u0103 Rom\u00e2nia \u00een Comitetul Executiv al Societ\u0103\u021bii Europene de \u0218tiin\u021be Farmaceutice. \u00cen prezent este numit\u0103 responsabil\u0103 pentru activitatea de audit a EUFEPS.
Urm\u0103toarele domenii pot fi men\u021bionate ca domenii de interes profesional: tehnologii medicale \u0219i farmaceutice, medicamente homeopate, medicamente radiofarmaceutice, fiind \u00een prezent implicat\u0103 \u0219i \u00een activit\u0103\u021bi profesionale la Institutul de Fizic\u0103 \u0219i Inginerie Nuclear\u0103 Horia Hulubei (M\u0103gurele) la Centrul de cercetare radiofarmaceutice. Din 2017 este persoan\u0103 calificat\u0103 \u00een domeniul produc\u021biei de medicamente pentru radiofarmaceutice \u0219i membru al echipei de cercetare \u00een mai multe proiecte realizate \u00een Universitatea de Medicin\u0103 \u0219i Farmacie Carol Davila, Bucure\u0219ti.
A fost manager al mai multor proiecte dedicate dezvolt\u0103rii resurselor umane (POSDRU) \u00een domeniul farmaceutic \u0219i este implicat\u0103 \u00een proiecte de dezvoltare institu\u021bional\u0103 privind etica \u0219i integritatea academic\u0103 \u00een activitatea didactic\u0103 \u00een universitate.
Este redactor \u0219ef adjunct al revistei Farmacist.ro, revist\u0103 care a fost lansat\u0103 \u00een 2004, indexat\u0103 \u00een EBSCO Academic Search & One Belt,
fiind \u00een acest moment cea mai cunoscut\u0103 publica\u0163ie independent\u0103 dedicat\u0103 farmaci\u015ftilor \u015fi asisten\u0163ilor de farmacie din Rom\u00e2nia, cu un concept editorial adaptat, at\u00e2t nevoilor speciali\u015ftilor \u00een domeniu, c\u00e2t \u015fi tendin\u0163elor pie\u0163ei farmaceutice.
<\/span><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ custom_padding=”61px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2022<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.16″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n
Operatorul PDI 2022<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” global_colors_info=”{}”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Prof. Univ. Dr. Doina Dr\u0103g\u0103nescuFacultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia Aderen\u021ba la tratamentul dermatologic \u2013 o problem\u0103 rezolvabil\u0103? Autor: Doina Dr\u0103g\u0103nescu Facultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia Cuvinte cheie: formulare farmaceutic\u0103, medicamente de uz topic Formularea unui medicament necesit\u0103 cunoa\u0219terea \u00een […]<\/p>\n","protected":false},"author":2,"featured_media":11271,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-9747","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9747","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=9747"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9747\/revisions"}],"predecessor-version":[{"id":11255,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9747\/revisions\/11255"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11271"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=9747"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=9747"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=9747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Doina Dr\u0103g\u0103nescu<\/span><\/p>\n
Facultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia Cuvinte cheie: formulare farmaceutic\u0103, medicamente de uz topic<\/p>\n Formularea unui medicament necesit\u0103 cunoa\u0219terea \u00een detaliu a factorilor fizico-chimici, tehnologici \u0219i fiziologici care influen\u021beaz\u0103 decisiv propriet\u0103\u021bile finale ale acestuia. Ace\u0219ti factori se reg\u0103sesc \u00een criteriile de calitate : puritatea, staabilitatea, inocuitatea \u0219i eficien\u021ba care sunt standardizate. Formulation of topical pharmaceutical products – the essential principles to be as close as possible to get the “Healing product”<\/span> Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania<\/p>\n Keywords: pharmaceutical formulation, topical pharmaceutical products<\/p>\n The formulation of a drug requires detailed knowledge of the physico-chemical, technological and physiological factors that decisively influence its final properties. These factors are found in the quality criteria: purity, stability, safety and efficiency which are standardized. Scurt CV<\/span><\/p>\n Doina Dr\u0103ganescu a absolvit \u00een 1988 Universitatea de Medicin\u0103 \u0219i Farmacie Carol Davila, Facultatea de Farmacie \u0219i a lucrat ca farmacist stagiar \u00een urm\u0103torii 2 ani, iar din 1990 c\u00e2nd a promovat concursul de asistent universitar lucreaz\u0103 la Disciplina de Fizic\u0103 farmaceutic\u0103 \u0219i Informatic\u0103 din facultatea de Farmacie. \u00cen prezent, Doina Dr\u0103ganescu este profesor la acela\u0219i departament, iar de la absolvire a sus\u021binut at\u00e2t activit\u0103\u021bi profesionale, c\u00e2t \u0219i administrative. Din 2016 este decanul Facult\u0103\u021bii de Farmacie, membru al Consiliului de Administra\u021bie al Universit\u0103\u021bii \u0219i al Senatului Universit\u0103\u021bii. [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.6″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ custom_padding=”61px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n Contacteaz\u0103 operatorul PDI 2022<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.16″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” 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button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n Operatorul PDI 2022<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” global_colors_info=”{}”]<\/p>\n <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.16″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_gallery gallery_ids=”7203,7204,9252,9464,10156,10157,10556″ fullwidth=”on” disabled_on=”on|on|on” _builder_version=”4.16″ transform_scale=”86%|86%” max_width=”63%” auto=”on” auto_speed=”3500″ hover_transition_duration=”100ms” hover_transition_delay=”50ms” hover_transition_speed_curve=”ease-in-out” disabled=”on” locked=”off” global_colors_info=”{}”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Prof. Univ. Dr. Doina Dr\u0103g\u0103nescuFacultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia Aderen\u021ba la tratamentul dermatologic \u2013 o problem\u0103 rezolvabil\u0103? Autor: Doina Dr\u0103g\u0103nescu Facultatea de Farmacie, Universitatea de Medicin\u0103 \u0219i Farmacie ” Carol Davila”din Bucure\u0219ti, Rom\u00e2nia Cuvinte cheie: formulare farmaceutic\u0103, medicamente de uz topic Formularea unui medicament necesit\u0103 cunoa\u0219terea \u00een […]<\/p>\n","protected":false},"author":2,"featured_media":11271,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-9747","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9747","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=9747"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9747\/revisions"}],"predecessor-version":[{"id":11255,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9747\/revisions\/11255"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11271"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=9747"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=9747"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=9747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/span><\/p>\n
Pentru fiecare form\u0103 farmaceutic\u0103 \u00een parte exist\u0103 obiective specifice care sunt urm\u0103rite atunci c\u00e2nd se are \u00een vedere ob\u021binerea unei noi formule.
Calea cutanat\u0103 de administrare a medicamentelor are \u00een vedere \u00een principal ac\u021biunea local\u0103 a substan\u021belor active, iar dac\u0103 exist\u0103 interes pentru o activitate sistemic\u0103, acesta este bazat pe posibilitatea de a evita efectul primului pasaj hepatic sau pe efectul de rezervor de acumulare a substan\u021bei active.
Ceea ce au de \u00eent\u00e2mpinat formulatorii sunt problemele care \u021bin de specificitatea permeabilit\u0103\u021bii pielii, ceea ce face ca unele medicamente s\u0103 o poat\u0103 traversa \u0219i s\u0103 aib\u0103 efectele terapeutice urm\u0103rite, altele s\u0103 genereze reac\u021bii secundare sau chiar toxice. Un drum deloc u\u0219or, urmat de fiecare dat\u0103, obligatoriu pentru fiecare produs farmaceutic \u00een parte.<\/p>\n
Author: Doina Dr\u0103g\u0103nescu<\/span><\/p>\n
For each pharmaceutical form there are specific objectives that are pursued when considering the obtaining of a new formula.
The cutaneous route of administration of the drug is mainly concerned with the local action of the active substances, and if there is interest in systemic activity, it is based on the possibility of avoiding the effect of the first hepatic passage or the reservoir effect of the active substance.
What the formulators have to deal with are the problems related to the specificity of the skin’s permeability, which makes some drugs able to cross it and have the intended therapeutic effects, others to generate side effects or even toxic. Not an easy road, followed every time, mandatory for each pharmaceutical product.<\/p>\n
Este membr\u0103 a Colegiului Farmaci\u0219tilor din Rom\u00e2nia \u0219i a Societ\u0103\u021bii Farmaceutice din Rom\u00e2nia din 1990, a Societ\u0103\u021bii Na\u021bionale de Chimie, a Societ\u0103\u021bii Na\u021bionale de Istorie a Farmaciei \u0219i a altor societ\u0103\u021bi profesionale din Rom\u00e2nia sau din str\u0103in\u0103tate. \u00cencep\u00e2nd cu 2012, este pre\u0219edintele filialei din Bucure\u0219ti a Societ\u0103\u021bii de \u0218tiin\u021be Farmaceutice din Rom\u00e2nia \u0219i reprezint\u0103 Rom\u00e2nia \u00een Comitetul Executiv al Societ\u0103\u021bii Europene de \u0218tiin\u021be Farmaceutice. \u00cen prezent este numit\u0103 responsabil\u0103 pentru activitatea de audit a EUFEPS.
Urm\u0103toarele domenii pot fi men\u021bionate ca domenii de interes profesional: tehnologii medicale \u0219i farmaceutice, medicamente homeopate, medicamente radiofarmaceutice, fiind \u00een prezent implicat\u0103 \u0219i \u00een activit\u0103\u021bi profesionale la Institutul de Fizic\u0103 \u0219i Inginerie Nuclear\u0103 Horia Hulubei (M\u0103gurele) la Centrul de cercetare radiofarmaceutice. Din 2017 este persoan\u0103 calificat\u0103 \u00een domeniul produc\u021biei de medicamente pentru radiofarmaceutice \u0219i membru al echipei de cercetare \u00een mai multe proiecte realizate \u00een Universitatea de Medicin\u0103 \u0219i Farmacie Carol Davila, Bucure\u0219ti.
A fost manager al mai multor proiecte dedicate dezvolt\u0103rii resurselor umane (POSDRU) \u00een domeniul farmaceutic \u0219i este implicat\u0103 \u00een proiecte de dezvoltare institu\u021bional\u0103 privind etica \u0219i integritatea academic\u0103 \u00een activitatea didactic\u0103 \u00een universitate.
Este redactor \u0219ef adjunct al revistei Farmacist.ro, revist\u0103 care a fost lansat\u0103 \u00een 2004, indexat\u0103 \u00een EBSCO Academic Search & One Belt,
fiind \u00een acest moment cea mai cunoscut\u0103 publica\u0163ie independent\u0103 dedicat\u0103 farmaci\u015ftilor \u015fi asisten\u0163ilor de farmacie din Rom\u00e2nia, cu un concept editorial adaptat, at\u00e2t nevoilor speciali\u015ftilor \u00een domeniu, c\u00e2t \u015fi tendin\u0163elor pie\u0163ei farmaceutice.
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