{"id":9868,"date":"2021-06-25T17:05:13","date_gmt":"2021-06-25T15:05:13","guid":{"rendered":"https:\/\/primaderma.ro\/?page_id=9868"},"modified":"2022-04-21T14:19:46","modified_gmt":"2022-04-21T12:19:46","slug":"dr-georgiana-mihaila","status":"publish","type":"post","link":"https:\/\/pdi.ro\/2022\/dr-georgiana-mihaila\/","title":{"rendered":"Dr. Georgiana Mih\u0103il\u0103"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|off|off” _builder_version=”4.14.7″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#75C221″ top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” global_module=”9062″ saved_tabs=”all” collapsed=”off” global_colors_info=”{}”][et_pb_fullwidth_header title=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@” text_orientation=”right” header_image_url=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2022\/02\/pdi2022.png” disabled_on=”on|on|off” _builder_version=”4.16″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”right” title_text_color=”#f0622a” title_font_size=”50px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” subhead_font=”||||||||” background_color=”#ef916b” background_image=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2021\/05\/PDI2021_header_1920x550px.jpg” background_blend=”luminosity” background_layout=”light” custom_margin=”0px||8px” custom_padding=”40px||40px||true” content_font_size_tablet=”” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop” global_colors_info=”{}”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/pdi.ro\/2022\/wp-content\/uploads\/2022\/04\/Georgiana-Mihaila-circle.png” title_text=”Georgiana Mihaila-circle” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.17.0″ max_width=”25%” border_radii=”on|100px|100px|100px|100px” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.17.0″ global_colors_info=”{}”]<\/p>\n

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Dr. Georgiana Mih\u0103il\u0103
Sec\u021bia Dermatologie, Spitalul de Urgent\u0103 E. Beldiman, B\u00e2rlad, Vaslui<\/strong><\/span><\/h4>\n

<\/strong><\/span><\/p>\n

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Psoriazis pustulos palmo-plantar \u0219i alopecie universalis dup\u0103 tratamentul cu Infliximab<\/span>
Autor: Georgiana Mih\u0103il\u0103<\/span><\/p>\n

Cuvinte cheie: psoriazis pustulos palmo-plantar, alopecie universalis, infliximab, terapii biologice<\/p>\n

Introducere: Infliximabul este un anticorp monoclonal care este folosit \u00een managementul terapeutic al multor afec\u021biuni inflamatorii, at\u00e2t \u00een dermatologie, reumatologie, gastroenterologie.Efectele secundare ale terapiei sunt cunoscute iar la nivel cutanat printer cele mai frecvente sunt citate psoriazisul \u0219i alopecia.
Material \u0219i metod\u0103: Prezent\u0103m cazul unui pacient de 37ani, aflat \u00een eviden\u021ba specialistului reumatolog cu spondilit\u0103 anchilopoetic\u0103, \u00een tratament cu infliximab de 12 ani. Pacientul prezent\u0103 de aproximativ 4 ani o pierdere total\u0103 a p\u0103rului \u0219i de aproximativ 3 luni leziuni palmo-plantare eritematoase, cu pustule pe suprafa\u021ba, fisuri \u0219i exfoliere. Biopsia cutanat\u0103 confirm\u0103 diagnosticul de psoriazis pustulos palmo-plantar.
Apari\u021bia psoriazisului pustulos palmo-plantar a fost observat dup\u0103 terapia cu anti-TNF-alpha, at\u00e2t dup\u0103 infliximab c\u00e2t \u0219i dup\u0103 etanercept sau adalimumab. Mecanismul patogenic nu este \u00eenc\u0103 pe deplin elucidat.
Rezultate: Dup\u0103 identificarea celor doua afec\u021biuni, secundare terapiei cu infliximab se decide \u00eenlocuirea agentului anti-TNF-alpha cu un anti-IL-17A.
Concluzii: Infliximabul poate cauza o serie de efecte secundare variate, inclusiv grea\u021ba, durere de cap, infec\u021bii, afec\u021biuni limfo-proliferative, sdr. lupus like \u0219i o serie de manifest\u0103ri cutanate. Inducerea unui psoriazis pustulos palmo-plantar a fost raportat c\u00e2t \u0219i alopecia.
Exist\u0103 putine cazuri raportate care sa le asocieze pe ambele la acela\u0219i pacient; \u00een special au fost raportate cazuri de alopecia areata; sc\u0103derea dozei de infliximab poate rezolv\u0103 aceste manifest\u0103ri dar am optat pentru schimbarea acestuia cu anti-IL-17A.<\/p>\n

Palmo-plantar pustular psoriasis and alopecia universalis after Infliximab theraphy<\/span>
Author: Georgiana Mih\u0103il\u0103<\/span><\/p>\n

Dermatology Department, E. Beldiman Emergency Hospital, B\u00e2rlad, Vaslui<\/p>\n

Keywords: palmo-plantar pustular psoriasis,alopecia universalis, infliximabum, biological theraphies<\/p>\n

Introduction: Infliximabum is a monoclonal antibody which is used in the therapeutic management of inflammatory diseases, in dermatologie, rheumatology and gastroenterology. The side effects of this therapy are known and the most frequently cutaneous involvement are: psoriasis and alopecia.
Case raport:We present the case of a young 37 years old male, who was diagnosed 11years ago with ankylosing spondylitis and he is treated for his disease with infliximabum. 4 years ago he presented a total loss of hair ( not investigated or treated for this condition) and three months ago he presented.
Dermatological examination showed symmetrical erythematous plaques, clusters of pustules associating pain, involving palms and soles. A total loss of hair was noticed. The punchy biopsy confirmed the diagnosis of palmo-plantar pustular psoriasis. Palmo-plantar psoriasis is observed after anti-TNF-alpha therapy including infliximabum, etanerceptum or adalimumabum. The pathogenic mechanism isn\u2019t yet elucidated.
Results: After we recognized those two second effects: alopecia and palmo-plantar pustular psoriasis we decided to stop infliximabum and to use anti-IL-17A therapy.
Conclusions: Infliximabum can cause various side effects as: nausea, headaches, infections,limfo-prolifetarative conditions, lupus-like sindrom and cutaneous involvement.
After using infliximabum palmo-plantar pustular psoriasis and alopecia were reported.There are rarely reported the association between palmo-plantar pustular psoriasis and alopecia universalis. Decreassing the dose of infliximabum can resolve this side effects but we choose to switch with anti-IL-17A.<\/p>\n

Simpozion NOVARTIS<\/span><\/p>\n

Cosentyx – It\u2019s all about the patient<\/span>
\u00a0Moderator
Prof Univ Dr Daciana Elena Br\u0103ni\u0219teanu
Lectori
Prof Univ Dr Codrina Ancu\u021ba
Dr Georgiana Mih\u0103il\u0103<\/span><\/p>\n

Boala psoriazic\u0103 este o afec\u021biune sistemic\u0103 inflamatorie, mediat\u0103 imun, progresiv\u0103, care afecteaz\u0103 \u00eentreg organismul, trec\u00e2nd dincolo de piele. Pentru pacien\u021bii cu boal\u0103 psoriazic\u0103, pielea este doar unul dintre aspectele bolii.<\/p>\n

Pacien\u021bii \u00ee\u0219i doresc un tratament cu eficien\u021b\u0103 dovedit\u0103 \u0219i profil favorabil de siguran\u021b\u0103, care s\u0103 \u021binteasc\u0103 toate manifest\u0103rile bolii psoriazice:
-Vindecarea leziunilor cutanate
-Remisiunea sus\u021binut\u0103 a artritei psoriazice
-Tratamentul complet al tuturor manifestarilor bolii, inclusiv al formelor \u201edificil de tratat\u201d
-Controlul comorbidit\u0103\u021bilor prezente \u0219i prevenirea aparitiei altor comorbidit\u0103\u021bi
-\u00cembun\u0103t\u0103\u021birea calit\u0103\u021bii vie\u021bii , at\u00e2t fizic c\u00e2t \u0219i psihic
\u00cendeplinirea acestor deziderate presupune diagnosticul, \u0219i implicit, tratamentul precoce al bolii.<\/p>\n

Date din literatura de specialitate relev\u0103 c\u0103, \u00een medie, exist\u0103 o \u00eent\u00e2rziere a diagnosticului de psoriazis de aproximativ 2,6 ani de la debutul bolii, \u00een timp ce pentru diagnosticul de artrit\u0103 psoriazic\u0103 aceast\u0103 \u00eent\u00e2rziere este \u00een medie de 1,8 ani de la debutul simptomelor.<\/p>\n

Cu at\u00e2t mai important\u0103 devine cunoa\u0219terea de c\u0103tre pacient a semnelor \u0219i simptomelor bolii psoriazice \u00eenc\u0103 din stadiul ini\u021bial.<\/p>\n

Un studiu recent derulat a scos \u00een eviden\u021b\u0103 faptul c\u0103 numero\u0219i pacien\u021bi cu boal\u0103 psoriazic\u0103 nu realizeaz\u0103 complexitatea acestei afec\u021biuni \u0219i nici rela\u021bia \u00eentre diferitele manifest\u0103ri ale bolii \u0219i comorbidit\u0103\u021bile asociate.<\/p>\n

Din acela\u0219i studiu reiese c\u0103, \u00een ceea ce prive\u0219te calitatea vie\u021bii, 73% dintre pacien\u021bi raporteaz\u0103 un impact moderat p\u00e2n\u0103 la foarte mare sau extrem de mare al bolii psoriazice.<\/p>\n

Tratamentul eficient \u0219i complet al manifest\u0103rilor multiple ale bolii psoriazice este esen\u021bial pentru \u00eembun\u0103t\u0103\u021birea calit\u0103\u021bii vie\u021bii pacien\u021bilor.<\/p>\n

Utilizat la nivel mondial la peste 500.000 pacien\u021bi, \u00een indica\u021biile aprobate, \u0219i f\u0103r\u0103 eviden\u021bierea de noi semnale privind siguran\u021ba de-a lungul a 5 ani, Cosentyx asigur\u0103 tratamentul complet pentru boala psoriazic\u0103.<\/p>\n

\u00cencep\u00e2nd din timp tratamentul bolii psoriazice \u0219i \u021bintind direct cauza bolii, inflama\u021bia sistemic\u0103, cu Cosentyx, ob\u021binem \u00een timp scurt o eficacitate \u00eenalt\u0103 care este sus\u021binut\u0103 pe termen lung, nu doar la nivelul pieli, dar \u0219i la nivel articular, \u00een condi\u021biile unui profil de siguran\u021b\u0103 favorabil \u0219i men\u021binut \u00een timp.<\/p>\n

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Contacteaz\u0103 operatorul PDI 2022<\/p>\n

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Operatorul PDI 2022<\/p>\n

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\"\"<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

Adresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n

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Parteneri Media<\/p>\n

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Dr. Georgiana Mih\u0103il\u0103Sec\u021bia Dermatologie, Spitalul de Urgent\u0103 E. Beldiman, B\u00e2rlad, Vaslui Psoriazis pustulos palmo-plantar \u0219i alopecie universalis dup\u0103 tratamentul cu Infliximab Autor: Georgiana Mih\u0103il\u0103 Cuvinte cheie: psoriazis pustulos palmo-plantar, alopecie universalis, infliximab, terapii biologice Introducere: Infliximabul este un anticorp monoclonal care este folosit \u00een managementul terapeutic al multor afec\u021biuni inflamatorii, at\u00e2t \u00een dermatologie, reumatologie, gastroenterologie.Efectele […]<\/p>\n","protected":false},"author":2,"featured_media":11418,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-9868","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9868","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/comments?post=9868"}],"version-history":[{"count":6,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9868\/revisions"}],"predecessor-version":[{"id":11623,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/posts\/9868\/revisions\/11623"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media\/11418"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/media?parent=9868"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/categories?post=9868"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2022\/wp-json\/wp\/v2\/tags?post=9868"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}