Prof. Dr. Torello Lotti

Prof. Dr. Torello Lotti
University of Studies Guglielmo Marconi, Roma, Italia

Cytokines – emergent role in the psychocutaneous disorders

Autor: Torello Lotti  
University of Rome “Guglielmo Marconi”, Rome, Italy 
President World Health Academy of Dermatology

Cytokines are small secreted proteins released by cells have a specific effect on the interactions and communications between cells. Cytokine is a general name; other names include lymphokine (cytokines made by lymphocytes), monokine (cytokines made by monocytes), chemokine (cytokines with chemotactic activities), and interleukin (cytokines made by one leukocyte and acting on other leukocytes). Cytokines may act on the cells that secrete them (autocrine action), on nearby cells (paracrine action), or in some instances on distant cells (endocrine action). There are both pro- inflammatory cytokines and anti-inflammatory cytokines. There is significant evidence showing that certain cytokines/chemokines are involved in not only the initiation but also the persistence of pathologic pain by directly activating nociceptive sensory neurons. Certain inflammatory cytokines are also involved in nerve-injury/inflammation-induced central sensitization, and are related to the development of contralateral hyperalgesia/allodynia. The discussion presented in this chapter describes several key pro-inflammatory cytokines/chemokines and anti-inflammatory cytokines, their relation with pathological pain in animals and human patients, and possible underlying mechanisms.

Microbiota/Microbiome – the New Protagonist of Psycho-Neuro- Endocrine Immune-Mediated Disorders

Torello Lotti
University of Rome “Guglielmo Marconi”, Rome, Italy
President World Health Academy of Dermatology

The P.N.E.I. (Psycho-Neuro-Endocrine-Immunology) approach is represented by the interdisciplinary concept of bidirectional cross-talk between the psycho-neuro-endocrine and immune systems, which can influence the immune response. The well-known Gut-Brain Axis and the Gut-Skin Axis can be merged in a bigger network- the Gut-Brain-Skin Axis, with complex regulation by cytokines, neuro- peptides, neuro-hormones and another messenger (signalling) molecules and maybe the most important modulator of the Gut-Brain-Skin Axis/ the gut microbiota.
The role of gut bacterial homeostasis is very important, and the homeostatic imbalance of the immune response may be a relevant etiologic/pathophysiologic factor for extra-intestinal and intestinal inflammatory, allergic and autoimmune diseases. The Low Dose Cytokines Medicine (LDM) is an innovative therapeutic approach. It is based on the most advanced knowledge in molecular biology and low dose pharmacology with the primary outcome. The SKA (Sequential Kinetic Activation) technology, codified and standardised by GUNA S.p.a. -Italy- makes the low doses of signalling molecules able to be active even below the minimum dose classically considered as effective and the significative efficacy of orally administered low-dose signalling molecules is the most representative aspect of LDM. The Physiologic Nutraceuticals and the Low Dose Medicine are two of the most promising approaches for the treatment of skin diseases based on the rebalance of the immune response and the recovery of gut dysbiosis.

Scurt CV

Prof. Lotti is Full Professor and Chairman of Dermatology and Venereology at University of Rome Guglielmo Marconi, Rome, Italy. He is President of the World Health Academy, Dermatology since 2013. Director, Centro Studi per la Ricerca Multidisciplinare Rigenerativa (CSRMR), of the University of Rome “G.Marconi”, Rome, Italy, since 2015.
He is Honorary Professor of Dermatology – China Medical University Shenyang (2011), Lecturer at the New York Academy of Sciences “Howard Fox Memorial Lecture” (14 March 2012 – New York, NY – USA), and Chair, Executive Scientific Committee Vitiligo Research Foundation, New York, NY USA. He has been Full Professor of the Dermatology and Venereology Division at University of Florence School of Medicine, Florence, Italy, from 2006 to 2010. He is Visiting Professor in six International Universities worldwide, and Key Note Lecturer in several international dermatology Societies.
His activities in serving Dermatology have been numerous: President of the Italian Society of Dermatology and Venereology (SIDeMaST , 2009-2011) and President of the International Society of Dermatology ( ISD, 2009-2011), President of the European Society for Cosmetic and Aesthetic Dermatology (2003-2004), Editor in Chief of the Journal of the European Academy of Dermatology and Venereology (1992-2002), Editor “Therapeutic Hotline”- Dermatologic Therapy (2007-) and served as Editor in Chief of the Giornale Italiano di Dermatologia in the period of presidency of the Societa’ Italiana di Dermatologia (2009-2011).
He is Ordinary Member of the main Scientific Societies worldwide (EADV, SIDEV, ESDR, ISD, AAD, SID) and Honorary Member of several Scientific Societies of the Dermatology field.
Moreover, he is a Scientific reviewer of ten sectorial journals, among which are the British Journal of Dermatology, Journal of Investigative Dermatology, Journal of the American Academy of Dermatology , Dermatologic Therapy.
Professor Lotti is presently Editor in Chief of Dermatologic Therapy by Wiley-Blackwell (Oxford U.K, Chicago IL).
Professor Lotti is Full Professor of Dermatology of the 1st Medical Univeristy of Moscow, since January 2020 and Full Professor and Chairman of Dermatology at Univeristy of Rome G. Marconi, Rome, Italy.
He has been invited as Keynote Speaker in 2.136 international and national Congresses and has served as Congress President or Chair of a Scientific session in 827 Congresses.
Prof. Lotti has authored 3.507 scientific publications (629 peer-reviewed articles, 388 book chapters, 3.650 abstracts and has edited or co-edited 59 books in the field of Dermatology and related fileds.