{"id":10064,"date":"2023-02-14T12:50:13","date_gmt":"2023-02-14T10:50:13","guid":{"rendered":"https:\/\/primaderma.ro\/?page_id=10064"},"modified":"2023-02-16T10:12:28","modified_gmt":"2023-02-16T08:12:28","slug":"sef-lucr-dr-porumb-andrese-elena","status":"publish","type":"post","link":"https:\/\/pdi.ro\/2023\/sef-lucr-dr-porumb-andrese-elena\/","title":{"rendered":"\u0218ef lucr. Dr.\u00a0Porumb-Andrese Elena"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; disabled_on=&#8221;on|off|off&#8221; _builder_version=&#8221;4.19.4&#8243; custom_margin=&#8221;||&#8221; custom_padding=&#8221;15px||29px&#8221; top_divider_style=&#8221;waves2&#8243; top_divider_color=&#8221;#F0622A&#8221; top_divider_flip=&#8221;horizontal|vertical&#8221; bottom_divider_style=&#8221;waves2&#8243; bottom_divider_color=&#8221;#fcdedb&#8221; bottom_divider_height=&#8221;105px&#8221; bottom_divider_flip=&#8221;vertical&#8221; global_module=&#8221;9062&#8243; saved_tabs=&#8221;all&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_header title=&#8221;@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@&#8221; disabled_on=&#8221;on|on|off&#8221; _builder_version=&#8221;4.19.4&#8243; _dynamic_attributes=&#8221;title&#8221; title_font=&#8221;Kaushan Script||||||||&#8221; title_text_align=&#8221;left&#8221; title_text_color=&#8221;#f0622a&#8221; title_font_size=&#8221;55px&#8221; content_font=&#8221;|600||on|||||&#8221; content_text_align=&#8221;center&#8221; content_text_color=&#8221;#686766&#8243; content_font_size=&#8221;15px&#8221; subhead_font=&#8221;||||||||&#8221; background_enable_color=&#8221;off&#8221; background_image=&#8221;https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg&#8221; background_blend=&#8221;luminosity&#8221; background_layout=&#8221;light&#8221; custom_margin=&#8221;||-5px||false|false&#8221; custom_padding=&#8221;150px||150px||true|false&#8221; content_font_size_tablet=&#8221;&#8221; content_font_size_phone=&#8221;15px&#8221; content_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2021\/07\/Porumb-AndreseElena.png&#8221; title_text=&#8221;Porumb-AndreseElena&#8221; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.16&#8243; max_width=&#8221;31%&#8221; border_radii=&#8221;on|100px|100px|100px|100px&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h4><span style=\"color: #ff6600;\"><strong><\/strong><\/span><\/h4>\n<h4><span style=\"color: #ff6600;\"><strong><\/strong><\/span><\/h4>\n<h4><span style=\"color: #ff6600;\"><strong><\/strong><\/span><\/h4>\n<h4><span style=\"color: #ff6600;\"><strong>\u0218ef lucr. Dr.\u00a0Porumb-Andrese Elena<\/strong><\/span><br \/>\n<span style=\"color: #ff6600;\"><strong>Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/h4>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.19.5&#8243; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><!--<\/p>\n\n\n\n\n<p style=\"text-align: justify;\"><span style=\"color: #ff6600;\">Cu \u0219i despre fotoprotec\u021bie<\/span>\n\n\n<span style=\"color: #ff6600;\">Autor: Porumb-Andrese Elena<\/span><\/p>\n\n\n\n\n<p style=\"text-align: justify;\"><span style=\"color: #ff6600;\">1Laborator Imunologie, Institutul National de Patologie \u201cVictor Babes\u201d, 050096 Bucuresti; 2Departamentul de Anatomie Patologica, Spitalul Clinic Colentina, 020125 Bucuresti; 3 Scoala Doctorala, Facultatea de Biologie, University of Bucharest, 050095 Bucharest, Romania; 4Department of Pathology, Faculty of Dental Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest <\/span><\/p>\n\n\n\n\n<p>Cuvinte cheie: SARS-CoV-2, anticorpi specifici, vaccinare<\/p>\n\n\n\n\n<p style=\"text-align: justify;\">Introducere. Dupa pandemia de gripa spaniola de la inceputul secolului 20 ne confrunt\u0103m cu cea mai extinsa epidemie din istoria modern\u0103 \u0219i pe m\u0103sur\u0103 ce dezvoltarea vaccinurilor specifice a ajuns in faza de imunizare \u00een mas\u0103, datele obtinute din protocoalele de vaccinare se acumuleaza. Materiale si metode. \u00cen prezentul studiu, un grup selectat de 103 lucr\u0103tori din domeniul s\u0103n\u0103t\u0103\u021bii care au expunere constant\u0103 la pacien\u021bi \u0219i probe infectate cu SARS-CoV-2 au fost monitoriza\u021bi pentru cuantificarea nivelurilor specifice de IgG \u0219i IgA \u00eenainte de vaccinare \u0219i dup\u0103 protocolul de vaccinare cu un vaccin pe baz\u0103 de ARNm. Testarea nivelurilor de IgG \u0219i IgA \u00een timpul protocolului de vaccinare a fost realizata la 21 de zile dup\u0103 prima inoculare \u0219i la dou\u0103 s\u0103pt\u0103m\u00e2ni dup\u0103 rapel. Testele standard ELISA aprobate de FDA au fost utilizate pentru cuantificarea IgG \u0219i IgA specifice. Rezultate. Nivelurile bazale de IgG \u0219i IgA la subiec\u021bii infecta\u021bi anterior \u0219i la subiec\u021bii naivi au diferit semnificativ. Vaccinarea a indus o cre\u0219tere robust\u0103 at\u00e2t a nivelurilor de IgG, c\u00e2t \u0219i a nivelului de IgA chiar \u0219i dup\u0103 prima doz\u0103 la majoritatea subiec\u021bilor din ambele grupuri. Dup\u0103 a doua doz\u0103, nivelele circulatorii de IgA \u0219i IgG au fost crescute. Asocierile dintre nivelurile de IgG \u0219i IgA la prima \u0219i a doua doz\u0103 de vaccinare au indicat faptul c\u0103 \u00een \u00eentregul grup, indiferent de expunerea anterioar\u0103 la agentul infec\u021bios, cre\u0219terea \u0219i nivelurile de IgG \u0219i IgA au fost similare. Concluzie. Nivelurile de IgG \u0219i IgA la vaccinare au fost statistic similare, indiferent de nivelele pr-vaccinare, seroconversia a fost realizat\u0103 \u00een proportie de 100% in intregul grup analizat dup\u0103 a doua doz\u0103, iar nivelurile au fost similare pentru anticorpii de tip IgG \u0219i IgA.<\/p>\n\n\n\n\n<p style=\"text-align: justify;\"><span style=\"color: #ff6600;\">SPECIFIC IgG AND IgA ANTIBODY DYNAMICS IN ANTI-SARS-COV2 VACCINATION<\/span><\/p>\n\n\n\n\n<p><span style=\"color: #ff6600;\">Authors: MONICA NEAGU1,2,3, LUCIANA NICHITA 2,4, C MOGODICI2, ALEXANDRA BASTIAN 2,4, CRISTIANA POPP2, MIRELA CIOPLEA 2,4, C SOCOLIUC 2,4, CAROLINA CONSTANTIN 1,2, SABINA ZURAC2,4<\/span><\/p>\n\n\n\n\n<p style=\"text-align: justify;\"><span style=\"color: #ff6600;\">1Immunology Laboratory, \u2018Victor Babes\u2019 National Institute of Pathology, 050096 Bucharest; 2Department of Pathology, Colentina University Hospital, 020125 Bucharest; 3Doctoral School of Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania; 4Department of Pathology, Faculty of Dental Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest <\/span><\/p>\n\n\n\n\n<p>Key words: SARS-CoV-2, specific antibodies, vaccination<\/p>\n\n\n\n\n<p style=\"text-align: justify;\">Introduction. As the world is currently facing one of the major outbreaks of viral infection in the modern history and as vaccine development has entered the mass immunization stage, data are being obtained from real-life specific vaccinations. Material and methods. In the present study, a selected group of 103 healthcare workers with documented exposure to SARS-CoV-2-infected patients and samples were monitored for specific IgG and IgA levels prior to vaccination, and after vaccination protocol with a mRNA-based vaccine. We have tested IgG and IgA levels during the vaccination protocol at 21 days after the first shot and two weeks after the second vaccination. ELISA standard tests approved by FDA were used for quantification of specific IgG and IgA. Results. The basal IgG and IgA levels in previously infected subjects and na\u00efve subjects differed markedly. The vaccination induced a consistent increase in both the IgG and IgA levels even after the first dose in the majority of subjects from both groups and after the second dose, the circulatory levels of IgA and IgG were increased again. The associations between the IgG and IgA levels upon the first and second dose of vaccination indicted that in the entire vaccination group, regardless of prior exposure to the infectious agent, the increment and the levels of IgG and IgA were similar. Conclusion. IgG and IgA levels upon vaccination were statistically similar irrespectively of the starting base-line before vaccination and seroconversion was achieved in 100% of the group after the second dose with similar high IgG and IgA antibodies levels.<\/p>\n\n\n\n\n<p>--><\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #ff6600;\">Scurt CV<\/span><\/p>\n<p style=\"text-align: justify;\"><strong>Experien\u0163a profesional\u0103:<\/strong><br \/>2018-prezent<br \/>Medic specialist Dermato-Venerologie &#8211; Spitalul Clinic Jude\u0163ean de Urgen\u0163e \u201cSf. Spiridon\u201d, Ia\u015fi, Romania<br \/>2021-prezent<br \/>\u0218ef lucrari Disciplina Dermatologie, Departamentul Medicale III, Facultatea Medicin\u0103 &#8211; Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<br \/>2011-2015<br \/>Medic rezident Dermato-Venerologie &#8211; Spitalul Clinic Jude\u0163ean de Urgen\u0163e \u201cSf. Spiridon\u201d, Ia\u015fi, Romania<\/p>\n<p><strong>Educa\u0163ie \u015fi formare:<\/strong><br \/>2016 &#8211; Diplom\u0103 de Doctor &#8211; Doctor \u00een Medicin\u0103 &#8211; Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<br \/>2002-2008 &#8211; Diplom\u0103 de Licen\u021b\u0103 &#8211; Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.19.4&#8243; background_color=&#8221;rgba(240,98,42,0.19)&#8221; background_image=&#8221;https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg&#8221; background_blend=&#8221;multiply&#8221; custom_padding=&#8221;54px|0px|0|0px|false|false&#8221; top_divider_style=&#8221;waves2&#8243; top_divider_color=&#8221;#ffffff&#8221; top_divider_height=&#8221;155px&#8221; top_divider_height_tablet=&#8221;&#8221; top_divider_height_phone=&#8221;97px&#8221; top_divider_height_last_edited=&#8221;on|desktop&#8221; bottom_divider_style=&#8221;waves2&#8243; bottom_divider_color=&#8221;#F0622A&#8221; bottom_divider_flip=&#8221;vertical&#8221; bottom_divider_height_tablet=&#8221;&#8221; bottom_divider_height_phone=&#8221;59px&#8221; bottom_divider_height_last_edited=&#8221;on|desktop&#8221; global_module=&#8221;9177&#8243; 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submit_button_text=&#8221;Trimite mesajul&#8221; _builder_version=&#8221;4.16&#8243; _unique_id=&#8221;794aaef5-e005-432a-99fb-9ca53e06d67b&#8221; title_font=&#8221;||||||||&#8221; custom_button=&#8221;on&#8221; button_text_color=&#8221;#F0622A&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_contact_field field_id=&#8221;Name&#8221; field_title=&#8221;Nume&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;off&#8221; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; 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field_type=&#8221;text&#8221; fullwidth_field=&#8221;on&#8221; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; button_text_size__hover_enabled=&#8221;off&#8221; button_one_text_size__hover_enabled=&#8221;off&#8221; button_two_text_size__hover_enabled=&#8221;off&#8221; button_text_color__hover_enabled=&#8221;off&#8221; button_one_text_color__hover_enabled=&#8221;off&#8221; button_two_text_color__hover_enabled=&#8221;off&#8221; button_border_width__hover_enabled=&#8221;off&#8221; button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;off&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;off&#8221; 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A. 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Dr.\u00a0Porumb-Andrese Elena Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi Scurt CV Experien\u0163a profesional\u0103:2018-prezentMedic specialist Dermato-Venerologie &#8211; Spitalul Clinic Jude\u0163ean de Urgen\u0163e \u201cSf. Spiridon\u201d, Ia\u015fi, Romania2021-prezent\u0218ef lucrari Disciplina Dermatologie, Departamentul Medicale III, Facultatea Medicin\u0103 &#8211; Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi2011-2015Medic rezident Dermato-Venerologie &#8211; Spitalul Clinic Jude\u0163ean de Urgen\u0163e [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":12397,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-10064","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/10064","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=10064"}],"version-history":[{"count":9,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/10064\/revisions"}],"predecessor-version":[{"id":12634,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/10064\/revisions\/12634"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/12397"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=10064"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=10064"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=10064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}