<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nDr. P\u00e2rvu Magda<\/strong><\/span>
Spitalul Clinic Colentina, Bucure\u015fti, Rom\u00e2nia<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”off|off|off” _builder_version=”4.19.5″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.19.5″ global_colors_info=”{}”]<\/p>\n
Anticorpii antinucleari \u00een bolile de \u021besut conjunctiv – c\u00e2nd avem nevoie \u0219i cum \u00eei interpretam?<\/span><\/p>\n Autor: Magda P\u00e2rvu<\/span><\/p>\nCuvinte cheie: anticorpi antinucleari, boli de \u021besut conjunctiv, fenotip specific, subtipuri de boal\u0103, activitate, severitate<\/p>\n
Bolile de \u021besut conjunctiv sunt adesea asociate cu o provocare diagnostic\u0103. Autoanticorpii pot fi detecta\u021bi \u00een cadrul acestor boli fiind utili \u00een stabilirea diagnosticului \u0219i prognosticului bolii. Adesea, fiecare anticorp este asociat cu un fenotip specific ajut\u00e2nd la o mai bun\u0103 definire a subtipurilor de boal\u0103, a activit\u0103\u021bii a consecin\u021belor bolii. Anticorpii antinucleari (AAN ) sunt anticorpi \u00eendrepta\u021bi \u00eempotriva antigenelor nucleare, detectarea lor prin imunofluorescen\u021b\u0103 indirecta permi\u021b\u00e2nd eviden\u021bierea a 29 de patternuri distincte astfel definite \u00een 2015 de c\u0103tre International Consensus on Antinuclear Antibody Pattern (ICAP). Astfel ICAP prezint\u0103 relevan\u021ba clinic\u0103 a celor 29 de modele distincte definit\u0103 \u00een contextul bolii suspectate incluz\u00e2nd \u0219i recomand\u0103ri pentru testarea ulterioar\u0103. Aceasta reprezint\u0103 perspectiva general\u0103 asupra AAN. Perspectiva specific\u0103 se concentreaz\u0103 asupra impactului clinic al autoanticorpilor prin asocierea lor cu un fenotip specific din cadrul bolii ajut\u00e2nd la o mai bun\u0103 definire a subtipurilor, activit\u0103\u021bii \u0219i consecin\u021belor\/complica\u021biilor bolii. Astfel sunt prezenta\u021bi anticorpii cei mai specifici din LES, sclerodermie, dermatopolimiozita, cu prevalenta, sensibilitatea, specificitatea \u0219i caracteristicile lor clinice. Sunt descrise corela\u021biile dintre subtipurile de lupus cutanat \u0219i tipul autoanticorpilor iar pentru morfee impactul pozitivit\u0103\u021bii AAN \u0219i a diferitelor subtipuri asupra severit\u0103\u021bii, profunzimii leziunilor \u0219i asocierii cu manifest\u0103rile extracutanate. Astfel detectarea AAN poate deveni un instrument util \u00een managementul pe termen lung al pacien\u021bilor.<\/p>\n
Antinuclear antibodies in connective tissue diseases – when we need them and how do we interpret them?<\/span><\/p>\nAuthor: Magda P\u00e2rvu<\/span><\/p>\nKeywords: antinuclear antibodies, connective tissue diseases, specific phenotype, disease subtypes, activity, severity<\/p>\n
Connective tissue diseases are often associated with a diagnostic challenge. Autoantibodies can be detected within these diseases. Often, each antibody is associated with a specific phenotype helping to better define the subtypes of the disease, the activity and the consequences of the disease. Antinuclear antibodies (AAN ) are antibodies directed against nuclear antigens, their detection by indirect immunofluorescence allowing the highlighting of 29 distinct patterns thus defined in 2015 by the International Consensus on Antinuclear Antibody Pattern (ICAP). Thus ICAP presents the clinical relevance of the 29 distinct models defined in the context of the suspected disease including recommendations for further testing. This is the general perspective on AAN. The specific perspective focuses on the clinical impact of autoantibodies by associating them with a specific phenotype within the disease helping to better define the subtypes, activity and consequences\/complications of the disease. Thus are presented the most specific antibodies from SLE, scleroderma, dermatopolymyositis, with their prevalence, sensitivity, specificity and clinical characteristics. We describe also the correlations between the cutaneous lupus subtypes and the type of autoantibodies and for the morphea the impact of AAN positivity on the severity, depth of lesions and association with extracutaneous manifestations. Thus, the detection of AAN can become a useful tool in the long-term management of patients.<\/p>\n
Scurt CV<\/span><\/p>\n\u2022\tAbsolventa a Facultatii de Medicina Generala si Farmacie \u201cCarol Davila\u201d Bucuresti
\n\u2022\tMedic primar in specialitatea medicina interna si reumatologie
\n\u2022\t Doctor in stiinte medicale
\n\u2022\tSef sectie reumatologie Spitalul clinic \u201cColentina\u201d, Bucuresti
\n\u2022\tStagiu postgradual in specialitatea Reumatologie in Belgia in \u201cService de Rhumatologie des Cliniques Universitaires Saint \u2013Luc\u201d, Bruxelles (prof. F. Houssiau) si \u201cCliniques Universitaires U.C.L de Mont-Godinne\u201d, Yvoir, (Prof. W. Esselincks) 2000
\n\u2022\tCompetenta internationala in Capilaroscopie obtinuta sub egida \u201cEuropean League Against Rheumatism\u201d (EULAR), Genova, Italia, 2004, 2011
\n\u2022\tAbsolventa a cursurilor internationale de ecografie musculoscheletala, 2005, 2007.
\n\u2022\tCompetenta internationala in \u201cDensitometrie Clinica\u201d (CCD \u2013 \u201cCertified Clinical Densitometrist\u201d) acordata de catre Societatea Internationala de Densitometrie Clinica (ISCD), SUA, 2006, 2012
\n\u2022\tCompetenta (certificare) in \u201cDensitometrie\u201d acordata de catre \u201cFundatia Internationala de Osteoporoza\u201d (\u201cInternational Osteoporosis Foundation\u201d), 2007
\n\u2022\tAbsolventa a cursului de \u201cEpidemiologie clinic\u0103\u201d efectuat in cadrul RECIF (R\u00e9seau d`\u00c9pid\u00e9miologie Clinique International), Bucure\u015fti, sub conducerea Prof. Dr. Pierre Duhaut, H\u00f4pital Edouard Herriot, Lyon, 2001
\n\u2022\tAbsolventa a cursului international de imagistica in reumatologie sub egida EULAR, organizat de \u201cRheumatology Unit of the Vall D`Hebron Hospital\u201d, Sitges, Spania, 2007
\n\u2022\tCertificare internationala in evaluarea scorurilor cutanate din sclerodermie conform criteriilor de competenta EUSTAR, 2008
\n\u2022\tMembra a Societatii Romane de Reumatologie din 2000, a Ligii Romane Contra Reumatismului si a Societatii Internationale de Densitometrie Clinica \u2013 ISCD (2007)
\n\u2022\tMembra in Comisia Europeana de Reumatologie a UEMS ( European Union of Medical Specialists) (2011 \u2013 2014)
\n\u2022\tMembra in comitetul stiintific al Societatii Romane de Reumatologie (2007 \u2013 2018)
\n\u2022\tMembra in Consiliul editorial al \u2018\u2019 Romanian Journal of Internal Medicine\u2019\u2019 (Revista romana de medicina interna) aflata sub patronajul Academiei Romane si a Academiei de Stiinte Medicale
\n\u2022\tMembra in Comisia de specialitate (consultativa) de reumatologie a Ministerului Sanatatii (2008 \u2013 2010)
\n\u2022\tMembra in Comisia de Experti de la nivelul Casei Nationale de Asigurari de Sanatate pentru tratamentul cu imunosupresoare in poliartrita reumatoida, artropatia psoriazica, spondilita anchilozanta si artrita juvenila (2009 \u2013 2016)
\n\u2022\tMembra a comisiei nationale de Bioetica (2015 \u2013 2016)
\n\u2022\tSecretar al Societatii Romane de Reumatologie (2011 \u2013 2016)
\n\u2022\tTrezorier al Societatii Romane de reumatologie (2016 – 2018)
\n\u2022\tSecretar general al Societatii Romane de Reumatologie (2018 -2021)
\n\u2022\tPresedinta Comisiei Stiintifice a Societatii Romane de Reumatologie (2018 pana in prezent)
\n\u2022\tMembra a grupului international \u201cEULAR Study Group on Microcirculation in Rheumatic Diseases\u201d (2014 pana in prezent)
\n\u2022\tCoordonator la nivelul spitalului clinic \u201cColentina\u201d a Programului national de tratament pentru boli rare respectiv \u201cTratamentul bolnavilor cu scleroza sistemica si ulcere digitale evolutive\u201d (2014 pana in prezent)
\n\u2022\tMembra a Comitetului stiintific al Registrului Roman de Boli Reumatice (RRBR) (2013 pana in prezent)
\n\u2022\tPriminvestigator in mai multe studii clinice internationale in specialitatea reumatologie.
\n\u2022\tResponsabil de proiecte (2) in cadrul programului PN2 (parteneriate in domeniile prioritare).
\n\u2022\tNumeroase lucrari publicate, comunicate oral sau poster la congrese nationale si internationale de reumatologie si medicina interna\n<\/p>\n
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Contacteaz\u0103 operatorul PDI 2023<\/p>\n
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Operatorul PDI 2023<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Dr. P\u00e2rvu MagdaSpitalul Clinic Colentina, Bucure\u015fti, Rom\u00e2niaAnticorpii antinucleari \u00een bolile de \u021besut conjunctiv – c\u00e2nd avem nevoie \u0219i cum \u00eei interpretam? Autor: Magda P\u00e2rvu Cuvinte cheie: anticorpi antinucleari, boli de \u021besut conjunctiv, fenotip specific, subtipuri de boal\u0103, activitate, severitate Bolile de \u021besut conjunctiv sunt adesea asociate cu o provocare diagnostic\u0103. Autoanticorpii pot fi detecta\u021bi \u00een […]<\/p>\n","protected":false},"author":2,"featured_media":12682,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-12357","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=12357"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12357\/revisions"}],"predecessor-version":[{"id":12685,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12357\/revisions\/12685"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/12682"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=12357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=12357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=12357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Dr. P\u00e2rvu Magda<\/strong><\/span>
Spitalul Clinic Colentina, Bucure\u015fti, Rom\u00e2nia<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”off|off|off” _builder_version=”4.19.5″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.19.5″ global_colors_info=”{}”]<\/p>\n
Anticorpii antinucleari \u00een bolile de \u021besut conjunctiv – c\u00e2nd avem nevoie \u0219i cum \u00eei interpretam?<\/span><\/p>\n Autor: Magda P\u00e2rvu<\/span><\/p>\nCuvinte cheie: anticorpi antinucleari, boli de \u021besut conjunctiv, fenotip specific, subtipuri de boal\u0103, activitate, severitate<\/p>\n
Bolile de \u021besut conjunctiv sunt adesea asociate cu o provocare diagnostic\u0103. Autoanticorpii pot fi detecta\u021bi \u00een cadrul acestor boli fiind utili \u00een stabilirea diagnosticului \u0219i prognosticului bolii. Adesea, fiecare anticorp este asociat cu un fenotip specific ajut\u00e2nd la o mai bun\u0103 definire a subtipurilor de boal\u0103, a activit\u0103\u021bii a consecin\u021belor bolii. Anticorpii antinucleari (AAN ) sunt anticorpi \u00eendrepta\u021bi \u00eempotriva antigenelor nucleare, detectarea lor prin imunofluorescen\u021b\u0103 indirecta permi\u021b\u00e2nd eviden\u021bierea a 29 de patternuri distincte astfel definite \u00een 2015 de c\u0103tre International Consensus on Antinuclear Antibody Pattern (ICAP). Astfel ICAP prezint\u0103 relevan\u021ba clinic\u0103 a celor 29 de modele distincte definit\u0103 \u00een contextul bolii suspectate incluz\u00e2nd \u0219i recomand\u0103ri pentru testarea ulterioar\u0103. Aceasta reprezint\u0103 perspectiva general\u0103 asupra AAN. Perspectiva specific\u0103 se concentreaz\u0103 asupra impactului clinic al autoanticorpilor prin asocierea lor cu un fenotip specific din cadrul bolii ajut\u00e2nd la o mai bun\u0103 definire a subtipurilor, activit\u0103\u021bii \u0219i consecin\u021belor\/complica\u021biilor bolii. Astfel sunt prezenta\u021bi anticorpii cei mai specifici din LES, sclerodermie, dermatopolimiozita, cu prevalenta, sensibilitatea, specificitatea \u0219i caracteristicile lor clinice. Sunt descrise corela\u021biile dintre subtipurile de lupus cutanat \u0219i tipul autoanticorpilor iar pentru morfee impactul pozitivit\u0103\u021bii AAN \u0219i a diferitelor subtipuri asupra severit\u0103\u021bii, profunzimii leziunilor \u0219i asocierii cu manifest\u0103rile extracutanate. Astfel detectarea AAN poate deveni un instrument util \u00een managementul pe termen lung al pacien\u021bilor.<\/p>\n
Antinuclear antibodies in connective tissue diseases – when we need them and how do we interpret them?<\/span><\/p>\nAuthor: Magda P\u00e2rvu<\/span><\/p>\nKeywords: antinuclear antibodies, connective tissue diseases, specific phenotype, disease subtypes, activity, severity<\/p>\n
Connective tissue diseases are often associated with a diagnostic challenge. Autoantibodies can be detected within these diseases. Often, each antibody is associated with a specific phenotype helping to better define the subtypes of the disease, the activity and the consequences of the disease. Antinuclear antibodies (AAN ) are antibodies directed against nuclear antigens, their detection by indirect immunofluorescence allowing the highlighting of 29 distinct patterns thus defined in 2015 by the International Consensus on Antinuclear Antibody Pattern (ICAP). Thus ICAP presents the clinical relevance of the 29 distinct models defined in the context of the suspected disease including recommendations for further testing. This is the general perspective on AAN. The specific perspective focuses on the clinical impact of autoantibodies by associating them with a specific phenotype within the disease helping to better define the subtypes, activity and consequences\/complications of the disease. Thus are presented the most specific antibodies from SLE, scleroderma, dermatopolymyositis, with their prevalence, sensitivity, specificity and clinical characteristics. We describe also the correlations between the cutaneous lupus subtypes and the type of autoantibodies and for the morphea the impact of AAN positivity on the severity, depth of lesions and association with extracutaneous manifestations. Thus, the detection of AAN can become a useful tool in the long-term management of patients.<\/p>\n
Scurt CV<\/span><\/p>\n\u2022\tAbsolventa a Facultatii de Medicina Generala si Farmacie \u201cCarol Davila\u201d Bucuresti
\n\u2022\tMedic primar in specialitatea medicina interna si reumatologie
\n\u2022\t Doctor in stiinte medicale
\n\u2022\tSef sectie reumatologie Spitalul clinic \u201cColentina\u201d, Bucuresti
\n\u2022\tStagiu postgradual in specialitatea Reumatologie in Belgia in \u201cService de Rhumatologie des Cliniques Universitaires Saint \u2013Luc\u201d, Bruxelles (prof. F. Houssiau) si \u201cCliniques Universitaires U.C.L de Mont-Godinne\u201d, Yvoir, (Prof. W. Esselincks) 2000
\n\u2022\tCompetenta internationala in Capilaroscopie obtinuta sub egida \u201cEuropean League Against Rheumatism\u201d (EULAR), Genova, Italia, 2004, 2011
\n\u2022\tAbsolventa a cursurilor internationale de ecografie musculoscheletala, 2005, 2007.
\n\u2022\tCompetenta internationala in \u201cDensitometrie Clinica\u201d (CCD \u2013 \u201cCertified Clinical Densitometrist\u201d) acordata de catre Societatea Internationala de Densitometrie Clinica (ISCD), SUA, 2006, 2012
\n\u2022\tCompetenta (certificare) in \u201cDensitometrie\u201d acordata de catre \u201cFundatia Internationala de Osteoporoza\u201d (\u201cInternational Osteoporosis Foundation\u201d), 2007
\n\u2022\tAbsolventa a cursului de \u201cEpidemiologie clinic\u0103\u201d efectuat in cadrul RECIF (R\u00e9seau d`\u00c9pid\u00e9miologie Clinique International), Bucure\u015fti, sub conducerea Prof. Dr. Pierre Duhaut, H\u00f4pital Edouard Herriot, Lyon, 2001
\n\u2022\tAbsolventa a cursului international de imagistica in reumatologie sub egida EULAR, organizat de \u201cRheumatology Unit of the Vall D`Hebron Hospital\u201d, Sitges, Spania, 2007
\n\u2022\tCertificare internationala in evaluarea scorurilor cutanate din sclerodermie conform criteriilor de competenta EUSTAR, 2008
\n\u2022\tMembra a Societatii Romane de Reumatologie din 2000, a Ligii Romane Contra Reumatismului si a Societatii Internationale de Densitometrie Clinica \u2013 ISCD (2007)
\n\u2022\tMembra in Comisia Europeana de Reumatologie a UEMS ( European Union of Medical Specialists) (2011 \u2013 2014)
\n\u2022\tMembra in comitetul stiintific al Societatii Romane de Reumatologie (2007 \u2013 2018)
\n\u2022\tMembra in Consiliul editorial al \u2018\u2019 Romanian Journal of Internal Medicine\u2019\u2019 (Revista romana de medicina interna) aflata sub patronajul Academiei Romane si a Academiei de Stiinte Medicale
\n\u2022\tMembra in Comisia de specialitate (consultativa) de reumatologie a Ministerului Sanatatii (2008 \u2013 2010)
\n\u2022\tMembra in Comisia de Experti de la nivelul Casei Nationale de Asigurari de Sanatate pentru tratamentul cu imunosupresoare in poliartrita reumatoida, artropatia psoriazica, spondilita anchilozanta si artrita juvenila (2009 \u2013 2016)
\n\u2022\tMembra a comisiei nationale de Bioetica (2015 \u2013 2016)
\n\u2022\tSecretar al Societatii Romane de Reumatologie (2011 \u2013 2016)
\n\u2022\tTrezorier al Societatii Romane de reumatologie (2016 – 2018)
\n\u2022\tSecretar general al Societatii Romane de Reumatologie (2018 -2021)
\n\u2022\tPresedinta Comisiei Stiintifice a Societatii Romane de Reumatologie (2018 pana in prezent)
\n\u2022\tMembra a grupului international \u201cEULAR Study Group on Microcirculation in Rheumatic Diseases\u201d (2014 pana in prezent)
\n\u2022\tCoordonator la nivelul spitalului clinic \u201cColentina\u201d a Programului national de tratament pentru boli rare respectiv \u201cTratamentul bolnavilor cu scleroza sistemica si ulcere digitale evolutive\u201d (2014 pana in prezent)
\n\u2022\tMembra a Comitetului stiintific al Registrului Roman de Boli Reumatice (RRBR) (2013 pana in prezent)
\n\u2022\tPriminvestigator in mai multe studii clinice internationale in specialitatea reumatologie.
\n\u2022\tResponsabil de proiecte (2) in cadrul programului PN2 (parteneriate in domeniile prioritare).
\n\u2022\tNumeroase lucrari publicate, comunicate oral sau poster la congrese nationale si internationale de reumatologie si medicina interna\n<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2023<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro\/2019″ submit_button_text=”Trimite mesajul” _builder_version=”4.16″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n
Operatorul PDI 2023<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” global_colors_info=”{}”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Dr. P\u00e2rvu MagdaSpitalul Clinic Colentina, Bucure\u015fti, Rom\u00e2niaAnticorpii antinucleari \u00een bolile de \u021besut conjunctiv – c\u00e2nd avem nevoie \u0219i cum \u00eei interpretam? Autor: Magda P\u00e2rvu Cuvinte cheie: anticorpi antinucleari, boli de \u021besut conjunctiv, fenotip specific, subtipuri de boal\u0103, activitate, severitate Bolile de \u021besut conjunctiv sunt adesea asociate cu o provocare diagnostic\u0103. Autoanticorpii pot fi detecta\u021bi \u00een […]<\/p>\n","protected":false},"author":2,"featured_media":12682,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-12357","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=12357"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12357\/revisions"}],"predecessor-version":[{"id":12685,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12357\/revisions\/12685"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/12682"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=12357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=12357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=12357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Magda P\u00e2rvu<\/span><\/p>\n Cuvinte cheie: anticorpi antinucleari, boli de \u021besut conjunctiv, fenotip specific, subtipuri de boal\u0103, activitate, severitate<\/p>\n Bolile de \u021besut conjunctiv sunt adesea asociate cu o provocare diagnostic\u0103. Autoanticorpii pot fi detecta\u021bi \u00een cadrul acestor boli fiind utili \u00een stabilirea diagnosticului \u0219i prognosticului bolii. Adesea, fiecare anticorp este asociat cu un fenotip specific ajut\u00e2nd la o mai bun\u0103 definire a subtipurilor de boal\u0103, a activit\u0103\u021bii a consecin\u021belor bolii. Anticorpii antinucleari (AAN ) sunt anticorpi \u00eendrepta\u021bi \u00eempotriva antigenelor nucleare, detectarea lor prin imunofluorescen\u021b\u0103 indirecta permi\u021b\u00e2nd eviden\u021bierea a 29 de patternuri distincte astfel definite \u00een 2015 de c\u0103tre International Consensus on Antinuclear Antibody Pattern (ICAP). Astfel ICAP prezint\u0103 relevan\u021ba clinic\u0103 a celor 29 de modele distincte definit\u0103 \u00een contextul bolii suspectate incluz\u00e2nd \u0219i recomand\u0103ri pentru testarea ulterioar\u0103. Aceasta reprezint\u0103 perspectiva general\u0103 asupra AAN. Perspectiva specific\u0103 se concentreaz\u0103 asupra impactului clinic al autoanticorpilor prin asocierea lor cu un fenotip specific din cadrul bolii ajut\u00e2nd la o mai bun\u0103 definire a subtipurilor, activit\u0103\u021bii \u0219i consecin\u021belor\/complica\u021biilor bolii. Astfel sunt prezenta\u021bi anticorpii cei mai specifici din LES, sclerodermie, dermatopolimiozita, cu prevalenta, sensibilitatea, specificitatea \u0219i caracteristicile lor clinice. Sunt descrise corela\u021biile dintre subtipurile de lupus cutanat \u0219i tipul autoanticorpilor iar pentru morfee impactul pozitivit\u0103\u021bii AAN \u0219i a diferitelor subtipuri asupra severit\u0103\u021bii, profunzimii leziunilor \u0219i asocierii cu manifest\u0103rile extracutanate. Astfel detectarea AAN poate deveni un instrument util \u00een managementul pe termen lung al pacien\u021bilor.<\/p>\n Antinuclear antibodies in connective tissue diseases – when we need them and how do we interpret them?<\/span><\/p>\n Author: Magda P\u00e2rvu<\/span><\/p>\n Keywords: antinuclear antibodies, connective tissue diseases, specific phenotype, disease subtypes, activity, severity<\/p>\n Connective tissue diseases are often associated with a diagnostic challenge. Autoantibodies can be detected within these diseases. Often, each antibody is associated with a specific phenotype helping to better define the subtypes of the disease, the activity and the consequences of the disease. Antinuclear antibodies (AAN ) are antibodies directed against nuclear antigens, their detection by indirect immunofluorescence allowing the highlighting of 29 distinct patterns thus defined in 2015 by the International Consensus on Antinuclear Antibody Pattern (ICAP). Thus ICAP presents the clinical relevance of the 29 distinct models defined in the context of the suspected disease including recommendations for further testing. This is the general perspective on AAN. The specific perspective focuses on the clinical impact of autoantibodies by associating them with a specific phenotype within the disease helping to better define the subtypes, activity and consequences\/complications of the disease. Thus are presented the most specific antibodies from SLE, scleroderma, dermatopolymyositis, with their prevalence, sensitivity, specificity and clinical characteristics. We describe also the correlations between the cutaneous lupus subtypes and the type of autoantibodies and for the morphea the impact of AAN positivity on the severity, depth of lesions and association with extracutaneous manifestations. Thus, the detection of AAN can become a useful tool in the long-term management of patients.<\/p>\n Scurt CV<\/span><\/p>\n \u2022\tAbsolventa a Facultatii de Medicina Generala si Farmacie \u201cCarol Davila\u201d Bucuresti [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” 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A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_slider disabled_on=”on|on|on” _builder_version=”4.19.4″ _module_preset=”default” position_origin_r=”bottom_left” width=”200px” max_width=”200px” content_width=”200px” content_max_width=”200px” min_height=”100px” height=”100px” max_height=”100px” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” auto=”on” auto_speed=”3000″ disabled=”on” global_colors_info=”{}”][et_pb_slide _builder_version=”4.17.3″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2022\/05\/ziaruldeiasi_.jpg” background_enable_image=”on” background_size=”initial” custom_padding=”0px||0px||false|false” link_option_url=”https:\/\/www.ziaruldeiasi.ro\/” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][et_pb_slide _builder_version=”4.17.3″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2022\/05\/timpul_.jpg” background_enable_image=”on” background_size=”initial” custom_padding=”0px||0px||false|false” link_option_url=”#” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][et_pb_slide _builder_version=”4.17.3″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2022\/05\/medical-market_.jpg” background_enable_image=”on” background_size=”initial” custom_padding=”0px||0px||false|false” link_option_url=”https:\/\/issuu.com\/finwatch\/docs\/dermato?fr=sYWIzMjQ1MDUxNTY” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][et_pb_slide _builder_version=”4.17.3″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2022\/05\/agerpress_.jpg” background_enable_image=”on” background_size=”initial” custom_padding=”0px||0px||false|false” link_option_url=”https:\/\/www.agerpres.ro\/” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Dr. P\u00e2rvu MagdaSpitalul Clinic Colentina, Bucure\u015fti, Rom\u00e2niaAnticorpii antinucleari \u00een bolile de \u021besut conjunctiv – c\u00e2nd avem nevoie \u0219i cum \u00eei interpretam? Autor: Magda P\u00e2rvu Cuvinte cheie: anticorpi antinucleari, boli de \u021besut conjunctiv, fenotip specific, subtipuri de boal\u0103, activitate, severitate Bolile de \u021besut conjunctiv sunt adesea asociate cu o provocare diagnostic\u0103. Autoanticorpii pot fi detecta\u021bi \u00een […]<\/p>\n","protected":false},"author":2,"featured_media":12682,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-12357","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=12357"}],"version-history":[{"count":7,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12357\/revisions"}],"predecessor-version":[{"id":12685,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12357\/revisions\/12685"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/12682"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=12357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=12357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=12357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n\u2022\tMedic primar in specialitatea medicina interna si reumatologie
\n\u2022\t Doctor in stiinte medicale
\n\u2022\tSef sectie reumatologie Spitalul clinic \u201cColentina\u201d, Bucuresti
\n\u2022\tStagiu postgradual in specialitatea Reumatologie in Belgia in \u201cService de Rhumatologie des Cliniques Universitaires Saint \u2013Luc\u201d, Bruxelles (prof. F. Houssiau) si \u201cCliniques Universitaires U.C.L de Mont-Godinne\u201d, Yvoir, (Prof. W. Esselincks) 2000
\n\u2022\tCompetenta internationala in Capilaroscopie obtinuta sub egida \u201cEuropean League Against Rheumatism\u201d (EULAR), Genova, Italia, 2004, 2011
\n\u2022\tAbsolventa a cursurilor internationale de ecografie musculoscheletala, 2005, 2007.
\n\u2022\tCompetenta internationala in \u201cDensitometrie Clinica\u201d (CCD \u2013 \u201cCertified Clinical Densitometrist\u201d) acordata de catre Societatea Internationala de Densitometrie Clinica (ISCD), SUA, 2006, 2012
\n\u2022\tCompetenta (certificare) in \u201cDensitometrie\u201d acordata de catre \u201cFundatia Internationala de Osteoporoza\u201d (\u201cInternational Osteoporosis Foundation\u201d), 2007
\n\u2022\tAbsolventa a cursului de \u201cEpidemiologie clinic\u0103\u201d efectuat in cadrul RECIF (R\u00e9seau d`\u00c9pid\u00e9miologie Clinique International), Bucure\u015fti, sub conducerea Prof. Dr. Pierre Duhaut, H\u00f4pital Edouard Herriot, Lyon, 2001
\n\u2022\tAbsolventa a cursului international de imagistica in reumatologie sub egida EULAR, organizat de \u201cRheumatology Unit of the Vall D`Hebron Hospital\u201d, Sitges, Spania, 2007
\n\u2022\tCertificare internationala in evaluarea scorurilor cutanate din sclerodermie conform criteriilor de competenta EUSTAR, 2008
\n\u2022\tMembra a Societatii Romane de Reumatologie din 2000, a Ligii Romane Contra Reumatismului si a Societatii Internationale de Densitometrie Clinica \u2013 ISCD (2007)
\n\u2022\tMembra in Comisia Europeana de Reumatologie a UEMS ( European Union of Medical Specialists) (2011 \u2013 2014)
\n\u2022\tMembra in comitetul stiintific al Societatii Romane de Reumatologie (2007 \u2013 2018)
\n\u2022\tMembra in Consiliul editorial al \u2018\u2019 Romanian Journal of Internal Medicine\u2019\u2019 (Revista romana de medicina interna) aflata sub patronajul Academiei Romane si a Academiei de Stiinte Medicale
\n\u2022\tMembra in Comisia de specialitate (consultativa) de reumatologie a Ministerului Sanatatii (2008 \u2013 2010)
\n\u2022\tMembra in Comisia de Experti de la nivelul Casei Nationale de Asigurari de Sanatate pentru tratamentul cu imunosupresoare in poliartrita reumatoida, artropatia psoriazica, spondilita anchilozanta si artrita juvenila (2009 \u2013 2016)
\n\u2022\tMembra a comisiei nationale de Bioetica (2015 \u2013 2016)
\n\u2022\tSecretar al Societatii Romane de Reumatologie (2011 \u2013 2016)
\n\u2022\tTrezorier al Societatii Romane de reumatologie (2016 – 2018)
\n\u2022\tSecretar general al Societatii Romane de Reumatologie (2018 -2021)
\n\u2022\tPresedinta Comisiei Stiintifice a Societatii Romane de Reumatologie (2018 pana in prezent)
\n\u2022\tMembra a grupului international \u201cEULAR Study Group on Microcirculation in Rheumatic Diseases\u201d (2014 pana in prezent)
\n\u2022\tCoordonator la nivelul spitalului clinic \u201cColentina\u201d a Programului national de tratament pentru boli rare respectiv \u201cTratamentul bolnavilor cu scleroza sistemica si ulcere digitale evolutive\u201d (2014 pana in prezent)
\n\u2022\tMembra a Comitetului stiintific al Registrului Roman de Boli Reumatice (RRBR) (2013 pana in prezent)
\n\u2022\tPriminvestigator in mai multe studii clinice internationale in specialitatea reumatologie.
\n\u2022\tResponsabil de proiecte (2) in cadrul programului PN2 (parteneriate in domeniile prioritare).
\n\u2022\tNumeroase lucrari publicate, comunicate oral sau poster la congrese nationale si internationale de reumatologie si medicina interna\n<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n