<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nConf. Univ. Dr. \u0218enil\u0103 Simona Corina<\/strong><\/span>
\nUniversitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj Napoca, Rom\u00e2nia
\nSpitalul Clinic Jude\u021bean de Urgen\u021b\u0103 Cluj-Napoca, Rom\u00e2nia<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”off|off|off” _builder_version=”4.19.5″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.2″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Rolul \u021besutului adipos \u00een dermatita atopic\u0103 \u0219i psoriazis. Observa\u021bii clinice din experien\u021ba personal\u0103<\/span><\/p>\n Autor: Simona \u0218enil\u0103<\/span><\/p>\nCuvinte cheie: adipocitokine, inflama\u021bie, dermatita atopic\u0103, psoriasis<\/p>\n
\u00cencep\u00e2nd cu anul 1975, \u00een \u00eentreaga lume obezitatea s-a triplat, astfel c\u0103 40% respectiv 13% dintre adul\u021bi sunt fie supraponderali fie obezi iar unul din cinci copii \u0219i adolescen\u021bi se confrunt\u0103 cu o greutate mai mare la nivel global. O acumulare excesiv\u0103 de \u021besut gras conduce la apari\u021bia unui nivel sc\u0103zut dar cronic de inflama\u021bie care interfer\u0103 cu men\u021binerea unui status optimal al s\u0103n\u0103t\u0103\u021bii. At\u00e2t psoriazisul c\u00e2t \u0219i dermatita atopic\u0103, dou\u0103 afec\u021biuni inflamatorii cronice recurente cutanate sunt asociate frecvent cu obezitatea. Tegumentul este afectat \u00een cadrul acesteia printr-un complex de factori care includ adipocitokinele, acizii gra\u0219i, hormoni \u0219i factori mecanici. \u00cen psoriasis, distensia pielii cu apari\u021bia de vergeturi datorit\u0103 \u021besutului gras \u00een exces, ar putea explica apari\u021bia pl\u0103cilor la acest nivel, fiind interpretat\u0103 ca un fenomen Koebner. \u00cen dermatita atopic\u0103, prezen\u021ba \u00een exces a gr\u0103simii subcutanate influen\u021beaz\u0103, prin alterarea barierei cutanate la nivel epidermic, pierderea transepidermal\u0103 de ap\u0103 constatat\u0103 mai frecvent la copiii obezi comparativ cu cei cu greutate normal\u0103, permi\u021b\u00e2nd astfel penetrarea mai u\u0219oar\u0103 a alergenilor prin bariera compromis\u0103 \u0219i apari\u021bia r\u0103spunsului imun. \u00cen acest context, vor fi discutate observa\u021bii clinice comparative din experien\u021ba personal\u0103 la pacien\u021bi cu psoriasis \u0219i dermatit\u0103 atopic\u0103.<\/p>\n
The role of adipose tissue in atopic dermatitis and psoriasis. Clinical observations from personal experience<\/span><\/p>\nAuthor: Simona \u0218enil\u0103<\/span><\/p>\nKeywords: adipocytokines, inflammation, atopic dermatitis, psoriasis<\/p>\n
Worldwide obesity has tripled since 1975, and currently, 40% and 13% of adults in the world are overweight and obese, respectively, and one in five children and adolescents are overweight globally. An abnormal accumulation of excessive body fat that leads to a chronic low-level inflammatory state of the body interferes with the maintenance of an optimal state of heath. Both PSO and atopic dermatitis (AD), two major chronic and recurrent inflammatory skin diseases, are closely associated with obesity. Skin is affected in obesity through a complex interaction of adipocytokines, hormones, fatty acids, and mechanical factors. Plaque PSO can develop along the striae distensae, suggesting that striae may be a potential precipitating factor for the Koebner phenomenon in PSO.
Excessive skin fat tissue expansion may impair the barrier function of the skin epidermis; skin transepidermal water loss (TEWL) values are significantly higher in children who are obese than in normal-weight children. Obesity may aggravate the severity of AD by impairing the barrier integrity and therefore allowing allergen entry, promoting an allergic response that leads to AD. In this context, comparative clinical observations from personal experience in patients with psoriasis and atopic dermatitis will be discussed.<\/p>\n
Scurt CV<\/span><\/p>\n\u00cen practica medical\u0103 zilnic\u0103, at\u00e2t \u00een serviciul public Clinica Dermatologie Cluj-Napoca c\u00e2t \u0219i \u00een cel privat de s\u0103natate (Centrul Medical Medstar Cluj-Napoca \u0219i Centrul Medical Estetderm Bistri\u021ba), desf\u0103\u0219oar\u0103 o activitate clinic\u0103 sus\u021binut\u0103 \u00een domeniul dermatologiei oncologice care reprezint\u0103 o parte semnificativ\u0103 din activitatea mea curent\u0103: examinarea clinic\u0103 \u0219i dermatoscopic\u0103 a leziunilor pigmentare cutaneo-mucoase, stabilirea caracterului benign\/malign al leziunilor, supravegherea dermatoscopic\u0103 a nevilor atipici, tratamentul chirurgical al leziunilor suspecte clinic si dermatoscopic, precum \u0219i urm\u0103rirea pacien\u021bilor diagnostica\u021bi \u0219i trata\u021bi de melanom (peste 250 de pacien\u021bi) \u00een cadrul echipei multidisciplinare de melanom constituit\u0103 \u00een cadrul Spitalului Clinic Jude\u021bean de Urgen\u021b\u0103 Cluj-Napoca. \u00cen ultimii 15 ani ca medic dermatolog cu integrare clinic\u0103, am efectuat peste 1800 de excizii chirurgicale pentru leziuni tumorale benigne sau maligne cutaneo-mucoase, cu interes deosebit pentru tehnicile chirurgicale mai noi (chirurgie micrografica Mohs). Asociat acestei preocup\u0103ri, sunt pasionat\u0103 de patologia cutanat\u0103 inflamatorie (psoriazis, dermatita atopica, colagenoze, etc) precum \u0219i de afec\u021biuni cutanate mai rare-patologie pilara (adul\u021bi \u0219i copii \u00een special pentru alopecia area\u021b\u0103, care a fost tema tezei de doctorat), patologie unghiala \u0219i genodermatoze. Activitatea de cercetare s-a materializat prin publicarea a 37 de articole indexate (\u00een calitate de autor\/co-autor), capitole de carte (contribu\u021bie la realizarea primului tratat de dermato-oncologie din Rom\u00e2nia), colaborari cu echipe de cercetare din \u021bar\u0103 \u0219i str\u0103in\u0103tate; membru \u00een 4 proiecte de cercetare na\u021bionale \u0219i 1 proiect interna\u021bional (Together against genodermatosis TAG). Colaborez cu medici neonatologi \u0219i pediatri pentru diagnosticul \u0219i managementul afec\u021biunilor cutanate la nou-n\u0103scut \u0219i copil. Am participat ca sub-investigator \/investigator \u00een 9 trialuri clinice \u0219i de-a lungul anilor am contribuit la formarea a peste 100 de medici reziden\u021bi \u00een dermatologie. Sunt membru \u00een societ\u0103\u021bi profesionale interna\u021bionale (Academia European\u0103 de Dermatologie \u0219i Venerologie EADV, Societatea European\u0103 de Cercetare a P\u0103rului ESHR, Societatea Interna\u021bional\u0103 de Dermatoscopie IDS) \u0219i na\u021bionale (Societatea Rom\u00e2n\u0103 de Dermato-oncologie SRDO-membru fondator \u0219i secretar, Societatea Rom\u00e2na de Dermatologie SRD \u0219i Asocia\u021bia Dermatologilor Transilvani ADT).<\/p>\n
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Contacteaz\u0103 operatorul PDI 2023<\/p>\n
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Operatorul PDI 2023<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
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Parteneri Media<\/p>\n
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Conf. Univ. Dr. \u0218enil\u0103 Simona Corina Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj Napoca, Rom\u00e2nia Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 Cluj-Napoca, Rom\u00e2niaRolul \u021besutului adipos \u00een dermatita atopic\u0103 \u0219i psoriazis. Observa\u021bii clinice din experien\u021ba personal\u0103 Autor: Simona \u0218enil\u0103 Cuvinte cheie: adipocitokine, inflama\u021bie, dermatita atopic\u0103, psoriasis \u00cencep\u00e2nd cu anul 1975, \u00een \u00eentreaga lume obezitatea s-a triplat, […]<\/p>\n","protected":false},"author":2,"featured_media":12669,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-12405","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12405","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=12405"}],"version-history":[{"count":9,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12405\/revisions"}],"predecessor-version":[{"id":12947,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12405\/revisions\/12947"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/12669"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=12405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=12405"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=12405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Conf. Univ. Dr. \u0218enil\u0103 Simona Corina<\/strong><\/span>
\nUniversitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj Napoca, Rom\u00e2nia
\nSpitalul Clinic Jude\u021bean de Urgen\u021b\u0103 Cluj-Napoca, Rom\u00e2nia<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”off|off|off” _builder_version=”4.19.5″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.2″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Rolul \u021besutului adipos \u00een dermatita atopic\u0103 \u0219i psoriazis. Observa\u021bii clinice din experien\u021ba personal\u0103<\/span><\/p>\n Autor: Simona \u0218enil\u0103<\/span><\/p>\nCuvinte cheie: adipocitokine, inflama\u021bie, dermatita atopic\u0103, psoriasis<\/p>\n
\u00cencep\u00e2nd cu anul 1975, \u00een \u00eentreaga lume obezitatea s-a triplat, astfel c\u0103 40% respectiv 13% dintre adul\u021bi sunt fie supraponderali fie obezi iar unul din cinci copii \u0219i adolescen\u021bi se confrunt\u0103 cu o greutate mai mare la nivel global. O acumulare excesiv\u0103 de \u021besut gras conduce la apari\u021bia unui nivel sc\u0103zut dar cronic de inflama\u021bie care interfer\u0103 cu men\u021binerea unui status optimal al s\u0103n\u0103t\u0103\u021bii. At\u00e2t psoriazisul c\u00e2t \u0219i dermatita atopic\u0103, dou\u0103 afec\u021biuni inflamatorii cronice recurente cutanate sunt asociate frecvent cu obezitatea. Tegumentul este afectat \u00een cadrul acesteia printr-un complex de factori care includ adipocitokinele, acizii gra\u0219i, hormoni \u0219i factori mecanici. \u00cen psoriasis, distensia pielii cu apari\u021bia de vergeturi datorit\u0103 \u021besutului gras \u00een exces, ar putea explica apari\u021bia pl\u0103cilor la acest nivel, fiind interpretat\u0103 ca un fenomen Koebner. \u00cen dermatita atopic\u0103, prezen\u021ba \u00een exces a gr\u0103simii subcutanate influen\u021beaz\u0103, prin alterarea barierei cutanate la nivel epidermic, pierderea transepidermal\u0103 de ap\u0103 constatat\u0103 mai frecvent la copiii obezi comparativ cu cei cu greutate normal\u0103, permi\u021b\u00e2nd astfel penetrarea mai u\u0219oar\u0103 a alergenilor prin bariera compromis\u0103 \u0219i apari\u021bia r\u0103spunsului imun. \u00cen acest context, vor fi discutate observa\u021bii clinice comparative din experien\u021ba personal\u0103 la pacien\u021bi cu psoriasis \u0219i dermatit\u0103 atopic\u0103.<\/p>\n
The role of adipose tissue in atopic dermatitis and psoriasis. Clinical observations from personal experience<\/span><\/p>\nAuthor: Simona \u0218enil\u0103<\/span><\/p>\nKeywords: adipocytokines, inflammation, atopic dermatitis, psoriasis<\/p>\n
Worldwide obesity has tripled since 1975, and currently, 40% and 13% of adults in the world are overweight and obese, respectively, and one in five children and adolescents are overweight globally. An abnormal accumulation of excessive body fat that leads to a chronic low-level inflammatory state of the body interferes with the maintenance of an optimal state of heath. Both PSO and atopic dermatitis (AD), two major chronic and recurrent inflammatory skin diseases, are closely associated with obesity. Skin is affected in obesity through a complex interaction of adipocytokines, hormones, fatty acids, and mechanical factors. Plaque PSO can develop along the striae distensae, suggesting that striae may be a potential precipitating factor for the Koebner phenomenon in PSO.
Excessive skin fat tissue expansion may impair the barrier function of the skin epidermis; skin transepidermal water loss (TEWL) values are significantly higher in children who are obese than in normal-weight children. Obesity may aggravate the severity of AD by impairing the barrier integrity and therefore allowing allergen entry, promoting an allergic response that leads to AD. In this context, comparative clinical observations from personal experience in patients with psoriasis and atopic dermatitis will be discussed.<\/p>\n
Scurt CV<\/span><\/p>\n\u00cen practica medical\u0103 zilnic\u0103, at\u00e2t \u00een serviciul public Clinica Dermatologie Cluj-Napoca c\u00e2t \u0219i \u00een cel privat de s\u0103natate (Centrul Medical Medstar Cluj-Napoca \u0219i Centrul Medical Estetderm Bistri\u021ba), desf\u0103\u0219oar\u0103 o activitate clinic\u0103 sus\u021binut\u0103 \u00een domeniul dermatologiei oncologice care reprezint\u0103 o parte semnificativ\u0103 din activitatea mea curent\u0103: examinarea clinic\u0103 \u0219i dermatoscopic\u0103 a leziunilor pigmentare cutaneo-mucoase, stabilirea caracterului benign\/malign al leziunilor, supravegherea dermatoscopic\u0103 a nevilor atipici, tratamentul chirurgical al leziunilor suspecte clinic si dermatoscopic, precum \u0219i urm\u0103rirea pacien\u021bilor diagnostica\u021bi \u0219i trata\u021bi de melanom (peste 250 de pacien\u021bi) \u00een cadrul echipei multidisciplinare de melanom constituit\u0103 \u00een cadrul Spitalului Clinic Jude\u021bean de Urgen\u021b\u0103 Cluj-Napoca. \u00cen ultimii 15 ani ca medic dermatolog cu integrare clinic\u0103, am efectuat peste 1800 de excizii chirurgicale pentru leziuni tumorale benigne sau maligne cutaneo-mucoase, cu interes deosebit pentru tehnicile chirurgicale mai noi (chirurgie micrografica Mohs). Asociat acestei preocup\u0103ri, sunt pasionat\u0103 de patologia cutanat\u0103 inflamatorie (psoriazis, dermatita atopica, colagenoze, etc) precum \u0219i de afec\u021biuni cutanate mai rare-patologie pilara (adul\u021bi \u0219i copii \u00een special pentru alopecia area\u021b\u0103, care a fost tema tezei de doctorat), patologie unghiala \u0219i genodermatoze. Activitatea de cercetare s-a materializat prin publicarea a 37 de articole indexate (\u00een calitate de autor\/co-autor), capitole de carte (contribu\u021bie la realizarea primului tratat de dermato-oncologie din Rom\u00e2nia), colaborari cu echipe de cercetare din \u021bar\u0103 \u0219i str\u0103in\u0103tate; membru \u00een 4 proiecte de cercetare na\u021bionale \u0219i 1 proiect interna\u021bional (Together against genodermatosis TAG). Colaborez cu medici neonatologi \u0219i pediatri pentru diagnosticul \u0219i managementul afec\u021biunilor cutanate la nou-n\u0103scut \u0219i copil. Am participat ca sub-investigator \/investigator \u00een 9 trialuri clinice \u0219i de-a lungul anilor am contribuit la formarea a peste 100 de medici reziden\u021bi \u00een dermatologie. Sunt membru \u00een societ\u0103\u021bi profesionale interna\u021bionale (Academia European\u0103 de Dermatologie \u0219i Venerologie EADV, Societatea European\u0103 de Cercetare a P\u0103rului ESHR, Societatea Interna\u021bional\u0103 de Dermatoscopie IDS) \u0219i na\u021bionale (Societatea Rom\u00e2n\u0103 de Dermato-oncologie SRDO-membru fondator \u0219i secretar, Societatea Rom\u00e2na de Dermatologie SRD \u0219i Asocia\u021bia Dermatologilor Transilvani ADT).<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
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Conf. Univ. Dr. \u0218enil\u0103 Simona Corina Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj Napoca, Rom\u00e2nia Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 Cluj-Napoca, Rom\u00e2niaRolul \u021besutului adipos \u00een dermatita atopic\u0103 \u0219i psoriazis. Observa\u021bii clinice din experien\u021ba personal\u0103 Autor: Simona \u0218enil\u0103 Cuvinte cheie: adipocitokine, inflama\u021bie, dermatita atopic\u0103, psoriasis \u00cencep\u00e2nd cu anul 1975, \u00een \u00eentreaga lume obezitatea s-a triplat, […]<\/p>\n","protected":false},"author":2,"featured_media":12669,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-12405","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12405","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=12405"}],"version-history":[{"count":9,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12405\/revisions"}],"predecessor-version":[{"id":12947,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12405\/revisions\/12947"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/12669"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=12405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=12405"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=12405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Simona \u0218enil\u0103<\/span><\/p>\n Cuvinte cheie: adipocitokine, inflama\u021bie, dermatita atopic\u0103, psoriasis<\/p>\n \u00cencep\u00e2nd cu anul 1975, \u00een \u00eentreaga lume obezitatea s-a triplat, astfel c\u0103 40% respectiv 13% dintre adul\u021bi sunt fie supraponderali fie obezi iar unul din cinci copii \u0219i adolescen\u021bi se confrunt\u0103 cu o greutate mai mare la nivel global. O acumulare excesiv\u0103 de \u021besut gras conduce la apari\u021bia unui nivel sc\u0103zut dar cronic de inflama\u021bie care interfer\u0103 cu men\u021binerea unui status optimal al s\u0103n\u0103t\u0103\u021bii. At\u00e2t psoriazisul c\u00e2t \u0219i dermatita atopic\u0103, dou\u0103 afec\u021biuni inflamatorii cronice recurente cutanate sunt asociate frecvent cu obezitatea. Tegumentul este afectat \u00een cadrul acesteia printr-un complex de factori care includ adipocitokinele, acizii gra\u0219i, hormoni \u0219i factori mecanici. \u00cen psoriasis, distensia pielii cu apari\u021bia de vergeturi datorit\u0103 \u021besutului gras \u00een exces, ar putea explica apari\u021bia pl\u0103cilor la acest nivel, fiind interpretat\u0103 ca un fenomen Koebner. \u00cen dermatita atopic\u0103, prezen\u021ba \u00een exces a gr\u0103simii subcutanate influen\u021beaz\u0103, prin alterarea barierei cutanate la nivel epidermic, pierderea transepidermal\u0103 de ap\u0103 constatat\u0103 mai frecvent la copiii obezi comparativ cu cei cu greutate normal\u0103, permi\u021b\u00e2nd astfel penetrarea mai u\u0219oar\u0103 a alergenilor prin bariera compromis\u0103 \u0219i apari\u021bia r\u0103spunsului imun. \u00cen acest context, vor fi discutate observa\u021bii clinice comparative din experien\u021ba personal\u0103 la pacien\u021bi cu psoriasis \u0219i dermatit\u0103 atopic\u0103.<\/p>\n The role of adipose tissue in atopic dermatitis and psoriasis. Clinical observations from personal experience<\/span><\/p>\n Author: Simona \u0218enil\u0103<\/span><\/p>\n Keywords: adipocytokines, inflammation, atopic dermatitis, psoriasis<\/p>\n Worldwide obesity has tripled since 1975, and currently, 40% and 13% of adults in the world are overweight and obese, respectively, and one in five children and adolescents are overweight globally. An abnormal accumulation of excessive body fat that leads to a chronic low-level inflammatory state of the body interferes with the maintenance of an optimal state of heath. Both PSO and atopic dermatitis (AD), two major chronic and recurrent inflammatory skin diseases, are closely associated with obesity. Skin is affected in obesity through a complex interaction of adipocytokines, hormones, fatty acids, and mechanical factors. Plaque PSO can develop along the striae distensae, suggesting that striae may be a potential precipitating factor for the Koebner phenomenon in PSO. Scurt CV<\/span><\/p>\n \u00cen practica medical\u0103 zilnic\u0103, at\u00e2t \u00een serviciul public Clinica Dermatologie Cluj-Napoca c\u00e2t \u0219i \u00een cel privat de s\u0103natate (Centrul Medical Medstar Cluj-Napoca \u0219i Centrul Medical Estetderm Bistri\u021ba), desf\u0103\u0219oar\u0103 o activitate clinic\u0103 sus\u021binut\u0103 \u00een domeniul dermatologiei oncologice care reprezint\u0103 o parte semnificativ\u0103 din activitatea mea curent\u0103: examinarea clinic\u0103 \u0219i dermatoscopic\u0103 a leziunilor pigmentare cutaneo-mucoase, stabilirea caracterului benign\/malign al leziunilor, supravegherea dermatoscopic\u0103 a nevilor atipici, tratamentul chirurgical al leziunilor suspecte clinic si dermatoscopic, precum \u0219i urm\u0103rirea pacien\u021bilor diagnostica\u021bi \u0219i trata\u021bi de melanom (peste 250 de pacien\u021bi) \u00een cadrul echipei multidisciplinare de melanom constituit\u0103 \u00een cadrul Spitalului Clinic Jude\u021bean de Urgen\u021b\u0103 Cluj-Napoca. \u00cen ultimii 15 ani ca medic dermatolog cu integrare clinic\u0103, am efectuat peste 1800 de excizii chirurgicale pentru leziuni tumorale benigne sau maligne cutaneo-mucoase, cu interes deosebit pentru tehnicile chirurgicale mai noi (chirurgie micrografica Mohs). Asociat acestei preocup\u0103ri, sunt pasionat\u0103 de patologia cutanat\u0103 inflamatorie (psoriazis, dermatita atopica, colagenoze, etc) precum \u0219i de afec\u021biuni cutanate mai rare-patologie pilara (adul\u021bi \u0219i copii \u00een special pentru alopecia area\u021b\u0103, care a fost tema tezei de doctorat), patologie unghiala \u0219i genodermatoze. Activitatea de cercetare s-a materializat prin publicarea a 37 de articole indexate (\u00een calitate de autor\/co-autor), capitole de carte (contribu\u021bie la realizarea primului tratat de dermato-oncologie din Rom\u00e2nia), colaborari cu echipe de cercetare din \u021bar\u0103 \u0219i str\u0103in\u0103tate; membru \u00een 4 proiecte de cercetare na\u021bionale \u0219i 1 proiect interna\u021bional (Together against genodermatosis TAG). Colaborez cu medici neonatologi \u0219i pediatri pentru diagnosticul \u0219i managementul afec\u021biunilor cutanate la nou-n\u0103scut \u0219i copil. Am participat ca sub-investigator \/investigator \u00een 9 trialuri clinice \u0219i de-a lungul anilor am contribuit la formarea a peste 100 de medici reziden\u021bi \u00een dermatologie. Sunt membru \u00een societ\u0103\u021bi profesionale interna\u021bionale (Academia European\u0103 de Dermatologie \u0219i Venerologie EADV, Societatea European\u0103 de Cercetare a P\u0103rului ESHR, Societatea Interna\u021bional\u0103 de Dermatoscopie IDS) \u0219i na\u021bionale (Societatea Rom\u00e2n\u0103 de Dermato-oncologie SRDO-membru fondator \u0219i secretar, Societatea Rom\u00e2na de Dermatologie SRD \u0219i Asocia\u021bia Dermatologilor Transilvani ADT).<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” 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Univ. Dr. \u0218enil\u0103 Simona Corina Universitatea de Medicin\u0103 \u0219i Farmacie “Iuliu Ha\u021bieganu”, Cluj Napoca, Rom\u00e2nia Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 Cluj-Napoca, Rom\u00e2niaRolul \u021besutului adipos \u00een dermatita atopic\u0103 \u0219i psoriazis. Observa\u021bii clinice din experien\u021ba personal\u0103 Autor: Simona \u0218enil\u0103 Cuvinte cheie: adipocitokine, inflama\u021bie, dermatita atopic\u0103, psoriasis \u00cencep\u00e2nd cu anul 1975, \u00een \u00eentreaga lume obezitatea s-a triplat, […]<\/p>\n","protected":false},"author":2,"featured_media":12669,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-12405","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12405","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=12405"}],"version-history":[{"count":9,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12405\/revisions"}],"predecessor-version":[{"id":12947,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/12405\/revisions\/12947"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/12669"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=12405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=12405"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=12405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Excessive skin fat tissue expansion may impair the barrier function of the skin epidermis; skin transepidermal water loss (TEWL) values are significantly higher in children who are obese than in normal-weight children. Obesity may aggravate the severity of AD by impairing the barrier integrity and therefore allowing allergen entry, promoting an allergic response that leads to AD. In this context, comparative clinical observations from personal experience in patients with psoriasis and atopic dermatitis will be discussed.<\/p>\n<\/span><\/p>\n
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