<\/strong><\/h4>\n<\/strong><\/h4>\nProf. Univ. Dr. Alecu Mihail<\/strong><\/span>
\n Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Dr. Victor Babe\u015f\u201d Bucure\u015fti<\/strong><\/span>
\n Universitatea “Titu Maiorescu” Facultatea de Medicin\u0103, Bucure\u015fti<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.4″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Autofagia \u00eentre necroz\u0103 \u0219i apoptoz\u0103<\/span>
\nAutori: M. Alecu1,2, Gabriela Coman2<\/span>
\n1Universitatea \u201dTitu Maiorescu\u201d, Facultatea de Medicin\u0103, Bucure\u0219ti, Rom\u00e2nia
\n2Bioderm Medical Center, Bucure\u0219ti, Rom\u00e2nia<\/p>\nAutofagia este un proces controlat genetic, de autodegradare a proteinelor \u0219i a organitelor celulare alterate, f\u0103r\u0103 s\u0103 se produc\u0103 moartea celulei. Produsele rezultate din degradare sunt apoi reutilizate pentru func\u021biile importante ale celulei. Autofagia apare \u00een condi\u021biile lipsei de nutrien\u021bi celulari, hipoxie, stres, infec\u021bii.
\nAutofagia presupune formarea unei vezicule cu membran\u0103 dubl\u0103 care \u00eenglobeaz\u0103 \u00een ea proteine cu diverse defecte, organite celulare, patogeni. Veziculele fuzioneaz\u0103 cu lizozomii care recicleaz\u0103 efectiv degradarea. Formarea veziculelor autofagice este un proces complex \u00een care intervin enzime \u0219i proteine ca: UCK1, BECLIN1, VPS34, mTOR, LC38, RUBICON.
\nAutofagia este considerat\u0103 un mecanism de supravie\u021buire celular\u0103 \u00een condi\u021bii deosebite. Exist\u0103 o balan\u021b\u0103 \u00eentre apoptoz\u0103 (care are ca rezultat moartea celular\u0103) \u0219i autofagie. Autofgia se opune poptozei dar autofagia excesiv\u0103 duce la apoptoz\u0103.
\nPrin autofagie sunt eliminate agregatele intracelulare degradate, promov\u00e2nd senescen\u021ba celular\u0103. Autofagia este asociat\u0103 cu procese fiziologice \u0219i patologice ca: diferen\u021bierea \u0219i dezvoltarea celular\u0103, imunitatea, infec\u021bia \u0219i proliferarea tumoral\u0103. \u00cen cazul prolifer\u0103rii tumorale autofagia este implicat\u0103 at\u00e2t \u00een promovarea prolifer\u0103rii tumorale c\u00e2t \u0219i \u00een inhibarea acestui proces. De asemenea autofagia este implicat\u0103 \u00een rezisten\u021ba la terapia antitumoral\u0103.
\nAlterarea mecanismelor autofagiei a fost asociat\u0103 cu numeroase afec\u021biuni cutanate cum ar fi: psoriazis, vitiligo, boli autoimune, procese inflamatorii \u0219i tumorale cutanate. Totodat\u0103, interven\u021bia asupra mecanismelor autofagice poate constitui o nou\u0103 direc\u021bie terapeutic\u0103 pentru aceste afec\u021biuni.\n<\/p>\n
Autophagy between necrosis and apoptosis<\/span>
\nAuthors: M. Alecu1,2, Gabriela Coman2<\/span>
\n1\u201dTitu Maiorescu\u201d University, Bucharest, Romania
\n2Bioderm Medical Center, Bucharest, Romania<\/p>\nAutophagy is a genetically controlled process of self-degradation of altered cellular proteins and organelles without causing cell death. The resulting degradation products are then reused for important cell functions. Autophagy occurs under conditions of lack of cellular nutrients, hypoxia, stress, infections.
\nAutophagy involves the formation of a double-membrane vesicle that includes proteins with various defects, cellular organelles, pathogens. The vesicles fuse with lysosomes which effectively recycle the degradation. The formation of autophagic vesicles is a complex process involving enzymes and proteins such as: UCK1, BECLIN1, VPS34, mTOR, LC38, RUBICON.
\nAutophagy is considered a cell survival mechanism under special conditions. There is a balance between apoptosis (which results in cell death) and autophagy. Autophagy opposes apoptosis but excessive autophagy leads to apoptosis.
\nAutophagy removes degraded intracellular aggregates, promoting cellular senescence. Autophagy is associated with physiological and pathological processes such as: cell differentiation and development, immunity, infection and tumor proliferation. In the case of tumor proliferation, autophagy is involved both in promoting tumor proliferation and in inhibiting this process. Autophagy is also involved in resistance to antitumor therapy.
\nAlteration of autophagy mechanisms has been associated with numerous cutaneous diseases such as: psoriasis, vitiligo, autoimmune diseases, inflammatory processes and skin tumors. At the same time, the intervention on the autophagic mechanisms can constitute a new therapeutic direction for these conditions.<\/p>\n
Scurt CV<\/span><\/p>\nStudii:<\/strong> Facultatea de Medicin\u0103 Bucure\u0219ti
\nSpecialitatea<\/strong>: Medicin\u0103 general\u0103
\nTitluri didactice, \u0219tiin\u021bifice \u0219i academice<\/strong>
\nCercetator \u0219tiin\u021bific principal gradul I
\nDoctor \u00een medicin\u0103 cu teza \u201dCitochinele \u00een tratamentul local al unor tumori maligne cutanate\u201d (1994), UMF Bucure\u0219ti
\nProfesor titular de curs Dermato-venerologie, Univ. Titu Maiorescu, Bucure\u0219ti
\nSpecialitate:<\/strong> – medic primar dermato-venerologie
\nmedic primar alergologie \u0219i imunologie clinic\u0103
\nMembru \u00een asocia\u021bii profesionale, academii:<\/strong>
\nSocietatea Rom\u00e2na de Dermatologie
\nSocietatea Rom\u00e2na de Alergologie \u0219i Imunologie Clinica
\nISIR (Asocia\u021bia Interna\u021bionala de Studiu a Interferonului \u0219i a citokinelor)
\nEADV (Asocia\u021bia Europeana de Dermato-Venerologie) Distinc\u021bii :
\nPremiul Academiei Rom\u00e2ne \u201d Daniel Danielopolu\u201d – 1990
\nPremiul Conferin\u021bei Interbalcanice de alergologie -Bucuresti \u2014 1995 e Premiul Academiei Rom\u00e2ne \u201dGheorghe Marinescu\u201d \u2013 2001
\n\u00cencadrarea prezenta \u0219i cea anterioara:<\/strong>
\nBucure\u0219ti, Spitalul Clinic de Boli Infec\u021bioase \u0219i Tropicale Dr. Victor Babe\u0219 Laboratorul de
\nImunologie, din 1981 p\u00e2na in prezent \u2014 Conducator Laborator Imunologie
\nLucrari \u0219tiin\u021bifice publicate:<\/strong>
\n-un numar de 100 de comunic\u0103ri \u0219i articole dintre care 25 articole publicate \u00een reviste de specialitate de circula\u021bie interna\u021bional\u0103, indexate
\nmonografii: \u201dSarcomul Kaposi\u201d Editura Tehnic\u0103, 1998, 230 pagini, unic autor \u201dApoptoza-Moartea celular\u0103 programat\u0103\u201d Ed. Academiei, 1999, 410 pagini, coautor Reac\u021bii alergice la medicamente\u201d Ed. Medical\u0103, 2002, 400 pagini, prim autor \u201dPatologia molecular\u0103 a pielii\u201d Ed. Medical\u0103, 2006, 495 pagini, unic autor \u201dDermato-Venerologie\u201d Ed. Didactic\u0103 \u0219i Pedagogic\u0103 2010, 300 pagini<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2023<\/p>\n
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Operatorul PDI 2023<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Prof. Univ. Dr. Alecu Mihail Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Dr. Victor Babe\u015f\u201d Bucure\u015fti Universitatea “Titu Maiorescu” Facultatea de Medicin\u0103, Bucure\u015ftiAutofagia \u00eentre necroz\u0103 \u0219i apoptoz\u0103 Autori: M. Alecu1,2, Gabriela Coman2 1Universitatea \u201dTitu Maiorescu\u201d, Facultatea de Medicin\u0103, Bucure\u0219ti, Rom\u00e2nia 2Bioderm Medical Center, Bucure\u0219ti, Rom\u00e2nia Autofagia este un proces controlat genetic, de autodegradare a proteinelor […]<\/p>\n","protected":false},"author":2,"featured_media":11336,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7441","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=7441"}],"version-history":[{"count":17,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7441\/revisions"}],"predecessor-version":[{"id":13135,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7441\/revisions\/13135"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11336"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=7441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=7441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=7441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Prof. Univ. Dr. Alecu Mihail<\/strong><\/span>
\n Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Dr. Victor Babe\u015f\u201d Bucure\u015fti<\/strong><\/span>
\n Universitatea “Titu Maiorescu” Facultatea de Medicin\u0103, Bucure\u015fti<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.4″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Autofagia \u00eentre necroz\u0103 \u0219i apoptoz\u0103<\/span>
\nAutori: M. Alecu1,2, Gabriela Coman2<\/span>
\n1Universitatea \u201dTitu Maiorescu\u201d, Facultatea de Medicin\u0103, Bucure\u0219ti, Rom\u00e2nia
\n2Bioderm Medical Center, Bucure\u0219ti, Rom\u00e2nia<\/p>\nAutofagia este un proces controlat genetic, de autodegradare a proteinelor \u0219i a organitelor celulare alterate, f\u0103r\u0103 s\u0103 se produc\u0103 moartea celulei. Produsele rezultate din degradare sunt apoi reutilizate pentru func\u021biile importante ale celulei. Autofagia apare \u00een condi\u021biile lipsei de nutrien\u021bi celulari, hipoxie, stres, infec\u021bii.
\nAutofagia presupune formarea unei vezicule cu membran\u0103 dubl\u0103 care \u00eenglobeaz\u0103 \u00een ea proteine cu diverse defecte, organite celulare, patogeni. Veziculele fuzioneaz\u0103 cu lizozomii care recicleaz\u0103 efectiv degradarea. Formarea veziculelor autofagice este un proces complex \u00een care intervin enzime \u0219i proteine ca: UCK1, BECLIN1, VPS34, mTOR, LC38, RUBICON.
\nAutofagia este considerat\u0103 un mecanism de supravie\u021buire celular\u0103 \u00een condi\u021bii deosebite. Exist\u0103 o balan\u021b\u0103 \u00eentre apoptoz\u0103 (care are ca rezultat moartea celular\u0103) \u0219i autofagie. Autofgia se opune poptozei dar autofagia excesiv\u0103 duce la apoptoz\u0103.
\nPrin autofagie sunt eliminate agregatele intracelulare degradate, promov\u00e2nd senescen\u021ba celular\u0103. Autofagia este asociat\u0103 cu procese fiziologice \u0219i patologice ca: diferen\u021bierea \u0219i dezvoltarea celular\u0103, imunitatea, infec\u021bia \u0219i proliferarea tumoral\u0103. \u00cen cazul prolifer\u0103rii tumorale autofagia este implicat\u0103 at\u00e2t \u00een promovarea prolifer\u0103rii tumorale c\u00e2t \u0219i \u00een inhibarea acestui proces. De asemenea autofagia este implicat\u0103 \u00een rezisten\u021ba la terapia antitumoral\u0103.
\nAlterarea mecanismelor autofagiei a fost asociat\u0103 cu numeroase afec\u021biuni cutanate cum ar fi: psoriazis, vitiligo, boli autoimune, procese inflamatorii \u0219i tumorale cutanate. Totodat\u0103, interven\u021bia asupra mecanismelor autofagice poate constitui o nou\u0103 direc\u021bie terapeutic\u0103 pentru aceste afec\u021biuni.\n<\/p>\n
Autophagy between necrosis and apoptosis<\/span>
\nAuthors: M. Alecu1,2, Gabriela Coman2<\/span>
\n1\u201dTitu Maiorescu\u201d University, Bucharest, Romania
\n2Bioderm Medical Center, Bucharest, Romania<\/p>\nAutophagy is a genetically controlled process of self-degradation of altered cellular proteins and organelles without causing cell death. The resulting degradation products are then reused for important cell functions. Autophagy occurs under conditions of lack of cellular nutrients, hypoxia, stress, infections.
\nAutophagy involves the formation of a double-membrane vesicle that includes proteins with various defects, cellular organelles, pathogens. The vesicles fuse with lysosomes which effectively recycle the degradation. The formation of autophagic vesicles is a complex process involving enzymes and proteins such as: UCK1, BECLIN1, VPS34, mTOR, LC38, RUBICON.
\nAutophagy is considered a cell survival mechanism under special conditions. There is a balance between apoptosis (which results in cell death) and autophagy. Autophagy opposes apoptosis but excessive autophagy leads to apoptosis.
\nAutophagy removes degraded intracellular aggregates, promoting cellular senescence. Autophagy is associated with physiological and pathological processes such as: cell differentiation and development, immunity, infection and tumor proliferation. In the case of tumor proliferation, autophagy is involved both in promoting tumor proliferation and in inhibiting this process. Autophagy is also involved in resistance to antitumor therapy.
\nAlteration of autophagy mechanisms has been associated with numerous cutaneous diseases such as: psoriasis, vitiligo, autoimmune diseases, inflammatory processes and skin tumors. At the same time, the intervention on the autophagic mechanisms can constitute a new therapeutic direction for these conditions.<\/p>\n
Scurt CV<\/span><\/p>\nStudii:<\/strong> Facultatea de Medicin\u0103 Bucure\u0219ti
\nSpecialitatea<\/strong>: Medicin\u0103 general\u0103
\nTitluri didactice, \u0219tiin\u021bifice \u0219i academice<\/strong>
\nCercetator \u0219tiin\u021bific principal gradul I
\nDoctor \u00een medicin\u0103 cu teza \u201dCitochinele \u00een tratamentul local al unor tumori maligne cutanate\u201d (1994), UMF Bucure\u0219ti
\nProfesor titular de curs Dermato-venerologie, Univ. Titu Maiorescu, Bucure\u0219ti
\nSpecialitate:<\/strong> – medic primar dermato-venerologie
\nmedic primar alergologie \u0219i imunologie clinic\u0103
\nMembru \u00een asocia\u021bii profesionale, academii:<\/strong>
\nSocietatea Rom\u00e2na de Dermatologie
\nSocietatea Rom\u00e2na de Alergologie \u0219i Imunologie Clinica
\nISIR (Asocia\u021bia Interna\u021bionala de Studiu a Interferonului \u0219i a citokinelor)
\nEADV (Asocia\u021bia Europeana de Dermato-Venerologie) Distinc\u021bii :
\nPremiul Academiei Rom\u00e2ne \u201d Daniel Danielopolu\u201d – 1990
\nPremiul Conferin\u021bei Interbalcanice de alergologie -Bucuresti \u2014 1995 e Premiul Academiei Rom\u00e2ne \u201dGheorghe Marinescu\u201d \u2013 2001
\n\u00cencadrarea prezenta \u0219i cea anterioara:<\/strong>
\nBucure\u0219ti, Spitalul Clinic de Boli Infec\u021bioase \u0219i Tropicale Dr. Victor Babe\u0219 Laboratorul de
\nImunologie, din 1981 p\u00e2na in prezent \u2014 Conducator Laborator Imunologie
\nLucrari \u0219tiin\u021bifice publicate:<\/strong>
\n-un numar de 100 de comunic\u0103ri \u0219i articole dintre care 25 articole publicate \u00een reviste de specialitate de circula\u021bie interna\u021bional\u0103, indexate
\nmonografii: \u201dSarcomul Kaposi\u201d Editura Tehnic\u0103, 1998, 230 pagini, unic autor \u201dApoptoza-Moartea celular\u0103 programat\u0103\u201d Ed. Academiei, 1999, 410 pagini, coautor Reac\u021bii alergice la medicamente\u201d Ed. Medical\u0103, 2002, 400 pagini, prim autor \u201dPatologia molecular\u0103 a pielii\u201d Ed. Medical\u0103, 2006, 495 pagini, unic autor \u201dDermato-Venerologie\u201d Ed. Didactic\u0103 \u0219i Pedagogic\u0103 2010, 300 pagini<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2023<\/p>\n
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Operatorul PDI 2023<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n
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Prof. Univ. Dr. Alecu Mihail Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Dr. Victor Babe\u015f\u201d Bucure\u015fti Universitatea “Titu Maiorescu” Facultatea de Medicin\u0103, Bucure\u015ftiAutofagia \u00eentre necroz\u0103 \u0219i apoptoz\u0103 Autori: M. Alecu1,2, Gabriela Coman2 1Universitatea \u201dTitu Maiorescu\u201d, Facultatea de Medicin\u0103, Bucure\u0219ti, Rom\u00e2nia 2Bioderm Medical Center, Bucure\u0219ti, Rom\u00e2nia Autofagia este un proces controlat genetic, de autodegradare a proteinelor […]<\/p>\n","protected":false},"author":2,"featured_media":11336,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7441","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=7441"}],"version-history":[{"count":17,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7441\/revisions"}],"predecessor-version":[{"id":13135,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7441\/revisions\/13135"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11336"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=7441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=7441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=7441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nAutori: M. Alecu1,2, Gabriela Coman2<\/span>
\n1Universitatea \u201dTitu Maiorescu\u201d, Facultatea de Medicin\u0103, Bucure\u0219ti, Rom\u00e2nia
\n2Bioderm Medical Center, Bucure\u0219ti, Rom\u00e2nia<\/p>\n
Autofagia este un proces controlat genetic, de autodegradare a proteinelor \u0219i a organitelor celulare alterate, f\u0103r\u0103 s\u0103 se produc\u0103 moartea celulei. Produsele rezultate din degradare sunt apoi reutilizate pentru func\u021biile importante ale celulei. Autofagia apare \u00een condi\u021biile lipsei de nutrien\u021bi celulari, hipoxie, stres, infec\u021bii.
\nAutofagia presupune formarea unei vezicule cu membran\u0103 dubl\u0103 care \u00eenglobeaz\u0103 \u00een ea proteine cu diverse defecte, organite celulare, patogeni. Veziculele fuzioneaz\u0103 cu lizozomii care recicleaz\u0103 efectiv degradarea. Formarea veziculelor autofagice este un proces complex \u00een care intervin enzime \u0219i proteine ca: UCK1, BECLIN1, VPS34, mTOR, LC38, RUBICON.
\nAutofagia este considerat\u0103 un mecanism de supravie\u021buire celular\u0103 \u00een condi\u021bii deosebite. Exist\u0103 o balan\u021b\u0103 \u00eentre apoptoz\u0103 (care are ca rezultat moartea celular\u0103) \u0219i autofagie. Autofgia se opune poptozei dar autofagia excesiv\u0103 duce la apoptoz\u0103.
\nPrin autofagie sunt eliminate agregatele intracelulare degradate, promov\u00e2nd senescen\u021ba celular\u0103. Autofagia este asociat\u0103 cu procese fiziologice \u0219i patologice ca: diferen\u021bierea \u0219i dezvoltarea celular\u0103, imunitatea, infec\u021bia \u0219i proliferarea tumoral\u0103. \u00cen cazul prolifer\u0103rii tumorale autofagia este implicat\u0103 at\u00e2t \u00een promovarea prolifer\u0103rii tumorale c\u00e2t \u0219i \u00een inhibarea acestui proces. De asemenea autofagia este implicat\u0103 \u00een rezisten\u021ba la terapia antitumoral\u0103.
\nAlterarea mecanismelor autofagiei a fost asociat\u0103 cu numeroase afec\u021biuni cutanate cum ar fi: psoriazis, vitiligo, boli autoimune, procese inflamatorii \u0219i tumorale cutanate. Totodat\u0103, interven\u021bia asupra mecanismelor autofagice poate constitui o nou\u0103 direc\u021bie terapeutic\u0103 pentru aceste afec\u021biuni.\n<\/p>\n
Autophagy between necrosis and apoptosis<\/span> Autophagy is a genetically controlled process of self-degradation of altered cellular proteins and organelles without causing cell death. The resulting degradation products are then reused for important cell functions. Autophagy occurs under conditions of lack of cellular nutrients, hypoxia, stress, infections. Scurt CV<\/span><\/p>\n Studii:<\/strong> Facultatea de Medicin\u0103 Bucure\u0219ti [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” 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A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_slider disabled_on=”off|off|off” _builder_version=”4.20.4″ _module_preset=”default” position_origin_r=”bottom_left” width=”200px” max_width=”200px” content_width=”200px” content_max_width=”200px” min_height=”100px” height=”100px” max_height=”100px” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” auto=”on” auto_speed=”3000″ global_colors_info=”{}”][et_pb_slide _builder_version=”4.20.2″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2022\/05\/timpul_.jpg” background_enable_image=”on” background_size=”initial” custom_padding=”0px||0px||false|false” link_option_url=”#” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][et_pb_slide _builder_version=”4.20.2″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2022\/05\/medical-market_.jpg” background_enable_image=”on” background_size=”initial” custom_padding=”0px||0px||false|false” link_option_url=”https:\/\/issuu.com\/finwatch\/docs\/dermato?fr=sYWIzMjQ1MDUxNTY” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][et_pb_slide button_text=”Click Here” _builder_version=”4.20.4″ _module_preset=”default” background_color=”RGBA(255,255,255,0)” background_enable_color=”on” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2023\/04\/Logo-JURMED-RGB.jpg” background_enable_image=”on” background_size=”contain” link_option_url=”https:\/\/jurmed.ro\/” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Prof. Univ. Dr. Alecu Mihail Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Dr. Victor Babe\u015f\u201d Bucure\u015fti Universitatea “Titu Maiorescu” Facultatea de Medicin\u0103, Bucure\u015ftiAutofagia \u00eentre necroz\u0103 \u0219i apoptoz\u0103 Autori: M. Alecu1,2, Gabriela Coman2 1Universitatea \u201dTitu Maiorescu\u201d, Facultatea de Medicin\u0103, Bucure\u0219ti, Rom\u00e2nia 2Bioderm Medical Center, Bucure\u0219ti, Rom\u00e2nia Autofagia este un proces controlat genetic, de autodegradare a proteinelor […]<\/p>\n","protected":false},"author":2,"featured_media":11336,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7441","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=7441"}],"version-history":[{"count":17,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7441\/revisions"}],"predecessor-version":[{"id":13135,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7441\/revisions\/13135"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11336"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=7441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=7441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=7441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nAuthors: M. Alecu1,2, Gabriela Coman2<\/span>
\n1\u201dTitu Maiorescu\u201d University, Bucharest, Romania
\n2Bioderm Medical Center, Bucharest, Romania<\/p>\n
\nAutophagy involves the formation of a double-membrane vesicle that includes proteins with various defects, cellular organelles, pathogens. The vesicles fuse with lysosomes which effectively recycle the degradation. The formation of autophagic vesicles is a complex process involving enzymes and proteins such as: UCK1, BECLIN1, VPS34, mTOR, LC38, RUBICON.
\nAutophagy is considered a cell survival mechanism under special conditions. There is a balance between apoptosis (which results in cell death) and autophagy. Autophagy opposes apoptosis but excessive autophagy leads to apoptosis.
\nAutophagy removes degraded intracellular aggregates, promoting cellular senescence. Autophagy is associated with physiological and pathological processes such as: cell differentiation and development, immunity, infection and tumor proliferation. In the case of tumor proliferation, autophagy is involved both in promoting tumor proliferation and in inhibiting this process. Autophagy is also involved in resistance to antitumor therapy.
\nAlteration of autophagy mechanisms has been associated with numerous cutaneous diseases such as: psoriasis, vitiligo, autoimmune diseases, inflammatory processes and skin tumors. At the same time, the intervention on the autophagic mechanisms can constitute a new therapeutic direction for these conditions.<\/p>\n
\nSpecialitatea<\/strong>: Medicin\u0103 general\u0103
\nTitluri didactice, \u0219tiin\u021bifice \u0219i academice<\/strong>
\nCercetator \u0219tiin\u021bific principal gradul I
\nDoctor \u00een medicin\u0103 cu teza \u201dCitochinele \u00een tratamentul local al unor tumori maligne cutanate\u201d (1994), UMF Bucure\u0219ti
\nProfesor titular de curs Dermato-venerologie, Univ. Titu Maiorescu, Bucure\u0219ti
\nSpecialitate:<\/strong> – medic primar dermato-venerologie
\nmedic primar alergologie \u0219i imunologie clinic\u0103
\nMembru \u00een asocia\u021bii profesionale, academii:<\/strong>
\nSocietatea Rom\u00e2na de Dermatologie
\nSocietatea Rom\u00e2na de Alergologie \u0219i Imunologie Clinica
\nISIR (Asocia\u021bia Interna\u021bionala de Studiu a Interferonului \u0219i a citokinelor)
\nEADV (Asocia\u021bia Europeana de Dermato-Venerologie) Distinc\u021bii :
\nPremiul Academiei Rom\u00e2ne \u201d Daniel Danielopolu\u201d – 1990
\nPremiul Conferin\u021bei Interbalcanice de alergologie -Bucuresti \u2014 1995 e Premiul Academiei Rom\u00e2ne \u201dGheorghe Marinescu\u201d \u2013 2001
\n\u00cencadrarea prezenta \u0219i cea anterioara:<\/strong>
\nBucure\u0219ti, Spitalul Clinic de Boli Infec\u021bioase \u0219i Tropicale Dr. Victor Babe\u0219 Laboratorul de
\nImunologie, din 1981 p\u00e2na in prezent \u2014 Conducator Laborator Imunologie
\nLucrari \u0219tiin\u021bifice publicate:<\/strong>
\n-un numar de 100 de comunic\u0103ri \u0219i articole dintre care 25 articole publicate \u00een reviste de specialitate de circula\u021bie interna\u021bional\u0103, indexate
\nmonografii: \u201dSarcomul Kaposi\u201d Editura Tehnic\u0103, 1998, 230 pagini, unic autor \u201dApoptoza-Moartea celular\u0103 programat\u0103\u201d Ed. Academiei, 1999, 410 pagini, coautor Reac\u021bii alergice la medicamente\u201d Ed. Medical\u0103, 2002, 400 pagini, prim autor \u201dPatologia molecular\u0103 a pielii\u201d Ed. Medical\u0103, 2006, 495 pagini, unic autor \u201dDermato-Venerologie\u201d Ed. Didactic\u0103 \u0219i Pedagogic\u0103 2010, 300 pagini<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n