{"id":7501,"date":"2023-02-14T15:15:16","date_gmt":"2023-02-14T13:15:16","guid":{"rendered":"https:\/\/primaderma.ro\/?page_id=7501"},"modified":"2023-04-21T14:55:34","modified_gmt":"2023-04-21T12:55:34","slug":"prof-dr-ciocoiu-manuela","status":"publish","type":"post","link":"https:\/\/pdi.ro\/2023\/prof-dr-ciocoiu-manuela\/","title":{"rendered":"Prof. Dr. Ciocoiu Manuela"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|off|off” _builder_version=”4.19.4″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#F0622A” top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” global_module=”9062″ saved_tabs=”all” collapsed=”off” global_colors_info=”{}”][et_pb_fullwidth_header title=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@” disabled_on=”on|on|off” _builder_version=”4.19.4″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”left” title_text_color=”#f0622a” title_font_size=”55px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” subhead_font=”||||||||” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”luminosity” background_layout=”light” custom_margin=”||-5px||false|false” custom_padding=”150px||150px||true|false” content_font_size_tablet=”” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop” global_colors_info=”{}”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/04\/Ciocoiu-Manuela-circle.png” title_text=”Ciocoiu Manuela-circle” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.19.5″ border_radii=”on|100px|100px|100px|100px” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.4″ global_colors_info=”{}”]<\/p>\n

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Prof. Dr. Ciocoiu Manuela<\/strong><\/span>
Prorector Studii universitare – <\/span>Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/strong><\/span><\/strong><\/span><\/h4>\n

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Interven\u0163ia flavonoidelor \u015fi non-flavonoidelor naturale \u00een afec\u0163iunile dermatologice<\/span><\/p>\n

Autori: Manuela Ciocoiu1, Codru\u0163a B\u0103descu2, Carmen Rodica Anton3, Teodor Ionescu1<\/span>
1 \u2013 Disciplina de Fiziopatologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi
2 \u2013 Departamentul Medicale I \u2013 Medicin\u0103 intern\u0103, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi
3 \u2013 Departamentul Medicale I- Semiologie Medical\u0103 \u015fi Gastroenterologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi<\/p>\n

Cuvinte cheie: flavonoide, non-flavonoide, antiinflamator, antioxidant, antimicrobian, antitumoral<\/p>\n

At\u00e2t flavonoidele, c\u00e2t \u015fi non-flavonoidele au o serie de efecte farmacologice: antioxidante, antiinflamatorii, bacteriostatice \u0219i antitumorale, \u00eempotriva diferitelor tipuri de boli dermatologice. Din grupul substan\u0163elor flavonoide fac parte: quercetin\u0103, epigalocatechin\u0103 galat, catechin\u0103, cianidin\u0103 \u0219i procianidin\u0103., etc. Din grupul substan\u0163elor non-flavonoide fac parte acizii fenolici, curcumina \u015fi deriva\u0163ii analogici, stilbene \u015fi lignani. Flavonoidele posed\u0103 propriet\u0103\u021bi antiinflamatorii puternice \u0219i pot ajuta \u00een reglarea sistemului imun din dermatita atopic\u0103, psoriazis vulgar, lichen plan. Resveratrolul, acidul clorogenic, acidul cafeic \u0219i pelargonina, moduleaz\u0103 expresia genelor proinflamatorii \u0219i produc\u021bia de citokine, influen\u021b\u00e2nd astfel celulele sistemului imun. Resveratrolul este cunoscut pentru efectele sale anti-\u00eemb\u0103tr\u00e2nire \u015fi propriet\u0103\u021bile antioxidante. Unii polifenoli naturali au efecte de protec\u021bie \u00eempotriva deterior\u0103rii celulare \u0219i a \u00eemb\u0103tr\u00e2nirii pielii. Extractul de Ginko biloba a fost asociat cu progresia vitiligo prin reducerea depigment\u0103rii \u0219i promovarea repigment\u0103rii. Structurile flavonoide din anghinare-apigenina \u015fi luteolina- pot \u00eembun\u0103t\u0103\u021bi vasodilata\u021bia \u0219i microcircula\u021bia \u00een celulelor endoteliale, pot \u00eembun\u0103t\u0103\u021bi elasticitatea \u0219i rugozitatea pielii prin inhibarea \u00eemb\u0103tr\u00e2nirii vasculare. Semin\u021bele de struguri cu o structura flavonoidic\u0103 \u015fi semin\u0163ele de rodie cu un con\u0163inut ridicat de taninuri \u015fi antocianidine (delfinidin, cianidin) au activitate antimicrobian\u0103, fiind mai eficiente \u00eempotriva bacteriilor Gram-pozitive. Compu\u0219ii naturali antitumorali, cum ar fi resveratrolul \u0219i curcumina induc apoptoza, au efect antioxidant \u015fi au rol \u00een suprimarea ciclului celular. Non-flavonoidele, de tipul taninurilor prezint\u0103 efecte antialergice, inclusiv inhibarea produc\u021biei de citokine \u0219i leucocite proinflamatorii, precum \u0219i eliberarea de histamin\u0103. Efectele benefice ale flavonoidelor\/non-flavonoidelor trebuie s\u0103 ia \u00een considerare interac\u021biunile enzimatice, propriet\u0103\u0163ile fizico-chimice ale acestora \u015fi abilitatea lor de a dep\u0103\u015fi bariera epidermal\u0103.<\/p>\n

The intervention of natural flavonoids and non-flavonoids in dermatological diseases<\/span><\/p>\n

Authors: Manuela Ciocoiu1, Codru\u0163a B\u0103descu2, Carmen Rodica Anton3, Teodor Ionescu1<\/span>
1 – Department of Pathophysiology, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi
2 – Medical Department I – Internal Medicine, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi
3 \u2013 Medical Department I \u2013 Medical Semiology and Gastroenterology, UMF \u201eGrigore T. Popa\u201d from Ia\u015fi<\/p>\n

Keywords: flavonoids, non-flavonoids, anti-inflammatory, antioxidant, antimicrobial, antitumor<\/p>\n

Both flavonoids and non-flavonoids have a series of pharmacological effects: antioxidant, anti-inflammatory, bacteriostatic and antitumor, against various types of dermatological diseases. The group of flavonoid substances includes: quercetin, epigallocatechin gallate, catechin, cyanidin and procyanidin, etc. The group of non-flavonoid substances includes phenolic acids, curcumin and analogue derivatives, stilbenes and lignans. Flavonoids possess strong anti-inflammatory properties and can help regulate the immune system in atopic dermatitis, psoriasis vulgaris, lichen planus. Resveratrol, chlorogenic acid, caffeic acid and pelargonin modulate the expression of pro-inflammatory genes and the production of cytokines, thus influencing the cells of the immune system. Resveratrol is known for its anti-aging effects and antioxidant properties. Some natural polyphenols have protective effects against cell damage and skin aging. Ginko biloba extract has been associated with vitiligo progression by reducing depigmentation and promoting repigmentation. The flavonoid structures in artichoke – apigenin and luteolin – can improve vasodilatation and microcirculation in endothelial cells, can improve skin elasticity and roughness by inhibiting vascular aging. Grape seeds with a flavonoid structure and pomegranate seeds with a high content of tannins and anthocyanidins (delphinidin, cyanidin) have antimicrobial activity, being more effective against Gram-positive bacteria. Natural antitumor compounds such as resveratrol and curcumin induce apoptosis, have an antioxidant effect and play a role in suppressing the cell cycle. Non-flavonoids, such as tannins, exhibit anti-allergic effects, including inhibition of pro-inflammatory cytokine and leukocyte production. The beneficial effects of flavonoids\/non-flavonoids must take into account the enzymatic interactions, their physico-chemical properties and their ability to overcome the epidermal barrier.<\/p>\n

\u00a0Scurt CV<\/span><\/p>\n

\u2022\tProrector Studii universitare – ciclul de studii \u00eenv\u0103\u021b\u0103m\u00e2nt fundamental
\n\u2022\tProfesor Universitar Abilitat, Disciplina de Fiziopatologie, Facultatea de Medicin\u0103, U.M.F. “Grigore T. Popa” din Ia\u0219i
\n\u2022\tCoordonator al activit\u0103\u021bii didactice la Disciplina de Fiziopatologie, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u0219i Farmacie \u201cGrigore T. Popa\u201ddin Ia\u0219i
\n\u2022\tDoctor \u020bn \u015ftiinte medicale- Fiziologie Normal\u0103 \u015fi Patologic\u0103
\n\u2022\tMedic primar Medicin\u0103 Intern\u0103
\n\u2022\tVicepre\u0219edintele Societ\u0103\u021bii Rom\u00e2ne de Fiziopatologie
\n\u2022\tAutor \u0219i coautor a numeroase capitole \u00een tratate \u015fi monografii, precum \u015fi articole cotate \u00een baze de date interna\u0163ionale
\n\u2022\tMembr\u0103 \u00een societ\u0103\u0163i \u015ftiin\u0163ifice:
\n– Societatea Rom\u00e2n\u0103 de Fiziopatologie (RPPS)
\n– Societatea Na\u0163ional\u0103 de Biologie Celular\u0103
\n– Societatea de Medici \u015fi Naturali\u015fti din Ia\u015fi
\n– International Society on Thrombosis and Haemostasis
\n– European Atherosclerosis Society (EAS)\n<\/p>\n

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Contacteaz\u0103 operatorul PDI 2023<\/p>\n

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Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
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Prof. Dr. Ciocoiu Manuela Prorector Studii universitare – Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fiInterven\u0163ia flavonoidelor \u015fi non-flavonoidelor naturale \u00een afec\u0163iunile dermatologice Autori: Manuela Ciocoiu1, Codru\u0163a B\u0103descu2, Carmen Rodica Anton3, Teodor Ionescu11 \u2013 Disciplina de Fiziopatologie, UMF \u201cGrigore T. Popa\u201d din Ia\u015fi2 \u2013 Departamentul Medicale I \u2013 Medicin\u0103 intern\u0103, UMF \u201cGrigore T. Popa\u201d […]<\/p>\n","protected":false},"author":2,"featured_media":11332,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7501","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=7501"}],"version-history":[{"count":17,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7501\/revisions"}],"predecessor-version":[{"id":13149,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7501\/revisions\/13149"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11332"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=7501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=7501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=7501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}