{"id":7510,"date":"2023-02-14T15:02:25","date_gmt":"2023-02-14T13:02:25","guid":{"rendered":"https:\/\/primaderma.ro\/?page_id=7510"},"modified":"2023-04-05T15:39:13","modified_gmt":"2023-04-05T13:39:13","slug":"prof-dr-deleanu-diana","status":"publish","type":"post","link":"https:\/\/pdi.ro\/2023\/prof-dr-deleanu-diana\/","title":{"rendered":"Prof. Dr. Deleanu Diana"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|off|off” _builder_version=”4.19.4″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#F0622A” top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” global_module=”9062″ saved_tabs=”all” collapsed=”off” global_colors_info=”{}”][et_pb_fullwidth_header title=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@” disabled_on=”on|on|off” _builder_version=”4.19.4″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”left” title_text_color=”#f0622a” title_font_size=”55px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” subhead_font=”||||||||” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”luminosity” background_layout=”light” custom_margin=”||-5px||false|false” custom_padding=”150px||150px||true|false” content_font_size_tablet=”” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop” global_colors_info=”{}”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/04\/Diana-Deleanu-circle.png” title_text=”Diana Deleanu-circle” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.19.5″ max_width=”32%” border_radii=”on|100px|100px|100px|100px” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ global_colors_info=”{}”]<\/p>\n

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Prof. Dr.\u00a0Deleanu Diana<\/strong><\/span>
Universitatea de Medicin\u0103 \u0219i Farmacie”Iuliu Ha\u021bieganu”, Cluj Napoca<\/strong><\/span><\/h4>\n

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Interferen\u0163e \u00eentre alergia alimentar\u0103 \u015fi dermatita atopic\u0103<\/span><\/p>\n

Autori: Diana Deleanu, Irena Pintea<\/span>
Universitatea de Medicin\u0103 \u015fi Farmacie Iuliu Ha\u0163ieganu Cluj-Napoca, Roma\u00e2ia
Institutul Regional de Gastro-enterologie \u015fi Hepatologie Prof Dr. Octavian Fodor, Dept. Alergologie, Cluj-Napoca, Rom\u00e2nia<\/p>\n

Cuvinte cheie: alergia alimentar\u0103, alergeni alimentari, dermatita atopic\u0103<\/p>\n

Alergiile alimentare (AA) \u015fi dermatita atopic\u0103 (DA) sunt dou\u0103 mnifest\u0103ri alergice tipice, a c\u0103ror frecven\u0163\u0103 este \u00een cre\u015ftere. Ele se \u00eent\u00e2lnesc mai frecvent la copii, dar sunt prezente \u015fi la adul\u0163i. AA \u015fi DA, pe l\u00e2ng\u0103 datele epidemiologic commune, mai au \u015fi mecanisme imunologice similar, respectiv inflama\u0163ia de tip T2, cu implicarea stratelor barier\u0103 (epiteliul gastro-intestinal \u015fi piele), celule generatoare de acest tip de inflama\u0163ie (limfocitele Th2, celulele limfoide \u00eenn\u0103scute de tip 2 -ILC2), citokine comune (alarmine, interleukine – IL, chemokine). Dou\u0103 ipoteze s-au n\u0103scut \u00een urma noilor date oferite de imunologia mecanismelor fizio-patogenetice ale AA \u015fi DA. Ipoteza barierei epiteliale, ca element activ, ce poate genera inflama\u0163ia de tip T2 odat\u0103 cu agresiunea (alergeni, microorganism, poluan\u0163i, substan\u0163e iritative etc) prin sinteza \u015fi eliberarea de alarmine (IL-25, IL-33, limfopoietina timic\u0103 stromal\u0103 – TSLP) care activeaz\u0103 celule ILC2, celulele dendritice \u015fi ulterior limfocitele Th2. Ipoteza expunerii duale la aliment: dac\u0103 expunerea se face oral se induce toleran\u0163\u0103 imunologic\u0103, dac\u0103 expunerea se face cutanat se induce sensibilizare \u015fi ulterior alergie. \u00cen popula\u0163ia noastr\u0103, la pacien\u0163ii cu DA (copii \u015fi adul\u0163i), alergenii alimnetari ce duc la simptome de AA \u015fi exacerbeaz\u0103 DA, sunt: laptele de vac\u0103, oul, gr\u00e2ul, mai rar am \u00eent\u00e2lnit nucile de copac, fructele de mare, arahidele. La cei cu simptomatologie sup\u0103r\u0103toare s-a realizat inducerea toleran\u0163ei la alergenul alimentar prin imunoterapie oral\u0103 (laptele de vac\u0103, ou, gr\u00e2u).<\/p>\n

Interferences between food allergy and atopic dermatitis<\/span><\/p>\n

Authors: Diana Deleanu, Irena Pintea<\/span>
University of Medicine & Pharmacy \u201cIuliu Ha\u021bieganu\u201d, Cluj-Napoca, Rom\u00e2nia
Regional Institute of Gastroenterology and \u00a0Hepatology \u201cProf dr. Octavian Fodor\u201d \u2013 Allergology; Cluj-Napoca, Rom\u00e2nia<\/p>\n

Keywords: food allergy, food allergen, atopic dermatitis<\/p>\n

Food allergies (FA) and atopic dermatitis (AD) are two manifestations of specific allergic diseases, which are increasing in prevalence. Both are more frequent in children, but they are also present in adulthood. FA and AD have in common epidemiology, but also immunological physiopathology. In both type T2 inflammation is present and is induced by protection barrier: gastro-intestinal epithelial and skin. The cells present in barrier generate T2 inflammation by activating Th2 cells and type 2 innate lymphoid cells (ILC2) through secretion and release of alarmins, interleukins and chemokines. Two new hypothesis explain the immunological physiopathology of FA and AD. Epithelial hypothesis brings arguments for active cells in inducing type T2 inflammation when they are aggressed by allergens, microorganisms, polluants, irritative substance. The epithelial cells secrete alarmins (IL-25, Il-33, TSLP) which activate ILC2, dendritic cells and in the end Th2 cells. Dual exposure hypothesis to food allergens show that oral exposure induces tolerance and skin exposure to allergens induce sensitization and that develops to allergy. In Romanian children and adults, the food allergen mostly involved, where proteins in cow milk, egg and wheat, less frequent our patients presented allergy to tree nuts, see food and peanuts. In our patients with severe disease we induced tolerance to food allergens by oral immunotherapy (desensitization), mainly to milk, egg and wheat.<\/p>\n

Scurt CV<\/span><\/p>\n

A absolvit Facultatea de Medicin\u0103 \u0219i Farmacie a Institutului de Medicin\u0103 \u0219i Farmacie Cluj-Napoca (actuala Universitate de Medicin\u0103 \u0219i Farmacie Iuliu Ha\u021bieganu) \u00een 1983. Este medic primar de Medicin\u0103 Intern\u0103 \u0219i de Alergologie \u0219i Imunologie Clinic\u0103 (din 1995). Este angajata la UMF Iuliu Ha\u021bieganu, disciplina de Imunologie \u0219i Alergologie (\u0219ef de disciplin\u0103) \u0219i la Institutul Regional de Gastroenterologie \u0219i Hepatologie (IRGH) \u201cProf. dr. Octavian Fodor\u201d, sec\u021bia Medicin\u0103 Intern\u0103 (\u0219ef de sec\u021bie) cu compartimente de Alergologie \u0219i de Imunologie. Conduce programul na\u021bional pentru boli rare \u2013 imunodeficiente primare.
Specializ\u0103ri la UMF Cluj-Napoca, UMF Carol Davila, Bucure\u0219ti, Universitatea de Medicin\u0103 Southampton (boli respiratorii), la Spitalul Brompton, Londra, Serviciul de recuperare boli respiratorii Paderborn, la Clinica Nantes, Universitatea Navarra, Clinica San Miguel (alergologie) din Pamplona. \u0218i-a sus\u021binut teza de doctorat \u00een domeniul medicinei cu o tema de imunologie, \u00een 1996. Autoare \u0219i coautoare a numeroase articole, cu indice Hirsch peste 9 \u0219i autoare la mai multe c\u0103r\u021bi, capitole de carte \u00een domeniul imunologiei \u0219i alergologiei. A introdus teste de provocare \u0219i imunoterapia specific\u0103. Pred\u0103 cursuri de imunologie \u0219i alergologie la studen\u021bii de la UMF “Iuliu Ha\u021bieganu” Cluj-Napoca, la anul 3 \u0219i 6 medicin\u0103 general\u0103, la medicin\u0103 dentar\u0103, farmacie, nutri\u021bie \u0219i este responsabil\u0103 de pregatirea medicilor reziden\u021bi \u00een specialitatea de Alergologie \u0219i Imunologie Clinic\u0103. Este investigator principal \u00een numeroase studii clinice interna\u021bionale privind bolile alergice (astm, rinita, \u0219oc anafilactic, urticarie). Participant la numeroase manifest\u0103rii de medicin\u0103, imunologie, alergologie, pediatrie, dermatologie regionale, na\u021bionale \u0219i interna\u021bionale. A organizat “\u0218coala de Var\u0103” 2007 la Cluj-Napoca, \u00eempreun\u0103 cu Academia European\u0103 de Alergologie \u0219i Imunologie Clinic\u0103 (EAACI). A fost vicepre\u0219edinte (200-2006) \u0219i pre\u0219edinte (2006-20017) al Societ\u0103\u021bii Na\u021bionale de Alergologie \u0219i Imunologie Clinic\u0103 (SRAIC), \u00een prezent este \u201cfost-pre\u0219edinte\u201d al SRAIC. Este membr\u0103 la mai multe societ\u0103\u021bi interna\u021bionale de alergologie (EAACI, organiza\u021bia mondial\u0103 de Alergologie \u2013 WAO, la AAAAI, la ACAAI etc) \u0219i face parte din Comisiile de specialitate ale MS \u0219i Colegiului Medicilor. Are doi copii \u0219i trei nepo\u021bi.<\/p>\n

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Contacteaz\u0103 operatorul PDI 2023<\/p>\n

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Operatorul PDI 2023<\/p>\n

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Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
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Prof. Dr.\u00a0Deleanu Diana Universitatea de Medicin\u0103 \u0219i Farmacie”Iuliu Ha\u021bieganu”, Cluj NapocaInterferen\u0163e \u00eentre alergia alimentar\u0103 \u015fi dermatita atopic\u0103 Autori: Diana Deleanu, Irena PinteaUniversitatea de Medicin\u0103 \u015fi Farmacie Iuliu Ha\u0163ieganu Cluj-Napoca, Roma\u00e2iaInstitutul Regional de Gastro-enterologie \u015fi Hepatologie Prof Dr. Octavian Fodor, Dept. Alergologie, Cluj-Napoca, Rom\u00e2nia Cuvinte cheie: alergia alimentar\u0103, alergeni alimentari, dermatita atopic\u0103 Alergiile alimentare (AA) \u015fi […]<\/p>\n","protected":false},"author":2,"featured_media":11331,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7510","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7510","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=7510"}],"version-history":[{"count":16,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7510\/revisions"}],"predecessor-version":[{"id":13082,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7510\/revisions\/13082"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11331"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=7510"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=7510"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=7510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}