<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nDr. Ungureanu Gabriela<\/span><\/strong>
\n Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.4″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Angioedemul ereditar prezentare de caz<\/span><\/p>\nAutor: Gabriela Ungureanu <\/span>
\u0218ef sec\u021bie dermatogie-alergologie – Spitalul jude\u021bean de urgen\u021b\u0103 Bacau<\/p>\nAngioedemul ereditar este o boal\u0103 genetic\u0103 rar\u0103, cu transmitere autosomal dominant\u0103, cauzat\u0103 de un deficit de C1 inhibitor esteraz\u0103, prin muta\u021bia genei SERPING1 ,caracterizat\u0103 clinic prin episoade recurente de angioedem subcutanat sau submucos ce implic\u0103 extremit\u0103\u021bile, fa\u021b\u0103, caile aeriene respiratorii superioare \u0219i tractul gastro-intestinal.
Fiziopatologic deficitul de C1 inhibitor esteraz\u0103 serologic sau func\u021bional duce la cresterea produc\u021biei de bradikinina ceea ce duce la cresterea permeabilit\u0103\u021bi vasculare cu apari\u021bia angioedemului.
Cel mai grav este angioedemul laringeal cu poten\u021bial fatal prin asfixie \u0219i care necesit\u0103 terapie imediat\u0103.
Diagnosticul corect \u0219i promt este esen\u021bial la pacientul cu angioedem ereditar care nu r\u0103spunde la medica\u021bia antihistaminic\u0103 \u0219i corticoterapia sistemic\u0103 tipic utilizat\u0103 \u00een angioedemul mediat histaminergic. \u00centarzierea diagnosticului poate fi amenin\u021b\u0103toare de via\u021ba la pacientul cu angioedem laringeal.
Accesul facil la medicul specialist \u0219i terapiile eficente din ultimi 10 ani au \u00eembun\u0103t\u0103\u021bit calitatea vie\u021bii pacientului cu angioedem ereditar \u0219i au redus rata mortalit\u0103\u021bi acestor pacien\u021bi.
Scopul terapiei \u00een atacurile acute, ca \u0219i profilaxia pe termen lung, este de a reduce frecven\u021ba \u0219i severitatea atacurilor prin monitorizare, terapie \u0219i administre de c\u0103tre pacien\u021bi la domiciliu a concentratelor de C1 inhibitori.<\/p>\n
Hereditary angioedema update and case report <\/span><\/p>\nAuthor: Gabriela Ungureanu <\/span>
Senior Physician in Allergology and clinical Immunology
Head of the Department of Dermatology and Allergology, Emergency Hospital Bacau<\/p>\nHereditary angioedema is a rare genetic disorder \u2013 autosomal dominant caused by C1 esterase inhibitor \u2013 C1INH deficiency and it\u2019s characterized by recurrent episodes of severe swelling which involves the face, limbs, airways or gastro-intestinal tract.
Deficiencies in C1INH plasma level or function lead to increased production of bradykinin, which mediates vascular permeability, thus causing angioedema.
Laryngeal oedema is potentially life-threatening as a result of asphyxiation and requires immediate treatment.
Prompt and accurate diagnosis is essential as patients with hereditary angioedema do not respond to drugs typically prescribed for histaminergic mediated angeoedema. Delays in diagnosis can be fatal, particularly in the case of laryngeal oedema.
Hereditary angioedema therapy aims to avoid fatalities and to reduce the frequency and severity of angioedema attacks by means of on demand and short \u2013 and long \u2013 term prophilactic treatment. Acute treatment option includes C1INH concentrate (icatibant or ecallantide) administratied on site or self administratied at home when swelling appears.
Acces to specialist care and effective treatment in the past 10 years has improved the quality of life and has reduced the mortality rate in patients with hereditary angioedema.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u021b\u0103:<\/strong>
Februarie 2022-prezent – \u0218ef Sec\u021bie Dermatologie Alergologie – Spitalul Jude\u021bean de Urgen\u021b\u0103 Bac\u0103u
Septembrie 2009- Ianuarie 2022 – Medic primar alergologie -imunologie clinic\u0103 – Spitalul Jude\u021bean de Urgen\u021b\u0103 Bac\u0103u
Septembrie 2004- August 2009 – Medic specialist alergologie -imunologie clinic\u0103 – Spitalul jude\u021bean de Urgen\u021b\u0103 Bac\u0103u
Octombrie 1999- Iulie 2004 – Medic rezident alergologie imunologie-clinic\u0103 – Spital clinic Nicolae Malaxa Bucure\u0219ti
Educa\u0163ie \u015fi formare<\/strong>
Februarie 2022-prezent – \u0218ef Sec\u021bie Dermatologie Venerologie
Februarie 2021 \u2013 Ianuarie 2022 – Managementul Serviciilor de S\u0103n\u0103tate – SNSPMSB Bucure\u0219ti
Septembrie 2014- Septembrie 2019 – Certificat Medic specialist DV
Septembrie 2004 \u2013 Iulie 2009 – Certificat medic primar alergologie \u0219i imunologie clinic\u0103 – UMF Carol Davila Bucure\u0219ti<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
Membru al Societ\u0103\u021bii Rom\u00e2ne de Alergologie \u0219i Imunologie clinic\u0103
Membru al Societ\u0103\u021bii Rom\u00e2ne de Pneumologie
Membru al European Respiratory Society
Membru al American Academy of Allergy Asthma and Immunology<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2023<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro” submit_button_text=”Trimite mesajul” disabled_on=”off|off|off” _builder_version=”4.20.2″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n
Operatorul PDI 2023<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
[\/et_pb_text][et_pb_slider disabled_on=”off|off|off” _builder_version=”4.20.2″ _module_preset=”default” position_origin_r=”bottom_left” width=”200px” max_width=”200px” content_width=”200px” content_max_width=”200px” min_height=”100px” height=”100px” max_height=”100px” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” auto=”on” auto_speed=”3000″ global_colors_info=”{}”][et_pb_slide _builder_version=”4.20.2″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2022\/05\/timpul_.jpg” background_enable_image=”on” background_size=”initial” custom_padding=”0px||0px||false|false” link_option_url=”#” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][et_pb_slide _builder_version=”4.20.2″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2022\/05\/medical-market_.jpg” background_enable_image=”on” background_size=”initial” custom_padding=”0px||0px||false|false” link_option_url=”https:\/\/issuu.com\/finwatch\/docs\/dermato?fr=sYWIzMjQ1MDUxNTY” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Dr. Ungureanu Gabriela Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103uAngioedemul ereditar prezentare de caz Autor: Gabriela Ungureanu \u0218ef sec\u021bie dermatogie-alergologie – Spitalul jude\u021bean de urgen\u021b\u0103 Bacau Angioedemul ereditar este o boal\u0103 genetic\u0103 rar\u0103, cu transmitere autosomal dominant\u0103, cauzat\u0103 de un deficit de C1 inhibitor esteraz\u0103, prin muta\u021bia genei SERPING1 ,caracterizat\u0103 clinic prin episoade recurente de angioedem subcutanat […]<\/p>\n","protected":false},"author":2,"featured_media":12894,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7995","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=7995"}],"version-history":[{"count":20,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7995\/revisions"}],"predecessor-version":[{"id":13068,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7995\/revisions\/13068"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/12894"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=7995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=7995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=7995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Dr. Ungureanu Gabriela<\/span><\/strong>
\n Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103u<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.4″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Angioedemul ereditar prezentare de caz<\/span><\/p>\nAutor: Gabriela Ungureanu <\/span>
\u0218ef sec\u021bie dermatogie-alergologie – Spitalul jude\u021bean de urgen\u021b\u0103 Bacau<\/p>\nAngioedemul ereditar este o boal\u0103 genetic\u0103 rar\u0103, cu transmitere autosomal dominant\u0103, cauzat\u0103 de un deficit de C1 inhibitor esteraz\u0103, prin muta\u021bia genei SERPING1 ,caracterizat\u0103 clinic prin episoade recurente de angioedem subcutanat sau submucos ce implic\u0103 extremit\u0103\u021bile, fa\u021b\u0103, caile aeriene respiratorii superioare \u0219i tractul gastro-intestinal.
Fiziopatologic deficitul de C1 inhibitor esteraz\u0103 serologic sau func\u021bional duce la cresterea produc\u021biei de bradikinina ceea ce duce la cresterea permeabilit\u0103\u021bi vasculare cu apari\u021bia angioedemului.
Cel mai grav este angioedemul laringeal cu poten\u021bial fatal prin asfixie \u0219i care necesit\u0103 terapie imediat\u0103.
Diagnosticul corect \u0219i promt este esen\u021bial la pacientul cu angioedem ereditar care nu r\u0103spunde la medica\u021bia antihistaminic\u0103 \u0219i corticoterapia sistemic\u0103 tipic utilizat\u0103 \u00een angioedemul mediat histaminergic. \u00centarzierea diagnosticului poate fi amenin\u021b\u0103toare de via\u021ba la pacientul cu angioedem laringeal.
Accesul facil la medicul specialist \u0219i terapiile eficente din ultimi 10 ani au \u00eembun\u0103t\u0103\u021bit calitatea vie\u021bii pacientului cu angioedem ereditar \u0219i au redus rata mortalit\u0103\u021bi acestor pacien\u021bi.
Scopul terapiei \u00een atacurile acute, ca \u0219i profilaxia pe termen lung, este de a reduce frecven\u021ba \u0219i severitatea atacurilor prin monitorizare, terapie \u0219i administre de c\u0103tre pacien\u021bi la domiciliu a concentratelor de C1 inhibitori.<\/p>\n
Hereditary angioedema update and case report <\/span><\/p>\nAuthor: Gabriela Ungureanu <\/span>
Senior Physician in Allergology and clinical Immunology
Head of the Department of Dermatology and Allergology, Emergency Hospital Bacau<\/p>\nHereditary angioedema is a rare genetic disorder \u2013 autosomal dominant caused by C1 esterase inhibitor \u2013 C1INH deficiency and it\u2019s characterized by recurrent episodes of severe swelling which involves the face, limbs, airways or gastro-intestinal tract.
Deficiencies in C1INH plasma level or function lead to increased production of bradykinin, which mediates vascular permeability, thus causing angioedema.
Laryngeal oedema is potentially life-threatening as a result of asphyxiation and requires immediate treatment.
Prompt and accurate diagnosis is essential as patients with hereditary angioedema do not respond to drugs typically prescribed for histaminergic mediated angeoedema. Delays in diagnosis can be fatal, particularly in the case of laryngeal oedema.
Hereditary angioedema therapy aims to avoid fatalities and to reduce the frequency and severity of angioedema attacks by means of on demand and short \u2013 and long \u2013 term prophilactic treatment. Acute treatment option includes C1INH concentrate (icatibant or ecallantide) administratied on site or self administratied at home when swelling appears.
Acces to specialist care and effective treatment in the past 10 years has improved the quality of life and has reduced the mortality rate in patients with hereditary angioedema.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u021b\u0103:<\/strong>
Februarie 2022-prezent – \u0218ef Sec\u021bie Dermatologie Alergologie – Spitalul Jude\u021bean de Urgen\u021b\u0103 Bac\u0103u
Septembrie 2009- Ianuarie 2022 – Medic primar alergologie -imunologie clinic\u0103 – Spitalul Jude\u021bean de Urgen\u021b\u0103 Bac\u0103u
Septembrie 2004- August 2009 – Medic specialist alergologie -imunologie clinic\u0103 – Spitalul jude\u021bean de Urgen\u021b\u0103 Bac\u0103u
Octombrie 1999- Iulie 2004 – Medic rezident alergologie imunologie-clinic\u0103 – Spital clinic Nicolae Malaxa Bucure\u0219ti
Educa\u0163ie \u015fi formare<\/strong>
Februarie 2022-prezent – \u0218ef Sec\u021bie Dermatologie Venerologie
Februarie 2021 \u2013 Ianuarie 2022 – Managementul Serviciilor de S\u0103n\u0103tate – SNSPMSB Bucure\u0219ti
Septembrie 2014- Septembrie 2019 – Certificat Medic specialist DV
Septembrie 2004 \u2013 Iulie 2009 – Certificat medic primar alergologie \u0219i imunologie clinic\u0103 – UMF Carol Davila Bucure\u0219ti<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
Membru al Societ\u0103\u021bii Rom\u00e2ne de Alergologie \u0219i Imunologie clinic\u0103
Membru al Societ\u0103\u021bii Rom\u00e2ne de Pneumologie
Membru al European Respiratory Society
Membru al American Academy of Allergy Asthma and Immunology<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2023<\/p>\n
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Operatorul PDI 2023<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n
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Dr. Ungureanu Gabriela Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103uAngioedemul ereditar prezentare de caz Autor: Gabriela Ungureanu \u0218ef sec\u021bie dermatogie-alergologie – Spitalul jude\u021bean de urgen\u021b\u0103 Bacau Angioedemul ereditar este o boal\u0103 genetic\u0103 rar\u0103, cu transmitere autosomal dominant\u0103, cauzat\u0103 de un deficit de C1 inhibitor esteraz\u0103, prin muta\u021bia genei SERPING1 ,caracterizat\u0103 clinic prin episoade recurente de angioedem subcutanat […]<\/p>\n","protected":false},"author":2,"featured_media":12894,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7995","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=7995"}],"version-history":[{"count":20,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7995\/revisions"}],"predecessor-version":[{"id":13068,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7995\/revisions\/13068"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/12894"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=7995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=7995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=7995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Gabriela Ungureanu <\/span> Angioedemul ereditar este o boal\u0103 genetic\u0103 rar\u0103, cu transmitere autosomal dominant\u0103, cauzat\u0103 de un deficit de C1 inhibitor esteraz\u0103, prin muta\u021bia genei SERPING1 ,caracterizat\u0103 clinic prin episoade recurente de angioedem subcutanat sau submucos ce implic\u0103 extremit\u0103\u021bile, fa\u021b\u0103, caile aeriene respiratorii superioare \u0219i tractul gastro-intestinal. Hereditary angioedema update and case report <\/span><\/p>\n Author: Gabriela Ungureanu <\/span> Hereditary angioedema is a rare genetic disorder \u2013 autosomal dominant caused by C1 esterase inhibitor \u2013 C1INH deficiency and it\u2019s characterized by recurrent episodes of severe swelling which involves the face, limbs, airways or gastro-intestinal tract. Scurt CV<\/span><\/p>\n Experien\u021b\u0103:<\/strong> Apartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ 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button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n Operatorul PDI 2023<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” global_colors_info=”{}”]<\/p>\n <\/span><\/p>\n <\/span><\/p>\n Adresa: Str. A. Panu nr. 13, Iasi<\/span> [\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n Parteneri Media<\/p>\n [\/et_pb_text][et_pb_slider disabled_on=”off|off|off” _builder_version=”4.20.2″ _module_preset=”default” position_origin_r=”bottom_left” width=”200px” max_width=”200px” content_width=”200px” content_max_width=”200px” min_height=”100px” height=”100px” max_height=”100px” custom_margin=”0px||0px||false|false” custom_padding=”0px||0px||false|false” auto=”on” auto_speed=”3000″ global_colors_info=”{}”][et_pb_slide _builder_version=”4.20.2″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2022\/05\/timpul_.jpg” background_enable_image=”on” background_size=”initial” custom_padding=”0px||0px||false|false” link_option_url=”#” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][et_pb_slide _builder_version=”4.20.2″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/pdi.ro\/2023\/2022\/wp-content\/uploads\/2022\/05\/medical-market_.jpg” background_enable_image=”on” background_size=”initial” custom_padding=”0px||0px||false|false” link_option_url=”https:\/\/issuu.com\/finwatch\/docs\/dermato?fr=sYWIzMjQ1MDUxNTY” link_option_url_new_window=”on” global_colors_info=”{}” sticky_transition=”on”][\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Dr. Ungureanu Gabriela Spitalul Jude\u0163ean de Urgen\u0163e Bac\u0103uAngioedemul ereditar prezentare de caz Autor: Gabriela Ungureanu \u0218ef sec\u021bie dermatogie-alergologie – Spitalul jude\u021bean de urgen\u021b\u0103 Bacau Angioedemul ereditar este o boal\u0103 genetic\u0103 rar\u0103, cu transmitere autosomal dominant\u0103, cauzat\u0103 de un deficit de C1 inhibitor esteraz\u0103, prin muta\u021bia genei SERPING1 ,caracterizat\u0103 clinic prin episoade recurente de angioedem subcutanat […]<\/p>\n","protected":false},"author":2,"featured_media":12894,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-7995","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7995","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=7995"}],"version-history":[{"count":20,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7995\/revisions"}],"predecessor-version":[{"id":13068,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/7995\/revisions\/13068"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/12894"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=7995"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=7995"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=7995"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\u0218ef sec\u021bie dermatogie-alergologie – Spitalul jude\u021bean de urgen\u021b\u0103 Bacau<\/p>\n
Fiziopatologic deficitul de C1 inhibitor esteraz\u0103 serologic sau func\u021bional duce la cresterea produc\u021biei de bradikinina ceea ce duce la cresterea permeabilit\u0103\u021bi vasculare cu apari\u021bia angioedemului.
Cel mai grav este angioedemul laringeal cu poten\u021bial fatal prin asfixie \u0219i care necesit\u0103 terapie imediat\u0103.
Diagnosticul corect \u0219i promt este esen\u021bial la pacientul cu angioedem ereditar care nu r\u0103spunde la medica\u021bia antihistaminic\u0103 \u0219i corticoterapia sistemic\u0103 tipic utilizat\u0103 \u00een angioedemul mediat histaminergic. \u00centarzierea diagnosticului poate fi amenin\u021b\u0103toare de via\u021ba la pacientul cu angioedem laringeal.
Accesul facil la medicul specialist \u0219i terapiile eficente din ultimi 10 ani au \u00eembun\u0103t\u0103\u021bit calitatea vie\u021bii pacientului cu angioedem ereditar \u0219i au redus rata mortalit\u0103\u021bi acestor pacien\u021bi.
Scopul terapiei \u00een atacurile acute, ca \u0219i profilaxia pe termen lung, este de a reduce frecven\u021ba \u0219i severitatea atacurilor prin monitorizare, terapie \u0219i administre de c\u0103tre pacien\u021bi la domiciliu a concentratelor de C1 inhibitori.<\/p>\n
Senior Physician in Allergology and clinical Immunology
Head of the Department of Dermatology and Allergology, Emergency Hospital Bacau<\/p>\n
Deficiencies in C1INH plasma level or function lead to increased production of bradykinin, which mediates vascular permeability, thus causing angioedema.
Laryngeal oedema is potentially life-threatening as a result of asphyxiation and requires immediate treatment.
Prompt and accurate diagnosis is essential as patients with hereditary angioedema do not respond to drugs typically prescribed for histaminergic mediated angeoedema. Delays in diagnosis can be fatal, particularly in the case of laryngeal oedema.
Hereditary angioedema therapy aims to avoid fatalities and to reduce the frequency and severity of angioedema attacks by means of on demand and short \u2013 and long \u2013 term prophilactic treatment. Acute treatment option includes C1INH concentrate (icatibant or ecallantide) administratied on site or self administratied at home when swelling appears.
Acces to specialist care and effective treatment in the past 10 years has improved the quality of life and has reduced the mortality rate in patients with hereditary angioedema.<\/p>\n
Februarie 2022-prezent – \u0218ef Sec\u021bie Dermatologie Alergologie – Spitalul Jude\u021bean de Urgen\u021b\u0103 Bac\u0103u
Septembrie 2009- Ianuarie 2022 – Medic primar alergologie -imunologie clinic\u0103 – Spitalul Jude\u021bean de Urgen\u021b\u0103 Bac\u0103u
Septembrie 2004- August 2009 – Medic specialist alergologie -imunologie clinic\u0103 – Spitalul jude\u021bean de Urgen\u021b\u0103 Bac\u0103u
Octombrie 1999- Iulie 2004 – Medic rezident alergologie imunologie-clinic\u0103 – Spital clinic Nicolae Malaxa Bucure\u0219ti
Educa\u0163ie \u015fi formare<\/strong>
Februarie 2022-prezent – \u0218ef Sec\u021bie Dermatologie Venerologie
Februarie 2021 \u2013 Ianuarie 2022 – Managementul Serviciilor de S\u0103n\u0103tate – SNSPMSB Bucure\u0219ti
Septembrie 2014- Septembrie 2019 – Certificat Medic specialist DV
Septembrie 2004 \u2013 Iulie 2009 – Certificat medic primar alergologie \u0219i imunologie clinic\u0103 – UMF Carol Davila Bucure\u0219ti<\/p>\n
Membru al Societ\u0103\u021bii Rom\u00e2ne de Alergologie \u0219i Imunologie clinic\u0103
Membru al Societ\u0103\u021bii Rom\u00e2ne de Pneumologie
Membru al European Respiratory Society
Membru al American Academy of Allergy Asthma and Immunology<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n