<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nConf. Univ. Dr. Onofrei Viviana<\/span><\/strong>
\nUniversitatea de Medicin\u0103 \u0219i Farmacie \u201dGrigore T. Popa\u201d, Ia\u0219i
\nSpitalul Jude\u021bean Clinic de Urgen\u021be, Sec\u021bia Cardiologie, Ia\u0219i, Rom\u00e2nia<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.2″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Lupusul eritematos cutanat \u0219i bolile cardiovasculare: cunoa\u0219tere actual\u0103<\/span><\/p>\nAutor: Viviana Onofrei<\/span>
\nUniversitatea de Medicin\u0103 \u0219i Farmacie “Gr. T. Popa” Ia\u0219i, Rom\u00e2nia
\nSpitalul Jude\u021bean Clinic de Urgen\u021be “Sf. Spiridon”, Clinica de Cardiologie, Ia\u0219i, Rom\u00e2nia<\/p>\nCuvinte cheie: lupus eritematos cutanat (LEC), boli cardiovasculare (BCV), inflama\u021bie, factori de risc<\/p>\n
Introducere: LEC este o afec\u021biune cutanat\u0103 inflamatorie cu prevalen\u021b\u0103 de 2-3 ori mai mare comparativ cu LE sistemic. Datele clinice actuale sugereaz\u0103 riscul crescut de BCV la pacien\u021bii cu LEC, dar mecanismele poten\u021biale nu sunt pe deplin \u00een\u021belese.
\nMaterial \u0219i metod\u0103: am analizat studiile observa\u021bionale care au investigat riscul de BCV, definite ca boal\u0103 coronarian\u0103 sau cerebrovascular\u0103, insuficien\u021b\u0103 cardiac\u0103, boal\u0103 arterial\u0103 periferic\u0103, evenimente acute cardiovasculare (CV), tromboembolism venos sau deces de cauz\u0103 CV, comparativ cu popula\u021bia general\u0103. De asemenea am discutat mecanismele poten\u021biale \u0219i rolul factorilor de risc studiate \u00een literatur\u0103.
\nRezutate: datele din studii sunt conflictuale \u00een ceea ce prive\u0219te prevalen\u021ba riscului global CV. Datele referitoare la evenimentele individuale coronariene\/arteriale periferice ischemice sau afec\u021biunile cerebrovasculare sunt de asemenea variabile. Pe de alt\u0103 parte, rela\u021bia cu tromboembolismul venos pare s\u0103 fie mai clar definit\u0103. Un mecanism poten\u021bial este r\u0103spunsul imun mediat de celulele T helper 1 via interferon gamma. TNF-\u03b1, stimulat de razele ultraviolete, \u0219i IL-7 sunt discutate \u00een medierea riscului CV. Prezen\u021ba frecvent\u0103 a factorilor de risc tradi\u021bionali ca sindromul metabolic sau fumatul \u00een LEC ridic\u0103 ipoteza unei rela\u021bii plauzibile cu BCV, dar rolul acestor factori nu este bine stabilit. Este discutat\u0103 \u0219i implicarea altor factori lega\u021bi de boal\u0103 \u2013 profil psiho-social, deficien\u021ba de vitamin\u0103 D sau medica\u021bia tip hidroxiclorochin\u0103, corticosteroizi, talidomid\u0103.
\nConcluzii: riscul de BCV la pacien\u021bii cu LEC este un domeniu care necesit\u0103 studii viitoare, deoarece implica\u021biile au importan\u021b\u0103 semnificativ\u0103 pentru managementul terapeutic.<\/p>\n
Cutaneous lupus erythematosus and cardiovascular disease: current knowledge<\/span><\/p>\nAuthor: Viviana Onofrei<\/span>
\n“Grigore T. Popa” University of Medicine and Pharmacy
\n“St. Spiridon” Emergency Districtual Clinical Hospital, Cardiology Department, Iasi, Romania<\/p>\nKey words: cutaneous lupus erythematosus (CLE), cardiovascular disease (CVD), inflammation, risk factors<\/p>\n
Introduction: CLE is a chronic inflammatory skin disease, which is 2-3 times more prevalent than systemic LE. Current clinical data reports the increased risk of CVD in patients with CLE, but the potential mechanisms are not entirely understood.
\nMaterial and method: we analyzed the observational studies that have investigated the risk of CVD, defined as coronary artery disease, cerebrovascular disease, heart failure, peripheral arterial disease, acute cardiovascular (CV) events, venous thromboembolism or CV death in patients with CLE as compared to the general population. We also discussed the potential mechanisms and the role of traditional risk factors studied in literature.
\nResults: the findings are conflicting between studies regarding the prevalence of global cardiovascular risk. Evidence for individual ischemic coronary\/peripheral arterial events or cerebrovascular entities is also inconsistent. On the other hand, the link to venous thromboembolism seems to be more clearly defined. A potential mechanism is the immune response involving T helper 1 cells, mediated by interferon gamma. TNF-\u03b1, upregulated by UV light and IL-7 are discussed to mediate cardiovascular risk. The common presence of traditional risk factors like the components of metabolic syndrome or smoking in CLE patients provides the hypothesis of a plausible link to CVD, but the role of these factors is not well understood. Other involved disease-associated factors as psychosocial profile, vitamin D deficiency or medications as hydroxychloroquine, corticosteroid, thalidomide are discussed.
\nConclusions: CVD risk in CLE patients is an area that needs further studies as the implications are of great significance for therapeutic management.<\/p>\n
Scurt CV<\/span><\/p>\nAbsolvent\u0103 a Facult\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie \u201dGrigore T. Popa\u201d Ia\u015fi, promo\u021bia 1991<\/p>\n
Experien\u0163a profesional\u0103:<\/strong>
\nConferen\u021biar universitar, Disciplina Medicin\u0103 Intern\u0103 (Cardiologie), Facultatea de Medicin\u0103, U.M.F. \u201cGrigore T. Popa\u201d Ia\u0219i
\nActivitate didactic\u0103 curicular\u0103 \u0219i extracuricular\u0103 continu\u0103 din 1996
\nMedic primar cardiologie \u0219i medicin\u0103 intern\u0103 la Clinica de Cardiologie, USTACC, Spitalul Jude\u021bean Clinic de Urgen\u021be \u201cSf. Spiridon\u201d Ia\u0219i
\nDoctor \u00een \u0219tiin\u021be medicale, teza de doctorat \u201dDisfunc\u021bia endotelial\u0103 \u00een hipertensiunea arterial\u0103\u201d, 2006
\nCompeten\u021be \u00een Ecocardiografie General\u0103 \u0219i Ultrasonografie General\u0103
\nMasterat “Bazele nutri\u0163iei clinice”, 2011<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
\nMembr\u0103 \u00een Societatea Rom\u00e2n\u0103 de Cardiologie
\nMembr\u0103 \u00een Societatea European\u0103 de Cardiologie
\nMembr\u0103 \u00een Societatea European\u0103 de Hipertensiune
\nMembr\u0103 \u00een American Heart Association\/American College of Cardiology)<\/p>\nDistinc\u021bii:<\/strong>
\nEuropean Hypertension Specialist
\nDiplom\u0103 de excelen\u021b\u0103 din partea Societ\u0103\u021bii Rom\u00e2ne de Hipertensiune
\nFellow of European Society of Cardiology<\/p>\nDomenii de interes \u015ftiin\u0163ific:<\/strong>
\nAfectarea cardiovascular\u0103 \u00een patologia medical\u0103, hipertensiunea arterial\u0103, disfunc\u0163ia endotelial\u0103 \u015fi rigiditatea arterial\u0103, insuficien\u0163a cardiac\u0103, bolile vasculare, boli metabolice.
\nImplicare activ\u0103 \u00een activitatea de cercetare \u0219tiin\u021bific\u0103 (granturi de cercetare \u0219tiin\u021bific\u0103, coinvestigator \u00een studii clinice multicentrice interna\u021bionale, colaborator \u00een registre na\u021bionale \u0219i europene de specialitate)
\nMetode de investiga\u0163ie sau tratament originale introduse \u00een premier\u0103 na\u021bional\u0103 (studiul comparativ \u015fi integrat al disfunc\u0163iei endoteliale \u00een hipertensiunea arterial\u0103 prin metoda Complior \u015fi ecografie vascular\u0103 (2001), tromboliza ghidat\u0103 pe cateter \u00een trombozele venoase profunde (echipa Prof. Dr. Datcu \u2013 2004)
\nEditor de c\u0103r\u021bi de specialitate cu colectiv na\u021bional, manuale, peste 100 lucr\u0103ri \u0219tiin\u021bifice \u00een reviste ISI \u0219i BDI<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”on|on|on” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” disabled=”on” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2023<\/p>\n
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Operatorul PDI 2023<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ. Dr. Onofrei Viviana Universitatea de Medicin\u0103 \u0219i Farmacie \u201dGrigore T. Popa\u201d, Ia\u0219i Spitalul Jude\u021bean Clinic de Urgen\u021be, Sec\u021bia Cardiologie, Ia\u0219i, Rom\u00e2niaLupusul eritematos cutanat \u0219i bolile cardiovasculare: cunoa\u0219tere actual\u0103 Autor: Viviana Onofrei Universitatea de Medicin\u0103 \u0219i Farmacie “Gr. T. Popa” Ia\u0219i, Rom\u00e2nia Spitalul Jude\u021bean Clinic de Urgen\u021be “Sf. Spiridon”, Clinica de Cardiologie, Ia\u0219i, Rom\u00e2nia […]<\/p>\n","protected":false},"author":2,"featured_media":11320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8086","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=8086"}],"version-history":[{"count":16,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8086\/revisions"}],"predecessor-version":[{"id":12886,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8086\/revisions\/12886"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11320"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=8086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=8086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=8086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Conf. Univ. Dr. Onofrei Viviana<\/span><\/strong>
\nUniversitatea de Medicin\u0103 \u0219i Farmacie \u201dGrigore T. Popa\u201d, Ia\u0219i
\nSpitalul Jude\u021bean Clinic de Urgen\u021be, Sec\u021bia Cardiologie, Ia\u0219i, Rom\u00e2nia<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.2″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Lupusul eritematos cutanat \u0219i bolile cardiovasculare: cunoa\u0219tere actual\u0103<\/span><\/p>\nAutor: Viviana Onofrei<\/span>
\nUniversitatea de Medicin\u0103 \u0219i Farmacie “Gr. T. Popa” Ia\u0219i, Rom\u00e2nia
\nSpitalul Jude\u021bean Clinic de Urgen\u021be “Sf. Spiridon”, Clinica de Cardiologie, Ia\u0219i, Rom\u00e2nia<\/p>\nCuvinte cheie: lupus eritematos cutanat (LEC), boli cardiovasculare (BCV), inflama\u021bie, factori de risc<\/p>\n
Introducere: LEC este o afec\u021biune cutanat\u0103 inflamatorie cu prevalen\u021b\u0103 de 2-3 ori mai mare comparativ cu LE sistemic. Datele clinice actuale sugereaz\u0103 riscul crescut de BCV la pacien\u021bii cu LEC, dar mecanismele poten\u021biale nu sunt pe deplin \u00een\u021belese.
\nMaterial \u0219i metod\u0103: am analizat studiile observa\u021bionale care au investigat riscul de BCV, definite ca boal\u0103 coronarian\u0103 sau cerebrovascular\u0103, insuficien\u021b\u0103 cardiac\u0103, boal\u0103 arterial\u0103 periferic\u0103, evenimente acute cardiovasculare (CV), tromboembolism venos sau deces de cauz\u0103 CV, comparativ cu popula\u021bia general\u0103. De asemenea am discutat mecanismele poten\u021biale \u0219i rolul factorilor de risc studiate \u00een literatur\u0103.
\nRezutate: datele din studii sunt conflictuale \u00een ceea ce prive\u0219te prevalen\u021ba riscului global CV. Datele referitoare la evenimentele individuale coronariene\/arteriale periferice ischemice sau afec\u021biunile cerebrovasculare sunt de asemenea variabile. Pe de alt\u0103 parte, rela\u021bia cu tromboembolismul venos pare s\u0103 fie mai clar definit\u0103. Un mecanism poten\u021bial este r\u0103spunsul imun mediat de celulele T helper 1 via interferon gamma. TNF-\u03b1, stimulat de razele ultraviolete, \u0219i IL-7 sunt discutate \u00een medierea riscului CV. Prezen\u021ba frecvent\u0103 a factorilor de risc tradi\u021bionali ca sindromul metabolic sau fumatul \u00een LEC ridic\u0103 ipoteza unei rela\u021bii plauzibile cu BCV, dar rolul acestor factori nu este bine stabilit. Este discutat\u0103 \u0219i implicarea altor factori lega\u021bi de boal\u0103 \u2013 profil psiho-social, deficien\u021ba de vitamin\u0103 D sau medica\u021bia tip hidroxiclorochin\u0103, corticosteroizi, talidomid\u0103.
\nConcluzii: riscul de BCV la pacien\u021bii cu LEC este un domeniu care necesit\u0103 studii viitoare, deoarece implica\u021biile au importan\u021b\u0103 semnificativ\u0103 pentru managementul terapeutic.<\/p>\n
Cutaneous lupus erythematosus and cardiovascular disease: current knowledge<\/span><\/p>\nAuthor: Viviana Onofrei<\/span>
\n“Grigore T. Popa” University of Medicine and Pharmacy
\n“St. Spiridon” Emergency Districtual Clinical Hospital, Cardiology Department, Iasi, Romania<\/p>\nKey words: cutaneous lupus erythematosus (CLE), cardiovascular disease (CVD), inflammation, risk factors<\/p>\n
Introduction: CLE is a chronic inflammatory skin disease, which is 2-3 times more prevalent than systemic LE. Current clinical data reports the increased risk of CVD in patients with CLE, but the potential mechanisms are not entirely understood.
\nMaterial and method: we analyzed the observational studies that have investigated the risk of CVD, defined as coronary artery disease, cerebrovascular disease, heart failure, peripheral arterial disease, acute cardiovascular (CV) events, venous thromboembolism or CV death in patients with CLE as compared to the general population. We also discussed the potential mechanisms and the role of traditional risk factors studied in literature.
\nResults: the findings are conflicting between studies regarding the prevalence of global cardiovascular risk. Evidence for individual ischemic coronary\/peripheral arterial events or cerebrovascular entities is also inconsistent. On the other hand, the link to venous thromboembolism seems to be more clearly defined. A potential mechanism is the immune response involving T helper 1 cells, mediated by interferon gamma. TNF-\u03b1, upregulated by UV light and IL-7 are discussed to mediate cardiovascular risk. The common presence of traditional risk factors like the components of metabolic syndrome or smoking in CLE patients provides the hypothesis of a plausible link to CVD, but the role of these factors is not well understood. Other involved disease-associated factors as psychosocial profile, vitamin D deficiency or medications as hydroxychloroquine, corticosteroid, thalidomide are discussed.
\nConclusions: CVD risk in CLE patients is an area that needs further studies as the implications are of great significance for therapeutic management.<\/p>\n
Scurt CV<\/span><\/p>\nAbsolvent\u0103 a Facult\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie \u201dGrigore T. Popa\u201d Ia\u015fi, promo\u021bia 1991<\/p>\n
Experien\u0163a profesional\u0103:<\/strong>
\nConferen\u021biar universitar, Disciplina Medicin\u0103 Intern\u0103 (Cardiologie), Facultatea de Medicin\u0103, U.M.F. \u201cGrigore T. Popa\u201d Ia\u0219i
\nActivitate didactic\u0103 curicular\u0103 \u0219i extracuricular\u0103 continu\u0103 din 1996
\nMedic primar cardiologie \u0219i medicin\u0103 intern\u0103 la Clinica de Cardiologie, USTACC, Spitalul Jude\u021bean Clinic de Urgen\u021be \u201cSf. Spiridon\u201d Ia\u0219i
\nDoctor \u00een \u0219tiin\u021be medicale, teza de doctorat \u201dDisfunc\u021bia endotelial\u0103 \u00een hipertensiunea arterial\u0103\u201d, 2006
\nCompeten\u021be \u00een Ecocardiografie General\u0103 \u0219i Ultrasonografie General\u0103
\nMasterat “Bazele nutri\u0163iei clinice”, 2011<\/p>\nApartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong>
\nMembr\u0103 \u00een Societatea Rom\u00e2n\u0103 de Cardiologie
\nMembr\u0103 \u00een Societatea European\u0103 de Cardiologie
\nMembr\u0103 \u00een Societatea European\u0103 de Hipertensiune
\nMembr\u0103 \u00een American Heart Association\/American College of Cardiology)<\/p>\nDistinc\u021bii:<\/strong>
\nEuropean Hypertension Specialist
\nDiplom\u0103 de excelen\u021b\u0103 din partea Societ\u0103\u021bii Rom\u00e2ne de Hipertensiune
\nFellow of European Society of Cardiology<\/p>\nDomenii de interes \u015ftiin\u0163ific:<\/strong>
\nAfectarea cardiovascular\u0103 \u00een patologia medical\u0103, hipertensiunea arterial\u0103, disfunc\u0163ia endotelial\u0103 \u015fi rigiditatea arterial\u0103, insuficien\u0163a cardiac\u0103, bolile vasculare, boli metabolice.
\nImplicare activ\u0103 \u00een activitatea de cercetare \u0219tiin\u021bific\u0103 (granturi de cercetare \u0219tiin\u021bific\u0103, coinvestigator \u00een studii clinice multicentrice interna\u021bionale, colaborator \u00een registre na\u021bionale \u0219i europene de specialitate)
\nMetode de investiga\u0163ie sau tratament originale introduse \u00een premier\u0103 na\u021bional\u0103 (studiul comparativ \u015fi integrat al disfunc\u0163iei endoteliale \u00een hipertensiunea arterial\u0103 prin metoda Complior \u015fi ecografie vascular\u0103 (2001), tromboliza ghidat\u0103 pe cateter \u00een trombozele venoase profunde (echipa Prof. Dr. Datcu \u2013 2004)
\nEditor de c\u0103r\u021bi de specialitate cu colectiv na\u021bional, manuale, peste 100 lucr\u0103ri \u0219tiin\u021bifice \u00een reviste ISI \u0219i BDI<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”on|on|on” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” disabled=”on” global_colors_info=”{}”]<\/p>\n
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Operatorul PDI 2023<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Conf. Univ. Dr. Onofrei Viviana Universitatea de Medicin\u0103 \u0219i Farmacie \u201dGrigore T. Popa\u201d, Ia\u0219i Spitalul Jude\u021bean Clinic de Urgen\u021be, Sec\u021bia Cardiologie, Ia\u0219i, Rom\u00e2niaLupusul eritematos cutanat \u0219i bolile cardiovasculare: cunoa\u0219tere actual\u0103 Autor: Viviana Onofrei Universitatea de Medicin\u0103 \u0219i Farmacie “Gr. T. Popa” Ia\u0219i, Rom\u00e2nia Spitalul Jude\u021bean Clinic de Urgen\u021be “Sf. Spiridon”, Clinica de Cardiologie, Ia\u0219i, Rom\u00e2nia […]<\/p>\n","protected":false},"author":2,"featured_media":11320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8086","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=8086"}],"version-history":[{"count":16,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8086\/revisions"}],"predecessor-version":[{"id":12886,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8086\/revisions\/12886"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11320"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=8086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=8086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=8086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autor: Viviana Onofrei<\/span> Cuvinte cheie: lupus eritematos cutanat (LEC), boli cardiovasculare (BCV), inflama\u021bie, factori de risc<\/p>\n Introducere: LEC este o afec\u021biune cutanat\u0103 inflamatorie cu prevalen\u021b\u0103 de 2-3 ori mai mare comparativ cu LE sistemic. Datele clinice actuale sugereaz\u0103 riscul crescut de BCV la pacien\u021bii cu LEC, dar mecanismele poten\u021biale nu sunt pe deplin \u00een\u021belese. Cutaneous lupus erythematosus and cardiovascular disease: current knowledge<\/span><\/p>\n Author: Viviana Onofrei<\/span> Key words: cutaneous lupus erythematosus (CLE), cardiovascular disease (CVD), inflammation, risk factors<\/p>\n Introduction: CLE is a chronic inflammatory skin disease, which is 2-3 times more prevalent than systemic LE. Current clinical data reports the increased risk of CVD in patients with CLE, but the potential mechanisms are not entirely understood. Scurt CV<\/span><\/p>\n Absolvent\u0103 a Facult\u0103\u0163ii de Medicin\u0103 \u015fi Farmacie \u201dGrigore T. Popa\u201d Ia\u015fi, promo\u021bia 1991<\/p>\n Experien\u0163a profesional\u0103:<\/strong> Apartenen\u0163a la Societ\u0103\u0163i \u015ftiin\u0163ifice:<\/strong> Distinc\u021bii:<\/strong> Domenii de interes \u015ftiin\u0163ific:<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”1_4,3_4″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”on|on|on” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” disabled=”on” global_colors_info=”{}”]<\/p>\n Contacteaz\u0103 operatorul PDI 2023<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro” submit_button_text=”Trimite mesajul” disabled_on=”on|on|on” _builder_version=”4.20.2″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” disabled=”on” 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button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” 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Univ. Dr. Onofrei Viviana Universitatea de Medicin\u0103 \u0219i Farmacie \u201dGrigore T. Popa\u201d, Ia\u0219i Spitalul Jude\u021bean Clinic de Urgen\u021be, Sec\u021bia Cardiologie, Ia\u0219i, Rom\u00e2niaLupusul eritematos cutanat \u0219i bolile cardiovasculare: cunoa\u0219tere actual\u0103 Autor: Viviana Onofrei Universitatea de Medicin\u0103 \u0219i Farmacie “Gr. T. Popa” Ia\u0219i, Rom\u00e2nia Spitalul Jude\u021bean Clinic de Urgen\u021be “Sf. Spiridon”, Clinica de Cardiologie, Ia\u0219i, Rom\u00e2nia […]<\/p>\n","protected":false},"author":2,"featured_media":11320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8086","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8086","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=8086"}],"version-history":[{"count":16,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8086\/revisions"}],"predecessor-version":[{"id":12886,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8086\/revisions\/12886"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11320"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=8086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=8086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=8086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nUniversitatea de Medicin\u0103 \u0219i Farmacie “Gr. T. Popa” Ia\u0219i, Rom\u00e2nia
\nSpitalul Jude\u021bean Clinic de Urgen\u021be “Sf. Spiridon”, Clinica de Cardiologie, Ia\u0219i, Rom\u00e2nia<\/p>\n
\nMaterial \u0219i metod\u0103: am analizat studiile observa\u021bionale care au investigat riscul de BCV, definite ca boal\u0103 coronarian\u0103 sau cerebrovascular\u0103, insuficien\u021b\u0103 cardiac\u0103, boal\u0103 arterial\u0103 periferic\u0103, evenimente acute cardiovasculare (CV), tromboembolism venos sau deces de cauz\u0103 CV, comparativ cu popula\u021bia general\u0103. De asemenea am discutat mecanismele poten\u021biale \u0219i rolul factorilor de risc studiate \u00een literatur\u0103.
\nRezutate: datele din studii sunt conflictuale \u00een ceea ce prive\u0219te prevalen\u021ba riscului global CV. Datele referitoare la evenimentele individuale coronariene\/arteriale periferice ischemice sau afec\u021biunile cerebrovasculare sunt de asemenea variabile. Pe de alt\u0103 parte, rela\u021bia cu tromboembolismul venos pare s\u0103 fie mai clar definit\u0103. Un mecanism poten\u021bial este r\u0103spunsul imun mediat de celulele T helper 1 via interferon gamma. TNF-\u03b1, stimulat de razele ultraviolete, \u0219i IL-7 sunt discutate \u00een medierea riscului CV. Prezen\u021ba frecvent\u0103 a factorilor de risc tradi\u021bionali ca sindromul metabolic sau fumatul \u00een LEC ridic\u0103 ipoteza unei rela\u021bii plauzibile cu BCV, dar rolul acestor factori nu este bine stabilit. Este discutat\u0103 \u0219i implicarea altor factori lega\u021bi de boal\u0103 \u2013 profil psiho-social, deficien\u021ba de vitamin\u0103 D sau medica\u021bia tip hidroxiclorochin\u0103, corticosteroizi, talidomid\u0103.
\nConcluzii: riscul de BCV la pacien\u021bii cu LEC este un domeniu care necesit\u0103 studii viitoare, deoarece implica\u021biile au importan\u021b\u0103 semnificativ\u0103 pentru managementul terapeutic.<\/p>\n
\n“Grigore T. Popa” University of Medicine and Pharmacy
\n“St. Spiridon” Emergency Districtual Clinical Hospital, Cardiology Department, Iasi, Romania<\/p>\n
\nMaterial and method: we analyzed the observational studies that have investigated the risk of CVD, defined as coronary artery disease, cerebrovascular disease, heart failure, peripheral arterial disease, acute cardiovascular (CV) events, venous thromboembolism or CV death in patients with CLE as compared to the general population. We also discussed the potential mechanisms and the role of traditional risk factors studied in literature.
\nResults: the findings are conflicting between studies regarding the prevalence of global cardiovascular risk. Evidence for individual ischemic coronary\/peripheral arterial events or cerebrovascular entities is also inconsistent. On the other hand, the link to venous thromboembolism seems to be more clearly defined. A potential mechanism is the immune response involving T helper 1 cells, mediated by interferon gamma. TNF-\u03b1, upregulated by UV light and IL-7 are discussed to mediate cardiovascular risk. The common presence of traditional risk factors like the components of metabolic syndrome or smoking in CLE patients provides the hypothesis of a plausible link to CVD, but the role of these factors is not well understood. Other involved disease-associated factors as psychosocial profile, vitamin D deficiency or medications as hydroxychloroquine, corticosteroid, thalidomide are discussed.
\nConclusions: CVD risk in CLE patients is an area that needs further studies as the implications are of great significance for therapeutic management.<\/p>\n
\nConferen\u021biar universitar, Disciplina Medicin\u0103 Intern\u0103 (Cardiologie), Facultatea de Medicin\u0103, U.M.F. \u201cGrigore T. Popa\u201d Ia\u0219i
\nActivitate didactic\u0103 curicular\u0103 \u0219i extracuricular\u0103 continu\u0103 din 1996
\nMedic primar cardiologie \u0219i medicin\u0103 intern\u0103 la Clinica de Cardiologie, USTACC, Spitalul Jude\u021bean Clinic de Urgen\u021be \u201cSf. Spiridon\u201d Ia\u0219i
\nDoctor \u00een \u0219tiin\u021be medicale, teza de doctorat \u201dDisfunc\u021bia endotelial\u0103 \u00een hipertensiunea arterial\u0103\u201d, 2006
\nCompeten\u021be \u00een Ecocardiografie General\u0103 \u0219i Ultrasonografie General\u0103
\nMasterat “Bazele nutri\u0163iei clinice”, 2011<\/p>\n
\nMembr\u0103 \u00een Societatea Rom\u00e2n\u0103 de Cardiologie
\nMembr\u0103 \u00een Societatea European\u0103 de Cardiologie
\nMembr\u0103 \u00een Societatea European\u0103 de Hipertensiune
\nMembr\u0103 \u00een American Heart Association\/American College of Cardiology)<\/p>\n
\nEuropean Hypertension Specialist
\nDiplom\u0103 de excelen\u021b\u0103 din partea Societ\u0103\u021bii Rom\u00e2ne de Hipertensiune
\nFellow of European Society of Cardiology<\/p>\n
\nAfectarea cardiovascular\u0103 \u00een patologia medical\u0103, hipertensiunea arterial\u0103, disfunc\u0163ia endotelial\u0103 \u015fi rigiditatea arterial\u0103, insuficien\u0163a cardiac\u0103, bolile vasculare, boli metabolice.
\nImplicare activ\u0103 \u00een activitatea de cercetare \u0219tiin\u021bific\u0103 (granturi de cercetare \u0219tiin\u021bific\u0103, coinvestigator \u00een studii clinice multicentrice interna\u021bionale, colaborator \u00een registre na\u021bionale \u0219i europene de specialitate)
\nMetode de investiga\u0163ie sau tratament originale introduse \u00een premier\u0103 na\u021bional\u0103 (studiul comparativ \u015fi integrat al disfunc\u0163iei endoteliale \u00een hipertensiunea arterial\u0103 prin metoda Complior \u015fi ecografie vascular\u0103 (2001), tromboliza ghidat\u0103 pe cateter \u00een trombozele venoase profunde (echipa Prof. Dr. Datcu \u2013 2004)
\nEditor de c\u0103r\u021bi de specialitate cu colectiv na\u021bional, manuale, peste 100 lucr\u0103ri \u0219tiin\u021bifice \u00een reviste ISI \u0219i BDI<\/p>\n<\/span><\/p>\n
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