<\/span><\/strong><\/h4>\n<\/span><\/strong><\/h4>\nC.\u0218. gr. I Dr. Benea Vasile<\/span><\/strong>
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.4″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Actualit\u0103\u021bi \u00een urticarie-angioedem<\/span><\/p>\nAutori: Vasile Benea1, Simona-Roxana Georgescu1,2<\/span>
1. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti<\/p>\nCuvinte cheie: urticarie, angioedem, antihistaminice, omalizumab<\/p>\n
Urticaria este o afec\u021biune cutanat\u0103 inflamatorie caracterizat\u0103 clinic prin pl\u0103ci eritemato-edematoase intens pruriginoase. \u00cen aproximativ 40-50% din cazuri se \u00eenso\u021be\u0219te de angioedem; de asemenea, \u00een p\u00e2n\u0103 la 13% din cazuri poate ap\u0103rea doar angioedemul. Urticaria are o evolu\u021bie imprevizibil\u0103, \u00een multe cazuri put\u00e2nd dura mai mul\u021bi ani, cu un impact considerabil asupra calit\u0103\u021bii vie\u021bii pacien\u021bilor.
\u00cen fiziopatologia bolii sunt implicate diverse celule, cum ar fi mastocitele, bazofilele \u0219i eozinofilele, dar \u0219i limfocitele B \u0219i T sau monocitele; \u00een urma interac\u021biunilor dintre acestea sunt elibera\u021bi mediatori vasoactivi ce contribuie la apari\u021bia manifest\u0103rilor clinice. De\u0219i histamina are un rol important \u00een apari\u021bia urticariei, \u00een patogenia acesteia sunt implicate multe alte citokine, factori chemotactici, proteaze etc., precum \u0219i componente ale sistemelor complementului \u0219i coagul\u0103rii.
De\u0219i au fost ob\u021binute progrese considerabile, nu exist\u0103 \u00eenc\u0103 un tratament curativ al urticariei. Mijloacele terapeutice actuale pot asigura controlul simptomatic al bolii, dar nu pot influen\u021ba evolu\u021bia natural\u0103 a acesteia. Antihistaminicele nesedative reprezint\u0103 prima linie de tratament, fiind eficiente \u00een 40-50% din cazuri; un beneficiu suplimentar (cre\u0219terea ratei de succes la 45-55%) poate fi ob\u021binut prin cre\u0219terea dozelor. O parte dintre pacien\u021bi neresponsivi pot beneficia de tratamentul cu anticorpi anti-IgE (omalizumab); cazurile care nu sunt influen\u021bate de omalizumab (de obicei cu urticarie autoimun\u0103 de tip IIb) pot r\u0103spunde la ciclosporin\u0103. O mai bun\u0103 cunoa\u0219tere a mecanismelor fiziopatologice implicate \u00een urticarie permite identificarea unor noi \u021binte \u0219i mijloace terapeutice, cum ar fi al\u021bi anticorpi anti-IgE, inhibitori ai BTK (Bruton’s tyrosine kinase – fenebrutinib \u0219i remibrutinib), dupilumab etc. care s\u0103 contribuie la un mai bun control al bolii.<\/p>\n
Urticaria-angioedema \u2013 an update<\/span><\/p>\nVasile Benea1, Simona-Roxana Georgescu1,2<\/span>
1Dermato-venereology Clinic, “Victor Babe\u0219” Clinical Hospital for Infectious and Tropical Diseases Bucharest.
2University of Medicine and Pharmacy “Carol Davila” Bucharest<\/p>\nKeywords: urticaria, angioedema, antihistamines, omalizumab<\/p>\n
Urticaria is an inflammatory skin condition clinically characterized by intensely itchy wheals. In approximately 40-50% of cases it is accompanied by angioedema; also, in up to 13% of cases, only angioedema may occur. Urticaria has an unpredictable evolution, which in many cases can last for several years, with a considerable impact on the patients’ quality of life.
Various cells are involved in the pathophysiology of the disease, such as mast cells, basophils and eosinophils, but also B and T lymphocytes or monocytes; following the interactions between them, vasoactive mediators are released that contribute to the appearance of clinical manifestations. Although histamine has an important role in the occurrence of urticaria, many other cytokines, chemotactic factors, proteases, etc., as well as components of the complement and coagulation systems are involved in its pathogenesis.
Although considerable progress has been made, there is still no curative treatment for urticaria. Current therapeutic means can provide symptomatic control of the disease, but cannot influence its natural history. Non-sedating antihistamines represent the first line of treatment, being effective in 40-50% of cases; an additional benefit (increasing the success rate to 45-55%) can be obtained by increasing the doses. Some unresponsive patients may benefit from treatment with anti-IgE antibodies (omalizumab); cases not affected by omalizumab (usually with autoimmune urticaria type IIb) may respond to ciclosporin. A better knowledge of the pathophysiological mechanisms involved in urticaria allows the identification of new targets and therapeutic means, such as other anti-IgE antibodies, BTK (Bruton’s tyrosine kinase) inhibitors (fenebrutinib and remibrutinib), dupilumab, etc. which will contribute to a better control of the disease.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103:<\/strong>
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, Bucure\u015fti
Educa\u0163ie \u015fi formare:<\/strong>
Perioada:
Calificarea \/ diploma ob\u0163inut\u0103:
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
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C.\u0218. gr. I Dr. Benea VasileSpitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015ftiActualit\u0103\u021bi \u00een urticarie-angioedem Autori: Vasile Benea1, Simona-Roxana Georgescu1,21. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti Cuvinte cheie: urticarie, angioedem, antihistaminice, omalizumab Urticaria este o afec\u021biune cutanat\u0103 inflamatorie […]<\/p>\n","protected":false},"author":2,"featured_media":11281,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8447","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=8447"}],"version-history":[{"count":25,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8447\/revisions"}],"predecessor-version":[{"id":13144,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8447\/revisions\/13144"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11281"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=8447"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=8447"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=8447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
C.\u0218. gr. I Dr. Benea Vasile<\/span><\/strong>
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015fti<\/span><\/strong><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.4″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Actualit\u0103\u021bi \u00een urticarie-angioedem<\/span><\/p>\nAutori: Vasile Benea1, Simona-Roxana Georgescu1,2<\/span>
1. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti<\/p>\nCuvinte cheie: urticarie, angioedem, antihistaminice, omalizumab<\/p>\n
Urticaria este o afec\u021biune cutanat\u0103 inflamatorie caracterizat\u0103 clinic prin pl\u0103ci eritemato-edematoase intens pruriginoase. \u00cen aproximativ 40-50% din cazuri se \u00eenso\u021be\u0219te de angioedem; de asemenea, \u00een p\u00e2n\u0103 la 13% din cazuri poate ap\u0103rea doar angioedemul. Urticaria are o evolu\u021bie imprevizibil\u0103, \u00een multe cazuri put\u00e2nd dura mai mul\u021bi ani, cu un impact considerabil asupra calit\u0103\u021bii vie\u021bii pacien\u021bilor.
\u00cen fiziopatologia bolii sunt implicate diverse celule, cum ar fi mastocitele, bazofilele \u0219i eozinofilele, dar \u0219i limfocitele B \u0219i T sau monocitele; \u00een urma interac\u021biunilor dintre acestea sunt elibera\u021bi mediatori vasoactivi ce contribuie la apari\u021bia manifest\u0103rilor clinice. De\u0219i histamina are un rol important \u00een apari\u021bia urticariei, \u00een patogenia acesteia sunt implicate multe alte citokine, factori chemotactici, proteaze etc., precum \u0219i componente ale sistemelor complementului \u0219i coagul\u0103rii.
De\u0219i au fost ob\u021binute progrese considerabile, nu exist\u0103 \u00eenc\u0103 un tratament curativ al urticariei. Mijloacele terapeutice actuale pot asigura controlul simptomatic al bolii, dar nu pot influen\u021ba evolu\u021bia natural\u0103 a acesteia. Antihistaminicele nesedative reprezint\u0103 prima linie de tratament, fiind eficiente \u00een 40-50% din cazuri; un beneficiu suplimentar (cre\u0219terea ratei de succes la 45-55%) poate fi ob\u021binut prin cre\u0219terea dozelor. O parte dintre pacien\u021bi neresponsivi pot beneficia de tratamentul cu anticorpi anti-IgE (omalizumab); cazurile care nu sunt influen\u021bate de omalizumab (de obicei cu urticarie autoimun\u0103 de tip IIb) pot r\u0103spunde la ciclosporin\u0103. O mai bun\u0103 cunoa\u0219tere a mecanismelor fiziopatologice implicate \u00een urticarie permite identificarea unor noi \u021binte \u0219i mijloace terapeutice, cum ar fi al\u021bi anticorpi anti-IgE, inhibitori ai BTK (Bruton’s tyrosine kinase – fenebrutinib \u0219i remibrutinib), dupilumab etc. care s\u0103 contribuie la un mai bun control al bolii.<\/p>\n
Urticaria-angioedema \u2013 an update<\/span><\/p>\nVasile Benea1, Simona-Roxana Georgescu1,2<\/span>
1Dermato-venereology Clinic, “Victor Babe\u0219” Clinical Hospital for Infectious and Tropical Diseases Bucharest.
2University of Medicine and Pharmacy “Carol Davila” Bucharest<\/p>\nKeywords: urticaria, angioedema, antihistamines, omalizumab<\/p>\n
Urticaria is an inflammatory skin condition clinically characterized by intensely itchy wheals. In approximately 40-50% of cases it is accompanied by angioedema; also, in up to 13% of cases, only angioedema may occur. Urticaria has an unpredictable evolution, which in many cases can last for several years, with a considerable impact on the patients’ quality of life.
Various cells are involved in the pathophysiology of the disease, such as mast cells, basophils and eosinophils, but also B and T lymphocytes or monocytes; following the interactions between them, vasoactive mediators are released that contribute to the appearance of clinical manifestations. Although histamine has an important role in the occurrence of urticaria, many other cytokines, chemotactic factors, proteases, etc., as well as components of the complement and coagulation systems are involved in its pathogenesis.
Although considerable progress has been made, there is still no curative treatment for urticaria. Current therapeutic means can provide symptomatic control of the disease, but cannot influence its natural history. Non-sedating antihistamines represent the first line of treatment, being effective in 40-50% of cases; an additional benefit (increasing the success rate to 45-55%) can be obtained by increasing the doses. Some unresponsive patients may benefit from treatment with anti-IgE antibodies (omalizumab); cases not affected by omalizumab (usually with autoimmune urticaria type IIb) may respond to ciclosporin. A better knowledge of the pathophysiological mechanisms involved in urticaria allows the identification of new targets and therapeutic means, such as other anti-IgE antibodies, BTK (Bruton’s tyrosine kinase) inhibitors (fenebrutinib and remibrutinib), dupilumab, etc. which will contribute to a better control of the disease.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103:<\/strong>
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, Bucure\u015fti
Educa\u0163ie \u015fi formare:<\/strong>
Perioada:
Calificarea \/ diploma ob\u0163inut\u0103:
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2023<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro” submit_button_text=”Trimite mesajul” disabled_on=”off|off|off” _builder_version=”4.20.2″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n
Operatorul PDI 2023<\/p>\n
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<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n
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C.\u0218. gr. I Dr. Benea VasileSpitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015ftiActualit\u0103\u021bi \u00een urticarie-angioedem Autori: Vasile Benea1, Simona-Roxana Georgescu1,21. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti Cuvinte cheie: urticarie, angioedem, antihistaminice, omalizumab Urticaria este o afec\u021biune cutanat\u0103 inflamatorie […]<\/p>\n","protected":false},"author":2,"featured_media":11281,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8447","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=8447"}],"version-history":[{"count":25,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8447\/revisions"}],"predecessor-version":[{"id":13144,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8447\/revisions\/13144"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11281"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=8447"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=8447"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=8447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Vasile Benea1, Simona-Roxana Georgescu1,2<\/span> Cuvinte cheie: urticarie, angioedem, antihistaminice, omalizumab<\/p>\n Urticaria este o afec\u021biune cutanat\u0103 inflamatorie caracterizat\u0103 clinic prin pl\u0103ci eritemato-edematoase intens pruriginoase. \u00cen aproximativ 40-50% din cazuri se \u00eenso\u021be\u0219te de angioedem; de asemenea, \u00een p\u00e2n\u0103 la 13% din cazuri poate ap\u0103rea doar angioedemul. Urticaria are o evolu\u021bie imprevizibil\u0103, \u00een multe cazuri put\u00e2nd dura mai mul\u021bi ani, cu un impact considerabil asupra calit\u0103\u021bii vie\u021bii pacien\u021bilor. Urticaria-angioedema \u2013 an update<\/span><\/p>\n Vasile Benea1, Simona-Roxana Georgescu1,2<\/span> Keywords: urticaria, angioedema, antihistamines, omalizumab<\/p>\n Urticaria is an inflammatory skin condition clinically characterized by intensely itchy wheals. In approximately 40-50% of cases it is accompanied by angioedema; also, in up to 13% of cases, only angioedema may occur. Urticaria has an unpredictable evolution, which in many cases can last for several years, with a considerable impact on the patients’ quality of life. Scurt CV<\/span><\/p>\n Experien\u0163a profesional\u0103:<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” 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I Dr. Benea VasileSpitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale “Victor Babe\u015f\u201d Bucure\u015ftiActualit\u0103\u021bi \u00een urticarie-angioedem Autori: Vasile Benea1, Simona-Roxana Georgescu1,21. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti Cuvinte cheie: urticarie, angioedem, antihistaminice, omalizumab Urticaria este o afec\u021biune cutanat\u0103 inflamatorie […]<\/p>\n","protected":false},"author":2,"featured_media":11281,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8447","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=8447"}],"version-history":[{"count":25,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8447\/revisions"}],"predecessor-version":[{"id":13144,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8447\/revisions\/13144"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11281"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=8447"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=8447"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=8447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
1. Clinica de Dermatovenerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2. Universitatea de Medicin\u0103 \u0219i Farmacie “Carol Davila” Bucure\u015fti<\/p>\n
\u00cen fiziopatologia bolii sunt implicate diverse celule, cum ar fi mastocitele, bazofilele \u0219i eozinofilele, dar \u0219i limfocitele B \u0219i T sau monocitele; \u00een urma interac\u021biunilor dintre acestea sunt elibera\u021bi mediatori vasoactivi ce contribuie la apari\u021bia manifest\u0103rilor clinice. De\u0219i histamina are un rol important \u00een apari\u021bia urticariei, \u00een patogenia acesteia sunt implicate multe alte citokine, factori chemotactici, proteaze etc., precum \u0219i componente ale sistemelor complementului \u0219i coagul\u0103rii.
De\u0219i au fost ob\u021binute progrese considerabile, nu exist\u0103 \u00eenc\u0103 un tratament curativ al urticariei. Mijloacele terapeutice actuale pot asigura controlul simptomatic al bolii, dar nu pot influen\u021ba evolu\u021bia natural\u0103 a acesteia. Antihistaminicele nesedative reprezint\u0103 prima linie de tratament, fiind eficiente \u00een 40-50% din cazuri; un beneficiu suplimentar (cre\u0219terea ratei de succes la 45-55%) poate fi ob\u021binut prin cre\u0219terea dozelor. O parte dintre pacien\u021bi neresponsivi pot beneficia de tratamentul cu anticorpi anti-IgE (omalizumab); cazurile care nu sunt influen\u021bate de omalizumab (de obicei cu urticarie autoimun\u0103 de tip IIb) pot r\u0103spunde la ciclosporin\u0103. O mai bun\u0103 cunoa\u0219tere a mecanismelor fiziopatologice implicate \u00een urticarie permite identificarea unor noi \u021binte \u0219i mijloace terapeutice, cum ar fi al\u021bi anticorpi anti-IgE, inhibitori ai BTK (Bruton’s tyrosine kinase – fenebrutinib \u0219i remibrutinib), dupilumab etc. care s\u0103 contribuie la un mai bun control al bolii.<\/p>\n
1Dermato-venereology Clinic, “Victor Babe\u0219” Clinical Hospital for Infectious and Tropical Diseases Bucharest.
2University of Medicine and Pharmacy “Carol Davila” Bucharest<\/p>\n
Various cells are involved in the pathophysiology of the disease, such as mast cells, basophils and eosinophils, but also B and T lymphocytes or monocytes; following the interactions between them, vasoactive mediators are released that contribute to the appearance of clinical manifestations. Although histamine has an important role in the occurrence of urticaria, many other cytokines, chemotactic factors, proteases, etc., as well as components of the complement and coagulation systems are involved in its pathogenesis.
Although considerable progress has been made, there is still no curative treatment for urticaria. Current therapeutic means can provide symptomatic control of the disease, but cannot influence its natural history. Non-sedating antihistamines represent the first line of treatment, being effective in 40-50% of cases; an additional benefit (increasing the success rate to 45-55%) can be obtained by increasing the doses. Some unresponsive patients may benefit from treatment with anti-IgE antibodies (omalizumab); cases not affected by omalizumab (usually with autoimmune urticaria type IIb) may respond to ciclosporin. A better knowledge of the pathophysiological mechanisms involved in urticaria allows the identification of new targets and therapeutic means, such as other anti-IgE antibodies, BTK (Bruton’s tyrosine kinase) inhibitors (fenebrutinib and remibrutinib), dupilumab, etc. which will contribute to a better control of the disease.<\/p>\n
Prezent: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2002 \u2013 2012: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1994: medic primar dermato-venerolog, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Centrul Dermato-venerologic, Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1989: medic specialist dermato-venerolog; Spitalul Clinic de Dermatologie \u201cProf. dr. Scarlat Longhin\u201d Bucure\u015fti;
1983: medic-doctor \u00een medicin\u0103 general\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti; prereparti\u0163ie \u00een cercetarea clinic\u0103 medical\u0103 la Centrul Dermato-venerologic Bucure\u015fti;
Coordonator al Laboratorului de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti
2009-2012: Manager, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
2004-2009: Director Medical, Spitalul Clinic de Dermatologie \u201cScarlat Longhin\u201d, Bucure\u015fti
1993 \u2013 prezent: \u015eeful Laboratorului de Alergologie, Laboratorul de cercetare dermato-venerologie;
Activit\u0103\u0163i \u015fi responsabilit\u0103\u0163i principale:
Activitate de cercetare \u2013 Laboratorul de cercetare dermato-venerologie, Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Asisten\u0163\u0103 medical\u0103 specialitatea dermato-venerologie \u2013 Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d Bucure\u015fti;
Spitalul Clinic de Boli Infec\u0163ioase \u015fi Tropicale \u201eVictor Babe\u015f\u201d, Bucure\u015fti
Educa\u0163ie \u015fi formare:<\/strong>
Perioada:
Calificarea \/ diploma ob\u0163inut\u0103:
2002: cercet\u0103tor \u015ftiin\u0163ific principal gr. I, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
2001: doctor \u00een \u015ftiin\u0163e medicale, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti;
1996: cercet\u0103tor \u015ftiin\u0163ific gr II, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1994: medic primar dermato-venerolog;
1989: cercet\u0103tor \u015ftiin\u0163ific gr III, Academia de \u015etiin\u0163e Medicale, Rom\u00e2nia;
1989: medic specialist dermato-venerolog;
1977-1983: Universitatea de Medicin\u0103 \u015fi Farmacie \u201cCarol Davila\u201d Bucure\u015fti, medic-doctor \u00een medicin\u0103 general\u0103,
1972-1976: Colegiul Na\u0163ional \u201eVasile Alecsandri\u201d Gala\u0163i.<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
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