<\/strong><\/span><\/h5>\n<\/strong><\/span><\/h5>\n<\/strong><\/span><\/h5>\n<\/strong><\/span><\/h5>\nProf. Dr. Cimpoe\u0219u Carmen Diana<\/strong><\/span>
Universitatea de Medicin\u0103 \u0219i Farmacie “Grigore T. Popa”, Ia\u0219i, Rom\u00e2nia
Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i, Rom\u00e2nia<\/strong><\/span><\/h5>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.2″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Rolul biomarkerilor \u00een managementul \u00een urgen\u021b\u0103 al sepsisului de cauza cutanat\u0103 <\/span><\/p>\nAutori: Diana Cimpoesu, Mihaela Corlade-Andrei<\/span>
Universitatea de Medicina si Farmacie “Grigore T Popa” Iasi
UPU-SMURD Ia\u0219i<\/p>\nCuvinte cheie: sepsis, biomarkeri, antibioterapie<\/p>\n
Sepsisul are prognostic sever \u0219i rate mari de mortalitate. Este dificil de recunoscut mai ales la debut, la v\u00e2rstnici \u0219i la cei cu multiple comorbidit\u0103\u021bi. Aceasta duce la \u00eent\u00e2rzierea tratamentului \u0219i prescrierea inadecvat\u0103 a antibioticelor. Cauzele sepsisului sunt infec\u021biile respiratorii, genito-urinare \u0219i infect\u00edile cutanate.
Biomarkerii sunt importan\u021bi pentru decizii clinice \u0219i management, au putere diagnostic\u0103, prognostic\u0103 \u0219i \u00een ghidarea tratamentului. Ghidurile Surviving Sepsis Campaign precizeaz\u0103 rolul complementar al biomarkerilor \u00een evaluarea clinic\u0103 \u0219i prognostic\u0103, dar defini\u021bia Sepsis-3 nu \u00eei include. Cei mai utiliza\u021bi sunt: lactatul, proteina C reactiva (CRP), procalcitonina (PCT) \u0219i Presepsina.
CRP are specificitate mare, sensibilitate sc\u0103zut\u0103, fiind utilizat\u0103 mai ales pentru valoarea predictiv\u0103 negativ\u0103. PCT are valoare diagnostic\u0103, prognostic\u0103 \u0219i \u00een ghidarea antibioterapiei. Lactatul trebuie evaluat \u00een prima or\u0103, iar nivelului s\u0103u constant crescut este corelat cu un prognostic nefavorabil.
Procalcitonina cre\u0219te la 3 \u2013 6 h, atinge maximul la 6 \u2013 8 \u0219i nivelurile r\u0103m\u00e2n crescute pentru 12 -48 h. Presepsina, subtipul sCD14 (sCD14-ST) cre\u0219te \u00een primele 2 \u2013 3 ore, cu o sc\u0103dere rapid\u0103 dup\u0103 dispari\u021bia simptomelor \u0219i este utilizat\u0103 pentru determinarea eficacit\u0103\u021bii tratamentului. Procalcitonina are niveluri crescute \u00een infec\u021bia sistemic\u0103, inflama\u021bia sever\u0103, boala renal\u0103, dar nu \u0219i in infec\u021bii virale, boli autoimune, neoplazii. Presepsina nu este influen\u021bat\u0103 de trauma f\u0103r\u0103 infec\u021bie, dar trebuie interpretat\u0103 precaut \u00een boala renal\u0103 stadiile 4 \u0219i 5.
Metodele noi de diagnostic de tip amplificare a acizilor nucleici (NAAT) au ap\u0103rut pentru cuantificarea biomarkerilor, identificarea micro-organismelor \u0219i antibiorezisten\u021bei. Provocarea actual\u0103 este de a identifica cei mai specifici biomarkeri \u0219i cele mai sensibile metode.<\/p>\n
The role of biomarkers in the emergency management of cutaneous sepsis<\/span><\/p>\nDiana Cimpoesu, Mihaela Corlade-Andrei<\/span><\/p>\nUniversity of Medicine and Pharmacy “Gr.T.Popa”, Iasi, Romania<\/span>
Emergency “St. Spiridon” Hospital, Iasi<\/span>, Romania<\/span><\/sup><\/p>\nKeywords: sepsis, biomarkers, antibiotic therapy<\/p>\n
Sepsis has severe prognosis and high mortality rates. It is difficult to recognize, especially at the onset, in the elderly and multiple comorbidities patients. This may lead to delayed treatment and inappropriate prescription of antibiotics. The causes of sepsis are respiratory, genitourinary and skin infections.
Biomarkers have diagnostic, prognostic and treatment guiding relevance. The Surviving Sepsis Campaign guidelines ascertain the complementary role of biomarkers in clinical and prognostic assessment, but are not included in the Sepsis-3 definition. The most used are: lactate, C-reactive protein (CRP), procalcitonin (PCT) and Presepsin.
CRP has high specificity and low sensitivity, being used mostly for its negative predictive importance. PCT has diagnostic and prognostic value, also relevant in guiding antibiotic therapy. Lactate must be measured in the first hour; its constantly increased level shows unfavourable prognosis.
Procalcitonin rises in 3-6 h, reaches a peak within 6 to 8 hours and its levels remain elevated for 12-48 hours. Presepsin, sCD14 subtype (sCD14-ST), rises in the first 2-3 h, with a rapid decline after symptoms disappearance, and is used to determine treatment effectiveness. Procalcitonin has increased levels in systemic infection, severe inflammation, kidney disease, but not in viral infections, autoimmune diseases and neoplasia. Presepsin, not influenced by trauma without infection, should be interpreted cautiously in the stages 4 or 5 of renal disease.
New diagnostic methods, such as nucleic acid amplification (NAAT), have emerged for biomarker quantification, identification of microorganisms and antibiotic resistance. Identifying the most specific biomarkers and the most sensitive methods is the current challenge.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103:<\/strong>
Martie-Aprilie 2016
Decan cu delegatie – Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi
Iunie 2015 \u2013 martie 2016
Prodecan – Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi
Martie 2014- p\u00e2n\u0103 \u00een prezent
Profesor Universitar Habilitat (iunie 2014) Disciplina Medicin\u0103 de Urgen\u021b\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGr. T. Popa\u201d Ia\u015fi
2008-2014
Conferen\u0163iar Disciplina Medicin\u0103 de Urgen\u0163\u0103 (\u015eef Disciplin\u0103 + coodonator direc\u0163ie curs), Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d, Ia\u015fi,
2013 ianuarie-iunie
Director Medical, Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
2004-2008
\u0218ef Lucr\u0103ri Disciplina Medicin\u0103 de Urgen\u0163\u0103 (\u015eef Disciplin\u0103), Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d, Ia\u015fi,
2011-2012
Membru \u00een Comisia pentru ob\u0163inerea titlului de Doctor \u00een \u015ftiin\u0163e – 5 teze
– iulie 2011 – Universitatea de Medicin\u0103 \u015fi Farmacie Tg. Mure\u015f
– iunie 2011 – Universitatea de Vest “Vasile Goldi\u015f\u201d Arad, Facultatea de Medicin\u0103, Farmacie \u015fi Medicin\u0103 Dentar\u0103
– ianuarie 2011 – Universitatea “Alexandru Ioan Cuza\u201d Ia\u015fi, Facultatea de Geografie \u015fi Geologie
– 2011-2015 – Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d Ia\u015fi
1999-2016
Medic \u0218ef al Unit\u0103\u0163ii Primire Urgen\u0163e \u015fi SMURD (\u00eenfiin\u021bat \u00een 2005), Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
2000-2016
Coordonator al Centrului de Formare \u00een Medicina de Urgen\u0163\u0103 din cadrul Unit\u0103\u0163ii Primire Urgen\u0163e \u015fi SMURD
2007-2016
Director de reziden\u021biat, Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
Decembrie 1998 \u2013 februarie 1999
Serviciul Jude\u021bean de Ambulan\u021b\u0103 Ia\u0219i<\/p>\nCalificarea\/diplom\u0103 ob\u0163inut\u0103<\/strong>
2013
Educator Master Class, Consiliul European de Resuscitare, Viena, Austria
2011-2016
Consiliul European de Resuscitare \u2013 ALS Full Instructor
2013
European Trauma Course instructor candidate, Consiliul European de Resuscitare
2005-2006
Master “Epidemiologia studiilor clinice\u201d, Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d, Ia\u015fi
Noiembrie 1997 – octombrie 2005
Doctor \u00een medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201dGrigore T. Popa\u201d, Ia\u015fi
2004- 2005
Atestat- Competen\u0163\u0103 \u00een ecografie general\u0103, U.M.F. \u201cGrigore T. Popa\u201d Ia\u015fi
2006
Atestat- Competen\u0163\u0103 in Managementul Serviciilor de S\u0103n\u0103tate, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d, Ia\u015fi
2001 – prezent
Medic Primar \u00een medicina de urgent\u0103
1998-2002
Licen\u0163\u0103- specializarea \u201cPsihopedagogie\u201d, Facultatea de Psihologie \u015fi \u015etiin\u0163e ale Educa\u0163iei,
Universitatea \u201cAl. I. Cuza\u201d Ia\u015fi
1997-1998
Medic specialist Medicina de Urgen\u0163\u0103, Serviciul Jude\u021bean de Ambulant\u0103 Ia\u0219i
Perioada
1992 – 1996
Medic rezident \u00een medicina de urgen\u021b\u0103, Spitalul Clinic de Urgen\u021b\u0103 Ia\u0219i
1986 – 1992
Diplom\u0103 de licen\u0163\u0103 Doctor-Medic, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
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Prof. Dr. Cimpoe\u0219u Carmen Diana Universitatea de Medicin\u0103 \u0219i Farmacie “Grigore T. Popa”, Ia\u0219i, Rom\u00e2nia Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i, Rom\u00e2niaRolul biomarkerilor \u00een managementul \u00een urgen\u021b\u0103 al sepsisului de cauza cutanat\u0103 Autori: Diana Cimpoesu, Mihaela Corlade-AndreiUniversitatea de Medicina si Farmacie “Grigore T Popa” IasiUPU-SMURD Ia\u0219i Cuvinte cheie: sepsis, biomarkeri, antibioterapie Sepsisul are […]<\/p>\n","protected":false},"author":2,"featured_media":11276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8721","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=8721"}],"version-history":[{"count":19,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721\/revisions"}],"predecessor-version":[{"id":12979,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721\/revisions\/12979"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11276"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=8721"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=8721"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=8721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/strong><\/span><\/h5>\n<\/strong><\/span><\/h5>\nProf. Dr. Cimpoe\u0219u Carmen Diana<\/strong><\/span>
Universitatea de Medicin\u0103 \u0219i Farmacie “Grigore T. Popa”, Ia\u0219i, Rom\u00e2nia
Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i, Rom\u00e2nia<\/strong><\/span><\/h5>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.2″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Rolul biomarkerilor \u00een managementul \u00een urgen\u021b\u0103 al sepsisului de cauza cutanat\u0103 <\/span><\/p>\nAutori: Diana Cimpoesu, Mihaela Corlade-Andrei<\/span>
Universitatea de Medicina si Farmacie “Grigore T Popa” Iasi
UPU-SMURD Ia\u0219i<\/p>\nCuvinte cheie: sepsis, biomarkeri, antibioterapie<\/p>\n
Sepsisul are prognostic sever \u0219i rate mari de mortalitate. Este dificil de recunoscut mai ales la debut, la v\u00e2rstnici \u0219i la cei cu multiple comorbidit\u0103\u021bi. Aceasta duce la \u00eent\u00e2rzierea tratamentului \u0219i prescrierea inadecvat\u0103 a antibioticelor. Cauzele sepsisului sunt infec\u021biile respiratorii, genito-urinare \u0219i infect\u00edile cutanate.
Biomarkerii sunt importan\u021bi pentru decizii clinice \u0219i management, au putere diagnostic\u0103, prognostic\u0103 \u0219i \u00een ghidarea tratamentului. Ghidurile Surviving Sepsis Campaign precizeaz\u0103 rolul complementar al biomarkerilor \u00een evaluarea clinic\u0103 \u0219i prognostic\u0103, dar defini\u021bia Sepsis-3 nu \u00eei include. Cei mai utiliza\u021bi sunt: lactatul, proteina C reactiva (CRP), procalcitonina (PCT) \u0219i Presepsina.
CRP are specificitate mare, sensibilitate sc\u0103zut\u0103, fiind utilizat\u0103 mai ales pentru valoarea predictiv\u0103 negativ\u0103. PCT are valoare diagnostic\u0103, prognostic\u0103 \u0219i \u00een ghidarea antibioterapiei. Lactatul trebuie evaluat \u00een prima or\u0103, iar nivelului s\u0103u constant crescut este corelat cu un prognostic nefavorabil.
Procalcitonina cre\u0219te la 3 \u2013 6 h, atinge maximul la 6 \u2013 8 \u0219i nivelurile r\u0103m\u00e2n crescute pentru 12 -48 h. Presepsina, subtipul sCD14 (sCD14-ST) cre\u0219te \u00een primele 2 \u2013 3 ore, cu o sc\u0103dere rapid\u0103 dup\u0103 dispari\u021bia simptomelor \u0219i este utilizat\u0103 pentru determinarea eficacit\u0103\u021bii tratamentului. Procalcitonina are niveluri crescute \u00een infec\u021bia sistemic\u0103, inflama\u021bia sever\u0103, boala renal\u0103, dar nu \u0219i in infec\u021bii virale, boli autoimune, neoplazii. Presepsina nu este influen\u021bat\u0103 de trauma f\u0103r\u0103 infec\u021bie, dar trebuie interpretat\u0103 precaut \u00een boala renal\u0103 stadiile 4 \u0219i 5.
Metodele noi de diagnostic de tip amplificare a acizilor nucleici (NAAT) au ap\u0103rut pentru cuantificarea biomarkerilor, identificarea micro-organismelor \u0219i antibiorezisten\u021bei. Provocarea actual\u0103 este de a identifica cei mai specifici biomarkeri \u0219i cele mai sensibile metode.<\/p>\n
The role of biomarkers in the emergency management of cutaneous sepsis<\/span><\/p>\nDiana Cimpoesu, Mihaela Corlade-Andrei<\/span><\/p>\nUniversity of Medicine and Pharmacy “Gr.T.Popa”, Iasi, Romania<\/span>
Emergency “St. Spiridon” Hospital, Iasi<\/span>, Romania<\/span><\/sup><\/p>\nKeywords: sepsis, biomarkers, antibiotic therapy<\/p>\n
Sepsis has severe prognosis and high mortality rates. It is difficult to recognize, especially at the onset, in the elderly and multiple comorbidities patients. This may lead to delayed treatment and inappropriate prescription of antibiotics. The causes of sepsis are respiratory, genitourinary and skin infections.
Biomarkers have diagnostic, prognostic and treatment guiding relevance. The Surviving Sepsis Campaign guidelines ascertain the complementary role of biomarkers in clinical and prognostic assessment, but are not included in the Sepsis-3 definition. The most used are: lactate, C-reactive protein (CRP), procalcitonin (PCT) and Presepsin.
CRP has high specificity and low sensitivity, being used mostly for its negative predictive importance. PCT has diagnostic and prognostic value, also relevant in guiding antibiotic therapy. Lactate must be measured in the first hour; its constantly increased level shows unfavourable prognosis.
Procalcitonin rises in 3-6 h, reaches a peak within 6 to 8 hours and its levels remain elevated for 12-48 hours. Presepsin, sCD14 subtype (sCD14-ST), rises in the first 2-3 h, with a rapid decline after symptoms disappearance, and is used to determine treatment effectiveness. Procalcitonin has increased levels in systemic infection, severe inflammation, kidney disease, but not in viral infections, autoimmune diseases and neoplasia. Presepsin, not influenced by trauma without infection, should be interpreted cautiously in the stages 4 or 5 of renal disease.
New diagnostic methods, such as nucleic acid amplification (NAAT), have emerged for biomarker quantification, identification of microorganisms and antibiotic resistance. Identifying the most specific biomarkers and the most sensitive methods is the current challenge.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103:<\/strong>
Martie-Aprilie 2016
Decan cu delegatie – Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi
Iunie 2015 \u2013 martie 2016
Prodecan – Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi
Martie 2014- p\u00e2n\u0103 \u00een prezent
Profesor Universitar Habilitat (iunie 2014) Disciplina Medicin\u0103 de Urgen\u021b\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGr. T. Popa\u201d Ia\u015fi
2008-2014
Conferen\u0163iar Disciplina Medicin\u0103 de Urgen\u0163\u0103 (\u015eef Disciplin\u0103 + coodonator direc\u0163ie curs), Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d, Ia\u015fi,
2013 ianuarie-iunie
Director Medical, Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
2004-2008
\u0218ef Lucr\u0103ri Disciplina Medicin\u0103 de Urgen\u0163\u0103 (\u015eef Disciplin\u0103), Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d, Ia\u015fi,
2011-2012
Membru \u00een Comisia pentru ob\u0163inerea titlului de Doctor \u00een \u015ftiin\u0163e – 5 teze
– iulie 2011 – Universitatea de Medicin\u0103 \u015fi Farmacie Tg. Mure\u015f
– iunie 2011 – Universitatea de Vest “Vasile Goldi\u015f\u201d Arad, Facultatea de Medicin\u0103, Farmacie \u015fi Medicin\u0103 Dentar\u0103
– ianuarie 2011 – Universitatea “Alexandru Ioan Cuza\u201d Ia\u015fi, Facultatea de Geografie \u015fi Geologie
– 2011-2015 – Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d Ia\u015fi
1999-2016
Medic \u0218ef al Unit\u0103\u0163ii Primire Urgen\u0163e \u015fi SMURD (\u00eenfiin\u021bat \u00een 2005), Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
2000-2016
Coordonator al Centrului de Formare \u00een Medicina de Urgen\u0163\u0103 din cadrul Unit\u0103\u0163ii Primire Urgen\u0163e \u015fi SMURD
2007-2016
Director de reziden\u021biat, Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
Decembrie 1998 \u2013 februarie 1999
Serviciul Jude\u021bean de Ambulan\u021b\u0103 Ia\u0219i<\/p>\nCalificarea\/diplom\u0103 ob\u0163inut\u0103<\/strong>
2013
Educator Master Class, Consiliul European de Resuscitare, Viena, Austria
2011-2016
Consiliul European de Resuscitare \u2013 ALS Full Instructor
2013
European Trauma Course instructor candidate, Consiliul European de Resuscitare
2005-2006
Master “Epidemiologia studiilor clinice\u201d, Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d, Ia\u015fi
Noiembrie 1997 – octombrie 2005
Doctor \u00een medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201dGrigore T. Popa\u201d, Ia\u015fi
2004- 2005
Atestat- Competen\u0163\u0103 \u00een ecografie general\u0103, U.M.F. \u201cGrigore T. Popa\u201d Ia\u015fi
2006
Atestat- Competen\u0163\u0103 in Managementul Serviciilor de S\u0103n\u0103tate, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d, Ia\u015fi
2001 – prezent
Medic Primar \u00een medicina de urgent\u0103
1998-2002
Licen\u0163\u0103- specializarea \u201cPsihopedagogie\u201d, Facultatea de Psihologie \u015fi \u015etiin\u0163e ale Educa\u0163iei,
Universitatea \u201cAl. I. Cuza\u201d Ia\u015fi
1997-1998
Medic specialist Medicina de Urgen\u0163\u0103, Serviciul Jude\u021bean de Ambulant\u0103 Ia\u0219i
Perioada
1992 – 1996
Medic rezident \u00een medicina de urgen\u021b\u0103, Spitalul Clinic de Urgen\u021b\u0103 Ia\u0219i
1986 – 1992
Diplom\u0103 de licen\u0163\u0103 Doctor-Medic, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
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Prof. Dr. Cimpoe\u0219u Carmen Diana Universitatea de Medicin\u0103 \u0219i Farmacie “Grigore T. Popa”, Ia\u0219i, Rom\u00e2nia Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i, Rom\u00e2niaRolul biomarkerilor \u00een managementul \u00een urgen\u021b\u0103 al sepsisului de cauza cutanat\u0103 Autori: Diana Cimpoesu, Mihaela Corlade-AndreiUniversitatea de Medicina si Farmacie “Grigore T Popa” IasiUPU-SMURD Ia\u0219i Cuvinte cheie: sepsis, biomarkeri, antibioterapie Sepsisul are […]<\/p>\n","protected":false},"author":2,"featured_media":11276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8721","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=8721"}],"version-history":[{"count":19,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721\/revisions"}],"predecessor-version":[{"id":12979,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721\/revisions\/12979"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11276"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=8721"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=8721"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=8721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Prof. Dr. Cimpoe\u0219u Carmen Diana<\/strong><\/span>
Universitatea de Medicin\u0103 \u0219i Farmacie “Grigore T. Popa”, Ia\u0219i, Rom\u00e2nia
Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i, Rom\u00e2nia<\/strong><\/span><\/h5>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.20.2″ hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n
Rolul biomarkerilor \u00een managementul \u00een urgen\u021b\u0103 al sepsisului de cauza cutanat\u0103 <\/span><\/p>\nAutori: Diana Cimpoesu, Mihaela Corlade-Andrei<\/span>
Universitatea de Medicina si Farmacie “Grigore T Popa” Iasi
UPU-SMURD Ia\u0219i<\/p>\nCuvinte cheie: sepsis, biomarkeri, antibioterapie<\/p>\n
Sepsisul are prognostic sever \u0219i rate mari de mortalitate. Este dificil de recunoscut mai ales la debut, la v\u00e2rstnici \u0219i la cei cu multiple comorbidit\u0103\u021bi. Aceasta duce la \u00eent\u00e2rzierea tratamentului \u0219i prescrierea inadecvat\u0103 a antibioticelor. Cauzele sepsisului sunt infec\u021biile respiratorii, genito-urinare \u0219i infect\u00edile cutanate.
Biomarkerii sunt importan\u021bi pentru decizii clinice \u0219i management, au putere diagnostic\u0103, prognostic\u0103 \u0219i \u00een ghidarea tratamentului. Ghidurile Surviving Sepsis Campaign precizeaz\u0103 rolul complementar al biomarkerilor \u00een evaluarea clinic\u0103 \u0219i prognostic\u0103, dar defini\u021bia Sepsis-3 nu \u00eei include. Cei mai utiliza\u021bi sunt: lactatul, proteina C reactiva (CRP), procalcitonina (PCT) \u0219i Presepsina.
CRP are specificitate mare, sensibilitate sc\u0103zut\u0103, fiind utilizat\u0103 mai ales pentru valoarea predictiv\u0103 negativ\u0103. PCT are valoare diagnostic\u0103, prognostic\u0103 \u0219i \u00een ghidarea antibioterapiei. Lactatul trebuie evaluat \u00een prima or\u0103, iar nivelului s\u0103u constant crescut este corelat cu un prognostic nefavorabil.
Procalcitonina cre\u0219te la 3 \u2013 6 h, atinge maximul la 6 \u2013 8 \u0219i nivelurile r\u0103m\u00e2n crescute pentru 12 -48 h. Presepsina, subtipul sCD14 (sCD14-ST) cre\u0219te \u00een primele 2 \u2013 3 ore, cu o sc\u0103dere rapid\u0103 dup\u0103 dispari\u021bia simptomelor \u0219i este utilizat\u0103 pentru determinarea eficacit\u0103\u021bii tratamentului. Procalcitonina are niveluri crescute \u00een infec\u021bia sistemic\u0103, inflama\u021bia sever\u0103, boala renal\u0103, dar nu \u0219i in infec\u021bii virale, boli autoimune, neoplazii. Presepsina nu este influen\u021bat\u0103 de trauma f\u0103r\u0103 infec\u021bie, dar trebuie interpretat\u0103 precaut \u00een boala renal\u0103 stadiile 4 \u0219i 5.
Metodele noi de diagnostic de tip amplificare a acizilor nucleici (NAAT) au ap\u0103rut pentru cuantificarea biomarkerilor, identificarea micro-organismelor \u0219i antibiorezisten\u021bei. Provocarea actual\u0103 este de a identifica cei mai specifici biomarkeri \u0219i cele mai sensibile metode.<\/p>\n
The role of biomarkers in the emergency management of cutaneous sepsis<\/span><\/p>\nDiana Cimpoesu, Mihaela Corlade-Andrei<\/span><\/p>\nUniversity of Medicine and Pharmacy “Gr.T.Popa”, Iasi, Romania<\/span>
Emergency “St. Spiridon” Hospital, Iasi<\/span>, Romania<\/span><\/sup><\/p>\nKeywords: sepsis, biomarkers, antibiotic therapy<\/p>\n
Sepsis has severe prognosis and high mortality rates. It is difficult to recognize, especially at the onset, in the elderly and multiple comorbidities patients. This may lead to delayed treatment and inappropriate prescription of antibiotics. The causes of sepsis are respiratory, genitourinary and skin infections.
Biomarkers have diagnostic, prognostic and treatment guiding relevance. The Surviving Sepsis Campaign guidelines ascertain the complementary role of biomarkers in clinical and prognostic assessment, but are not included in the Sepsis-3 definition. The most used are: lactate, C-reactive protein (CRP), procalcitonin (PCT) and Presepsin.
CRP has high specificity and low sensitivity, being used mostly for its negative predictive importance. PCT has diagnostic and prognostic value, also relevant in guiding antibiotic therapy. Lactate must be measured in the first hour; its constantly increased level shows unfavourable prognosis.
Procalcitonin rises in 3-6 h, reaches a peak within 6 to 8 hours and its levels remain elevated for 12-48 hours. Presepsin, sCD14 subtype (sCD14-ST), rises in the first 2-3 h, with a rapid decline after symptoms disappearance, and is used to determine treatment effectiveness. Procalcitonin has increased levels in systemic infection, severe inflammation, kidney disease, but not in viral infections, autoimmune diseases and neoplasia. Presepsin, not influenced by trauma without infection, should be interpreted cautiously in the stages 4 or 5 of renal disease.
New diagnostic methods, such as nucleic acid amplification (NAAT), have emerged for biomarker quantification, identification of microorganisms and antibiotic resistance. Identifying the most specific biomarkers and the most sensitive methods is the current challenge.<\/p>\n
Scurt CV<\/span><\/p>\nExperien\u0163a profesional\u0103:<\/strong>
Martie-Aprilie 2016
Decan cu delegatie – Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi
Iunie 2015 \u2013 martie 2016
Prodecan – Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi
Martie 2014- p\u00e2n\u0103 \u00een prezent
Profesor Universitar Habilitat (iunie 2014) Disciplina Medicin\u0103 de Urgen\u021b\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGr. T. Popa\u201d Ia\u015fi
2008-2014
Conferen\u0163iar Disciplina Medicin\u0103 de Urgen\u0163\u0103 (\u015eef Disciplin\u0103 + coodonator direc\u0163ie curs), Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d, Ia\u015fi,
2013 ianuarie-iunie
Director Medical, Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
2004-2008
\u0218ef Lucr\u0103ri Disciplina Medicin\u0103 de Urgen\u0163\u0103 (\u015eef Disciplin\u0103), Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d, Ia\u015fi,
2011-2012
Membru \u00een Comisia pentru ob\u0163inerea titlului de Doctor \u00een \u015ftiin\u0163e – 5 teze
– iulie 2011 – Universitatea de Medicin\u0103 \u015fi Farmacie Tg. Mure\u015f
– iunie 2011 – Universitatea de Vest “Vasile Goldi\u015f\u201d Arad, Facultatea de Medicin\u0103, Farmacie \u015fi Medicin\u0103 Dentar\u0103
– ianuarie 2011 – Universitatea “Alexandru Ioan Cuza\u201d Ia\u015fi, Facultatea de Geografie \u015fi Geologie
– 2011-2015 – Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d Ia\u015fi
1999-2016
Medic \u0218ef al Unit\u0103\u0163ii Primire Urgen\u0163e \u015fi SMURD (\u00eenfiin\u021bat \u00een 2005), Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
2000-2016
Coordonator al Centrului de Formare \u00een Medicina de Urgen\u0163\u0103 din cadrul Unit\u0103\u0163ii Primire Urgen\u0163e \u015fi SMURD
2007-2016
Director de reziden\u021biat, Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
Decembrie 1998 \u2013 februarie 1999
Serviciul Jude\u021bean de Ambulan\u021b\u0103 Ia\u0219i<\/p>\nCalificarea\/diplom\u0103 ob\u0163inut\u0103<\/strong>
2013
Educator Master Class, Consiliul European de Resuscitare, Viena, Austria
2011-2016
Consiliul European de Resuscitare \u2013 ALS Full Instructor
2013
European Trauma Course instructor candidate, Consiliul European de Resuscitare
2005-2006
Master “Epidemiologia studiilor clinice\u201d, Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d, Ia\u015fi
Noiembrie 1997 – octombrie 2005
Doctor \u00een medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201dGrigore T. Popa\u201d, Ia\u015fi
2004- 2005
Atestat- Competen\u0163\u0103 \u00een ecografie general\u0103, U.M.F. \u201cGrigore T. Popa\u201d Ia\u015fi
2006
Atestat- Competen\u0163\u0103 in Managementul Serviciilor de S\u0103n\u0103tate, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d, Ia\u015fi
2001 – prezent
Medic Primar \u00een medicina de urgent\u0103
1998-2002
Licen\u0163\u0103- specializarea \u201cPsihopedagogie\u201d, Facultatea de Psihologie \u015fi \u015etiin\u0163e ale Educa\u0163iei,
Universitatea \u201cAl. I. Cuza\u201d Ia\u015fi
1997-1998
Medic specialist Medicina de Urgen\u0163\u0103, Serviciul Jude\u021bean de Ambulant\u0103 Ia\u0219i
Perioada
1992 – 1996
Medic rezident \u00een medicina de urgen\u021b\u0103, Spitalul Clinic de Urgen\u021b\u0103 Ia\u0219i
1986 – 1992
Diplom\u0103 de licen\u0163\u0103 Doctor-Medic, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n
Contacteaz\u0103 operatorul PDI 2023<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro” submit_button_text=”Trimite mesajul” disabled_on=”off|off|off” _builder_version=”4.20.2″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Adresa de e-mail” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” global_colors_info=”{}”]<\/p>\n
Operatorul PDI 2023<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.16″ text_font=”||||||||” global_colors_info=”{}”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAdresa: Str. A. Panu nr. 13, Iasi<\/span>
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][et_pb_text disabled_on=”on|on|on” _builder_version=”4.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” disabled=”on” locked=”off” global_colors_info=”{}”]<\/p>\n
Parteneri Media<\/p>\n
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Prof. Dr. Cimpoe\u0219u Carmen Diana Universitatea de Medicin\u0103 \u0219i Farmacie “Grigore T. Popa”, Ia\u0219i, Rom\u00e2nia Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i, Rom\u00e2niaRolul biomarkerilor \u00een managementul \u00een urgen\u021b\u0103 al sepsisului de cauza cutanat\u0103 Autori: Diana Cimpoesu, Mihaela Corlade-AndreiUniversitatea de Medicina si Farmacie “Grigore T Popa” IasiUPU-SMURD Ia\u0219i Cuvinte cheie: sepsis, biomarkeri, antibioterapie Sepsisul are […]<\/p>\n","protected":false},"author":2,"featured_media":11276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8721","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=8721"}],"version-history":[{"count":19,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721\/revisions"}],"predecessor-version":[{"id":12979,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721\/revisions\/12979"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11276"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=8721"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=8721"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=8721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Autori: Diana Cimpoesu, Mihaela Corlade-Andrei<\/span> Cuvinte cheie: sepsis, biomarkeri, antibioterapie<\/p>\n Sepsisul are prognostic sever \u0219i rate mari de mortalitate. Este dificil de recunoscut mai ales la debut, la v\u00e2rstnici \u0219i la cei cu multiple comorbidit\u0103\u021bi. Aceasta duce la \u00eent\u00e2rzierea tratamentului \u0219i prescrierea inadecvat\u0103 a antibioticelor. Cauzele sepsisului sunt infec\u021biile respiratorii, genito-urinare \u0219i infect\u00edile cutanate. The role of biomarkers in the emergency management of cutaneous sepsis<\/span><\/p>\n Diana Cimpoesu, Mihaela Corlade-Andrei<\/span><\/p>\n University of Medicine and Pharmacy “Gr.T.Popa”, Iasi, Romania<\/span> Keywords: sepsis, biomarkers, antibiotic therapy<\/p>\n Sepsis has severe prognosis and high mortality rates. It is difficult to recognize, especially at the onset, in the elderly and multiple comorbidities patients. This may lead to delayed treatment and inappropriate prescription of antibiotics. The causes of sepsis are respiratory, genitourinary and skin infections. Scurt CV<\/span><\/p>\n Experien\u0163a profesional\u0103:<\/strong> Calificarea\/diplom\u0103 ob\u0163inut\u0103<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.19.4″ background_color=”rgba(240,98,42,0.19)” background_image=”https:\/\/pdi.ro\/2023\/wp-content\/uploads\/2022\/12\/PDI2023_header__-scaled.jpg” background_blend=”multiply” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”97px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#F0622A” bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”59px” bottom_divider_height_last_edited=”on|desktop” global_module=”9177″ saved_tabs=”all” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.19.4″ custom_padding=”100px|0px|69px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.20.2″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height=”1.2em” header_font=”||||||||” background_layout=”dark” text_font_size_tablet=”” text_font_size_phone=”” text_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n Contacteaz\u0103 operatorul PDI 2023<\/p>\n [\/et_pb_text][et_pb_contact_form email=”contact@pdi.ro” submit_button_text=”Trimite mesajul” disabled_on=”off|off|off” _builder_version=”4.20.2″ _unique_id=”794aaef5-e005-432a-99fb-9ca53e06d67b” title_font=”||||||||” custom_button=”on” button_text_color=”#F0622A” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Nume” _builder_version=”4.16″ global_colors_info=”{}” 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button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Mesajul dvs.” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” 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A. 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Popa”, Ia\u0219i, Rom\u00e2nia Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i, Rom\u00e2niaRolul biomarkerilor \u00een managementul \u00een urgen\u021b\u0103 al sepsisului de cauza cutanat\u0103 Autori: Diana Cimpoesu, Mihaela Corlade-AndreiUniversitatea de Medicina si Farmacie “Grigore T Popa” IasiUPU-SMURD Ia\u0219i Cuvinte cheie: sepsis, biomarkeri, antibioterapie Sepsisul are […]<\/p>\n","protected":false},"author":2,"featured_media":11276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[12],"tags":[],"class_list":["post-8721","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lectori"],"_links":{"self":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/comments?post=8721"}],"version-history":[{"count":19,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721\/revisions"}],"predecessor-version":[{"id":12979,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/posts\/8721\/revisions\/12979"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media\/11276"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/media?parent=8721"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/categories?post=8721"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pdi.ro\/2023\/wp-json\/wp\/v2\/tags?post=8721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Universitatea de Medicina si Farmacie “Grigore T Popa” Iasi
UPU-SMURD Ia\u0219i<\/p>\n
Biomarkerii sunt importan\u021bi pentru decizii clinice \u0219i management, au putere diagnostic\u0103, prognostic\u0103 \u0219i \u00een ghidarea tratamentului. Ghidurile Surviving Sepsis Campaign precizeaz\u0103 rolul complementar al biomarkerilor \u00een evaluarea clinic\u0103 \u0219i prognostic\u0103, dar defini\u021bia Sepsis-3 nu \u00eei include. Cei mai utiliza\u021bi sunt: lactatul, proteina C reactiva (CRP), procalcitonina (PCT) \u0219i Presepsina.
CRP are specificitate mare, sensibilitate sc\u0103zut\u0103, fiind utilizat\u0103 mai ales pentru valoarea predictiv\u0103 negativ\u0103. PCT are valoare diagnostic\u0103, prognostic\u0103 \u0219i \u00een ghidarea antibioterapiei. Lactatul trebuie evaluat \u00een prima or\u0103, iar nivelului s\u0103u constant crescut este corelat cu un prognostic nefavorabil.
Procalcitonina cre\u0219te la 3 \u2013 6 h, atinge maximul la 6 \u2013 8 \u0219i nivelurile r\u0103m\u00e2n crescute pentru 12 -48 h. Presepsina, subtipul sCD14 (sCD14-ST) cre\u0219te \u00een primele 2 \u2013 3 ore, cu o sc\u0103dere rapid\u0103 dup\u0103 dispari\u021bia simptomelor \u0219i este utilizat\u0103 pentru determinarea eficacit\u0103\u021bii tratamentului. Procalcitonina are niveluri crescute \u00een infec\u021bia sistemic\u0103, inflama\u021bia sever\u0103, boala renal\u0103, dar nu \u0219i in infec\u021bii virale, boli autoimune, neoplazii. Presepsina nu este influen\u021bat\u0103 de trauma f\u0103r\u0103 infec\u021bie, dar trebuie interpretat\u0103 precaut \u00een boala renal\u0103 stadiile 4 \u0219i 5.
Metodele noi de diagnostic de tip amplificare a acizilor nucleici (NAAT) au ap\u0103rut pentru cuantificarea biomarkerilor, identificarea micro-organismelor \u0219i antibiorezisten\u021bei. Provocarea actual\u0103 este de a identifica cei mai specifici biomarkeri \u0219i cele mai sensibile metode.<\/p>\n
Emergency “St. Spiridon” Hospital, Iasi<\/span>, Romania<\/span><\/sup><\/p>\n
Biomarkers have diagnostic, prognostic and treatment guiding relevance. The Surviving Sepsis Campaign guidelines ascertain the complementary role of biomarkers in clinical and prognostic assessment, but are not included in the Sepsis-3 definition. The most used are: lactate, C-reactive protein (CRP), procalcitonin (PCT) and Presepsin.
CRP has high specificity and low sensitivity, being used mostly for its negative predictive importance. PCT has diagnostic and prognostic value, also relevant in guiding antibiotic therapy. Lactate must be measured in the first hour; its constantly increased level shows unfavourable prognosis.
Procalcitonin rises in 3-6 h, reaches a peak within 6 to 8 hours and its levels remain elevated for 12-48 hours. Presepsin, sCD14 subtype (sCD14-ST), rises in the first 2-3 h, with a rapid decline after symptoms disappearance, and is used to determine treatment effectiveness. Procalcitonin has increased levels in systemic infection, severe inflammation, kidney disease, but not in viral infections, autoimmune diseases and neoplasia. Presepsin, not influenced by trauma without infection, should be interpreted cautiously in the stages 4 or 5 of renal disease.
New diagnostic methods, such as nucleic acid amplification (NAAT), have emerged for biomarker quantification, identification of microorganisms and antibiotic resistance. Identifying the most specific biomarkers and the most sensitive methods is the current challenge.<\/p>\n
Martie-Aprilie 2016
Decan cu delegatie – Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi
Iunie 2015 \u2013 martie 2016
Prodecan – Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi
Martie 2014- p\u00e2n\u0103 \u00een prezent
Profesor Universitar Habilitat (iunie 2014) Disciplina Medicin\u0103 de Urgen\u021b\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201eGr. T. Popa\u201d Ia\u015fi
2008-2014
Conferen\u0163iar Disciplina Medicin\u0103 de Urgen\u0163\u0103 (\u015eef Disciplin\u0103 + coodonator direc\u0163ie curs), Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d, Ia\u015fi,
2013 ianuarie-iunie
Director Medical, Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
2004-2008
\u0218ef Lucr\u0103ri Disciplina Medicin\u0103 de Urgen\u0163\u0103 (\u015eef Disciplin\u0103), Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d, Ia\u015fi,
2011-2012
Membru \u00een Comisia pentru ob\u0163inerea titlului de Doctor \u00een \u015ftiin\u0163e – 5 teze
– iulie 2011 – Universitatea de Medicin\u0103 \u015fi Farmacie Tg. Mure\u015f
– iunie 2011 – Universitatea de Vest “Vasile Goldi\u015f\u201d Arad, Facultatea de Medicin\u0103, Farmacie \u015fi Medicin\u0103 Dentar\u0103
– ianuarie 2011 – Universitatea “Alexandru Ioan Cuza\u201d Ia\u015fi, Facultatea de Geografie \u015fi Geologie
– 2011-2015 – Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d Ia\u015fi
1999-2016
Medic \u0218ef al Unit\u0103\u0163ii Primire Urgen\u0163e \u015fi SMURD (\u00eenfiin\u021bat \u00een 2005), Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
2000-2016
Coordonator al Centrului de Formare \u00een Medicina de Urgen\u0163\u0103 din cadrul Unit\u0103\u0163ii Primire Urgen\u0163e \u015fi SMURD
2007-2016
Director de reziden\u021biat, Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 “Sf. Spiridon\u201d Ia\u0219i
Decembrie 1998 \u2013 februarie 1999
Serviciul Jude\u021bean de Ambulan\u021b\u0103 Ia\u0219i<\/p>\n
2013
Educator Master Class, Consiliul European de Resuscitare, Viena, Austria
2011-2016
Consiliul European de Resuscitare \u2013 ALS Full Instructor
2013
European Trauma Course instructor candidate, Consiliul European de Resuscitare
2005-2006
Master “Epidemiologia studiilor clinice\u201d, Universitatea de Medicin\u0103 \u015fi Farmacie “Grigore T. Popa\u201d, Ia\u015fi
Noiembrie 1997 – octombrie 2005
Doctor \u00een medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201dGrigore T. Popa\u201d, Ia\u015fi
2004- 2005
Atestat- Competen\u0163\u0103 \u00een ecografie general\u0103, U.M.F. \u201cGrigore T. Popa\u201d Ia\u015fi
2006
Atestat- Competen\u0163\u0103 in Managementul Serviciilor de S\u0103n\u0103tate, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d, Ia\u015fi
2001 – prezent
Medic Primar \u00een medicina de urgent\u0103
1998-2002
Licen\u0163\u0103- specializarea \u201cPsihopedagogie\u201d, Facultatea de Psihologie \u015fi \u015etiin\u0163e ale Educa\u0163iei,
Universitatea \u201cAl. I. Cuza\u201d Ia\u015fi
1997-1998
Medic specialist Medicina de Urgen\u0163\u0103, Serviciul Jude\u021bean de Ambulant\u0103 Ia\u0219i
Perioada
1992 – 1996
Medic rezident \u00een medicina de urgen\u021b\u0103, Spitalul Clinic de Urgen\u021b\u0103 Ia\u0219i
1986 – 1992
Diplom\u0103 de licen\u0163\u0103 Doctor-Medic, Facultatea de Medicin\u0103, Universitatea de Medicin\u0103 \u015fi Farmacie \u201cGrigore T. Popa\u201d Ia\u015fi<\/p>\n<\/span><\/p>\n
Tel.: 0332.40.88.00-05<\/span>
E-mail: contact@pdi.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n