<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nNeagu Monica MD<\/strong><\/span>
“Victor Babe\u015f” National Institute, Bucharest<\/strong><\/span>
Clinical Hospital “Colentina”, Bucharest<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.3.4″ hover_enabled=”0″]<\/p>\n
Immunological advances in cutaneous squamous cell carcinoma<\/span>
Authors: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac<\/span><\/p>\nInvasive cutaneous squamous cell carcinoma (cSCC) in Caucazian population is one of the most common cancers accounting for 20% of all cutaneous malignancies. cSCC etiopathogenesis has multi-factorial trait. Therefore, environmental factors like ultraviolet radiation exposure, advanced age, male sex, smoking along with genetic factors are contributing to the onset of cSCC. Immunosuppressive conditions, like HIV infection, transplant, or chronic lymphocytic leukemia (CLL), are immune-based favoring condition for cSCC. In immunosuppressed patients, locoregional recurrence has an increased incidence, the risk of metastatic cSCC doubles, hence the outcome for advanced disease is significantly worse.
\nIn the quest to both monitor and predict the disease recurrence we have embarked in the search of various immune-related markers that can hint towards the clinical outcome of patients.
\nIn cSCC patients before and after surgery peripheral blood was immediately tested for immune cell populations using flow citometry and the IVD kit BD Multitest™ IMK Kit. Within the test we have analyzed various immune cell circulatory populations: T lymphocytes (CD3+), B lymphocytes (CD19+), helper\/inducer T lymphocytes (CD3+CD4+), suppressor\/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) lymphocytes (CD3\u2013CD16+ and\/ or CD56+). For the investigated cases prior to the surgical resection total CD3+ T cells and CD4+ T cell sub-population were in the normal ranges. CD8+ T cells depicting cytotoxic lymphocytes are statistically reduced compared the normal values, thus leading to an increased ratio CD4\/CD8. In cCSC patients circulatory B lymphocytes (CD19+) have a decreased value while peripheral NK cells are increased. This immune compensatory process between these two types of cell populations has been reported by us in other neoplasias as well. We can conclude that peripheral immune cells can be useful for monitoring disease progression in these types of cancer.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”77px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”54px” bottom_divider_height_last_edited=”on|desktop” global_module=”516″ saved_tabs=”all”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.3.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” text_line_height_tablet=”” text_line_height_phone=”1.2em” text_line_height_last_edited=”on|desktop”]<\/p>\n
Contact PDI 2020’s PCO<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro” submit_button_text=”Send” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Name” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”E-mail address” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Message” field_type=”text” fullwidth_field=”on” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.3.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
PCO of PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.3.4″ text_font=”||||||||”]<\/p>\n
![\"\"](\"https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAddress: A. Panu St. no. 13, Iasi<\/span>
Tel.: +40 332.40.88.05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|off|off” _builder_version=”3.22″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#f0622a” top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” collapsed=”off”][et_pb_fullwidth_header title=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@” text_orientation=”right” header_image_url=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2020\/03\/pdi2020_new.png” disabled_on=”on|on|off” _builder_version=”4.3.4″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”right” title_text_color=”#f0622a” title_font_size=”50px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” subhead_font=”||||||||” background_color=”rgba(239,145,107,0.54)” background_image=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/back.jpg” background_layout=”light” custom_margin=”0px||8px” custom_padding=”40px||40px||true” hover_enabled=”0″ content_font_size_tablet=”” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row column_structure=”2_5,3_5″ _builder_version=”3.25″][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/03\/Neagu-Monica.png” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ max_width=”35%” […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5513"}],"collection":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/comments?post=5513"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5513\/revisions"}],"predecessor-version":[{"id":8226,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5513\/revisions\/8226"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/media?parent=5513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/strong><\/span><\/h4>\nNeagu Monica MD<\/strong><\/span>
“Victor Babe\u015f” National Institute, Bucharest<\/strong><\/span>
Clinical Hospital “Colentina”, Bucharest<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.3.4″ hover_enabled=”0″]<\/p>\n
Immunological advances in cutaneous squamous cell carcinoma<\/span>
Authors: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac<\/span><\/p>\nInvasive cutaneous squamous cell carcinoma (cSCC) in Caucazian population is one of the most common cancers accounting for 20% of all cutaneous malignancies. cSCC etiopathogenesis has multi-factorial trait. Therefore, environmental factors like ultraviolet radiation exposure, advanced age, male sex, smoking along with genetic factors are contributing to the onset of cSCC. Immunosuppressive conditions, like HIV infection, transplant, or chronic lymphocytic leukemia (CLL), are immune-based favoring condition for cSCC. In immunosuppressed patients, locoregional recurrence has an increased incidence, the risk of metastatic cSCC doubles, hence the outcome for advanced disease is significantly worse.
\nIn the quest to both monitor and predict the disease recurrence we have embarked in the search of various immune-related markers that can hint towards the clinical outcome of patients.
\nIn cSCC patients before and after surgery peripheral blood was immediately tested for immune cell populations using flow citometry and the IVD kit BD Multitest™ IMK Kit. Within the test we have analyzed various immune cell circulatory populations: T lymphocytes (CD3+), B lymphocytes (CD19+), helper\/inducer T lymphocytes (CD3+CD4+), suppressor\/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) lymphocytes (CD3\u2013CD16+ and\/ or CD56+). For the investigated cases prior to the surgical resection total CD3+ T cells and CD4+ T cell sub-population were in the normal ranges. CD8+ T cells depicting cytotoxic lymphocytes are statistically reduced compared the normal values, thus leading to an increased ratio CD4\/CD8. In cCSC patients circulatory B lymphocytes (CD19+) have a decreased value while peripheral NK cells are increased. This immune compensatory process between these two types of cell populations has been reported by us in other neoplasias as well. We can conclude that peripheral immune cells can be useful for monitoring disease progression in these types of cancer.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_tablet=”” top_divider_height_phone=”77px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_tablet=”” bottom_divider_height_phone=”54px” bottom_divider_height_last_edited=”on|desktop” global_module=”516″ saved_tabs=”all”][et_pb_row column_structure=”3_5,2_5″ _builder_version=”3.25″ custom_padding=”61px|0px|69px|0px|false|false”][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.3.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark” text_line_height_tablet=”” text_line_height_phone=”1.2em” text_line_height_last_edited=”on|desktop”]<\/p>\n
Contact PDI 2020’s PCO<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro” submit_button_text=”Send” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Name” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”E-mail address” field_type=”email” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Message” field_type=”text” fullwidth_field=”on” _builder_version=”3.19.4″ button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.3.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
PCO of PDI 2020<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.3.4″ text_font=”||||||||”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAddress: A. Panu St. no. 13, Iasi<\/span>
Tel.: +40 332.40.88.05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|off|off” _builder_version=”3.22″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#f0622a” top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” collapsed=”off”][et_pb_fullwidth_header title=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IiIsImFmdGVyIjoiIn19@” text_orientation=”right” header_image_url=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2020\/03\/pdi2020_new.png” disabled_on=”on|on|off” _builder_version=”4.3.4″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”right” title_text_color=”#f0622a” title_font_size=”50px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” subhead_font=”||||||||” background_color=”rgba(239,145,107,0.54)” background_image=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/back.jpg” background_layout=”light” custom_margin=”0px||8px” custom_padding=”40px||40px||true” hover_enabled=”0″ content_font_size_tablet=”” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row column_structure=”2_5,3_5″ _builder_version=”3.25″][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/03\/Neagu-Monica.png” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ max_width=”35%” […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5513"}],"collection":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/comments?post=5513"}],"version-history":[{"count":5,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5513\/revisions"}],"predecessor-version":[{"id":8226,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5513\/revisions\/8226"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/media?parent=5513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
“Victor Babe\u015f” National Institute, Bucharest<\/strong><\/span>
Clinical Hospital “Colentina”, Bucharest<\/strong><\/span><\/h4>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.3.4″ hover_enabled=”0″]<\/p>\n
Immunological advances in cutaneous squamous cell carcinoma<\/span> Invasive cutaneous squamous cell carcinoma (cSCC) in Caucazian population is one of the most common cancers accounting for 20% of all cutaneous malignancies. cSCC etiopathogenesis has multi-factorial trait. Therefore, environmental factors like ultraviolet radiation exposure, advanced age, male sex, smoking along with genetic factors are contributing to the onset of cSCC. Immunosuppressive conditions, like HIV infection, transplant, or chronic lymphocytic leukemia (CLL), are immune-based favoring condition for cSCC. In immunosuppressed patients, locoregional recurrence has an increased incidence, the risk of metastatic cSCC doubles, hence the outcome for advanced disease is significantly worse. 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Authors: Monica Neagu, Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac<\/span><\/p>\n
\nIn the quest to both monitor and predict the disease recurrence we have embarked in the search of various immune-related markers that can hint towards the clinical outcome of patients.
\nIn cSCC patients before and after surgery peripheral blood was immediately tested for immune cell populations using flow citometry and the IVD kit BD Multitest™ IMK Kit. Within the test we have analyzed various immune cell circulatory populations: T lymphocytes (CD3+), B lymphocytes (CD19+), helper\/inducer T lymphocytes (CD3+CD4+), suppressor\/cytotoxic T lymphocytes (CD3+CD8+), and natural killer (NK) lymphocytes (CD3\u2013CD16+ and\/ or CD56+). For the investigated cases prior to the surgical resection total CD3+ T cells and CD4+ T cell sub-population were in the normal ranges. CD8+ T cells depicting cytotoxic lymphocytes are statistically reduced compared the normal values, thus leading to an increased ratio CD4\/CD8. In cCSC patients circulatory B lymphocytes (CD19+) have a decreased value while peripheral NK cells are increased. This immune compensatory process between these two types of cell populations has been reported by us in other neoplasias as well. We can conclude that peripheral immune cells can be useful for monitoring disease progression in these types of cancer.<\/p>\n<\/span><\/p>\n
Tel.: +40 332.40.88.05<\/span>
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