<\/strong><\/span><\/h4>\n<\/strong><\/span><\/h4>\nBrigitte Balme MD<\/strong><\/span>
CHLS Lyon France<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.4″][et_pb_column type=”4_4″ _builder_version=”3.19.4″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.4″]<\/p>\n
Muco-cutaneous Ulceration Associated with EBV in the Setting of immunosuppression with methotrexate<\/span>
Author: Brigitte Balme<\/span><\/p>\nHerein, we report a case of a 74 years old lady suffering from Rheumatoid Polyarthritis and thus treated by Methothrexate since 2008.
In October 2018, her hairdresser observed an asymptomatic purple plaque on the vertex. The lesion rapidly grew in to a 4cm ulcerated nodule.
A skin biopsy of the lesion was therefore performed. It showed diffuse infiltration of the dermis and hypodermis by large immunoblasts. The lesion was ulcerated. There was obvious necrosis in the lesion due to the angiocentrism iof the nfiltrate and vascular thrombosis.
The immunoblasts were B cells expressing CD20+, PAX5+, OCT2+), CD30+. We noted an Eber expression of RNA using the Fish technique. The ki67 proliferation index was about 70%. The PCR techniques demonstrated a rearrangement of kappa B and gamma T gene receptor .
We thereby proposed the diagnosis of muco-cutaneous ulceration associated with EBV in the setting of iatrogen immunosuppression with methotrexate.
It is a new entity described first in 2018 (OMS).
The lesion regressed completely when the treatment was discontinued.<\/p>\n
\n
Short CV<\/span><\/p>\nPathology Unit, Centre Hospitalier Lyon
Doctor es Medecine in 1980 (University of LYON France)
Certificat d\u2019\u00e9tudes sp\u00e9cialis\u00e9es de dermatologie (national board) in 1979
Certificat d\u2019\u00e9tudes sp\u00e9cialis\u00e9es d\u2019anatomie pathologie (national board) in 1983.<\/p>\n
Member of the French Society of Dermatology
Member of the section of dermatopathology of the French Society of Pathology
Member of the International Society of Dermatopathology
Functions
Since 1980 m\u00e9decin attach\u00e9 des H\u00f4pitaux
Since 1996, Praticien Hospitalier et since 2018, praticien hospitailer contractuel (department of dermatopathology, service of pathology, Pr M. Devouassoux, CHLS, Centre hospitalier Lyon Sud, 69415, PIERRE BENITE France).<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_phone=”77px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_phone=”54px” bottom_divider_height_last_edited=”on|desktop” global_module=”516″ saved_tabs=”all”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height_phone=”1.2em” text_line_height_last_edited=”on|desktop” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contact PDI 2019’s PCO<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro” submit_button_text=”Send” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Name” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”E-mail address” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Message” field_type=”text” fullwidth_field=”on” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
PCO of PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/p>\n
![\"\"](\"https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/eventer_logo_150px.png\")
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAddress: A. Panu St. no. 13, Iasi<\/span>
Tel.: +40 332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.4″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#f0622a” top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” collapsed=”off”][et_pb_fullwidth_header title=”{%22dynamic%22:true,%22content%22:%22post_title%22,%22settings%22:{%22before%22:%22%22,%22after%22:%22%22}}” text_orientation=”right” header_image_url=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/Primaderma2019_logo_300px.png” disabled_on=”on|on|off” _builder_version=”3.19.4″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”right” title_text_color=”#f0622a” title_font_size=”50px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop” subhead_font=”||||||||” background_color=”rgba(239,145,107,0.54)” background_image=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/back.jpg” background_layout=”light” custom_margin=”0px||8px” custom_padding=”40px||40px||true”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″][et_pb_row _builder_version=”3.19.4″][et_pb_column type=”2_5″ _builder_version=”3.19.4″ parallax=”off” parallax_method=”on”][et_pb_image align=”center” border_radii=”on|100px|100px|100px|100px” max_width=”35%” src=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/04\/Balme-Brigitte.png” _builder_version=”3.19.4″][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”3.19.4″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.4″] Brigitte […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5741"}],"collection":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/comments?post=5741"}],"version-history":[{"count":6,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5741\/revisions"}],"predecessor-version":[{"id":5767,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5741\/revisions\/5767"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/media?parent=5741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Brigitte Balme MD<\/strong><\/span>
CHLS Lyon France<\/strong><\/span><\/h4>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.19.4″][et_pb_column type=”4_4″ _builder_version=”3.19.4″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.4″]<\/p>\n
Muco-cutaneous Ulceration Associated with EBV in the Setting of immunosuppression with methotrexate<\/span>
Author: Brigitte Balme<\/span><\/p>\nHerein, we report a case of a 74 years old lady suffering from Rheumatoid Polyarthritis and thus treated by Methothrexate since 2008.
In October 2018, her hairdresser observed an asymptomatic purple plaque on the vertex. The lesion rapidly grew in to a 4cm ulcerated nodule.
A skin biopsy of the lesion was therefore performed. It showed diffuse infiltration of the dermis and hypodermis by large immunoblasts. The lesion was ulcerated. There was obvious necrosis in the lesion due to the angiocentrism iof the nfiltrate and vascular thrombosis.
The immunoblasts were B cells expressing CD20+, PAX5+, OCT2+), CD30+. We noted an Eber expression of RNA using the Fish technique. The ki67 proliferation index was about 70%. The PCR techniques demonstrated a rearrangement of kappa B and gamma T gene receptor .
We thereby proposed the diagnosis of muco-cutaneous ulceration associated with EBV in the setting of iatrogen immunosuppression with methotrexate.
It is a new entity described first in 2018 (OMS).
The lesion regressed completely when the treatment was discontinued.<\/p>\n
\n
Short CV<\/span><\/p>\nPathology Unit, Centre Hospitalier Lyon
Doctor es Medecine in 1980 (University of LYON France)
Certificat d\u2019\u00e9tudes sp\u00e9cialis\u00e9es de dermatologie (national board) in 1979
Certificat d\u2019\u00e9tudes sp\u00e9cialis\u00e9es d\u2019anatomie pathologie (national board) in 1983.<\/p>\n
Member of the French Society of Dermatology
Member of the section of dermatopathology of the French Society of Pathology
Member of the International Society of Dermatopathology
Functions
Since 1980 m\u00e9decin attach\u00e9 des H\u00f4pitaux
Since 1996, Praticien Hospitalier et since 2018, praticien hospitailer contractuel (department of dermatopathology, service of pathology, Pr M. Devouassoux, CHLS, Centre hospitalier Lyon Sud, 69415, PIERRE BENITE France).<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_phone=”77px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_phone=”54px” bottom_divider_height_last_edited=”on|desktop” global_module=”516″ saved_tabs=”all”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” text_line_height_phone=”1.2em” text_line_height_last_edited=”on|desktop” header_font=”||||||||” background_layout=”dark”]<\/p>\n
Contact PDI 2019’s PCO<\/p>\n
[\/et_pb_text][et_pb_contact_form email=”contact@primaderma.ro” submit_button_text=”Send” _builder_version=”3.19.4″ title_font=”||||||||”][et_pb_contact_field field_id=”Name” field_title=”Name” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”E-mail address” field_type=”email” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Message” field_type=”text” fullwidth_field=”on” _builder_version=”3.19.4″ border_radii=”on||||” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n
PCO of PDI 2019<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/p>\n
<\/span><\/p>\n<\/span><\/p>\n<\/span><\/p>\nAddress: A. Panu St. no. 13, Iasi<\/span>
Tel.: +40 332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.4″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#f0622a” top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” collapsed=”off”][et_pb_fullwidth_header title=”{%22dynamic%22:true,%22content%22:%22post_title%22,%22settings%22:{%22before%22:%22%22,%22after%22:%22%22}}” text_orientation=”right” header_image_url=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/Primaderma2019_logo_300px.png” disabled_on=”on|on|off” _builder_version=”3.19.4″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”right” title_text_color=”#f0622a” title_font_size=”50px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop” subhead_font=”||||||||” background_color=”rgba(239,145,107,0.54)” background_image=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/back.jpg” background_layout=”light” custom_margin=”0px||8px” custom_padding=”40px||40px||true”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″][et_pb_row _builder_version=”3.19.4″][et_pb_column type=”2_5″ _builder_version=”3.19.4″ parallax=”off” parallax_method=”on”][et_pb_image align=”center” border_radii=”on|100px|100px|100px|100px” max_width=”35%” src=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/04\/Balme-Brigitte.png” _builder_version=”3.19.4″][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”3.19.4″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.4″] Brigitte […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5741"}],"collection":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/comments?post=5741"}],"version-history":[{"count":6,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5741\/revisions"}],"predecessor-version":[{"id":5767,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5741\/revisions\/5767"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/media?parent=5741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Author: Brigitte Balme<\/span><\/p>\n
Herein, we report a case of a 74 years old lady suffering from Rheumatoid Polyarthritis and thus treated by Methothrexate since 2008.
In October 2018, her hairdresser observed an asymptomatic purple plaque on the vertex. The lesion rapidly grew in to a 4cm ulcerated nodule.
A skin biopsy of the lesion was therefore performed. It showed diffuse infiltration of the dermis and hypodermis by large immunoblasts. The lesion was ulcerated. There was obvious necrosis in the lesion due to the angiocentrism iof the nfiltrate and vascular thrombosis.
The immunoblasts were B cells expressing CD20+, PAX5+, OCT2+), CD30+. We noted an Eber expression of RNA using the Fish technique. The ki67 proliferation index was about 70%. The PCR techniques demonstrated a rearrangement of kappa B and gamma T gene receptor .
We thereby proposed the diagnosis of muco-cutaneous ulceration associated with EBV in the setting of iatrogen immunosuppression with methotrexate.
It is a new entity described first in 2018 (OMS).
The lesion regressed completely when the treatment was discontinued.<\/p>\n
\n
Short CV<\/span><\/p>\n Pathology Unit, Centre Hospitalier Lyon Member of the French Society of Dermatology [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″ background_color=”rgba(117,194,33,0.23)” background_image=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/back_justflowers_overlay1.png” background_blend=”luminosity” custom_padding=”54px|0px|0|0px|false|false” top_divider_style=”waves2″ top_divider_color=”#ffffff” top_divider_height=”155px” top_divider_height_phone=”77px” top_divider_height_last_edited=”on|desktop” bottom_divider_style=”waves2″ bottom_divider_color=”#75c221″ bottom_divider_flip=”vertical” bottom_divider_height_phone=”54px” bottom_divider_height_last_edited=”on|desktop” global_module=”516″ saved_tabs=”all”][et_pb_row custom_padding=”61px|0px|69px|0px|false|false” _builder_version=”3.18.9″][et_pb_column type=”3_5″ _builder_version=”3.18.9″ parallax=”off” parallax_method=”on”][et_pb_text 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button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.18.9″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.4″ text_font=”Kaushan Script||||||||” text_text_color=”#f0622a” text_font_size=”30px” header_font=”||||||||” background_layout=”dark”]<\/p>\n PCO of PDI 2019<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.19.4″ text_font=”||||||||”]<\/p>\n <\/span><\/p>\n <\/span><\/p>\n Address: A. Panu St. no. 13, Iasi<\/span> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" [et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.19.4″ custom_margin=”||” custom_padding=”15px||29px” top_divider_style=”waves2″ top_divider_color=”#f0622a” top_divider_flip=”horizontal|vertical” bottom_divider_style=”waves2″ bottom_divider_color=”#fcdedb” bottom_divider_height=”105px” bottom_divider_flip=”vertical” collapsed=”off”][et_pb_fullwidth_header title=”{%22dynamic%22:true,%22content%22:%22post_title%22,%22settings%22:{%22before%22:%22%22,%22after%22:%22%22}}” text_orientation=”right” header_image_url=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/Primaderma2019_logo_300px.png” disabled_on=”on|on|off” _builder_version=”3.19.4″ _dynamic_attributes=”title” title_font=”Kaushan Script||||||||” title_text_align=”right” title_text_color=”#f0622a” title_font_size=”50px” content_font=”|600||on|||||” content_text_align=”center” content_text_color=”#686766″ content_font_size=”15px” content_font_size_phone=”15px” content_font_size_last_edited=”on|desktop” subhead_font=”||||||||” background_color=”rgba(239,145,107,0.54)” background_image=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/01\/back.jpg” background_layout=”light” custom_margin=”0px||8px” custom_padding=”40px||40px||true”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.19.4″][et_pb_row _builder_version=”3.19.4″][et_pb_column type=”2_5″ _builder_version=”3.19.4″ parallax=”off” parallax_method=”on”][et_pb_image align=”center” border_radii=”on|100px|100px|100px|100px” max_width=”35%” src=”https:\/\/primaderma.ro\/en\/wp-content\/uploads\/2019\/04\/Balme-Brigitte.png” _builder_version=”3.19.4″][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”3.19.4″ parallax=”off” parallax_method=”on”][et_pb_text _builder_version=”3.19.4″] Brigitte […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5741"}],"collection":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/comments?post=5741"}],"version-history":[{"count":6,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5741\/revisions"}],"predecessor-version":[{"id":5767,"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/pages\/5741\/revisions\/5767"}],"wp:attachment":[{"href":"https:\/\/pdi.ro\/en\/wp-json\/wp\/v2\/media?parent=5741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Doctor es Medecine in 1980 (University of LYON France)
Certificat d\u2019\u00e9tudes sp\u00e9cialis\u00e9es de dermatologie (national board) in 1979
Certificat d\u2019\u00e9tudes sp\u00e9cialis\u00e9es d\u2019anatomie pathologie (national board) in 1983.<\/p>\n
Member of the section of dermatopathology of the French Society of Pathology
Member of the International Society of Dermatopathology
Functions
Since 1980 m\u00e9decin attach\u00e9 des H\u00f4pitaux
Since 1996, Praticien Hospitalier et since 2018, praticien hospitailer contractuel (department of dermatopathology, service of pathology, Pr M. Devouassoux, CHLS, Centre hospitalier Lyon Sud, 69415, PIERRE BENITE France).<\/p>\n<\/span><\/p>\n
Tel.: +40 332.40.88.00-05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n