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Proteomics approaches for circulating biomarkers in skin cancer<\/span> The immune backdrop in tumor process grasps a key role in antitumor therapy efficacy assessment. Evaluating certain potential biomarkers for therapy response prediction is nowadays an expanding domain. Besides biomarkers, omics methodologies and biomedical modern techniques are a robust tool mandatory for assuring data consistency, accuracy and reproducibility. Within proteomics platforms, protein microarray resides in a specific and important niche for biomarkers discovery, taking into account that in the last decade formats for diagnostic purposes has been also developed. 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Authors: Carolina Constantin, Mihaela Surcel, Ana Caruntu, Sabina Zurac, Monica Neagu <\/span><\/p>\n
\nImmune cell populations are an invaluable biomarkers source that should be continuously correlated with actual therapeutic tendencies including immune checkpoint inhibitors, bi-specific antibodies and anti-tumor vaccines. In skin cancer, especially in cutaneous melanoma, high tumor heterogeneity and complex immune interactions claims combining analysis methods from genes signatures to cellular phenotype decoding. As proteins dictate phenotype fate, proteomic approaches would measure biological effects caused by genomic alterations. Soluble biomarkers such as cytokines or different growth factors (e.g., MIF, IL-6, IL-10 etc.) could generate an inflammatory milieu representing a steady component of neoplastic process. Other unconventional factors in relation to markers studied in tumor framework (e.g. leptin) could correlate immune and metabolic axis sustaining the tumor therapy efficacy assessment. Thus, recent data reveal that leptin, a hormone increased in obesity, directly influence T cells function and further PD-1 axis blockade response. Deciphering mechanisms underlying pathological processes would be insufficient only by genomic lens. Proteomic approaches detect protein alterations levels but also expand knowledge through important physiological axis to new therapeutic targets characterization.<\/p>\n
Tel.: +40 332.40.88.05<\/span>
E-mail: inscrieri@primaderma.ro<\/a>
<\/span>Website:\u00a0<\/span>www.eventernet.ro<\/a><\/p>\n